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Protein

Interleukin-5

Gene

Il5

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.UniRule annotation

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-5UniRule annotation
Alternative name(s):
Eosinophil differentiation factorUniRule annotation
Gene namesi
Name:Il5Imported
Synonyms:IL-5Imported, IL5UniRule annotation
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2900. Il5.

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17UniRule annotationAdd BLAST17
ChainiPRO_500903195218 – 132Interleukin-5UniRule annotationAdd BLAST115

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PaxDbiQ9R2C9.

Expressioni

Gene expression databases

GenevisibleiQ9R2C9. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010729.

Structurei

3D structure databases

ProteinModelPortaliQ9R2C9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-5 family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410IYJN. Eukaryota.
ENOG41117ER. LUCA.
HOVERGENiHBG003865.
KOiK05428.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000186. IL-5.
PfamiView protein in Pfam
PF02025. IL5. 1 hit.
PRINTSiPR00432. INTERLEUKIN5.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006721. Interleukin_5. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9R2C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMLLCLNVL TLSCVWAIAM EIPMSTVVKE TLIQLSTHRA LLTSNETMRL
60 70 80 90 100
PVPTHKNHQL CIGEIFQGLD ILKNQTVRGG TVEIPFQNLS LIKKYIDGQK
110 120 130
EKCGEERRKT RHFLDYLQEF LGVMSTEWAM EV
Length:132
Mass (Da):15,191
Last modified:May 1, 2000 - v1
Checksum:i814A87CB4C04702B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011299 mRNA. Translation: CAA09587.1.
RefSeqiNP_068606.1. NM_021834.1.
UniGeneiRn.44227.

Genome annotation databases

GeneIDi24497.
KEGGirno:24497.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011299 mRNA. Translation: CAA09587.1.
RefSeqiNP_068606.1. NM_021834.1.
UniGeneiRn.44227.

3D structure databases

ProteinModelPortaliQ9R2C9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010729.

Proteomic databases

PaxDbiQ9R2C9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24497.
KEGGirno:24497.

Organism-specific databases

CTDi3567.
RGDi2900. Il5.

Phylogenomic databases

eggNOGiENOG410IYJN. Eukaryota.
ENOG41117ER. LUCA.
HOVERGENiHBG003865.
KOiK05428.

Gene expression databases

GenevisibleiQ9R2C9. RN.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000186. IL-5.
PfamiView protein in Pfam
PF02025. IL5. 1 hit.
PRINTSiPR00432. INTERLEUKIN5.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006721. Interleukin_5. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9R2C9_RAT
AccessioniPrimary (citable) accession number: Q9R2C9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: February 15, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.