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Q9RAJ5

- PUR9_MYCPA

UniProt

Q9RAJ5 - PUR9_MYCPA

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (15 Mar 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciMAVI262316:GCQR-920-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:MAP_0903
    OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
    Taxonomic identifieri262316 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
    ProteomesiUP000000580: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 527527Bifunctional purine biosynthesis protein PurHPRO_0000192105Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262316.MAP0903.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9RAJ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    KOiK00602.
    OMAiHRRAHAC.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9RAJ5-1 [UniParc]FASTAAdd to Basket

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    MSTDDWRENA KRPIRRALIS VYDKTGLVEL AQGLTEAGVE IVSTGSTAKV    50
    IAEKGIPVTR VEVLTGFPEV LDGRVKTLHP RVHAGLLADL RKPEHAAALE 100
    QLGIAAFELV VVNLYPFTET VDSGAGIDEC VEQIDIGGPS MVRAAAKNHP 150
    SVAVVVDPLG YDGVLAAVRH GGFTLAERKR LAALAFQHTA DYDIAVATWM 200
    ESTLAPEHPP TTFPKWLGRS WRRSAMLRYG ENPHQQASLY SDPGAWPGLA 250
    QAEQLHGKEM SYNNFTDADA AWRAAFDHEQ TCVAIIKHAN PCGIAISSIS 300
    VADAHRKAHE CDPLSAFGGV IAANTEVSVE MAEYVSTIFT EVIIAPAYQP 350
    AALEILTRKK NIRVLVASEP LTGGTELRPI SGGLLVQQRD ELDAHGDNPA 400
    NWTLATGAPA DPATLADLVF AWRVCRAVKS NAIVIAAGGA TIGVGMGQVN 450
    RVDAARLAVE RGGDRVRGAV AASDAFFPFP DGLETLTGAG VKAVVHPGGS 500
    VRDDEVTAAA ANAGITLYLT GARHFAH 527
    Length:527
    Mass (Da):55,888
    Last modified:March 15, 2004 - v2
    Checksum:i8B4459CFB40EC338
    GO

    Sequence cautioni

    The sequence AAS03220.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti63 – 631V → E in AAF05727. 1 PublicationCurated
    Sequence conflicti522 – 5221A → V in AAF05727. 1 PublicationCurated
    Sequence conflicti526 – 5261A → V in AAF05727. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF191543 Genomic DNA. Translation: AAF05727.1.
    AE016958 Genomic DNA. Translation: AAS03220.1. Different initiation.
    RefSeqiNP_959837.1. NC_002944.2.

    Genome annotation databases

    EnsemblBacteriaiAAS03220; AAS03220; MAP_0903.
    GeneIDi2718397.
    KEGGimpa:MAP0903.
    PATRICi17994221. VBIMycAvi108102_0944.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF191543 Genomic DNA. Translation: AAF05727.1 .
    AE016958 Genomic DNA. Translation: AAS03220.1 . Different initiation.
    RefSeqi NP_959837.1. NC_002944.2.

    3D structure databases

    ProteinModelPortali Q9RAJ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262316.MAP0903.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS03220 ; AAS03220 ; MAP_0903 .
    GeneIDi 2718397.
    KEGGi mpa:MAP0903.
    PATRICi 17994221. VBIMycAvi108102_0944.

    Phylogenomic databases

    eggNOGi COG0138.
    KOi K00602.
    OMAi HRRAHAC.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci MAVI262316:GCQR-920-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the purine biosynthetic genes purN and purH in Mycobacterium avium subsp. paratuberculosis."
      Urbanic K.U., Raymond M., Mutharia L.M.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 19698 / CIP 103963 / DSM 44133 / TMC 807.
    2. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
      Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
      Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-968 / K-10.

    Entry informationi

    Entry nameiPUR9_MYCPA
    AccessioniPrimary (citable) accession number: Q9RAJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: March 15, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3