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Q9R9N5 (ODPA_RHIME) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component subunit alpha

EC=1.2.4.1
Gene names
Name:pdhA
Synonyms:pdhAalpha
Ordered Locus Names:R01445
ORF Names:SMc01030
OrganismRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) [Complete proteome] [HAMAP]
Taxonomic identifier266834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactor

Thiamine pyrophosphate By similarity.

Subunit structure

Heterodimer of an alpha and a beta chain.

Ontologies

Keywords
   Biological processGlycolysis
   LigandPyruvate
Thiamine pyrophosphate
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintracellular membrane-bounded organelle

Inferred from electronic annotation. Source: InterPro

   Molecular_functionpyruvate dehydrogenase (acetyl-transferring) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Pyruvate dehydrogenase E1 component subunit alpha
PRO_0000162202

Sequences

Sequence LengthMass (Da)Tools
Q9R9N5 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 671DBC015C03CC78

FASTA34838,113
        10         20         30         40         50         60 
MAPRKSASVS SRKTAAKPAK KDFAGGTIAE FSKEDDLKAY REMLLIRRFE EKAGQLYGMG 

        70         80         90        100        110        120 
FIGGFCHLYI GQEAVVVGMQ LALKEGDQVI TGYRDHGHML ACGMSARGVM AELTGRRGGL 

       130        140        150        160        170        180 
SKGKGGSMHM FSKEKHFYGG HGIVGAQVSL GTGLAFANRY RGNDNVSLAY FGDGAANQGQ 

       190        200        210        220        230        240 
VYESFNMAAL WKLPVIYIVE NNRYAMGTSV SRASAQTDFS QRGASFGIPG YQVDGMDVRA 

       250        260        270        280        290        300 
VKAAADEAVE HCRSGKGPII LEMLTYRYRG HSMSDPAKYR SKDEVQKMRS EHDPIEQVKA 

       310        320        330        340 
RLTDKGWATE DELKQIDKEV RDIVADSADF AQSDPEPDVS ELYTDILL 

« Hide

References

« Hide 'large scale' references
[1]"Symbiotic induction of pyruvate dehydrogenase genes from Sinorhizobium meliloti."
Cabanes D., Boistard P., Batut J.
Mol. Plant Microbe Interact. 13:483-493(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: RCR2011 / SU47.
[2]"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021."
Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D. expand/collapse author list , Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.
Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1021.
[3]"The composite genome of the legume symbiont Sinorhizobium meliloti."
Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F., Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G., Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P., Cowie A. expand/collapse author list , Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S., Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I., Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S., Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C., Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R., Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H., Wong K., Yeh K.-C., Batut J.
Science 293:668-672(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1021.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF190792 Genomic DNA. Translation: AAF04587.1.
AL591688 Genomic DNA. Translation: CAC46024.1.
RefSeqNP_385551.1. NC_003047.1.

3D structure databases

ProteinModelPortalQ9R9N5.
SMRQ9R9N5. Positions 26-347.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266834.SMc01030.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC46024; CAC46024; SMc01030.
GeneID1233098.
KEGGsme:SMc01030.
PATRIC23632227. VBISinMel96828_2865.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1071.
HOGENOMHOG000281336.
KOK00161.
OMAEYAMGTS.
OrthoDBEOG6JMMWC.

Enzyme and pathway databases

BioCycSMEL266834:GJF6-1480-MONOMER.

Family and domain databases

Gene3D3.40.50.970. 1 hit.
InterProIPR001017. DH_E1.
IPR017597. Pyrv_DH_E1_asu_subgrp-y.
IPR029061. THDP-binding.
[Graphical view]
PfamPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 1 hit.
TIGRFAMsTIGR03182. PDH_E1_alph_y. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODPA_RHIME
AccessionPrimary (citable) accession number: Q9R9N5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program