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Q9RAA9

- DPO1_RICFE

UniProt

Q9RAA9 - DPO1_RICFE

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Protein
DNA polymerase I
Gene
polA, RF_1239
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase 5' to 3' exonuclease activity By similarity.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
  3. exonuclease activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1274-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
Gene namesi
Name:polA
Ordered Locus Names:RF_1239
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 922922DNA polymerase I
PRO_0000101249Add
BLAST

Interactioni

Subunit structurei

Single-chain monomer with multiple functions By similarity.

Protein-protein interaction databases

STRINGi315456.RF_1239.

Structurei

3D structure databases

ProteinModelPortaliQ9RAA9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 2832835'-3' exonuclease
Add
BLAST
Domaini439 – 48749RPE1 insert
Add
BLAST

Sequence similaritiesi

Contains 1 RPE1 insert domain.

Phylogenomic databases

eggNOGiCOG0258.
HOGENOMiHOG000020998.
KOiK02335.
OMAiAPMQGSA.
OrthoDBiEOG6SJJH7.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProiIPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR005728. Rickett_RPE.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSiPR00868. DNAPOLI.
SMARTiSM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
TIGR01045. RPE1. 1 hit.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RAA9-1 [UniParc]FASTAAdd to Basket

« Hide

MTQKNTLLLI DGYGFVFRAY YAQQPLTSPK GEPVGALYGF ASMLLKLLSD    50
FKPKHVAVVF DSGGKNFRHH IYPEYKANRP PPPEDLVVQL PLVRDVASNL 100
NFPILEKNGY EADDIIATFA AKTAALGEDV VVISSDKDLL QLMGENIKIY 150
DPLKGKYITE DDVVKKFGTT SDKLREVMAL IGDRSDNIPG VPSIGPKTAS 200
SLITQFGSVE NIFNSLEQVS SLKQRETLQN SKEAALISWQ LIGLDSNVDL 250
DFQLNNLEWS PPNSDKLTGF LQEYGFKSLY KRAENLFDIK INDHKEIVEN 300
KVTEAKEISN ASELADFAKK AEKIGIFGIY LLQHKGDNVA LILSLQNQSY 350
IIKISNTSHD LFSYNTKNNN DWFSDIIFNL LTDKSIRKIT YSLKPLLKFY 400
AEQSHEITAI EDLELMQYAL SAGLSQKNLF EEALKEDNRH LSKPAYREEF 450
KGDTEALATA AYKSVREDAS TGSTSKLPLE TKFGKMSNVI NESARIVAEF 500
TSLYKQNILE LKDNKAFRLY SNIDLPICFI LDKMEKIGIK VDANYLNQLS 550
AEFGAEILKL EEEIFALSGT KFNIGSPKQL GEILFEKMQL PFGKASAKAS 600
SYSTGAEILE KLSEHGYNIA DLLLRWRQLT KLKNTYTDSL PKQIDNITHR 650
VHTTFLQTST TTGRLSSQEP NLQNVPIRSS EGNKIRQAFI AEEGYKLISA 700
DYSQIELRIL SHIANIDALK QAFINKDDIH TQTACQIFNL QKHELTSEHR 750
RKAKAINFGI IYGISAFGLA KQLNVSNGEA SEYIKKYFAE YKGVQEYMEQ 800
TKAFASSNGY VINFFGRKCF VPLIHDKKLK QFAERAAINA PIQGTNADII 850
KIAMINLDQE IEKNNLKTRL VLQIHDELLF EVPEDEVELV TPIIKKIMEN 900
STNMDVPIIT EIRVGNNWME IH 922
Length:922
Mass (Da):104,006
Last modified:May 1, 2000 - v1
Checksum:iEA47F799536948A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ238763 Genomic DNA. Translation: CAB56067.1.
CP000053 Genomic DNA. Translation: AAY62090.1.
RefSeqiWP_011271539.1. NC_007109.1.
YP_247255.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY62090; AAY62090; RF_1239.
GeneIDi3401350.
KEGGirfe:RF_1239.
PATRICi17893358. VBIRicFel64634_1491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ238763 Genomic DNA. Translation: CAB56067.1 .
CP000053 Genomic DNA. Translation: AAY62090.1 .
RefSeqi WP_011271539.1. NC_007109.1.
YP_247255.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q9RAA9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_1239.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY62090 ; AAY62090 ; RF_1239 .
GeneIDi 3401350.
KEGGi rfe:RF_1239.
PATRICi 17893358. VBIRicFel64634_1491.

Phylogenomic databases

eggNOGi COG0258.
HOGENOMi HOG000020998.
KOi K02335.
OMAi APMQGSA.
OrthoDBi EOG6SJJH7.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-1274-MONOMER.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProi IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR005728. Rickett_RPE.
IPR012337. RNaseH-like_dom.
[Graphical view ]
Pfami PF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view ]
PRINTSi PR00868. DNAPOLI.
SMARTi SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsi TIGR00593. pola. 1 hit.
TIGR01045. RPE1. 1 hit.
PROSITEi PS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome degradation is an ongoing process in Rickettsia."
    Andersson J.O., Andersson S.G.E.
    Mol. Biol. Evol. 16:1178-1191(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.
  3. Cited for: DOMAIN RPE1.

Entry informationi

Entry nameiDPO1_RICFE
AccessioniPrimary (citable) accession number: Q9RAA9
Secondary accession number(s): Q4UK45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi