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Protein

Short transient receptor potential channel 2

Gene

Trpc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Thought to form a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Is not activated by intracellular calcium store depletion.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 2
Short name:
TrpC2
Alternative name(s):
Transient receptor protein 2
Short name:
TRP-2
Short name:
rTrp2
Gene namesi
Name:Trpc2
Synonyms:Trp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628819. Trpc2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 627CytoplasmicSequence analysisAdd BLAST627
Transmembranei628 – 648HelicalSequence analysisAdd BLAST21
Topological domaini649 – 658ExtracellularSequence analysis10
Transmembranei659 – 679HelicalSequence analysisAdd BLAST21
Topological domaini680 – 701CytoplasmicSequence analysisAdd BLAST22
Transmembranei702 – 722HelicalSequence analysisAdd BLAST21
Topological domaini723 – 737ExtracellularSequence analysisAdd BLAST15
Transmembranei738 – 758HelicalSequence analysisAdd BLAST21
Topological domaini759 – 788CytoplasmicSequence analysisAdd BLAST30
Transmembranei789 – 809HelicalSequence analysisAdd BLAST21
Topological domaini810 – 832ExtracellularSequence analysisAdd BLAST23
Transmembranei833 – 853HelicalSequence analysisAdd BLAST21
Topological domaini854 – 898CytoplasmicSequence analysisAdd BLAST45
Transmembranei899 – 919HelicalSequence analysisAdd BLAST21
Topological domaini920 – 1170ExtracellularSequence analysisAdd BLAST251

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153081 – 1170Short transient receptor potential channel 2Add BLAST1170

Proteomic databases

PaxDbiQ9R283.
PRIDEiQ9R283.

Expressioni

Tissue specificityi

Expressed exclusively in vomeronasal organ neurons (sensory microvilli).

Gene expression databases

BgeeiENSRNOG00000020188.
ExpressionAtlasiQ9R283. differential.
GenevisibleiQ9R283. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047354.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati300 – 329ANK 1Add BLAST30
Repeati346 – 376ANK 2Add BLAST31
Repeati377 – 405ANK 3Add BLAST29
Repeati429 – 458ANK 4Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1030 – 1068Sequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi197 – 201Poly-Ser5
Compositional biasi1136 – 1141Poly-Ser6

Sequence similaritiesi

Contains 4 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000137678.
HOVERGENiHBG061894.
InParanoidiQ9R283.
KOiK04965.
OMAiITRVRNS.
OrthoDBiEOG091G0KP0.
PhylomeDBiQ9R283.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.120.260. 1 hit.
InterProiIPR020683. Ankyrin_rpt-contain_dom.
IPR008979. Galactose-bd-like.
IPR005821. Ion_trans_dom.
IPR013555. TRP_dom.
IPR005458. TRPC2_channel.
IPR002153. TRPC_channel.
IPR002706. Xrcc1_N.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF6. PTHR10117:SF6. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
PF01834. XRCC1_N. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01643. TRPCHANNEL2.
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF49785. SSF49785. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9R283-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLMSLTDSKE GKNRSGVRMF KDDDFLIPAS GESWDRLRLT CSQPFTRHQS
60 70 80 90 100
FGLAFLRVRS SLDSLSDPVK DPSSPGSSGL NQNSSDKLES DPSPWLTNPS
110 120 130 140 150
IRRTFFPDPQ TSTKEISALK GMLKQLQPGP LGRAARMVLS AAHKAPPASV
160 170 180 190 200
VSPNNSHGEP DSSHPERAEP RAEEPNRKNN ASRGKRRKVQ EQRRPLSSSS
210 220 230 240 250
SQPNRRATGR TKQRQQRPQA KSDGSGVQAT GQCPICTGSF SIEALPRHAA
260 270 280 290 300
TCGESSPPQP ASPTSLSSSE SVLRCLHVAL TPVPLIPKPN WTEIVNKKLK
310 320 330 340 350
FPPTLLRAIQ EGQLGLVQQL LESGSDPSGA GPGGPLRNVE ESEDRSWREA
360 370 380 390 400
LNLAIRLGHE VITDVLLANV KFDFRQIHEA LLVAVDTNQP AVVRRLLARL
410 420 430 440 450
EREKGRKVDT KSFSLAFFDS SIDGSRFAPG VTPLTLACQK DLYEIAQLLM
460 470 480 490 500
DQGHTIARPH PVSCACLECS NARRYDLLKF SLSRINTYRG IASRAHLSLA
510 520 530 540 550
SEDAMLAAFQ LSRELRRLAR KEPEFKPQYI ALESLCQDYG FELLGMCRNQ
560 570 580 590 600
SEVTAVLNDL GEDSETEPEA EGLGQAFEEG IPNLARLRLA VNYNQKQFVA
610 620 630 640 650
HPICQQVLSS IWCGNLAGWR GSTTIWKLFV AFLIFLTMPF LCIGYWLAPK
660 670 680 690 700
SRLGRLLKIP VLKFLLHSAS YLWFLIFLLG ESLVMETQLS TFKGRSQSVW
710 720 730 740 750
ETSLHMIWVT GFLWFECKEV WIEGLRSYLL DWWNFLDVVI LSLYLASFAL
760 770 780 790 800
RLLLAGLAYM HCRDASDSST CRYFTTAERS EWRTEDPQFL AEVLFAVTSM
810 820 830 840 850
LSFTRLAYIL PAHESLGTLQ ISIGKMIDDM IRFMFILMII LTAFLCGLNN
860 870 880 890 900
IYVPYQETEK LGNFNETFQF LFWTMFGMEE HSVVDMPQFL VPEFVGRAMY
910 920 930 940 950
GIFTIVMVIV LLNMLIAMIT NSFQKIEDDA DVEWKFARSK LYLSYFREGL
960 970 980 990 1000
TLPVPFNILP SPKAAFYLLR RIFRFICCGS SCCKAKKSDY PPIPTFTNPG
1010 1020 1030 1040 1050
ARAGPGEGEH VSYRLRVIKA LVQRYIETAR REFEETRRKD LGNRLTELTK
1060 1070 1080 1090 1100
TVSRLQSEVA SVQKTVAAGG ALRPPDGASI LSRYITRVRN SFQNLGPPAP
1110 1120 1130 1140 1150
DTPAELTMPG IVETEVSLED SLDATGEAGT PASGESSSSS SAHVLVHREQ
1160 1170
EAEGAGDLPL GEDLETKGES
Note: No experimental confirmation available. Inferred from mouse sequence.
Length:1,170
Mass (Da):130,467
Last modified:May 5, 2009 - v2
Checksum:iBDF876A83B28CA5C
GO
Isoform 2 (identifier: Q9R283-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-283: Missing.
     284-288: PLIPK → MDPLS

Note: No experimental confirmation available.
Show »
Length:887
Mass (Da):99,809
Checksum:iF8A516AEB39F3A50
GO
Isoform 3 (identifier: Q9R283-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAPVKISHVV...PFVTLLPATM
     274-315: RCLHVALTPV...LRAIQEGQLG → WVSSPESSPP...ASVCGEVFPA
     316-1170: Missing.

Note: No experimental confirmation available.
Show »
Length:407
Mass (Da):44,359
Checksum:i3C1FAF331F007681
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1010H → R in AAD31453 (PubMed:10318963).Curated1
Sequence conflicti1069 – 1070Missing in AAD31453 (PubMed:10318963).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0372361 – 283Missing in isoform 2. 1 PublicationAdd BLAST283
Alternative sequenceiVSP_0388071M → MAPVKISHVVSFSSQDPKYP VENLLNPDSHKGPWLSCPRD KTGQLKVEFQLERAVPISYI DVGNCGCAFLQIDVGRSSWP LDRPFVTLLPATM in isoform 3. 1 Publication1
Alternative sequenceiVSP_037238274 – 315RCLHV…EGQLG → WVSSPESSPPPSSWVQCPIC ELQFSAREIEEHASVCGEVF PA in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_037237284 – 288PLIPK → MDPLS in isoform 2. 1 Publication5
Alternative sequenceiVSP_037239316 – 1170Missing in isoform 3. 1 PublicationAdd BLAST855

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136401 mRNA. Translation: AAD31453.1.
AABR03002379 Genomic DNA. No translation available.
AABR03010502 Genomic DNA. No translation available.
AABR03010734 Genomic DNA. No translation available.
AABR03001253 Genomic DNA. No translation available.
BC169022 mRNA. Translation: AAI69022.1.
AF061874 mRNA. Translation: AAC16726.1.
RefSeqiNP_001316819.1. NM_001329890.1. [Q9R283-3]
XP_006223495.1. XM_006223433.3. [Q9R283-3]
XP_006229966.1. XM_006229904.3. [Q9R283-3]
UniGeneiRn.48766.

Genome annotation databases

EnsembliENSRNOT00000048172; ENSRNOP00000047354; ENSRNOG00000020188. [Q9R283-1]
GeneIDi102549471.
KEGGirno:102549471.
rno:64573.
UCSCiRGD:628819. rat. [Q9R283-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136401 mRNA. Translation: AAD31453.1.
AABR03002379 Genomic DNA. No translation available.
AABR03010502 Genomic DNA. No translation available.
AABR03010734 Genomic DNA. No translation available.
AABR03001253 Genomic DNA. No translation available.
BC169022 mRNA. Translation: AAI69022.1.
AF061874 mRNA. Translation: AAC16726.1.
RefSeqiNP_001316819.1. NM_001329890.1. [Q9R283-3]
XP_006223495.1. XM_006223433.3. [Q9R283-3]
XP_006229966.1. XM_006229904.3. [Q9R283-3]
UniGeneiRn.48766.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047354.

Proteomic databases

PaxDbiQ9R283.
PRIDEiQ9R283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000048172; ENSRNOP00000047354; ENSRNOG00000020188. [Q9R283-1]
GeneIDi102549471.
KEGGirno:102549471.
rno:64573.
UCSCiRGD:628819. rat. [Q9R283-1]

Organism-specific databases

CTDi7221.
RGDi628819. Trpc2.

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000137678.
HOVERGENiHBG061894.
InParanoidiQ9R283.
KOiK04965.
OMAiITRVRNS.
OrthoDBiEOG091G0KP0.
PhylomeDBiQ9R283.

Miscellaneous databases

PROiQ9R283.

Gene expression databases

BgeeiENSRNOG00000020188.
ExpressionAtlasiQ9R283. differential.
GenevisibleiQ9R283. RN.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.120.260. 1 hit.
InterProiIPR020683. Ankyrin_rpt-contain_dom.
IPR008979. Galactose-bd-like.
IPR005821. Ion_trans_dom.
IPR013555. TRP_dom.
IPR005458. TRPC2_channel.
IPR002153. TRPC_channel.
IPR002706. Xrcc1_N.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF6. PTHR10117:SF6. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
PF01834. XRCC1_N. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01643. TRPCHANNEL2.
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF49785. SSF49785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPC2_RAT
AccessioniPrimary (citable) accession number: Q9R283
Secondary accession number(s): B5DFD7, O70485
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.