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Q9R283

- TRPC2_RAT

UniProt

Q9R283 - TRPC2_RAT

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Protein

Short transient receptor potential channel 2

Gene
Trpc2, Trp2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Thought to form a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Is not activated by intracellular calcium store depletion.

GO - Molecular functioni

  1. damaged DNA binding Source: InterPro
  2. diacylglycerol binding Source: Ensembl
  3. inositol 1,4,5 trisphosphate binding Source: Ensembl
  4. store-operated calcium channel activity Source: Ensembl

GO - Biological processi

  1. acrosome reaction Source: Ensembl
  2. female courtship behavior Source: Ensembl
  3. inter-male aggressive behavior Source: Ensembl
  4. mating behavior, sex discrimination Source: Ensembl
  5. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  6. response to pheromone Source: Ensembl
  7. single strand break repair Source: InterPro
  8. territorial aggressive behavior Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 2
Short name:
TrpC2
Alternative name(s):
Transient receptor protein 2
Short name:
TRP-2
Short name:
rTrp2
Gene namesi
Name:Trpc2
Synonyms:Trp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi628819. Trpc2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 627627Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei628 – 64821Helical; Reviewed predictionAdd
BLAST
Topological domaini649 – 65810Extracellular Reviewed prediction
Transmembranei659 – 67921Helical; Reviewed predictionAdd
BLAST
Topological domaini680 – 70122Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei702 – 72221Helical; Reviewed predictionAdd
BLAST
Topological domaini723 – 73715Extracellular Reviewed predictionAdd
BLAST
Transmembranei738 – 75821Helical; Reviewed predictionAdd
BLAST
Topological domaini759 – 78830Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei789 – 80921Helical; Reviewed predictionAdd
BLAST
Topological domaini810 – 83223Extracellular Reviewed predictionAdd
BLAST
Transmembranei833 – 85321Helical; Reviewed predictionAdd
BLAST
Topological domaini854 – 89845Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei899 – 91921Helical; Reviewed predictionAdd
BLAST
Topological domaini920 – 1170251Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. dendrite membrane Source: Ensembl
  2. endoplasmic reticulum membrane Source: Ensembl
  3. Golgi membrane Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. nuclear envelope Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11701170Short transient receptor potential channel 2PRO_0000215308Add
BLAST

Proteomic databases

PaxDbiQ9R283.
PRIDEiQ9R283.

Expressioni

Tissue specificityi

Expressed exclusively in vomeronasal organ neurons (sensory microvilli).

Gene expression databases

GenevestigatoriQ9R283.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027391.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati300 – 32930ANK 1Add
BLAST
Repeati346 – 37631ANK 2Add
BLAST
Repeati377 – 40529ANK 3Add
BLAST
Repeati429 – 45830ANK 4Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1030 – 106839 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi197 – 2015Poly-Ser
Compositional biasi1136 – 11416Poly-Ser

Sequence similaritiesi

Contains 4 ANK repeats.

