SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9RB01

- BLAB2_ELIME

UniProt

Q9RB01 - BLAB2_ELIME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Carbapenem-hydrolyzing beta-lactamase BlaB-2
Gene
blaB2, blaB
Organism
Elizabethkingia meningoseptica (Chryseobacterium meningosepticum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes penicillins, cephalosporins (including cefoxitin), carbapenems and 6-beta-iodopenicillanate By similarity.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi98 – 981Zinc 1 By similarity
Metal bindingi100 – 1001Zinc 1 By similarity
Metal bindingi102 – 1021Zinc 2 By similarity
Metal bindingi161 – 1611Zinc 1 By similarity
Metal bindingi180 – 1801Zinc 2 By similarity
Metal bindingi222 – 2221Zinc 2 By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Carbapenem-hydrolyzing beta-lactamase BlaB-2 (EC:3.5.2.6)
Short name:
CHbetaL-2
Alternative name(s):
Class B carbapenemase BlaB-2
Gene namesi
Name:blaB2
Synonyms:blaB
OrganismiElizabethkingia meningoseptica (Chryseobacterium meningosepticum)
Taxonomic identifieri238 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeElizabethkingia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 By similarity
Add
BLAST
Chaini23 – 249227Carbapenem-hydrolyzing beta-lactamase BlaB-2
PRO_0000016950Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9RB01.
SMRiQ9RB01. Positions 27-245.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
PROSITEiPS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9RB01-1 [UniParc]FASTAAdd to Basket

« Hide

MLKKIKISLI LALGLTSLQA FGQENPDVKI DKLKDNLYVY TTYNTFNGTK    50
YAANAVYLVT DKGVVVIDCP WGEDKFKSFT DEIYKKHGKK VIMNIATHSH 100
DDRAGGLEYF GKIGAKTYST KMTDSILAKE NKPRAQYTFD NNKSFKVGKS 150
EFQVYYPGKG HTADNVVVWF PKEKVLVGGC IIKSADSKDL GYIGEAYVND 200
WTQSVHNIQQ KFSGAQYVVA GHDDWKDQRS IQRTLDLINE YQQKQKASN 249
Length:249
Mass (Da):28,149
Last modified:May 1, 2000 - v1
Checksum:iFE6050F18DF898E6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF126542 Genomic DNA. Translation: AAD43145.1.
AF189300 Genomic DNA. Translation: AAF89156.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF126542 Genomic DNA. Translation: AAD43145.1 .
AF189300 Genomic DNA. Translation: AAF89156.1 .

3D structure databases

ProteinModelPortali Q9RB01.
SMRi Q9RB01. Positions 27-245.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.15.10. 1 hit.
InterProi IPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view ]
Pfami PF00753. Lactamase_B. 1 hit.
[Graphical view ]
SMARTi SM00849. Lactamase_B. 1 hit.
[Graphical view ]
SUPFAMi SSF56281. SSF56281. 1 hit.
PROSITEi PS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the beta-lactamase gene, blaB2, conferring resistance to carbapenem antibiotics in a clinical isolate of Chryseobacterium (Flavobacterium) meningosepticum."
    Woodford N., Babini G.S., Palepou M.-F.I., Livermore D.M.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 97/P/5448.
  2. "Molecular and biochemical heterogeneity of class B carbapenem-hydrolyzing beta-lactamases in Chryseobacterium meningosepticum."
    Bellais S., Aubert D., Naas T., Nordmann P.
    Antimicrob. Agents Chemother. 44:1878-1886(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AMA.

Entry informationi

Entry nameiBLAB2_ELIME
AccessioniPrimary (citable) accession number: Q9RB01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi