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Q9RAE7

- ALR2_RHIL3

UniProt

Q9RAE7 - ALR2_RHIL3

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Protein
Alanine racemase, catabolic
Gene
dadX, pRL120416
Organism
Rhizobium leguminosarum bv. viciae (strain 3841)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by DadA.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511Proton acceptor; specific for D-alanine By similarity
Binding sitei150 – 1501Substrate By similarity
Active sitei272 – 2721Proton acceptor; specific for L-alanine By similarity
Binding sitei320 – 3201Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. alanine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRLEG216596:GKE5-5230-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemase, catabolic (EC:5.1.1.1)
Gene namesi
Name:dadX
Ordered Locus Names:pRL120416
Encoded oniPlasmid pRL121 Publication
OrganismiRhizobium leguminosarum bv. viciae (strain 3841)
Taxonomic identifieri216596 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000006575: Plasmid pRL12

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Alanine racemase, catabolicUniRule annotation
PRO_0000114554Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi216596.pRL120416.

Structurei

3D structure databases

ProteinModelPortaliQ9RAE7.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031445.
KOiK01775.
OMAiFIMSHLA.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RAE7-1 [UniParc]FASTAAdd to Basket

« Hide

MDSDILVSRT RTATIAQGAT GYLMIDLAAL GRNYRKLVSM LAPVRAGAVV    50
KADAYGLGAE RVARTLYSEG CRHFFVAQFV EAVRLRPALA HDAQIFVLNG 100
LQPGNEIACA EMGIVPVLNS LAQWRQWSAA ARILKRCLPA VLQFDTGMSR 150
LGFPREERRE LAAALRDGSN VEILFIMSHL ASADDMGSEQ NGEQFAEMSR 200
IADEFPGFDI SFANSGGVFL GEAYYGVLAR PGIALYGGAP NAGEKNPMEP 250
VVSLNVAVVQ TRTVPAGAKV GYGGAHVTQR ETRLATIAAG YADGLPRCLS 300
DRGAVYFKGV RLPIVGRVSM DSTTVDITAL PEGALTFGSL VEVLGRHQTL 350
EDIARDAGTI SYEILTGLGD RYDRQYR 377
Length:377
Mass (Da):40,548
Last modified:June 27, 2006 - v3
Checksum:iBB38DAC35BD3DBF2
GO

Sequence cautioni

The sequence CAB53547.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ249196 Genomic DNA. Translation: CAB53547.1. Different initiation.
AM236086 Genomic DNA. Translation: CAK12125.1.
RefSeqiYP_764923.1. NC_008378.1.

Genome annotation databases

EnsemblBacteriaiCAK12125; CAK12125; pRL120416.
GeneIDi4398234.
KEGGirle:pRL120416.
PATRICi23134919. VBIRhiLeg32091_0421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ249196 Genomic DNA. Translation: CAB53547.1 . Different initiation.
AM236086 Genomic DNA. Translation: CAK12125.1 .
RefSeqi YP_764923.1. NC_008378.1.

3D structure databases

ProteinModelPortali Q9RAE7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216596.pRL120416.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAK12125 ; CAK12125 ; pRL120416 .
GeneIDi 4398234.
KEGGi rle:pRL120416.
PATRICi 23134919. VBIRhiLeg32091_0421.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031445.
KOi K01775.
OMAi FIMSHLA.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

BioCyci RLEG216596:GKE5-5230-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of alanine dehydrogenase and its role in mixed secretion of ammonium and alanine by pea bacteroids."
    Allaway D.A., Lodwig E.M., Crompton L.A., Wood M., Parsons R., Wheeler T.R., Poole P.S.
    Mol. Microbiol. 36:508-515(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 3841.
    Plasmid: pRL12

Entry informationi

Entry nameiALR2_RHIL3
AccessioniPrimary (citable) accession number: Q9RAE7
Secondary accession number(s): Q1M447
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 27, 2006
Last modified: June 11, 2014
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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