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257288.
GeneTreeiENSGT00680000099764.
HOGENOMiHOG000137678.
HOVERGENiHBG061894.
InParanoidiO70485.
OMAiRKDLGNR.
OrthoDBiEOG76X5ZD.
PhylomeDBiQ9R283.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.120.260. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR008979. Galactose-bd-like.
IPR005821. Ion_trans_dom.
IPR013555. TRP_dom.
IPR005458. TRPC2_channel.
IPR002153. TRPC_channel.
IPR002706. Xrcc1_N.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF6. PTHR10117:SF6. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
PF01834. XRCC1_N. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01643. TRPCHANNEL2.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF49785. SSF49785. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9R283-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLMSLTDSKE GKNRSGVRMF KDDDFLIPAS GESWDRLRLT CSQPFTRHQS     50
FGLAFLRVRS SLDSLSDPVK DPSSPGSSGL NQNSSDKLES DPSPWLTNPS 100
IRRTFFPDPQ TSTKEISALK GMLKQLQPGP LGRAARMVLS AAHKAPPASV 150
VSPNNSHGEP DSSHPERAEP RAEEPNRKNN ASRGKRRKVQ EQRRPLSSSS 200
SQPNRRATGR TKQRQQRPQA KSDGSGVQAT GQCPICTGSF SIEALPRHAA 250
TCGESSPPQP ASPTSLSSSE SVLRCLHVAL TPVPLIPKPN WTEIVNKKLK 300
FPPTLLRAIQ EGQLGLVQQL LESGSDPSGA GPGGPLRNVE ESEDRSWREA 350
LNLAIRLGHE VITDVLLANV KFDFRQIHEA LLVAVDTNQP AVVRRLLARL 400
EREKGRKVDT KSFSLAFFDS SIDGSRFAPG VTPLTLACQK DLYEIAQLLM 450
DQGHTIARPH PVSCACLECS NARRYDLLKF SLSRINTYRG IASRAHLSLA 500
SEDAMLAAFQ LSRELRRLAR KEPEFKPQYI ALESLCQDYG FELLGMCRNQ 550
SEVTAVLNDL GEDSETEPEA EGLGQAFEEG IPNLARLRLA VNYNQKQFVA 600
HPICQQVLSS IWCGNLAGWR GSTTIWKLFV AFLIFLTMPF LCIGYWLAPK 650
SRLGRLLKIP VLKFLLHSAS YLWFLIFLLG ESLVMETQLS TFKGRSQSVW 700
ETSLHMIWVT GFLWFECKEV WIEGLRSYLL DWWNFLDVVI LSLYLASFAL 750
RLLLAGLAYM HCRDASDSST CRYFTTAERS EWRTEDPQFL AEVLFAVTSM 800
LSFTRLAYIL PAHESLGTLQ ISIGKMIDDM IRFMFILMII LTAFLCGLNN 850
IYVPYQETEK LGNFNETFQF LFWTMFGMEE HSVVDMPQFL VPEFVGRAMY 900
GIFTIVMVIV LLNMLIAMIT NSFQKIEDDA DVEWKFARSK LYLSYFREGL 950
TLPVPFNILP SPKAAFYLLR RIFRFICCGS SCCKAKKSDY PPIPTFTNPG 1000
ARAGPGEGEH VSYRLRVIKA LVQRYIETAR REFEETRRKD LGNRLTELTK 1050
TVSRLQSEVA SVQKTVAAGG ALRPPDGASI LSRYITRVRN SFQNLGPPAP 1100
DTPAELTMPG IVETEVSLED SLDATGEAGT PASGESSSSS SAHVLVHREQ 1150
EAEGAGDLPL GEDLETKGES 1170

Note: No experimental confirmation available. Inferred from mouse sequence.

Length:1,170
Mass (Da):130,467
Last modified:May 5, 2009 - v2
Checksum:iBDF876A83B28CA5C
GO
Isoform 2 (identifier: Q9R283-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-283: Missing.
     284-288: PLIPK → MDPLS

Note: No experimental confirmation available.

Show »
Length:887
Mass (Da):99,809
Checksum:iF8A516AEB39F3A50
GO
Isoform 3 (identifier: Q9R283-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAPVKISHVV...PFVTLLPATM
     274-315: RCLHVALTPV...LRAIQEGQLG → WVSSPESSPP...ASVCGEVFPA
     316-1170: Missing.

Note: No experimental confirmation available.

Show »
Length:407
Mass (Da):44,359
Checksum:i3C1FAF331F007681
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 283283Missing in isoform 2. VSP_037236Add
BLAST
Alternative sequencei1 – 11M → MAPVKISHVVSFSSQDPKYP VENLLNPDSHKGPWLSCPRD KTGQLKVEFQLERAVPISYI DVGNCGCAFLQIDVGRSSWP LDRPFVTLLPATM in isoform 3. VSP_038807
Alternative sequencei274 – 31542RCLHV…EGQLG → WVSSPESSPPPSSWVQCPIC ELQFSAREIEEHASVCGEVF PA in isoform 3. VSP_037238Add
BLAST
Alternative sequencei284 – 2885PLIPK → MDPLS in isoform 2. VSP_037237
Alternative sequencei316 – 1170855Missing in isoform 3. VSP_037239Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1010 – 10101H → R in AAD31453. 1 Publication
Sequence conflicti1069 – 10702Missing in AAD31453. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF136401 mRNA. Translation: AAD31453.1.
AABR03002379 Genomic DNA. No translation available.
AABR03010502 Genomic DNA. No translation available.
AABR03010734 Genomic DNA. No translation available.
AABR03001253 Genomic DNA. No translation available.
BC169022 mRNA. Translation: AAI69022.1.
AF061874 mRNA. Translation: AAC16726.1.
RefSeqiXP_006223494.1. XM_006223432.1. [Q9R283-3]
XP_006223495.1. XM_006223433.1. [Q9R283-3]
XP_006229965.1. XM_006229903.1. [Q9R283-3]
XP_006229966.1. XM_006229904.1. [Q9R283-3]
UniGeneiRn.48766.

