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Q9R9N3

- ODP2_RHIME

UniProt

Q9R9N3 - ODP2_RHIME

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Protein

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

Gene

pdhC

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

Cofactori

Binds 1 lipoyl cofactor covalently.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei420 – 4201Sequence Analysis

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Glycolysis

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-1482-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (EC:2.3.1.12)
Alternative name(s):
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
E2
Gene namesi
Name:pdhC
Synonyms:pdhB
Ordered Locus Names:R01447
ORF Names:SMc01032
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complexPRO_0000162284Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431N6-lipoyllysineBy similarity

Proteomic databases

ProMEXiQ9R9N3.

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry.By similarity

Protein-protein interaction databases

STRINGi266834.SMc01032.

Structurei

3D structure databases

ProteinModelPortaliQ9R9N3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7777Lipoyl-bindingAdd
BLAST

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.Curated
Contains 1 lipoyl-binding domain.Curated

Keywords - Domaini

Lipoyl

Phylogenomic databases

eggNOGiCOG0508.
HOGENOMiHOG000281566.
KOiK00627.
OMAiPISNIRK.
OrthoDBiEOG610413.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R9N3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPINITMPAL SPTMEEGNLA KWLVKEGDKV KSGDVIAEIE TDKATMEVEA
60 70 80 90 100
VDEGTVAKIV VPAGTEGVKV NALIAVLAAE GEDVATAAKG GNGAAGAVPA
110 120 130 140 150
PKPKETAETA PAAAPAPAAA PAPQAAAPAS PAPADGEGKR IFSSPLARRL
160 170 180 190 200
AKEAGIDLSA IAGSGPHGRV VKKDVETAVS GGAAKPAGAP AAAPAPATLA
210 220 230 240 250
KGMSEDAVLK LFEPGSYELV PHDGMRKTIA KRLVESKQTI PHFYVSVDCE
260 270 280 290 300
LDALMALRAQ LNAAAPEKDG KPVYKLSVND MVIKALALAL RDVPDANVSW
310 320 330 340 350
TDQNMVKHKH ADVGVAVSIP GGLITPIVRQ AELKSLSAIS NEMKDLGKRA
360 370 380 390 400
KERKLKPEEY QGGTTAVSNM GMMGVKDFAA VVNPPHATIL AVGAGEDRVV
410 420 430 440
VRNKEMVIAN VMTVTLSTDH RCVDGALGAE LLAAFKRYIE NPMGMLV
Length:447
Mass (Da):46,140
Last modified:May 1, 2000 - v1
Checksum:i48B1CAC4E2FDC2AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF190792 Genomic DNA. Translation: AAF04589.1.
AL591688 Genomic DNA. Translation: CAC46026.1.
RefSeqiNP_385553.1. NC_003047.1.
WP_010969228.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC46026; CAC46026; SMc01032.
GeneIDi1233100.
KEGGisme:SMc01032.
PATRICi23632231. VBISinMel96828_2867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF190792 Genomic DNA. Translation: AAF04589.1 .
AL591688 Genomic DNA. Translation: CAC46026.1 .
RefSeqi NP_385553.1. NC_003047.1.
WP_010969228.1. NC_003047.1.

3D structure databases

ProteinModelPortali Q9R9N3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMc01032.

Proteomic databases

ProMEXi Q9R9N3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC46026 ; CAC46026 ; SMc01032 .
GeneIDi 1233100.
KEGGi sme:SMc01032.
PATRICi 23632231. VBISinMel96828_2867.

Phylogenomic databases

eggNOGi COG0508.
HOGENOMi HOG000281566.
KOi K00627.
OMAi PISNIRK.
OrthoDBi EOG610413.

Enzyme and pathway databases

BioCyci SMEL266834:GJF6-1482-MONOMER.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Symbiotic induction of pyruvate dehydrogenase genes from Sinorhizobium meliloti."
    Cabanes D., Boistard P., Batut J.
    Mol. Plant Microbe Interact. 13:483-493(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: RCR2011 / SU47.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiODP2_RHIME
AccessioniPrimary (citable) accession number: Q9R9N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 2000
Last modified: October 1, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3