Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9RAA9

- DPO1_RICFE

UniProt

Q9RAA9 - DPO1_RICFE

Protein

DNA polymerase I

Gene

polA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    In addition to polymerase activity, this DNA polymerase 5' to 3' exonuclease activity.By similarity

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
    3. exonuclease activity Source: UniProtKB-KW

    GO - Biological processi

    1. DNA repair Source: UniProtKB-KW

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA damage, DNA repair, DNA replication

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-1274-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase I (EC:2.7.7.7)
    Short name:
    POL I
    Gene namesi
    Name:polA
    Ordered Locus Names:RF_1239
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 922922DNA polymerase IPRO_0000101249Add
    BLAST

    Interactioni

    Subunit structurei

    Single-chain monomer with multiple functions.By similarity

    Protein-protein interaction databases

    STRINGi315456.RF_1239.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9RAA9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 2832835'-3' exonucleaseAdd
    BLAST
    Domaini439 – 48749RPE1 insertAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DNA polymerase type-A family.Curated
    Contains 1 5'-3' exonuclease domain.Curated
    Contains 1 RPE1 insert domain.Curated

    Phylogenomic databases

    eggNOGiCOG0258.
    HOGENOMiHOG000020998.
    KOiK02335.
    OMAiAPMQGSA.
    OrthoDBiEOG6SJJH7.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    3.40.50.1010. 1 hit.
    InterProiIPR020046. 5-3_exonucl_a-hlix_arch_N.
    IPR020045. 5-3_exonuclease_C.
    IPR002421. 5-3_exonuclease_N.
    IPR019760. DNA-dir_DNA_pol_A_CS.
    IPR001098. DNA-dir_DNA_pol_A_palm_dom.
    IPR018320. DNA_polymerase_1.
    IPR002298. DNA_polymerase_A.
    IPR008918. HhH2.
    IPR029060. PIN_domain-like.
    IPR005728. Rickett_RPE.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PfamiPF01367. 5_3_exonuc. 1 hit.
    PF02739. 5_3_exonuc_N. 1 hit.
    PF00476. DNA_pol_A. 1 hit.
    [Graphical view]
    PRINTSiPR00868. DNAPOLI.
    SMARTiSM00475. 53EXOc. 1 hit.
    SM00279. HhH2. 1 hit.
    SM00482. POLAc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47807. SSF47807. 1 hit.
    SSF53098. SSF53098. 1 hit.
    SSF88723. SSF88723. 1 hit.
    TIGRFAMsiTIGR00593. pola. 1 hit.
    TIGR01045. RPE1. 1 hit.
    PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9RAA9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQKNTLLLI DGYGFVFRAY YAQQPLTSPK GEPVGALYGF ASMLLKLLSD    50
    FKPKHVAVVF DSGGKNFRHH IYPEYKANRP PPPEDLVVQL PLVRDVASNL 100
    NFPILEKNGY EADDIIATFA AKTAALGEDV VVISSDKDLL QLMGENIKIY 150
    DPLKGKYITE DDVVKKFGTT SDKLREVMAL IGDRSDNIPG VPSIGPKTAS 200
    SLITQFGSVE NIFNSLEQVS SLKQRETLQN SKEAALISWQ LIGLDSNVDL 250
    DFQLNNLEWS PPNSDKLTGF LQEYGFKSLY KRAENLFDIK INDHKEIVEN 300
    KVTEAKEISN ASELADFAKK AEKIGIFGIY LLQHKGDNVA LILSLQNQSY 350
    IIKISNTSHD LFSYNTKNNN DWFSDIIFNL LTDKSIRKIT YSLKPLLKFY 400
    AEQSHEITAI EDLELMQYAL SAGLSQKNLF EEALKEDNRH LSKPAYREEF 450
    KGDTEALATA AYKSVREDAS TGSTSKLPLE TKFGKMSNVI NESARIVAEF 500
    TSLYKQNILE LKDNKAFRLY SNIDLPICFI LDKMEKIGIK VDANYLNQLS 550
    AEFGAEILKL EEEIFALSGT KFNIGSPKQL GEILFEKMQL PFGKASAKAS 600
    SYSTGAEILE KLSEHGYNIA DLLLRWRQLT KLKNTYTDSL PKQIDNITHR 650
    VHTTFLQTST TTGRLSSQEP NLQNVPIRSS EGNKIRQAFI AEEGYKLISA 700
    DYSQIELRIL SHIANIDALK QAFINKDDIH TQTACQIFNL QKHELTSEHR 750
    RKAKAINFGI IYGISAFGLA KQLNVSNGEA SEYIKKYFAE YKGVQEYMEQ 800
    TKAFASSNGY VINFFGRKCF VPLIHDKKLK QFAERAAINA PIQGTNADII 850
    KIAMINLDQE IEKNNLKTRL VLQIHDELLF EVPEDEVELV TPIIKKIMEN 900
    STNMDVPIIT EIRVGNNWME IH 922
    Length:922
    Mass (Da):104,006
    Last modified:May 1, 2000 - v1
    Checksum:iEA47F799536948A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ238763 Genomic DNA. Translation: CAB56067.1.
    CP000053 Genomic DNA. Translation: AAY62090.1.
    RefSeqiWP_011271539.1. NC_007109.1.
    YP_247255.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY62090; AAY62090; RF_1239.
    GeneIDi3401350.
    KEGGirfe:RF_1239.
    PATRICi17893358. VBIRicFel64634_1491.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ238763 Genomic DNA. Translation: CAB56067.1 .
    CP000053 Genomic DNA. Translation: AAY62090.1 .
    RefSeqi WP_011271539.1. NC_007109.1.
    YP_247255.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q9RAA9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_1239.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY62090 ; AAY62090 ; RF_1239 .
    GeneIDi 3401350.
    KEGGi rfe:RF_1239.
    PATRICi 17893358. VBIRicFel64634_1491.

