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Protein

Alanine racemase, catabolic

Gene

dadX

Organism
Rhizobium leguminosarum bv. viciae (strain 3841)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by DadA.

Catalytic activityi

L-alanine = D-alanine.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511Proton acceptor; specific for D-alanineBy similarity
Binding sitei150 – 1501SubstrateBy similarity
Active sitei272 – 2721Proton acceptor; specific for L-alanineBy similarity
Binding sitei320 – 3201Substrate; via amide nitrogenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRLEG216596:GKE5-5230-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemase, catabolic (EC:5.1.1.1)
Gene namesi
Name:dadX
Ordered Locus Names:pRL120416
Encoded oniPlasmid pRL121 Publication
OrganismiRhizobium leguminosarum bv. viciae (strain 3841)
Taxonomic identifieri216596 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000006575 Componenti: Plasmid pRL12

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Alanine racemase, catabolicPRO_0000114554Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511N6-(pyridoxal phosphate)lysineBy similarity

Structurei

3D structure databases

ProteinModelPortaliQ9RAE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.Curated

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031445.
KOiK01775.
OMAiEILFIMS.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RAE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDILVSRT RTATIAQGAT GYLMIDLAAL GRNYRKLVSM LAPVRAGAVV
60 70 80 90 100
KADAYGLGAE RVARTLYSEG CRHFFVAQFV EAVRLRPALA HDAQIFVLNG
110 120 130 140 150
LQPGNEIACA EMGIVPVLNS LAQWRQWSAA ARILKRCLPA VLQFDTGMSR
160 170 180 190 200
LGFPREERRE LAAALRDGSN VEILFIMSHL ASADDMGSEQ NGEQFAEMSR
210 220 230 240 250
IADEFPGFDI SFANSGGVFL GEAYYGVLAR PGIALYGGAP NAGEKNPMEP
260 270 280 290 300
VVSLNVAVVQ TRTVPAGAKV GYGGAHVTQR ETRLATIAAG YADGLPRCLS
310 320 330 340 350
DRGAVYFKGV RLPIVGRVSM DSTTVDITAL PEGALTFGSL VEVLGRHQTL
360 370
EDIARDAGTI SYEILTGLGD RYDRQYR
Length:377
Mass (Da):40,548
Last modified:June 27, 2006 - v3
Checksum:iBB38DAC35BD3DBF2
GO

Sequence cautioni

The sequence CAB53547.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249196 Genomic DNA. Translation: CAB53547.1. Different initiation.
AM236086 Genomic DNA. Translation: CAK12125.1.
RefSeqiWP_011649181.1. NC_008378.1.

Genome annotation databases

EnsemblBacteriaiCAK12125; CAK12125; pRL120416.
KEGGirle:pRL120416.
PATRICi23134919. VBIRhiLeg32091_0421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249196 Genomic DNA. Translation: CAB53547.1. Different initiation.
AM236086 Genomic DNA. Translation: CAK12125.1.
RefSeqiWP_011649181.1. NC_008378.1.

3D structure databases

ProteinModelPortaliQ9RAE7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAK12125; CAK12125; pRL120416.
KEGGirle:pRL120416.
PATRICi23134919. VBIRhiLeg32091_0421.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031445.
KOiK01775.
OMAiEILFIMS.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

BioCyciRLEG216596:GKE5-5230-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of alanine dehydrogenase and its role in mixed secretion of ammonium and alanine by pea bacteroids."
    Allaway D.A., Lodwig E.M., Crompton L.A., Wood M., Parsons R., Wheeler T.R., Poole P.S.
    Mol. Microbiol. 36:508-515(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 3841.
    Plasmid: pRL12

Entry informationi

Entry nameiALR2_RHIL3
AccessioniPrimary (citable) accession number: Q9RAE7
Secondary accession number(s): Q1M447
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 27, 2006
Last modified: July 22, 2015
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.