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Q9R2A0

- Q9R2A0_RAT

UniProt

Q9R2A0 - Q9R2A0_RAT

Protein
Submitted name:

Fibroblast growth factor receptor 2

Gene

Fgfr2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. fibroblast growth factor-activated receptor activity Source: RGD
    2. fibroblast growth factor binding Source: RGD

    GO - Biological processi

    1. embryonic cranial skeleton morphogenesis Source: InterPro
    2. epithelial to mesenchymal transition Source: RGD
    3. fibroblast growth factor receptor signaling pathway Source: RGD
    4. mesodermal cell differentiation Source: RGD
    5. negative regulation of epithelial cell proliferation Source: RGD
    6. positive regulation of smooth muscle cell proliferation Source: RGD

    Keywords - Molecular functioni

    ReceptorImported

    Enzyme and pathway databases

    ReactomeiREACT_198665. Signaling by FGFR mutants.
    REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198813. Activated point mutants of FGFR2.
    REACT_198815. Signaling by FGFR2 amplification mutants.
    REACT_198995. Negative regulation of FGFR signaling.
    REACT_202034. Phospholipase C-mediated cascade.
    REACT_79133. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Fibroblast growth factor receptor 2Imported
    Submitted name:
    Fibroblast growth factor receptor-2Imported
    Gene namesi
    Name:Fgfr2Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi2611. Fgfr2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: RGD
    2. cytoplasm Source: RGD
    3. nucleus Source: RGD

    Expressioni

    Gene expression databases

    GenevestigatoriQ9R2A0.

    Family & Domainsi

    Phylogenomic databases

    InParanoidiQ9R2A0.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR028175. FGF_rcpt_2.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    [Graphical view]
    PANTHERiPTHR24416:SF130. PTHR24416:SF130. 1 hit.
    PfamiPF07679. I-set. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9R2A0-1 [UniParc]FASTAAdd to Basket

    « Hide

    AAGVNTTDKE IEVLYIRNVT FEDAGEYTCL AGNSIGISFH SAWLTVLP     48
    Length:48
    Mass (Da):5,188
    Last modified:May 1, 2000 - v1
    Checksum:i70B9F2AA9DC87C38
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei48 – 481Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF456422 Genomic DNA. Translation: AAL77412.1.
    D83495 Genomic DNA. Translation: BAA77279.1.
    UniGeneiRn.12732.

    Genome annotation databases

    UCSCiRGD:2611. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF456422 Genomic DNA. Translation: AAL77412.1 .
    D83495 Genomic DNA. Translation: BAA77279.1 .
    UniGenei Rn.12732.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:2611. rat.

    Organism-specific databases

    RGDi 2611. Fgfr2.

    Phylogenomic databases

    InParanoidi Q9R2A0.

    Enzyme and pathway databases

    Reactomei REACT_198665. Signaling by FGFR mutants.
    REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198813. Activated point mutants of FGFR2.
    REACT_198815. Signaling by FGFR2 amplification mutants.
    REACT_198995. Negative regulation of FGFR signaling.
    REACT_202034. Phospholipase C-mediated cascade.
    REACT_79133. SHC-mediated cascade.

    Gene expression databases

    Genevestigatori Q9R2A0.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR028175. FGF_rcpt_2.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    [Graphical view ]
    PANTHERi PTHR24416:SF130. PTHR24416:SF130. 1 hit.
    Pfami PF07679. I-set. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rat oligodendrocytes and astrocytes preferentially express fibroblast growth factor receptor-2 and -3 mRNAs."
      Miyake A., Hattori Y., Ohta M., Itoh N.
      J. Neurosci. Res. 45:534-541(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: WistarImported.
    2. "An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing."
      Carstens R.P., McKeehan W.L., Garcia-Blanco M.A.
      Mol. Cell. Biol. 18:2205-2217(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Carstens R.P., Garcia-Blanco M.A.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9R2A0_RAT
    AccessioniPrimary (citable) accession number: Q9R2A0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)