ID Q9R2A0_RAT Unreviewed; 48 AA. AC Q9R2A0; DT 01-MAY-2000, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 1. DT 27-MAR-2024, entry version 110. DE SubName: Full=Fibroblast growth factor receptor 2 {ECO:0000313|EMBL:AAL77412.1, ECO:0000313|EMBL:BAA77279.1}; DE Flags: Fragment; GN Name=Fgfr2 {ECO:0000313|EMBL:AAL77412.1, ECO:0000313|RGD:2611}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:BAA77279.1}; RN [1] {ECO:0000313|EMBL:BAA77279.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Wistar {ECO:0000313|EMBL:BAA77279.1}; RX PubMed=8875318; RX DOI=10.1002/(SICI)1097-4547(19960901)45:5<534::AID-JNR3>3.0.CO;2-D; RA Miyake A., Hattori Y., Ohta M., Itoh N.; RT "Rat oligodendrocytes and astrocytes preferentially express fibroblast RT growth factor receptor-2 and -3 mRNAs."; RL J. Neurosci. Res. 45:534-541(1996). RN [2] {ECO:0000313|EMBL:AAL77412.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=9528792; RA Carstens R.P., McKeehan W.L., Garcia-Blanco M.A.; RT "An intronic sequence element mediates both activation and repression of RT rat fibroblast growth factor receptor 2 pre-mRNA splicing."; RL Mol. Cell. Biol. 18:2205-2217(1998). RN [3] {ECO:0000313|EMBL:AAL77412.1} RP NUCLEOTIDE SEQUENCE. RA Carstens R.P., Garcia-Blanco M.A.; RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF456422; AAL77412.1; -; Genomic_DNA. DR EMBL; D83495; BAA77279.1; -; Genomic_DNA. DR AlphaFoldDB; Q9R2A0; -. DR UCSC; RGD:2611; rat. DR AGR; RGD:2611; -. DR RGD; 2611; Fgfr2. DR GO; GO:0005938; C:cell cortex; ISO:RGD. DR GO; GO:0009986; C:cell surface; IDA:RGD. DR GO; GO:0005737; C:cytoplasm; ISO:RGD. DR GO; GO:0060076; C:excitatory synapse; ISO:RGD. DR GO; GO:0005634; C:nucleus; ISO:RGD. DR GO; GO:0005886; C:plasma membrane; ISO:RGD. DR GO; GO:0043235; C:receptor complex; IBA:GO_Central. DR GO; GO:0017134; F:fibroblast growth factor binding; IDA:RGD. DR GO; GO:0005007; F:fibroblast growth factor receptor activity; IDA:RGD. DR GO; GO:0042803; F:protein homodimerization activity; ISO:RGD. DR GO; GO:0001525; P:angiogenesis; ISO:RGD. DR GO; GO:0009887; P:animal organ morphogenesis; ISO:RGD. DR GO; GO:0007409; P:axonogenesis; ISO:RGD. DR GO; GO:0060348; P:bone development; ISO:RGD. DR GO; GO:0030282; P:bone mineralization; ISO:RGD. DR GO; GO:0060349; P:bone morphogenesis; ISO:RGD. DR GO; GO:0060667; P:branch elongation involved in salivary gland morphogenesis; ISO:RGD. DR GO; GO:0060670; P:branching involved in labyrinthine layer morphogenesis; ISO:RGD. DR GO; GO:0060442; P:branching involved in prostate gland morphogenesis; ISO:RGD. DR GO; GO:0060445; P:branching involved in salivary gland morphogenesis; ISO:RGD. DR GO; GO:0048755; P:branching morphogenesis of a nerve; ISO:RGD. DR GO; GO:0060449; P:bud elongation involved in lung branching; ISO:RGD. DR GO; GO:0060070; P:canonical Wnt signaling pathway; ISO:RGD. DR GO; GO:0060038; P:cardiac muscle cell proliferation; ISO:RGD. DR GO; GO:0051301; P:cell division; ISO:RGD. DR GO; GO:0045165; P:cell fate commitment; ISO:RGD. DR GO; GO:0008283; P:cell population proliferation; ISO:RGD. DR GO; GO:0007267; P:cell-cell signaling; ISO:RGD. DR GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IMP:RGD. DR GO; GO:0071456; P:cellular response to hypoxia; IEP:RGD. DR GO; GO:0071300; P:cellular response to retinoic acid; IEP:RGD. DR GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:RGD. DR