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Q9R976

- BLO19_PSEAI

UniProt

Q9R976 - BLO19_PSEAI

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Protein

Beta-lactamase OXA-19

Gene

bla

Organism
Pseudomonas aeruginosa
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Acyl-ester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. penicillin binding Source: InterPro

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase OXA-19 (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:bla
Synonyms:oxa19
OrganismiPseudomonas aeruginosa
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 266246Beta-lactamase OXA-19PRO_0000313799Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701N6-carboxylysineBy similarity

Structurei

3D structure databases

ProteinModelPortaliQ9R976.
SMRiQ9R976. Positions 20-266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni205 – 2073Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-D beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R976-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTFAAYVIT ACLSSTALAS SITENTSWNK EFSAEAVNGV FVLCKSSSKS
60 70 80 90 100
CATNNLARAS KEYLPASTFK IPNAIIGLET GVIKNEHQVF KWDGKPRAMK
110 120 130 140 150
QWERDLSLRG AIQVSAVPVF QQIAREVGEV RMQKYLKKFS YGNQNISGGI
160 170 180 190 200
DKFWLEDQLR ISAVNQVEFL ESLFLNKLSA SKENQLIVKE ALVTEAAPEY
210 220 230 240 250
LVHSKTGFSG VGTESNPGVA WWVGWVEKGT EVYFFAFNMD IDNENKLPLR
260
KSIPTKIMAS EGIIGG
Length:266
Mass (Da):29,449
Last modified:May 1, 2000 - v1
Checksum:iE8EBBA429B3F6008
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF043381 Genomic DNA. Translation: AAD02245.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF043381 Genomic DNA. Translation: AAD02245.1 .

3D structure databases

ProteinModelPortali Q9R976.
SMRi Q9R976. Positions 20-266.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view ]
Pfami PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Novel OXA-10-derived extended-spectrum beta-lactamases selected in vivo or in vitro."
    Mugnier P., Casin I., Bouthors A.T., Collatz E.
    Antimicrob. Agents Chemother. 42:3113-3116(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PAe191.

Entry informationi

Entry nameiBLO19_PSEAI
AccessioniPrimary (citable) accession number: Q9R976
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2000
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3