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Q9R283 (TRPC2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Short transient receptor potential channel 2

Short name=TrpC2
Alternative name(s):
Transient receptor protein 2
Short name=TRP-2
Short name=rTrp2
Gene names
Name:Trpc2
Synonyms:Trp2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1170 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Thought to form a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Is not activated by intracellular calcium store depletion.

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Tissue specificity

Expressed exclusively in vomeronasal organ neurons (sensory microvilli).

Sequence similarities

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC2 sub-subfamily. [View classification]

Contains 4 ANK repeats.

Ontologies

Keywords
   Biological processCalcium transport
Ion transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainANK repeat
Coiled coil
Repeat
Transmembrane
Transmembrane helix
   LigandCalcium
   Molecular functionCalcium channel
Ion channel
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processacrosome reaction

Inferred from electronic annotation. Source: Ensembl

female courtship behavior

Inferred from electronic annotation. Source: Ensembl

inter-male aggressive behavior

Inferred from electronic annotation. Source: Ensembl

mating behavior, sex discrimination

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

response to pheromone

Inferred from electronic annotation. Source: Ensembl

single strand break repair

Inferred from electronic annotation. Source: InterPro

territorial aggressive behavior

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi membrane

Inferred from electronic annotation. Source: Ensembl

dendrite membrane

Inferred from electronic annotation. Source: Ensembl

endoplasmic reticulum membrane

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

nuclear envelope

Inferred from electronic annotation. Source: Ensembl

   Molecular_functiondamaged DNA binding

Inferred from electronic annotation. Source: InterPro

diacylglycerol binding

Inferred from electronic annotation. Source: Ensembl

inositol 1,4,5 trisphosphate binding

Inferred from electronic annotation. Source: Ensembl

store-operated calcium channel activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9R283-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available. Inferred from mouse sequence.
Isoform 2 (identifier: Q9R283-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-283: Missing.
     284-288: PLIPK → MDPLS
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9R283-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAPVKISHVV...PFVTLLPATM
     274-315: RCLHVALTPV...LRAIQEGQLG → WVSSPESSPP...ASVCGEVFPA
     316-1170: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11701170Short transient receptor potential channel 2
PRO_0000215308

Regions

Topological domain1 – 627627Cytoplasmic Potential
Transmembrane628 – 64821Helical; Potential
Topological domain649 – 65810Extracellular Potential
Transmembrane659 – 67921Helical; Potential
Topological domain680 – 70122Cytoplasmic Potential
Transmembrane702 – 72221Helical; Potential
Topological domain723 – 73715Extracellular Potential
Transmembrane738 – 75821Helical; Potential
Topological domain759 – 78830Cytoplasmic Potential
Transmembrane789 – 80921Helical; Potential
Topological domain810 – 83223Extracellular Potential
Transmembrane833 – 85321Helical; Potential
Topological domain854 – 89845Cytoplasmic Potential
Transmembrane899 – 91921Helical; Potential
Topological domain920 – 1170251Extracellular Potential
Repeat300 – 32930ANK 1
Repeat346 – 37631ANK 2
Repeat377 – 40529ANK 3
Repeat429 – 45830ANK 4
Coiled coil1030 – 106839 Potential
Compositional bias197 – 2015Poly-Ser
Compositional bias1136 – 11416Poly-Ser

Natural variations

Alternative sequence1 – 283283Missing in isoform 2.
VSP_037236
Alternative sequence11M → MAPVKISHVVSFSSQDPKYP VENLLNPDSHKGPWLSCPRD KTGQLKVEFQLERAVPISYI DVGNCGCAFLQIDVGRSSWP LDRPFVTLLPATM in isoform 3.
VSP_038807
Alternative sequence274 – 31542RCLHV…EGQLG → WVSSPESSPPPSSWVQCPIC ELQFSAREIEEHASVCGEVF PA in isoform 3.
VSP_037238
Alternative sequence284 – 2885PLIPK → MDPLS in isoform 2.
VSP_037237
Alternative sequence316 – 1170855Missing in isoform 3.
VSP_037239

Experimental info

Sequence conflict10101H → R in AAD31453. Ref.1
Sequence conflict1069 – 10702Missing in AAD31453. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: BDF876A83B28CA5C

FASTA1,170130,467
        10         20         30         40         50         60 
MLMSLTDSKE GKNRSGVRMF KDDDFLIPAS GESWDRLRLT CSQPFTRHQS FGLAFLRVRS 

        70         80         90        100        110        120 
SLDSLSDPVK DPSSPGSSGL NQNSSDKLES DPSPWLTNPS IRRTFFPDPQ TSTKEISALK 

       130        140        150        160        170        180 
GMLKQLQPGP LGRAARMVLS AAHKAPPASV VSPNNSHGEP DSSHPERAEP RAEEPNRKNN 

       190        200        210        220        230        240 
ASRGKRRKVQ EQRRPLSSSS SQPNRRATGR TKQRQQRPQA KSDGSGVQAT GQCPICTGSF 

       250        260        270        280        290        300 
SIEALPRHAA TCGESSPPQP ASPTSLSSSE SVLRCLHVAL TPVPLIPKPN WTEIVNKKLK 

       310        320        330        340        350        360 
FPPTLLRAIQ EGQLGLVQQL LESGSDPSGA GPGGPLRNVE ESEDRSWREA LNLAIRLGHE 

       370        380        390        400        410        420 
VITDVLLANV KFDFRQIHEA LLVAVDTNQP AVVRRLLARL EREKGRKVDT KSFSLAFFDS 