Genome annotation databases

EnsembliENSRNOT00000027358; ENSRNOP00000027358; ENSRNOG00000020188. [Q9R283-3]
ENSRNOT00000045726; ENSRNOP00000042378; ENSRNOG00000020188. [Q9R283-2]
ENSRNOT00000048172; ENSRNOP00000047354; ENSRNOG00000020188. [Q9R283-1]
GeneIDi102549471.
KEGGirno:102549471.
UCSCiRGD:628819. rat. [Q9R283-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF136401 mRNA. Translation: AAD31453.1 .
AABR03002379 Genomic DNA. No translation available.
AABR03010502 Genomic DNA. No translation available.
AABR03010734 Genomic DNA. No translation available.
AABR03001253 Genomic DNA. No translation available.
BC169022 mRNA. Translation: AAI69022.1 .
AF061874 mRNA. Translation: AAC16726.1 .
RefSeqi XP_006223494.1. XM_006223432.1. [Q9R283-3 ]
XP_006223495.1. XM_006223433.1. [Q9R283-3 ]
XP_006229965.1. XM_006229903.1. [Q9R283-3 ]
XP_006229966.1. XM_006229904.1. [Q9R283-3 ]
UniGenei Rn.48766.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000027391.

Proteomic databases

PaxDbi Q9R283.
PRIDEi Q9R283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000027358 ; ENSRNOP00000027358 ; ENSRNOG00000020188 . [Q9R283-3 ]
ENSRNOT00000045726 ; ENSRNOP00000042378 ; ENSRNOG00000020188 . [Q9R283-2 ]
ENSRNOT00000048172 ; ENSRNOP00000047354 ; ENSRNOG00000020188 . [Q9R283-1 ]
GeneIDi 102549471.
KEGGi rno:102549471.
UCSCi RGD:628819. rat. [Q9R283-1 ]

Organism-specific databases

RGDi 628819. Trpc2.

Phylogenomic databases

eggNOGi NOG257288.
GeneTreei ENSGT00680000099764.
HOGENOMi HOG000137678.
HOVERGENi HBG061894.
InParanoidi O70485.
OMAi RKDLGNR.
OrthoDBi EOG76X5ZD.
PhylomeDBi Q9R283.

Miscellaneous databases

PROi Q9R283.

Gene expression databases

Genevestigatori Q9R283.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
2.60.120.260. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR008979. Galactose-bd-like.
IPR005821. Ion_trans_dom.
IPR013555. TRP_dom.
IPR005458. TRPC2_channel.
IPR002153. TRPC_channel.
IPR002706. Xrcc1_N.
[Graphical view ]
PANTHERi PTHR10117. PTHR10117. 1 hit.
PTHR10117:SF6. PTHR10117:SF6. 1 hit.
Pfami PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
PF01834. XRCC1_N. 1 hit.
[Graphical view ]
PRINTSi PR01097. TRNSRECEPTRP.
PR01643. TRPCHANNEL2.
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF49785. SSF49785. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TRP2: a candidate transduction channel for mammalian pheromone sensory signaling."
    Liman E.R., Corey D.P., Dulac C.
    Proc. Natl. Acad. Sci. U.S.A. 96:5791-5796(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Embryo.
  4. "Expression patterns of mammalian trp homologues in rat excitable cells."
    Koizumi S., Ripley S.J., Bootman M.D., Lipp P., Berridge M.J., Bobanovic L.K.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 867-930 (ISOFORM 1/2).
    Strain: Wistar.
    Tissue: Heart.

Entry informationi

Entry nameiTRPC2_RAT
AccessioniPrimary (citable) accession number: Q9R283
Secondary accession number(s): B5DFD7, O70485
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 5, 2009
Last modified: June 11, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi