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Q9R9N5

- ODPA_RHIME

UniProt

Q9R9N5 - ODPA_RHIME

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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-1480-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Synonyms:pdhAalpha
Ordered Locus Names:R01445
ORF Names:SMc01030
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular membrane-bounded organelle Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Pyruvate dehydrogenase E1 component subunit alphaPRO_0000162202Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

STRINGi266834.SMc01030.

Structurei

3D structure databases

ProteinModelPortaliQ9R9N5.
SMRiQ9R9N5. Positions 26-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1071.
HOGENOMiHOG000281336.
KOiK00161.
OMAiEYAMGTS.
OrthoDBiEOG6JMMWC.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9R9N5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPRKSASVS SRKTAAKPAK KDFAGGTIAE FSKEDDLKAY REMLLIRRFE
60 70 80 90 100
EKAGQLYGMG FIGGFCHLYI GQEAVVVGMQ LALKEGDQVI TGYRDHGHML
110 120 130 140 150
ACGMSARGVM AELTGRRGGL SKGKGGSMHM FSKEKHFYGG HGIVGAQVSL
160 170 180 190 200
GTGLAFANRY RGNDNVSLAY FGDGAANQGQ VYESFNMAAL WKLPVIYIVE
210 220 230 240 250
NNRYAMGTSV SRASAQTDFS QRGASFGIPG YQVDGMDVRA VKAAADEAVE
260 270 280 290 300
HCRSGKGPII LEMLTYRYRG HSMSDPAKYR SKDEVQKMRS EHDPIEQVKA
310 320 330 340
RLTDKGWATE DELKQIDKEV RDIVADSADF AQSDPEPDVS ELYTDILL
Length:348
Mass (Da):38,113
Last modified:May 1, 2000 - v1
Checksum:i671DBC015C03CC78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190792 Genomic DNA. Translation: AAF04587.1.
AL591688 Genomic DNA. Translation: CAC46024.1.
RefSeqiNP_385551.1. NC_003047.1.
WP_003535472.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC46024; CAC46024; SMc01030.
GeneIDi1233098.
KEGGisme:SMc01030.
PATRICi23632227. VBISinMel96828_2865.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190792 Genomic DNA. Translation: AAF04587.1 .
AL591688 Genomic DNA. Translation: CAC46024.1 .
RefSeqi NP_385551.1. NC_003047.1.
WP_003535472.1. NC_003047.1.

3D structure databases

ProteinModelPortali Q9R9N5.
SMRi Q9R9N5. Positions 26-347.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMc01030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC46024 ; CAC46024 ; SMc01030 .
GeneIDi 1233098.
KEGGi sme:SMc01030.
PATRICi 23632227. VBISinMel96828_2865.

Phylogenomic databases

eggNOGi COG1071.
HOGENOMi HOG000281336.
KOi K00161.
OMAi EYAMGTS.
OrthoDBi EOG6JMMWC.

Enzyme and pathway databases

BioCyci SMEL266834:GJF6-1480-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 1 hit.
InterProi IPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view ]
Pfami PF00676. E1_dh. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
TIGRFAMsi TIGR03182. PDH_E1_alph_y. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Symbiotic induction of pyruvate dehydrogenase genes from Sinorhizobium meliloti."
    Cabanes D., Boistard P., Batut J.
    Mol. Plant Microbe Interact. 13:483-493(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RCR2011 / SU47.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiODPA_RHIME
AccessioniPrimary (citable) accession number: Q9R9N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3