       430        440        450        460        470        480 
SIDGSRFAPG VTPLTLACQK DLYEIAQLLM DQGHTIARPH PVSCACLECS NARRYDLLKF 

       490        500        510        520        530        540 
SLSRINTYRG IASRAHLSLA SEDAMLAAFQ LSRELRRLAR KEPEFKPQYI ALESLCQDYG 

       550        560        570        580        590        600 
FELLGMCRNQ SEVTAVLNDL GEDSETEPEA EGLGQAFEEG IPNLARLRLA VNYNQKQFVA 

       610        620        630        640        650        660 
HPICQQVLSS IWCGNLAGWR GSTTIWKLFV AFLIFLTMPF LCIGYWLAPK SRLGRLLKIP 

       670        680        690        700        710        720 
VLKFLLHSAS YLWFLIFLLG ESLVMETQLS TFKGRSQSVW ETSLHMIWVT GFLWFECKEV 

       730        740        750        760        770        780 
WIEGLRSYLL DWWNFLDVVI LSLYLASFAL RLLLAGLAYM HCRDASDSST CRYFTTAERS 

       790        800        810        820        830        840 
EWRTEDPQFL AEVLFAVTSM LSFTRLAYIL PAHESLGTLQ ISIGKMIDDM IRFMFILMII 

       850        860        870        880        890        900 
LTAFLCGLNN IYVPYQETEK LGNFNETFQF LFWTMFGMEE HSVVDMPQFL VPEFVGRAMY 

       910        920        930        940        950        960 
GIFTIVMVIV LLNMLIAMIT NSFQKIEDDA DVEWKFARSK LYLSYFREGL TLPVPFNILP 

       970        980        990       1000       1010       1020 
SPKAAFYLLR RIFRFICCGS SCCKAKKSDY PPIPTFTNPG ARAGPGEGEH VSYRLRVIKA 

      1030       1040       1050       1060       1070       1080 
LVQRYIETAR REFEETRRKD LGNRLTELTK TVSRLQSEVA SVQKTVAAGG ALRPPDGASI 

      1090       1100       1110       1120       1130       1140 
LSRYITRVRN SFQNLGPPAP DTPAELTMPG IVETEVSLED SLDATGEAGT PASGESSSSS 

      1150       1160       1170 
SAHVLVHREQ EAEGAGDLPL GEDLETKGES 

« Hide

Isoform 2 [UniParc].

Checksum: F8A516AEB39F3A50
Show »

FASTA88799,809
Isoform 3 [UniParc].

Checksum: 3C1FAF331F007681
Show »

FASTA40744,359

References

« Hide 'large scale' references
[1]"TRP2: a candidate transduction channel for mammalian pheromone sensory signaling."
Liman E.R., Corey D.P., Dulac C.
Proc. Natl. Acad. Sci. U.S.A. 96:5791-5796(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Embryo.
[4]"Expression patterns of mammalian trp homologues in rat excitable cells."
Koizumi S., Ripley S.J., Bootman M.D., Lipp P., Berridge M.J., Bobanovic L.K.
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 867-930 (ISOFORM 1/2).
Strain: Wistar.
Tissue: Heart.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF136401 mRNA. Translation: AAD31453.1.
AABR03002379 Genomic DNA. No translation available.
AABR03010502 Genomic DNA. No translation available.
AABR03010734 Genomic DNA. No translation available.
AABR03001253 Genomic DNA. No translation available.
BC169022 mRNA. Translation: AAI69022.1.
AF061874 mRNA. Translation: AAC16726.1.
RefSeqXP_006223494.1. XM_006223432.1.
XP_006223495.1. XM_006223433.1.
XP_006229965.1. XM_006229903.1.
XP_006229966.1. XM_006229904.1.
UniGeneRn.48766.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000027391.

Proteomic databases

PaxDbQ9R283.
PRIDEQ9R283.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000027358; ENSRNOP00000027358; ENSRNOG00000020188. [Q9R283-3]
ENSRNOT00000045726; ENSRNOP00000042378; ENSRNOG00000020188. [Q9R283-2]
ENSRNOT00000048172; ENSRNOP00000047354; ENSRNOG00000020188. [Q9R283-1]
GeneID102549471.
UCSCRGD:628819. rat. [Q9R283-1]

Organism-specific databases

RGD628819. Trpc2.

Phylogenomic databases

eggNOGNOG257288.
GeneTreeENSGT00680000099764.
HOGENOMHOG000137678.
HOVERGENHBG061894.
InParanoidO70485.
OMARKDLGNR.
OrthoDBEOG76X5ZD.
PhylomeDBQ9R283.

Gene expression databases

GenevestigatorQ9R283.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
2.60.120.260. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR008979. Galactose-bd-like.
IPR005821. Ion_trans_dom.
IPR013555. TRP_dom.
IPR005458. TRPC2_channel.
IPR002153. TRPC_channel.
IPR002706. Xrcc1_N.
[Graphical view]
PANTHERPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF6. PTHR10117:SF6. 1 hit.
PfamPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
PF01834. XRCC1_N. 1 hit.
[Graphical view]
PRINTSPR01097. TRNSRECEPTRP.
PR01643. TRPCHANNEL2.
SMARTSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
SSF49785. SSF49785. 1 hit.
ProtoNetSearch...

Other

PROQ9R283.

Entry information

Entry nameTRPC2_RAT
AccessionPrimary (citable) accession number: Q9R283
Secondary accession number(s): B5DFD7, O70485
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 5, 2009
Last modified: April 16, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families