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Q9RAE7

- ALR2_RHIL3

UniProt

Q9RAE7 - ALR2_RHIL3

Protein

Alanine racemase, catabolic

Gene

dadX

Organism
Rhizobium leguminosarum bv. viciae (strain 3841)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 3 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by DadA.

    Catalytic activityi

    L-alanine = D-alanine.

    Cofactori

    Pyridoxal phosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei51 – 511Proton acceptor; specific for D-alanineBy similarity
    Binding sitei150 – 1501SubstrateBy similarity
    Active sitei272 – 2721Proton acceptor; specific for L-alanineBy similarity
    Binding sitei320 – 3201Substrate; via amide nitrogenBy similarity

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. alanine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciRLEG216596:GKE5-5230-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemase, catabolic (EC:5.1.1.1)
    Gene namesi
    Name:dadX
    Ordered Locus Names:pRL120416
    Encoded oniPlasmid pRL121 Publication
    OrganismiRhizobium leguminosarum bv. viciae (strain 3841)
    Taxonomic identifieri216596 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
    ProteomesiUP000006575: Plasmid pRL12

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377Alanine racemase, catabolicPRO_0000114554Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei51 – 511N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi216596.pRL120416.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9RAE7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.Curated

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031445.
    KOiK01775.
    OMAiFIMSHLA.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9RAE7-1 [UniParc]FASTAAdd to Basket

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    MDSDILVSRT RTATIAQGAT GYLMIDLAAL GRNYRKLVSM LAPVRAGAVV    50
    KADAYGLGAE RVARTLYSEG CRHFFVAQFV EAVRLRPALA HDAQIFVLNG 100
    LQPGNEIACA EMGIVPVLNS LAQWRQWSAA ARILKRCLPA VLQFDTGMSR 150
    LGFPREERRE LAAALRDGSN VEILFIMSHL ASADDMGSEQ NGEQFAEMSR 200
    IADEFPGFDI SFANSGGVFL GEAYYGVLAR PGIALYGGAP NAGEKNPMEP 250
    VVSLNVAVVQ TRTVPAGAKV GYGGAHVTQR ETRLATIAAG YADGLPRCLS 300
    DRGAVYFKGV RLPIVGRVSM DSTTVDITAL PEGALTFGSL VEVLGRHQTL 350
    EDIARDAGTI SYEILTGLGD RYDRQYR 377
    Length:377
    Mass (Da):40,548
    Last modified:June 27, 2006 - v3
    Checksum:iBB38DAC35BD3DBF2
    GO

    Sequence cautioni

    The sequence CAB53547.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ249196 Genomic DNA. Translation: CAB53547.1. Different initiation.
    AM236086 Genomic DNA. Translation: CAK12125.1.
    RefSeqiYP_764923.1. NC_008378.1.

    Genome annotation databases

    EnsemblBacteriaiCAK12125; CAK12125; pRL120416.
    GeneIDi4398234.
    KEGGirle:pRL120416.
    PATRICi23134919. VBIRhiLeg32091_0421.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ249196 Genomic DNA. Translation: CAB53547.1 . Different initiation.
    AM236086 Genomic DNA. Translation: CAK12125.1 .
    RefSeqi YP_764923.1. NC_008378.1.

    3D structure databases

    ProteinModelPortali Q9RAE7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216596.pRL120416.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAK12125 ; CAK12125 ; pRL120416 .
    GeneIDi 4398234.
    KEGGi rle:pRL120416.
    PATRICi 23134919. VBIRhiLeg32091_0421.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031445.
    KOi K01775.
    OMAi FIMSHLA.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    BioCyci RLEG216596:GKE5-5230-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of alanine dehydrogenase and its role in mixed secretion of ammonium and alanine by pea bacteroids."
      Allaway D.A., Lodwig E.M., Crompton L.A., Wood M., Parsons R., Wheeler T.R., Poole P.S.
      Mol. Microbiol. 36:508-515(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 3841.
      Plasmid: pRL12

    Entry informationi

    Entry nameiALR2_RHIL3
    AccessioniPrimary (citable) accession number: Q9RAE7
    Secondary accession number(s): Q1M447
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 5, 2002
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 89 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3