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Q9R2A0

- Q9R2A0_RAT

UniProt

Q9R2A0 - Q9R2A0_RAT

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Protein
Submitted name:

Fibroblast growth factor receptor 2

Gene

Fgfr2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. fibroblast growth factor-activated receptor activity Source: RGD
  2. fibroblast growth factor binding Source: RGD

GO - Biological processi

  1. embryonic cranial skeleton morphogenesis Source: InterPro
  2. epithelial to mesenchymal transition Source: RGD
  3. fibroblast growth factor receptor signaling pathway Source: RGD
  4. mesodermal cell differentiation Source: RGD
  5. negative regulation of epithelial cell proliferation Source: RGD
  6. positive regulation of smooth muscle cell proliferation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiREACT_198665. Signaling by FGFR mutants.
REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198813. Activated point mutants of FGFR2.
REACT_198815. Signaling by FGFR2 amplification mutants.
REACT_198995. Negative regulation of FGFR signaling.
REACT_202034. Phospholipase C-mediated cascade.
REACT_79133. SHC-mediated cascade.

Names & Taxonomyi

Protein namesi
Submitted name:
Fibroblast growth factor receptor 2Imported
Submitted name:
Fibroblast growth factor receptor-2Imported
Gene namesi
Name:Fgfr2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2611. Fgfr2.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: RGD
  2. cytoplasm Source: RGD
  3. nucleus Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ9R2A0.

Family & Domainsi

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR028175. FGF_rcpt_2.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
[Graphical view]
PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
PfamiPF07679. I-set. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9R2A0 [UniParc]FASTAAdd to Basket

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        10         20         30         40
AAGVNTTDKE IEVLYIRNVT FEDAGEYTCL AGNSIGISFH SAWLTVLP
Length:48
Mass (Da):5,188
Last modified:May 1, 2000 - v1
Checksum:i70B9F2AA9DC87C38
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei48 – 481Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF456422 Genomic DNA. Translation: AAL77412.1.
D83495 Genomic DNA. Translation: BAA77279.1.
UniGeneiRn.12732.

Genome annotation databases

UCSCiRGD:2611. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF456422 Genomic DNA. Translation: AAL77412.1 .
D83495 Genomic DNA. Translation: BAA77279.1 .
UniGenei Rn.12732.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:2611. rat.

Organism-specific databases

RGDi 2611. Fgfr2.

Enzyme and pathway databases

Reactomei REACT_198665. Signaling by FGFR mutants.
REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198813. Activated point mutants of FGFR2.
REACT_198815. Signaling by FGFR2 amplification mutants.
REACT_198995. Negative regulation of FGFR signaling.
REACT_202034. Phospholipase C-mediated cascade.
REACT_79133. SHC-mediated cascade.

Gene expression databases

Genevestigatori Q9R2A0.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR028175. FGF_rcpt_2.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
[Graphical view ]
PANTHERi PTHR24416:SF130. PTHR24416:SF130. 1 hit.
Pfami PF07679. I-set. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rat oligodendrocytes and astrocytes preferentially express fibroblast growth factor receptor-2 and -3 mRNAs."
    Miyake A., Hattori Y., Ohta M., Itoh N.
    J. Neurosci. Res. 45:534-541(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WistarImported.
  2. "An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing."
    Carstens R.P., McKeehan W.L., Garcia-Blanco M.A.
    Mol. Cell. Biol. 18:2205-2217(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Carstens R.P., Garcia-Blanco M.A.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9R2A0_RAT
AccessioniPrimary (citable) accession number: Q9R2A0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)