ID   TRPC2_RAT               Reviewed;        1170 AA.
AC   Q9R283; B5DFD7; O70485;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   27-MAR-2024, entry version 166.
DE   RecName: Full=Short transient receptor potential channel 2;
DE            Short=TrpC2;
DE   AltName: Full=Transient receptor protein 2;
DE            Short=TRP-2;
DE            Short=rTrp2;
GN   Name=Trpc2; Synonyms=Trp2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX   PubMed=10318963; DOI=10.1073/pnas.96.10.5791;
RA   Liman E.R., Corey D.P., Dulac C.;
RT   "TRP2: a candidate transduction channel for mammalian pheromone sensory
RT   signaling.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:5791-5796(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Embryo;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 867-930 (ISOFORM 1/2).
RC   STRAIN=Wistar; TISSUE=Heart;
RA   Koizumi S., Ripley S.J., Bootman M.D., Lipp P., Berridge M.J.,
RA   Bobanovic L.K.;
RT   "Expression patterns of mammalian trp homologues in rat excitable cells.";
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Thought to form a receptor-activated calcium permeant cation
CC       channel. Probably is operated by a phosphatidylinositol second
CC       messenger system activated by receptor tyrosine kinases or G-protein
CC       coupled receptors. Is not activated by intracellular calcium store
CC       depletion.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q9R283-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9R283-2; Sequence=VSP_037236, VSP_037237;
CC       Name=3;
CC         IsoId=Q9R283-3; Sequence=VSP_038807, VSP_037238, VSP_037239;
CC   -!- TISSUE SPECIFICITY: Expressed exclusively in vomeronasal organ neurons
CC       (sensory microvilli).
CC   -!- MISCELLANEOUS: [Isoform 1]: Inferred from mouse sequence.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC
CC       subfamily. TRPC2 sub-subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF136401; AAD31453.1; -; mRNA.
DR   EMBL; AABR03002379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03010502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03010734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03001253; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC169022; AAI69022.1; -; mRNA.
DR   EMBL; AF061874; AAC16726.1; -; mRNA.
DR   RefSeq; NP_001316819.1; NM_001329890.1. [Q9R283-3]
DR   RefSeq; XP_006223495.1; XM_006223433.3.
DR   RefSeq; XP_006229966.1; XM_006229904.3. [Q9R283-3]
DR   AlphaFoldDB; Q9R283; -.
DR   SMR; Q9R283; -.
DR   STRING; 10116.ENSRNOP00000047354; -.
DR   PhosphoSitePlus; Q9R283; -.
DR   PaxDb; 10116-ENSRNOP00000047354; -.
DR   Ensembl; ENSRNOT00000045726.5; ENSRNOP00000042378.5; ENSRNOG00000020188.9. [Q9R283-2]
DR   Ensembl; ENSRNOT00000048172.6; ENSRNOP00000047354.3; ENSRNOG00000020188.9. [Q9R283-1]
DR   GeneID; 102549471; -.
DR   KEGG; rno:102549471; -.
DR   UCSC; RGD:628819; rat. [Q9R283-1]
DR   AGR; RGD:628819; -.
DR   AGR; RGD:7692537; -.
DR   CTD; 102443350; -.
DR   RGD; 628819; Trpc2.
DR   eggNOG; KOG3609; Eukaryota.
DR   GeneTree; ENSGT01060000248588; -.
DR   HOGENOM; CLU_005716_2_0_1; -.
DR   InParanoid; Q9R283; -.
DR   OMA; MIDDMMF; -.
DR   OrthoDB; 5406916at2759; -.
DR   PhylomeDB; Q9R283; -.
DR   PRO; PR:Q9R283; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000020188; Expressed in testis and 16 other cell types or tissues.
DR   ExpressionAtlas; Q9R283; baseline and differential.
DR   GO; GO:0034703; C:cation channel complex; IBA:GO_Central.
DR   GO; GO:0032590; C:dendrite membrane; ISO:RGD.
DR   GO; GO:0012505; C:endomembrane system; ISO:RGD.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:RGD.
DR   GO; GO:0000139; C:Golgi membrane; ISO:RGD.
DR   GO; GO:0005635; C:nuclear envelope; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0019992; F:diacylglycerol binding; ISO:RGD.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; ISO:RGD.
DR   GO; GO:0015279; F:store-operated calcium channel activity; ISO:RGD.
DR   GO; GO:0007340; P:acrosome reaction; ISO:RGD.
DR   GO; GO:0002118; P:aggressive behavior; ISO:RGD.
DR   GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006816; P:calcium ion transport; ISO:RGD.
DR   GO; GO:0008050; P:female courtship behavior; ISO:RGD.
DR   GO; GO:0002121; P:inter-male aggressive behavior; ISO:RGD.
DR   GO; GO:0048047; P:mating behavior, sex discrimination; ISO:RGD.
DR   GO; GO:1902436; P:negative regulation of male mating behavior; ISO:RGD.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:RGD.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
DR   GO; GO:0019236; P:response to pheromone; ISO:RGD.
DR   GO; GO:0007338; P:single fertilization; IBA:GO_Central.
DR   GO; GO:0000012; P:single strand break repair; IEA:InterPro.
DR   GO; GO:0002124; P:territorial aggressive behavior; ISO:RGD.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005458; TRPC2_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   InterPro; IPR002706; Xrcc1_N.
