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Q9R2B2

- Q9R2B2_MOUSE

UniProt

Q9R2B2 - Q9R2B2_MOUSE

Protein
Submitted name:

Cdc42/Rac effector kinase

Gene

Paka

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. protein serine/threonine kinase activity Source: Ensembl

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: Ensembl
    2. branching morphogenesis of an epithelial tube Source: Ensembl
    3. cellular response to insulin stimulus Source: Ensembl
    4. negative regulation of cell proliferation involved in contact inhibition Source: Ensembl
    5. neuron projection morphogenesis Source: Ensembl
    6. positive regulation of intracellular estrogen receptor signaling pathway Source: Ensembl
    7. positive regulation of JUN kinase activity Source: Ensembl
    8. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    9. positive regulation of stress fiber assembly Source: Ensembl
    10. protein autophosphorylation Source: Ensembl
    11. response to hypoxia Source: Ensembl
    12. wound healing Source: Ensembl

    Keywords - Molecular functioni

    KinaseImported, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_188530. FCERI mediated MAPK activation.
    REACT_198374. Regulation of actin dynamics for phagocytic cup formation.
    REACT_215461. Signal transduction by L1.
    REACT_225768. Generation of second messenger molecules.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cdc42/Rac effector kinaseImported
    Gene namesi
    Name:PakaImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cytosol Source: Ensembl
    3. dendrite Source: Ensembl
    4. Golgi apparatus Source: Ensembl
    5. intercalated disc Source: Ensembl
    6. nuclear membrane Source: Ensembl
    7. plasma membrane Source: Ensembl
    8. protein complex Source: Ensembl
    9. ruffle Source: Ensembl
    10. Z disc Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ9R2B2.
    BgeeiQ9R2B2.
    GenevestigatoriQ9R2B2.

    Family & Domainsi

    Phylogenomic databases

    InParanoidiQ9R2B2.

    Sequencei

    Sequence statusi: Fragment.

    Q9R2B2-1 [UniParc]FASTAAdd to Basket

    « Hide

    IQDKPPAPPM RNTSTMIGAG SKDTGTLNHG SKPLPPNPEE KKKKDRFYRS   50
    ILPGDK 56
    Length:56
    Mass (Da):6,144
    Last modified:May 1, 2000 - v1
    Checksum:iD92E7F3D2AB4D21F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei56 – 561Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ133881 Genomic DNA. Translation: CAB41618.1.
    UniGeneiMm.260227.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ133881 Genomic DNA. Translation: CAB41618.1 .
    UniGenei Mm.260227.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    InParanoidi Q9R2B2.

    Enzyme and pathway databases

    Reactomei REACT_188530. FCERI mediated MAPK activation.
    REACT_198374. Regulation of actin dynamics for phagocytic cup formation.
    REACT_215461. Signal transduction by L1.
    REACT_225768. Generation of second messenger molecules.

    Gene expression databases

    ArrayExpressi Q9R2B2.
    Bgeei Q9R2B2.
    Genevestigatori Q9R2B2.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "A fraction of mouse sperm chromatin is organized in nucleosomal hypersensitive domains enriched in retroposon."
      Pittoggi C., Renzi L., Zaccagnini G., Cimini D., Degrassi F., Giordano R., Magnano A.R., Lorenzini R., Lavia P., Spadafora C.
      J. Cell Sci. 112:3537-3548(1999)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CD1Imported.
      Tissue: Cauda epididymisImported.

    Entry informationi

    Entry nameiQ9R2B2_MOUSE
    AccessioniPrimary (citable) accession number: Q9R2B2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)