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Protein
Submitted name:

Vacuolating cytotoxin

Gene

vacA

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Vacuolating cytotoxinImported
Gene namesi
Name:vacAImported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliQ9R959.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1021 – 1294Autotransporter (TC 1.B.12)InterPro annotationAdd BLAST274

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELQQTHRKI NRPLVSLALV GLLVSITPQK SHAAFFTTVI IPAIVGGIAS
60 70 80 90 100
GAAVGTVSGL LGWGLKQAEE ANKTPDKPDK VWRIQAGRGF NEFPNKEYDL
110 120 130 140 150
YKSLLSSKID GGWDWGNAAR HYWVKGGQWN KLEVDMKDAV GTYKLSGLRN
160 170 180 190 200
YTGGDLDVNM QKATLRLGQF NGNSFTSFKD SADRTTRVDF NAKNISIDNF
210 220 230 240 250
LEINNRVGSG AGRKASSTVL TLQASEGITS GKNAEISLYD GATLNLASNS
260 270 280 290 300
VKLMGNVWMG RLQYVGAYLA PSYSTINTSK VTGEVNFNHL TVGDRNAAQA
310 320 330 340 350
GIIASKKTYI GTLDLWQSAG LNIIAPPEGG YKDKPNNTTS QSGAKSDKNE
360 370 380 390 400
SAKNDKQESS QNNSNTQVIN PPNSGQKTEI QPTQVIDGPF AGAKDTMVNI
410 420 430 440 450
NRINTNADGT IKVGGYTASL TTNAANLDIG KGGVNLSNQA SGRSLLVENL
460 470 480 490 500
TGNITVDGAL MVNNQVGGYA LAGSSANFEF KAGVDTKNGT IAFNNNISLG
510 520 530 540 550
RFVNLKASAH TVNFKDIDTG NGGFNTLDFS GVTNKVNINK LITASTNVAI
560 570 580 590 600
KNFNINELLV KTNGISVGEY TNFSEDIGNQ SRINTVRLET GTRSIYSGGV
610 620 630 640 650
KFKGGEKLVI NDFYYAPWNY FDARNIKNVE ITNKLAFGPQ GSPWGTAKLM
660 670 680 690 700
FNNLTLGPNA VMDYSQFSNV TIQGNFINNQ GTINYLVRGG NIETLSVGNA
710 720 730 740 750
AVMSFNNDID SATGFYKPLI KINSAQDLIK NKEHVLLKAK IIGYDNVSLG
760 770 780 790 800
TNSISNANLI EQFNERLALY NNNNRMDTCV VRNTDDVKAC GMAIGNQAMV
810 820 830 840 850
NNPDNYKYLI GKAWKNIGIS KTANGSKISV RYLGNATPAD PTDLPKNAEN
860 870 880 890 900
STEKPLNNAL LARSAFSTQP NATPNLVAIN KHNFGAIESV FELANRSKDI
910 920 930 940 950
DTLYAKSGAQ GRDLLQTLLI DSHNAGYART MIDATSANEI TKQLNEANSA
960 970 980 990 1000
LNNIASLEHK TNGLQTLSLS NAMILNSRLV NLSRRHTNNI DSFAQRLQAL
1010 1020 1030 1040 1050
KDQRFASLES AAEVLYQFAP KYEKPTNVWA NAIGGASLNS GGNTSLYGTS
1060 1070 1080 1090 1100
AGVDAYLNEK VEAIVGGFGS YGYSSFNNQA NSLNSGANNA NFGVYSRIFA
1110 1120 1130 1140 1150
NRHEFDFEAQ GAVGSDQSSL NFKSALLRDL NQSYNYLAYG AATRASYGYD
1160 1170 1180 1190 1200
FAFFRNALVL KPSVGVSYNH LGSTNFESNS TNKTALKNGA SSQHLFNASA
1210 1220 1230 1240 1250
NVEARYYYGD TSYFYMNAGV LQEFANFGSS NALSLNTFKV NAARNPLNTH
1260 1270 1280 1290
ARVMMGGELK LAKEVFLNLG FIYLHNLISN AGYFASNLGM RYSF
Length:1,294
Mass (Da):139,754
Last modified:May 1, 2000 - v1
Checksum:iBC06F076E8261D5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049642 Genomic DNA. Translation: AAD04277.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049642 Genomic DNA. Translation: AAD04277.1.

3D structure databases

ProteinModelPortaliQ9R959.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9R959_HELPX
AccessioniPrimary (citable) accession number: Q9R959
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 5, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.