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Q9R976

- BLO19_PSEAI

UniProt

Q9R976 - BLO19_PSEAI

Protein

Beta-lactamase OXA-19

Gene

bla

Organism
Pseudomonas aeruginosa
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    • Comment

    Functioni

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei67 – 671Acyl-ester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC
    2. penicillin binding Source: InterPro

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase OXA-19 (EC:3.5.2.6)
    Alternative name(s):
    Penicillinase
    Gene namesi
    Name:bla
    Synonyms:oxa19
    OrganismiPseudomonas aeruginosa
    Taxonomic identifieri287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 266246Beta-lactamase OXA-19PRO_0000313799Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei70 – 701N6-carboxylysineBy similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R976.
    SMRiQ9R976. Positions 20-266.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni205 – 2073Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-D beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR002137. Beta-lactam_class-D_AS.
    IPR001460. PCN-bd_Tpept.
    [Graphical view]
    PfamiPF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9R976-1 [UniParc]FASTAAdd to Basket

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    MKTFAAYVIT ACLSSTALAS SITENTSWNK EFSAEAVNGV FVLCKSSSKS    50
    CATNNLARAS KEYLPASTFK IPNAIIGLET GVIKNEHQVF KWDGKPRAMK 100
    QWERDLSLRG AIQVSAVPVF QQIAREVGEV RMQKYLKKFS YGNQNISGGI 150
    DKFWLEDQLR ISAVNQVEFL ESLFLNKLSA SKENQLIVKE ALVTEAAPEY 200
    LVHSKTGFSG VGTESNPGVA WWVGWVEKGT EVYFFAFNMD IDNENKLPLR 250
    KSIPTKIMAS EGIIGG 266
    Length:266
    Mass (Da):29,449
    Last modified:May 1, 2000 - v1
    Checksum:iE8EBBA429B3F6008
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043381 Genomic DNA. Translation: AAD02245.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043381 Genomic DNA. Translation: AAD02245.1 .

    3D structure databases

    ProteinModelPortali Q9R976.
    SMRi Q9R976. Positions 20-266.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR002137. Beta-lactam_class-D_AS.
    IPR001460. PCN-bd_Tpept.
    [Graphical view ]
    Pfami PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00337. BETA_LACTAMASE_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel OXA-10-derived extended-spectrum beta-lactamases selected in vivo or in vitro."
      Mugnier P., Casin I., Bouthors A.T., Collatz E.
      Antimicrob. Agents Chemother. 42:3113-3116(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: PAe191.

    Entry informationi

    Entry nameiBLO19_PSEAI
    AccessioniPrimary (citable) accession number: Q9R976
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3