GO; GO:0060365; P:coronal suture morphogenesis; ISO:RGD. DR GO; GO:0048565; P:digestive tract development; ISO:RGD. DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; ISO:RGD. DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; ISO:RGD. DR GO; GO:0048568; P:embryonic organ development; ISO:RGD. DR GO; GO:0048562; P:embryonic organ morphogenesis; ISO:RGD. DR GO; GO:0009880; P:embryonic pattern specification; ISO:RGD. DR GO; GO:0003416; P:endochondral bone growth; IEP:RGD. DR GO; GO:0061031; P:endodermal digestive tract morphogenesis; ISO:RGD. DR GO; GO:0048730; P:epidermis morphogenesis; ISO:RGD. DR GO; GO:0030855; P:epithelial cell differentiation; ISO:RGD. DR GO; GO:0050673; P:epithelial cell proliferation; ISO:RGD. DR GO; GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis; ISO:RGD. DR GO; GO:0001837; P:epithelial to mesenchymal transition; IDA:RGD. DR GO; GO:0060441; P:epithelial tube branching involved in lung morphogenesis; ISO:RGD. DR GO; GO:0070371; P:ERK1 and ERK2 cascade; ISO:RGD. DR GO; GO:1902178; P:fibroblast growth factor receptor apoptotic signaling pathway; ISO:RGD. DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IDA:RGD. DR GO; GO:0035603; P:fibroblast growth factor receptor signaling pathway involved in hemopoiesis; ISO:RGD. DR GO; GO:0060595; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification; ISO:RGD. DR GO; GO:0035602; P:fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell; ISO:RGD. DR GO; GO:0035607; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; ISO:RGD. DR GO; GO:0035604; P:fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow; ISO:RGD. DR GO; GO:0022612; P:gland morphogenesis; ISO:RGD. DR GO; GO:0031069; P:hair follicle morphogenesis; ISO:RGD. DR GO; GO:0001701; P:in utero embryonic development; ISO:RGD. DR GO; GO:0042472; P:inner ear morphogenesis; ISO:RGD. DR GO; GO:0032808; P:lacrimal gland development; ISO:RGD. DR GO; GO:0060601; P:lateral sprouting from an epithelium; ISO:RGD. DR GO; GO:0070307; P:lens fiber cell development; ISO:RGD. DR GO; GO:0060174; P:limb bud formation; ISO:RGD. DR GO; GO:0048286; P:lung alveolus development; ISO:RGD. DR GO; GO:0030324; P:lung development; ISO:RGD. DR GO; GO:0060463; P:lung lobe morphogenesis; ISO:RGD. DR GO; GO:0060484; P:lung-associated mesenchyme development; ISO:RGD. DR GO; GO:0060615; P:mammary gland bud formation; ISO:RGD. DR GO; GO:0003149; P:membranous septum morphogenesis; ISO:RGD. DR GO; GO:0048762; P:mesenchymal cell differentiation; ISO:RGD. DR GO; GO:0060915; P:mesenchymal cell differentiation involved in lung development; ISO:RGD. DR GO; GO:0010463; P:mesenchymal cell proliferation; ISO:RGD. DR GO; GO:0060916; P:mesenchymal cell proliferation involved in lung development; ISO:RGD. DR GO; GO:0048333; P:mesodermal cell differentiation; IEP:RGD. DR GO; GO:0030901; P:midbrain development; ISO:RGD. DR GO; GO:0140014; P:mitotic nuclear division; ISO:RGD. DR GO; GO:0016331; P:morphogenesis of embryonic epithelium; ISO:RGD. DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IDA:RGD. DR GO; GO:0010839; P:negative regulation of keratinocyte proliferation; ISO:RGD. DR GO; GO:0045839; P:negative regulation of mitotic nuclear division; ISO:RGD. