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Protein

DNA polymerase I

Gene

polA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
Gene namesi
Name:polA
Ordered Locus Names:RF_1239
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012491 – 922DNA polymerase IAdd BLAST922

Proteomic databases

PRIDEiQ9RAA9

Interactioni

Subunit structurei

Single-chain monomer with multiple functions.By similarity

Protein-protein interaction databases

STRINGi315456.RF_1239

Structurei

3D structure databases

ProteinModelPortaliQ9RAA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 2835'-3' exonucleaseAdd BLAST283
Domaini439 – 487RPE1 insertAdd BLAST49

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated

Phylogenomic databases

eggNOGiENOG4105C2M Bacteria
COG0258 LUCA
COG0749 LUCA
HOGENOMiHOG000020998
KOiK02335
OMAiETGRVHT
OrthoDBiPOG091H00PR

Family and domain databases

CDDicd09898 H3TH_53EXO, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR020046 5-3_exonucl_a-hlix_arch_N
IPR036279 5-3_exonuclease_C_sf
IPR002421 5-3_exonuclease_N
IPR019760 DNA-dir_DNA_pol_A_CS
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR020045 DNA_polI_H3TH
IPR018320 DNA_polymerase_1
IPR002298 DNA_polymerase_A
IPR008918 HhH2
IPR029060 PIN-like_dom_sf
IPR005728 Rickett_RPE
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10133 PTHR10133, 1 hit
PfamiView protein in Pfam
PF01367 5_3_exonuc, 1 hit
PF02739 5_3_exonuc_N, 1 hit
PF00476 DNA_pol_A, 1 hit
PRINTSiPR00868 DNAPOLI
SMARTiView protein in SMART
SM00475 53EXOc, 1 hit
SM00279 HhH2, 1 hit
SM00482 POLAc, 1 hit
SUPFAMiSSF47807 SSF47807, 1 hit
SSF53098 SSF53098, 1 hit
SSF88723 SSF88723, 1 hit
TIGRFAMsiTIGR00593 pola, 1 hit
TIGR01045 RPE1, 1 hit
PROSITEiView protein in PROSITE
PS00447 DNA_POLYMERASE_A, 1 hit

Sequencei

Sequence statusi: Complete.

Q9RAA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQKNTLLLI DGYGFVFRAY YAQQPLTSPK GEPVGALYGF ASMLLKLLSD
60 70 80 90 100
FKPKHVAVVF DSGGKNFRHH IYPEYKANRP PPPEDLVVQL PLVRDVASNL
110 120 130 140 150
NFPILEKNGY EADDIIATFA AKTAALGEDV VVISSDKDLL QLMGENIKIY
160 170 180 190 200
DPLKGKYITE DDVVKKFGTT SDKLREVMAL IGDRSDNIPG VPSIGPKTAS
210 220 230 240 250
SLITQFGSVE NIFNSLEQVS SLKQRETLQN SKEAALISWQ LIGLDSNVDL
260 270 280 290 300
DFQLNNLEWS PPNSDKLTGF LQEYGFKSLY KRAENLFDIK INDHKEIVEN
310 320 330 340 350
KVTEAKEISN ASELADFAKK AEKIGIFGIY LLQHKGDNVA LILSLQNQSY
360 370 380 390 400
IIKISNTSHD LFSYNTKNNN DWFSDIIFNL LTDKSIRKIT YSLKPLLKFY
410 420 430 440 450
AEQSHEITAI EDLELMQYAL SAGLSQKNLF EEALKEDNRH LSKPAYREEF
460 470 480 490 500
KGDTEALATA AYKSVREDAS TGSTSKLPLE TKFGKMSNVI NESARIVAEF
510 520 530 540 550
TSLYKQNILE LKDNKAFRLY SNIDLPICFI LDKMEKIGIK VDANYLNQLS
560 570 580 590 600
AEFGAEILKL EEEIFALSGT KFNIGSPKQL GEILFEKMQL PFGKASAKAS
610 620 630 640 650
SYSTGAEILE KLSEHGYNIA DLLLRWRQLT KLKNTYTDSL PKQIDNITHR
660 670 680 690 700
VHTTFLQTST TTGRLSSQEP NLQNVPIRSS EGNKIRQAFI AEEGYKLISA
710 720 730 740 750
DYSQIELRIL SHIANIDALK QAFINKDDIH TQTACQIFNL QKHELTSEHR
760 770 780 790 800
RKAKAINFGI IYGISAFGLA KQLNVSNGEA SEYIKKYFAE YKGVQEYMEQ
810 820 830 840 850
TKAFASSNGY VINFFGRKCF VPLIHDKKLK QFAERAAINA PIQGTNADII
860 870 880 890 900
KIAMINLDQE IEKNNLKTRL VLQIHDELLF EVPEDEVELV TPIIKKIMEN
910 920
STNMDVPIIT EIRVGNNWME IH
Length:922
Mass (Da):104,006
Last modified:May 1, 2000 - v1
Checksum:iEA47F799536948A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238763 Genomic DNA Translation: CAB56067.1
CP000053 Genomic DNA Translation: AAY62090.1
RefSeqiWP_011271539.1, NC_007109.1

Genome annotation databases

EnsemblBacteriaiAAY62090; AAY62090; RF_1239
KEGGirfe:RF_1239

Similar proteinsi

Entry informationi

Entry nameiDPO1_RICFE
AccessioniPrimary (citable) accession number: Q9RAA9
Secondary accession number(s): Q4UK45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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