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Protein

Malonyl CoA-acyl carrier protein transacylase

Gene

fenF

Organism
Bacillus subtilis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Is involved in the mycosubtilin synthetase assembly, by catalyzing the transfer of malonyl groups to a specific acyl-carrier-protein domain on MycA.1 Publication

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].1 Publication

Kineticsi

  1. KM=45 µM for malonyl-CoA1 Publication
  2. KM=950 µM for acyl-carrier-protein domain of MycA1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Active sitei92By similarity1
    Active sitei201By similarity1

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Molecular functionAcyltransferase, Transferase
    Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    SABIO-RKiQ9R9J2

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
    Short name:
    MCT
    Gene namesi
    Name:fenF
    OrganismiBacillus subtilis
    Taxonomic identifieri1423 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003854541 – 400Malonyl CoA-acyl carrier protein transacylaseAdd BLAST400

    Proteomic databases

    PRIDEiQ9R9J2

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R9J2
    SMRiQ9R9J2
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FabD family.Curated

    Family and domain databases

    Gene3Di3.40.366.10, 2 hits
    InterProiView protein in InterPro
    IPR001227 Ac_transferase_dom_sf
    IPR014043 Acyl_transferase
    IPR016035 Acyl_Trfase/lysoPLipase
    IPR004410 Malonyl_CoA-ACP_transAc_FabD
    IPR016036 Malonyl_transacylase_ACP-bd
    IPR020801 PKS_acyl_transferase
    PfamiView protein in Pfam
    PF00698 Acyl_transf_1, 1 hit
    SMARTiView protein in SMART
    SM00827 PKS_AT, 1 hit
    SUPFAMiSSF52151 SSF52151, 2 hits
    SSF55048 SSF55048, 1 hit
    TIGRFAMsiTIGR00128 fabD, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q9R9J2-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MNNLAFLFPG QGSQFVGMGK SFWNDFVLAK RLFEEASDAI SMDVKKLCFD
    60 70 80 90 100
    GDMTELTRTM NAQPAILTVS VIAYQVYMQE IGIKPHFLAG HSLGEYSALV
    110 120 130 140 150
    CAGVLSFQEA VKLIRQRGIL MQNADPEQLG TMAAITQVYI QPLQDLCTEI
    160 170 180 190 200
    STEDFPVGVA CMNSDQQHVI SGHRQAVEFV IKKAERMGAN HTYLNVSAPF
    210 220 230 240 250
    HSSMMRSASE QFQTALNQYS FRDAEWPIIS NVTAIPYNNG HSVREHLQTH
    260 270 280 290 300
    MTMPVRWAES MHYLLLHGVT EVIEMGPKNV LVGLLKKITN HIAAYPLGQT
    310 320 330 340 350
    SDLHLLSDSA ERNENIVNLR KKQLNKMMIQ SIIARNYNKD AKTYSNLTTP
    360 370 380 390 400
    LFPQIQLLKE RVERKEVELS AEELEHSIHL CQLICEAKQL PTWEQLRILK
    Length:400
    Mass (Da):45,222
    Last modified:May 1, 2000 - v1
    Checksum:i2A4430664C90C578
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF184956 Genomic DNA Translation: AAF08794.1
    PIRiT44805

    Genome annotation databases

    PATRICifig|1423.172.peg.141

    Similar proteinsi

    Entry informationi

    Entry nameiFENF_BACIU
    AccessioniPrimary (citable) accession number: Q9R9J2
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: May 1, 2000
    Last modified: May 23, 2018
    This is version 63 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

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