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD. DR GO; GO:0007528; P:neuromuscular junction development; ISO:RGD. DR GO; GO:0042476; P:odontogenesis; ISO:RGD. DR GO; GO:0021769; P:orbitofrontal cortex development; ISO:RGD. DR GO; GO:0035265; P:organ growth; ISO:RGD. DR GO; GO:0030916; P:otic vesicle formation; ISO:RGD. DR GO; GO:0003148; P:outflow tract septum morphogenesis; ISO:RGD. DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISO:RGD. DR GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; ISO:RGD. DR GO; GO:0045787; P:positive regulation of cell cycle; ISO:RGD. DR GO; GO:0051781; P:positive regulation of cell division; ISO:RGD. DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD. DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISO:RGD. DR GO; GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis; ISO:RGD. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:RGD. DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD. DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:RGD. DR GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; ISO:RGD. DR GO; GO:2000648; P:positive regulation of stem cell proliferation; ISO:RGD. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD. DR GO; GO:0050677; P:positive regulation of urothelial cell proliferation; ISO:RGD. DR GO; GO:1904707; P:positive regulation of vascular associated smooth muscle cell proliferation; IMP:RGD. DR GO; GO:0030177; P:positive regulation of Wnt signaling pathway; ISO:RGD. DR GO; GO:0009791; P:post-embryonic development; ISO:RGD. DR GO; GO:0060527; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; ISO:RGD. DR GO; GO:0060523; P:prostate epithelial cord elongation; ISO:RGD. DR GO; GO:0060512; P:prostate gland morphogenesis; ISO:RGD. DR GO; GO:0021860; P:pyramidal neuron development; ISO:RGD. DR GO; GO:0050678; P:regulation of epithelial cell proliferation; ISO:RGD. DR GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; ISO:RGD. DR GO; GO:0060688; P:regulation of morphogenesis of a branching structure; ISO:RGD. DR GO; GO:0033688; P:regulation of osteoblast proliferation; ISO:RGD. DR GO; GO:0051150; P:regulation of smooth muscle cell differentiation; ISO:RGD. DR GO; GO:0008589; P:regulation of smoothened signaling pathway; ISO:RGD. DR GO; GO:0048608; P:reproductive structure development; ISO:RGD. DR GO; GO:0045471; P:response to ethanol; IEP:RGD. DR GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD. DR GO; GO:0060529; P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; ISO:RGD. DR GO; GO:0048863; P:stem cell differentiation; ISO:RGD. DR GO; GO:0072089; P:stem cell proliferation; ISO:RGD. DR GO; GO:0048489; P:synaptic vesicle transport; ISO:RGD. DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central. DR GO; GO:0001657; P:ureteric bud development; ISO:RGD. DR GO; GO:0050674; P:urothelial cell proliferation; ISO:RGD. DR GO; GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; ISO:RGD. DR GO; GO:0021847; P:ventricular zone neuroblast division; ISO:RGD. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR Pfam; PF07679; I-set; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. PE 4: Predicted; KW Receptor {ECO:0000313|EMBL:BAA77279.1}. FT DOMAIN 8..46 FT /note="Immunoglobulin I-set" FT /evidence="ECO:0000259|Pfam:PF07679" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:BAA77279.1" FT NON_TER 48 FT /evidence="ECO:0000313|EMBL:BAA77279.1" SQ SEQUENCE 48 AA; 5188 MW; 70B9F2AA9DC87C38 CRC64; AAGVNTTDKE IEVLYIRNVT FEDAGEYTCL AGNSIGISFH SAWLTVLP //