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Q9R976 (BLO19_PSEAI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase OXA-19

EC=3.5.2.6
Alternative name(s):
Penicillinase
Gene names
Name:bla
Synonyms:oxa19
OrganismPseudomonas aeruginosa
Taxonomic identifier287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-D beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processantibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

penicillin binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 By similarity
Chain21 – 266246Beta-lactamase OXA-19
PRO_0000313799

Regions

Region205 – 2073Substrate binding By similarity

Sites

Active site671Acyl-ester intermediate By similarity

Amino acid modifications

Modified residue701N6-carboxylysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9R976 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: E8EBBA429B3F6008

FASTA26629,449
        10         20         30         40         50         60 
MKTFAAYVIT ACLSSTALAS SITENTSWNK EFSAEAVNGV FVLCKSSSKS CATNNLARAS 

        70         80         90        100        110        120 
KEYLPASTFK IPNAIIGLET GVIKNEHQVF KWDGKPRAMK QWERDLSLRG AIQVSAVPVF 

       130        140        150        160        170        180 
QQIAREVGEV RMQKYLKKFS YGNQNISGGI DKFWLEDQLR ISAVNQVEFL ESLFLNKLSA 

       190        200        210        220        230        240 
SKENQLIVKE ALVTEAAPEY LVHSKTGFSG VGTESNPGVA WWVGWVEKGT EVYFFAFNMD 

       250        260 
IDNENKLPLR KSIPTKIMAS EGIIGG 

« Hide

References

[1]"Novel OXA-10-derived extended-spectrum beta-lactamases selected in vivo or in vitro."
Mugnier P., Casin I., Bouthors A.T., Collatz E.
Antimicrob. Agents Chemother. 42:3113-3116(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: PAe191.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF043381 Genomic DNA. Translation: AAD02245.1.

3D structure databases

ProteinModelPortalQ9R976.
SMRQ9R976. Positions 20-266.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLO19_PSEAI
AccessionPrimary (citable) accession number: Q9R976
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2000
Last modified: October 16, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families