Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q9RAE7 (ALR2_RHIL3)

Last modified January 19, 2010. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Alanine racemase, catabolic
    EC=5.1.1.1
Gene names
Name: dadX
Ordered Locus Names: pRL120416
Encoded onPlasmid pRL12 Ref.2
OrganismRhizobium leguminosarum bv. viciae (strain 3841) [Complete proteome] [HAMAP]
Taxonomic identifier216596 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by dadA. HAMAP MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201

Induction

By alanine. HAMAP MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Alanine racemase, catabolic HAMAP MF_01201
PRO_0000114554

Sites

Active site511Proton acceptor; specific for D-alanine By similarity
Active site2721Proton acceptor; specific for L-alanine By similarity

Amino acid modifications

Modified residue511N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9RAE7-1 [UniParc].

Last modified June 27, 2006. Version 3.
Checksum: BB38DAC35BD3DBF2

FASTA37740,548
        10         20         30         40         50         60 
MDSDILVSRT RTATIAQGAT GYLMIDLAAL GRNYRKLVSM LAPVRAGAVV KADAYGLGAE 

        70         80         90        100        110        120 
RVARTLYSEG CRHFFVAQFV EAVRLRPALA HDAQIFVLNG LQPGNEIACA EMGIVPVLNS 

       130        140        150        160        170        180 
LAQWRQWSAA ARILKRCLPA VLQFDTGMSR LGFPREERRE LAAALRDGSN VEILFIMSHL 

       190        200        210        220        230        240 
ASADDMGSEQ NGEQFAEMSR IADEFPGFDI SFANSGGVFL GEAYYGVLAR PGIALYGGAP 

       250        260        270        280        290        300 
NAGEKNPMEP VVSLNVAVVQ TRTVPAGAKV GYGGAHVTQR ETRLATIAAG YADGLPRCLS 

       310        320        330        340        350        360 
DRGAVYFKGV RLPIVGRVSM DSTTVDITAL PEGALTFGSL VEVLGRHQTL EDIARDAGTI 

       370 
SYEILTGLGD RYDRQYR 

« Hide

References

« Hide 'large scale' references
[1]"Identification of alanine dehydrogenase and its role in mixed secretion of ammonium and alanine by pea bacteroids."
Allaway D.A., Lodwig E.M., Crompton L.A., Wood M., Parsons R., Wheeler T.R., Poole P.S.
Mol. Microbiol. 36:508-515(2000) [PubMed: 10792736] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome of Rhizobium leguminosarum has recognizable core and accessory components."
Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R., Ghazoui Z.F., Hull K.H., Wexler M., Curson A.R.J., Todd J.D., Poole P.S., Mauchline T.H., East A.K., Quail M.A., Churcher C., Arrowsmith C., Cherevach I., Chillingworth T., Clarke K. expand/collapse author list , Cronin A., Davis P., Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M., Whitehead S., Parkhill J.
Genome Biol. 7:R34.1-R34.20(2006) [PubMed: 16640791] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ249196 Genomic DNA. Translation: CAB53547.1. Different initiation.
AM236086 Genomic DNA. Translation: CAK12125.1.
RefSeqYP_764923.1.

3D structure databases

SMRQ9RAE7. Positions 22-377.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9RAE7.

Genome annotation databases

GeneID4398234.
GenomeReviewsGene locus pRL120416 in contig AM236086_GR.
KEGGrle:pRL120416.
NMPDRfig|216596.1.peg.6120.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHBG712172.
OMARIADEFP.
PhylomeDBQ9RAE7.

Family and domain databases

HAMAPMF_01201. Ala_racemase.
[Tree]
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR2_RHIL3
AccessionPrimary (citable) accession number: Q9RAE7
Secondary accession number(s): Q1M447
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 27, 2006
Last modified: January 19, 2010
This is version 60 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents