Aminoglycoside 6'-N-acetyltransferase - Salmonella enteritidis

Preferred order of sections

Names and origin

Protein names

Submitted name:
Aminoglycoside 6'-N-acetyltransferase EMBL AAF03532.1

Gene names

Name:

aac(6')-Iy EMBL AAF03532.1

Organism

Salmonella enteritidis EMBL AAF03532.1

Taxonomic identifier

149539 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Molecular function	Transferase EMBL AAF03532.1
Technical term	3D-structure PDB 1S5K PDB 1S60 PDB 1S3Z PDB 2VBQ
Gene Ontology (GO)
Molecular function	N-acetyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Region

81 – 83

3

Coenzyme A binding PDB 1S5K PDB 1S60 PDB 1S3Z

Region

89 – 94

6

Coenzyme A binding PDB 1S5K PDB 1S60 PDB 1S3Z

Sites

Binding site

120

1

Coenzyme A PDB 1S5K PDB 1S3Z

Sequences

Sequence

Length

Mass (Da)

Tools

Q9R381 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 9CD8BBFD48BC43A2
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FASTA

145

16,362

        10         20         30         40         50         60 
MDIRQMNKTH LEHWRGLRKQ LWPGHPDDAH LADGEEILQA DHLASFIAMA DGVAIGFADA 

        70         80         90        100        110        120 
SIRHDYVNGC DSSPVVFLEG IFVLPSFRQR GVAKQLIAAV QRWGTNKGCR EMASDTSPEN 

       130        140 
TISQKVHQAL GFEETERVIF YRKRC

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References

[1]	"Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6'-N-acetyltransferase." Magalhaes M.L., Vetting M.W., Gao F., Freiburger L., Auclair K., Blanchard J.S. Biochemistry 47:579-584(2008) [PubMed: 18095712] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
[2]	"A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones." Vetting M.W., Magnet S., Nieves E., Roderick S.L., Blanchard J.S. Chem. Biol. 11:565-573(2004) [PubMed: 15123251] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH COENZYME A.
[3]	"Activation of the cryptic aac(6')-Iy aminoglycoside resistance gene of Salmonella by a chromosomal deletion generating a transcriptional fusion." Magnet S., Courvalin P., Lambert T. J. Bacteriol. 181:6650-6655(1999) [PubMed: 10542165] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BM4361 EMBL AAF03531.1 and BM4362 EMBL AAF03532.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF144880 Genomic DNA. Translation: AAF03531.1.
AF144881 Genomic DNA. Translation: AAF03532.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1S3Z	X-ray	2.00	A/B	1-145	[»]
1S5K	X-ray	2.40	A/B	1-145	[»]
1S60	X-ray	3.00	A	1-145	[»]
2VBQ	X-ray	2.00	A/B	1-145	[»]

ProteinModelPortal

Q9R381.

SMR

Q9R381. Positions 1-145.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR000182. AcTrfase_GCN5-related_dom.
IPR016181. Acyl_CoA_acyltransferase.
IPR024170. Aminoglycoside_N6-AcTrfrase.
[Graphical view]

Gene3D

G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.

Pfam

PF00583. Acetyltransf_1. 1 hit.
[Graphical view]

PIRSF

PIRSF000452. 6-N-acetyltransf. 1 hit.

SUPFAM

SSF55729. Acyl_CoA_acyltransferase. 1 hit.

PROSITE

PS51186. GNAT. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q9R381_SALEN

Accession

Primary (citable) accession number: Q9R381

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	September 21, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)