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Q9R9N5

- ODPA_RHIME

UniProt

Q9R9N5 - ODPA_RHIME

Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Pyruvate, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciSMEL266834:GJF6-1480-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
    Gene namesi
    Name:pdhA
    Synonyms:pdhAalpha
    Ordered Locus Names:R01445
    ORF Names:SMc01030
    OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    Taxonomic identifieri266834 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000001976: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular membrane-bounded organelle Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348Pyruvate dehydrogenase E1 component subunit alphaPRO_0000162202Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.

    Protein-protein interaction databases

    STRINGi266834.SMc01030.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R9N5.
    SMRiQ9R9N5. Positions 26-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1071.
    HOGENOMiHOG000281336.
    KOiK00161.
    OMAiEYAMGTS.
    OrthoDBiEOG6JMMWC.

    Family and domain databases

    Gene3Di3.40.50.970. 1 hit.
    InterProiIPR001017. DH_E1.
    IPR017597. Pyrv_DH_E1_asu_subgrp-y.
    IPR029061. THDP-binding.
    [Graphical view]
    PfamiPF00676. E1_dh. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 1 hit.
    TIGRFAMsiTIGR03182. PDH_E1_alph_y. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9R9N5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPRKSASVS SRKTAAKPAK KDFAGGTIAE FSKEDDLKAY REMLLIRRFE    50
    EKAGQLYGMG FIGGFCHLYI GQEAVVVGMQ LALKEGDQVI TGYRDHGHML 100
    ACGMSARGVM AELTGRRGGL SKGKGGSMHM FSKEKHFYGG HGIVGAQVSL 150
    GTGLAFANRY RGNDNVSLAY FGDGAANQGQ VYESFNMAAL WKLPVIYIVE 200
    NNRYAMGTSV SRASAQTDFS QRGASFGIPG YQVDGMDVRA VKAAADEAVE 250
    HCRSGKGPII LEMLTYRYRG HSMSDPAKYR SKDEVQKMRS EHDPIEQVKA 300
    RLTDKGWATE DELKQIDKEV RDIVADSADF AQSDPEPDVS ELYTDILL 348
    Length:348
    Mass (Da):38,113
    Last modified:May 1, 2000 - v1
    Checksum:i671DBC015C03CC78
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF190792 Genomic DNA. Translation: AAF04587.1.
    AL591688 Genomic DNA. Translation: CAC46024.1.
    RefSeqiNP_385551.1. NC_003047.1.
    WP_003535472.1. NC_003047.1.

    Genome annotation databases

    EnsemblBacteriaiCAC46024; CAC46024; SMc01030.
    GeneIDi1233098.
    KEGGisme:SMc01030.
    PATRICi23632227. VBISinMel96828_2865.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF190792 Genomic DNA. Translation: AAF04587.1 .
    AL591688 Genomic DNA. Translation: CAC46024.1 .
    RefSeqi NP_385551.1. NC_003047.1.
    WP_003535472.1. NC_003047.1.

    3D structure databases

    ProteinModelPortali Q9R9N5.
    SMRi Q9R9N5. Positions 26-347.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266834.SMc01030.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC46024 ; CAC46024 ; SMc01030 .
    GeneIDi 1233098.
    KEGGi sme:SMc01030.
    PATRICi 23632227. VBISinMel96828_2865.

    Phylogenomic databases

    eggNOGi COG1071.
    HOGENOMi HOG000281336.
    KOi K00161.
    OMAi EYAMGTS.
    OrthoDBi EOG6JMMWC.

    Enzyme and pathway databases

    BioCyci SMEL266834:GJF6-1480-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 1 hit.
    InterProi IPR001017. DH_E1.
    IPR017597. Pyrv_DH_E1_asu_subgrp-y.
    IPR029061. THDP-binding.
    [Graphical view ]
    Pfami PF00676. E1_dh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 1 hit.
    TIGRFAMsi TIGR03182. PDH_E1_alph_y. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Symbiotic induction of pyruvate dehydrogenase genes from Sinorhizobium meliloti."
      Cabanes D., Boistard P., Batut J.
      Mol. Plant Microbe Interact. 13:483-493(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: RCR2011 / SU47.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1021.

    Entry informationi

    Entry nameiODPA_RHIME
    AccessioniPrimary (citable) accession number: Q9R9N5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3