Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Cdc42/Rac effector kinase

Gene

Paka

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. protein serine/threonine kinase activity Source: Ensembl

GO - Biological processi

  1. actin cytoskeleton reorganization Source: Ensembl
  2. branching morphogenesis of an epithelial tube Source: Ensembl
  3. cellular response to insulin stimulus Source: Ensembl
  4. negative regulation of cell proliferation involved in contact inhibition Source: Ensembl
  5. neuron projection morphogenesis Source: Ensembl
  6. positive regulation of intracellular estrogen receptor signaling pathway Source: Ensembl
  7. positive regulation of JUN kinase activity Source: Ensembl
  8. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  9. positive regulation of stress fiber assembly Source: Ensembl
  10. protein autophosphorylation Source: Ensembl
  11. response to hypoxia Source: Ensembl
  12. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Enzyme and pathway databases

ReactomeiREACT_188530. FCERI mediated MAPK activation.
REACT_198374. Regulation of actin dynamics for phagocytic cup formation.
REACT_215461. Signal transduction by L1.
REACT_225768. Generation of second messenger molecules.
REACT_241951. Ephrin signaling.
REACT_243212. DSCAM interactions.
REACT_254306. Sema3A PAK dependent Axon repulsion.
REACT_257656. EPHB-mediated forward signaling.
REACT_260744. Activation of Rac.
REACT_261451. CD28 dependent Vav1 pathway.
REACT_261840. VEGFR2 mediated vascular permeability.

Names & Taxonomyi

Protein namesi
Submitted name:
Cdc42/Rac effector kinaseImported
Gene namesi
Name:PakaImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cytosol Source: Ensembl
  3. dendrite Source: Ensembl
  4. intercalated disc Source: Ensembl
  5. nuclear membrane Source: Ensembl
  6. plasma membrane Source: Ensembl
  7. protein complex Source: Ensembl
  8. ruffle Source: Ensembl
  9. Z disc Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9R2B2.
ExpressionAtlasiQ9R2B2. baseline and differential.
GenevestigatoriQ9R2B2.

Sequencei

Sequence statusi: Fragment.

Q9R2B2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
IQDKPPAPPM RNTSTMIGAG SKDTGTLNHG SKPLPPNPEE KKKKDRFYRS

ILPGDK
Length:56
Mass (Da):6,144
Last modified:May 1, 2000 - v1
Checksum:iD92E7F3D2AB4D21F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei56 – 561Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133881 Genomic DNA. Translation: CAB41618.1.
UniGeneiMm.260227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133881 Genomic DNA. Translation: CAB41618.1.
UniGeneiMm.260227.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

ReactomeiREACT_188530. FCERI mediated MAPK activation.
REACT_198374. Regulation of actin dynamics for phagocytic cup formation.
REACT_215461. Signal transduction by L1.
REACT_225768. Generation of second messenger molecules.
REACT_241951. Ephrin signaling.
REACT_243212. DSCAM interactions.
REACT_254306. Sema3A PAK dependent Axon repulsion.
REACT_257656. EPHB-mediated forward signaling.
REACT_260744. Activation of Rac.
REACT_261451. CD28 dependent Vav1 pathway.
REACT_261840. VEGFR2 mediated vascular permeability.

Gene expression databases

BgeeiQ9R2B2.
ExpressionAtlasiQ9R2B2. baseline and differential.
GenevestigatoriQ9R2B2.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "A fraction of mouse sperm chromatin is organized in nucleosomal hypersensitive domains enriched in retroposon."
    Pittoggi C., Renzi L., Zaccagnini G., Cimini D., Degrassi F., Giordano R., Magnano A.R., Lorenzini R., Lavia P., Spadafora C.
    J. Cell Sci. 112:3537-3548(1999)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CD1Imported.
    Tissue: Cauda epididymisImported.

Entry informationi

Entry nameiQ9R2B2_MOUSE
AccessioniPrimary (citable) accession number: Q9R2B2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.