Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9RAA9 (DPO1_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA polymerase I

Short name=POL I
EC=2.7.7.7
Gene names
Name:polA
Ordered Locus Names:RF_1239
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length922 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In addition to polymerase activity, this DNA polymerase 5' to 3' exonuclease activity By similarity.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Subunit structure

Single-chain monomer with multiple functions By similarity.

Sequence similarities

Belongs to the DNA polymerase type-A family.

Contains 1 5'-3' exonuclease domain.

Contains 1 RPE1 insert domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 922922DNA polymerase I
PRO_0000101249

Regions

Domain1 – 2832835'-3' exonuclease
Domain439 – 48749RPE1 insert

Sequences

Sequence LengthMass (Da)Tools
Q9RAA9 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: EA47F799536948A0

FASTA922104,006
        10         20         30         40         50         60 
MTQKNTLLLI DGYGFVFRAY YAQQPLTSPK GEPVGALYGF ASMLLKLLSD FKPKHVAVVF 

        70         80         90        100        110        120 
DSGGKNFRHH IYPEYKANRP PPPEDLVVQL PLVRDVASNL NFPILEKNGY EADDIIATFA 

       130        140        150        160        170        180 
AKTAALGEDV VVISSDKDLL QLMGENIKIY DPLKGKYITE DDVVKKFGTT SDKLREVMAL 

       190        200        210        220        230        240 
IGDRSDNIPG VPSIGPKTAS SLITQFGSVE NIFNSLEQVS SLKQRETLQN SKEAALISWQ 

       250        260        270        280        290        300 
LIGLDSNVDL DFQLNNLEWS PPNSDKLTGF LQEYGFKSLY KRAENLFDIK INDHKEIVEN 

       310        320        330        340        350        360 
KVTEAKEISN ASELADFAKK AEKIGIFGIY LLQHKGDNVA LILSLQNQSY IIKISNTSHD 

       370        380        390        400        410        420 
LFSYNTKNNN DWFSDIIFNL LTDKSIRKIT YSLKPLLKFY AEQSHEITAI EDLELMQYAL 

       430        440        450        460        470        480 
SAGLSQKNLF EEALKEDNRH LSKPAYREEF KGDTEALATA AYKSVREDAS TGSTSKLPLE 

       490        500        510        520        530        540 
TKFGKMSNVI NESARIVAEF TSLYKQNILE LKDNKAFRLY SNIDLPICFI LDKMEKIGIK 

       550        560        570        580        590        600 
VDANYLNQLS AEFGAEILKL EEEIFALSGT KFNIGSPKQL GEILFEKMQL PFGKASAKAS 

       610        620        630        640        650        660 
SYSTGAEILE KLSEHGYNIA DLLLRWRQLT KLKNTYTDSL PKQIDNITHR VHTTFLQTST 

       670        680        690        700        710        720 
TTGRLSSQEP NLQNVPIRSS EGNKIRQAFI AEEGYKLISA DYSQIELRIL SHIANIDALK 

       730        740        750        760        770        780 
QAFINKDDIH TQTACQIFNL QKHELTSEHR RKAKAINFGI IYGISAFGLA KQLNVSNGEA 

       790        800        810        820        830        840 
SEYIKKYFAE YKGVQEYMEQ TKAFASSNGY VINFFGRKCF VPLIHDKKLK QFAERAAINA 

       850        860        870        880        890        900 
PIQGTNADII KIAMINLDQE IEKNNLKTRL VLQIHDELLF EVPEDEVELV TPIIKKIMEN 

       910        920 
STNMDVPIIT EIRVGNNWME IH 

« Hide

References

« Hide 'large scale' references
[1]"Genome degradation is an ongoing process in Rickettsia."
Andersson J.O., Andersson S.G.E.
Mol. Biol. Evol. 16:1178-1191(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.
[3]"Selfish DNA in protein-coding genes of Rickettsia."
Ogata H., Audic S., Barbe V., Artiguenave F., Fournier P.-E., Raoult D., Claverie J.-M.
Science 290:347-350(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: DOMAIN RPE1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ238763 Genomic DNA. Translation: CAB56067.1.
CP000053 Genomic DNA. Translation: AAY62090.1.
RefSeqYP_247255.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ9RAA9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_1239.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY62090; AAY62090; RF_1239.
GeneID3401350.
KEGGrfe:RF_1239.
PATRIC17893358. VBIRicFel64634_1491.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0258.
HOGENOMHOG000020998.
KOK02335.
OMAAPMQGSA.
OrthoDBEOG6SJJH7.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-1274-MONOMER.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProIPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR005728. Rickett_RPE.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSPR00868. DNAPOLI.
SMARTSM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsTIGR00593. pola. 1 hit.
TIGR01045. RPE1. 1 hit.
PROSITEPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDPO1_RICFE
AccessionPrimary (citable) accession number: Q9RAA9
Secondary accession number(s): Q4UK45
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names