DR   PANTHER; PTHR10117:SF6; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 2; 1.
DR   PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   Pfam; PF01834; XRCC1_N; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01643; TRPCHANNEL2.
DR   SMART; SM01420; TRP_2; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   Genevisible; Q9R283; RN.
PE   2: Evidence at transcript level;
KW   Alternative splicing; ANK repeat; Calcium; Calcium channel;
KW   Calcium transport; Coiled coil; Ion channel; Ion transport; Membrane;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1170
FT                   /note="Short transient receptor potential channel 2"
FT                   /id="PRO_0000215308"
FT   TOPO_DOM        1..627
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        628..648
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        649..658
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        659..679
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        680..701
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        702..722
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        723..737
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        738..758
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        759..788
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        789..809
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        810..832
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        833..853
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        854..898
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        899..919
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        920..1170
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REPEAT          300..329
FT                   /note="ANK 1"
FT   REPEAT          346..376
FT                   /note="ANK 2"
FT   REPEAT          377..405
FT                   /note="ANK 3"
FT   REPEAT          429..458
FT                   /note="ANK 4"
FT   REGION          64..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          142..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1118..1170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1030..1068
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        66..113
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..180
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..231
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1130..1145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1146..1170
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..283
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:10318963"
FT                   /id="VSP_037236"
FT   VAR_SEQ         1
FT                   /note="M -> MAPVKISHVVSFSSQDPKYPVENLLNPDSHKGPWLSCPRDKTGQLKV
FT                   EFQLERAVPISYIDVGNCGCAFLQIDVGRSSWPLDRPFVTLLPATM (in isoform
FT                   3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_038807"
FT   VAR_SEQ         274..315
FT                   /note="RCLHVALTPVPLIPKPNWTEIVNKKLKFPPTLLRAIQEGQLG -> WVSSPE
FT                   SSPPPSSWVQCPICELQFSAREIEEHASVCGEVFPA (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_037238"
FT   VAR_SEQ         284..288
FT                   /note="PLIPK -> MDPLS (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:10318963"
FT                   /id="VSP_037237"
FT   VAR_SEQ         316..1170
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_037239"
FT   CONFLICT        1010
FT                   /note="H -> R (in Ref. 1; AAD31453)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1069..1070
FT                   /note="Missing (in Ref. 1; AAD31453)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1170 AA;  130467 MW;  BDF876A83B28CA5C CRC64;
     MLMSLTDSKE GKNRSGVRMF KDDDFLIPAS GESWDRLRLT CSQPFTRHQS FGLAFLRVRS
     SLDSLSDPVK DPSSPGSSGL NQNSSDKLES DPSPWLTNPS IRRTFFPDPQ TSTKEISALK
     GMLKQLQPGP LGRAARMVLS AAHKAPPASV VSPNNSHGEP DSSHPERAEP RAEEPNRKNN
     ASRGKRRKVQ EQRRPLSSSS SQPNRRATGR TKQRQQRPQA KSDGSGVQAT GQCPICTGSF
     SIEALPRHAA TCGESSPPQP ASPTSLSSSE SVLRCLHVAL TPVPLIPKPN WTEIVNKKLK
     FPPTLLRAIQ EGQLGLVQQL LESGSDPSGA GPGGPLRNVE ESEDRSWREA LNLAIRLGHE
     VITDVLLANV KFDFRQIHEA LLVAVDTNQP AVVRRLLARL EREKGRKVDT KSFSLAFFDS
     SIDGSRFAPG VTPLTLACQK DLYEIAQLLM DQGHTIARPH PVSCACLECS NARRYDLLKF
     SLSRINTYRG IASRAHLSLA SEDAMLAAFQ LSRELRRLAR KEPEFKPQYI ALESLCQDYG
     FELLGMCRNQ SEVTAVLNDL GEDSETEPEA EGLGQAFEEG IPNLARLRLA VNYNQKQFVA
     HPICQQVLSS IWCGNLAGWR GSTTIWKLFV AFLIFLTMPF LCIGYWLAPK SRLGRLLKIP
     VLKFLLHSAS YLWFLIFLLG ESLVMETQLS TFKGRSQSVW ETSLHMIWVT GFLWFECKEV
     WIEGLRSYLL DWWNFLDVVI LSLYLASFAL RLLLAGLAYM HCRDASDSST CRYFTTAERS
     EWRTEDPQFL AEVLFAVTSM LSFTRLAYIL PAHESLGTLQ ISIGKMIDDM IRFMFILMII
     LTAFLCGLNN IYVPYQETEK LGNFNETFQF LFWTMFGMEE HSVVDMPQFL VPEFVGRAMY
     GIFTIVMVIV LLNMLIAMIT NSFQKIEDDA DVEWKFARSK LYLSYFREGL TLPVPFNILP
     SPKAAFYLLR RIFRFICCGS SCCKAKKSDY PPIPTFTNPG ARAGPGEGEH VSYRLRVIKA
     LVQRYIETAR REFEETRRKD LGNRLTELTK TVSRLQSEVA SVQKTVAAGG ALRPPDGASI
     LSRYITRVRN SFQNLGPPAP DTPAELTMPG IVETEVSLED SLDATGEAGT PASGESSSSS
     SAHVLVHREQ EAEGAGDLPL GEDLETKGES
//