    Phylogenomic databases

    eggNOGi COG0258.
    HOGENOMi HOG000020998.
    KOi K02335.
    OMAi APMQGSA.
    OrthoDBi EOG6SJJH7.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-1274-MONOMER.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    3.40.50.1010. 1 hit.
    InterProi IPR020046. 5-3_exonucl_a-hlix_arch_N.
    IPR020045. 5-3_exonuclease_C.
    IPR002421. 5-3_exonuclease_N.
    IPR019760. DNA-dir_DNA_pol_A_CS.
    IPR001098. DNA-dir_DNA_pol_A_palm_dom.
    IPR018320. DNA_polymerase_1.
    IPR002298. DNA_polymerase_A.
    IPR008918. HhH2.
    IPR029060. PIN_domain-like.
    IPR005728. Rickett_RPE.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    Pfami PF01367. 5_3_exonuc. 1 hit.
    PF02739. 5_3_exonuc_N. 1 hit.
    PF00476. DNA_pol_A. 1 hit.
    [Graphical view ]
    PRINTSi PR00868. DNAPOLI.
    SMARTi SM00475. 53EXOc. 1 hit.
    SM00279. HhH2. 1 hit.
    SM00482. POLAc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47807. SSF47807. 1 hit.
    SSF53098. SSF53098. 1 hit.
    SSF88723. SSF88723. 1 hit.
    TIGRFAMsi TIGR00593. pola. 1 hit.
    TIGR01045. RPE1. 1 hit.
    PROSITEi PS00447. DNA_POLYMERASE_A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome degradation is an ongoing process in Rickettsia."
      Andersson J.O., Andersson S.G.E.
      Mol. Biol. Evol. 16:1178-1191(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.
    3. Cited for: DOMAIN RPE1.

    Entry informationi

    Entry nameiDPO1_RICFE
    AccessioniPrimary (citable) accession number: Q9RAA9
    Secondary accession number(s): Q4UK45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3