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Q9R283

- TRPC2_RAT

UniProt

Q9R283 - TRPC2_RAT

Protein

Short transient receptor potential channel 2

Gene

Trpc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Thought to form a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Is not activated by intracellular calcium store depletion.

    GO - Molecular functioni

    1. damaged DNA binding Source: InterPro
    2. diacylglycerol binding Source: Ensembl
    3. inositol 1,4,5 trisphosphate binding Source: Ensembl
    4. store-operated calcium channel activity Source: Ensembl

    GO - Biological processi

    1. acrosome reaction Source: Ensembl
    2. female courtship behavior Source: Ensembl
    3. inter-male aggressive behavior Source: Ensembl
    4. mating behavior, sex discrimination Source: Ensembl
    5. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    6. response to pheromone Source: Ensembl
    7. single strand break repair Source: InterPro
    8. territorial aggressive behavior Source: Ensembl

    Keywords - Molecular functioni

    Calcium channel, Ion channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Short transient receptor potential channel 2
    Short name:
    TrpC2
    Alternative name(s):
    Transient receptor protein 2
    Short name:
    TRP-2
    Short name:
    rTrp2
    Gene namesi
    Name:Trpc2
    Synonyms:Trp2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi628819. Trpc2.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite membrane Source: Ensembl
    2. endoplasmic reticulum membrane Source: Ensembl
    3. Golgi membrane Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. nuclear envelope Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11701170Short transient receptor potential channel 2PRO_0000215308Add
    BLAST

    Proteomic databases

    PaxDbiQ9R283.
    PRIDEiQ9R283.

    Expressioni

    Tissue specificityi

    Expressed exclusively in vomeronasal organ neurons (sensory microvilli).

    Gene expression databases

    GenevestigatoriQ9R283.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000027391.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 627627CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini649 – 65810ExtracellularSequence Analysis
    Topological domaini680 – 70122CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini723 – 73715ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini759 – 78830CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini810 – 83223ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini854 – 89845CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini920 – 1170251ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei628 – 64821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei659 – 67921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei702 – 72221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei738 – 75821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei789 – 80921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei833 – 85321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei899 – 91921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati300 – 32930ANK 1Add
    BLAST
    Repeati346 – 37631ANK 2Add
    BLAST
    Repeati377 – 40529ANK 3Add
    BLAST
    Repeati429 – 45830ANK 4Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1030 – 106839Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi197 – 2015Poly-Ser
    Compositional biasi1136 – 11416Poly-Ser

    Sequence similaritiesi

    Contains 4 ANK repeats.Curated

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257288.
    GeneTreeiENSGT00680000099764.
    HOGENOMiHOG000137678.
    HOVERGENiHBG061894.
    InParanoidiO70485.
    OMAiRKDLGNR.
    OrthoDBiEOG76X5ZD.
    PhylomeDBiQ9R283.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    2.60.120.260. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR008979. Galactose-bd-like.
    IPR005821. Ion_trans_dom.
    IPR013555. TRP_dom.
    IPR005458. TRPC2_channel.
    IPR002153. TRPC_channel.
    IPR002706. Xrcc1_N.
    [Graphical view]
    PANTHERiPTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF6. PTHR10117:SF6. 1 hit.
    PfamiPF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    PF01834. XRCC1_N. 1 hit.
    [Graphical view]
    PRINTSiPR01097. TRNSRECEPTRP.
    PR01643. TRPCHANNEL2.
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF49785. SSF49785. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9R283-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLMSLTDSKE GKNRSGVRMF KDDDFLIPAS GESWDRLRLT CSQPFTRHQS     50
    FGLAFLRVRS SLDSLSDPVK DPSSPGSSGL NQNSSDKLES DPSPWLTNPS 100
    IRRTFFPDPQ TSTKEISALK GMLKQLQPGP LGRAARMVLS AAHKAPPASV 150
    VSPNNSHGEP DSSHPERAEP RAEEPNRKNN ASRGKRRKVQ EQRRPLSSSS 200
    SQPNRRATGR TKQRQQRPQA KSDGSGVQAT GQCPICTGSF SIEALPRHAA 250
    TCGESSPPQP ASPTSLSSSE SVLRCLHVAL TPVPLIPKPN WTEIVNKKLK 300
    FPPTLLRAIQ EGQLGLVQQL LESGSDPSGA GPGGPLRNVE ESEDRSWREA 350
    LNLAIRLGHE VITDVLLANV KFDFRQIHEA LLVAVDTNQP AVVRRLLARL 400
    EREKGRKVDT KSFSLAFFDS SIDGSRFAPG VTPLTLACQK DLYEIAQLLM 450
    DQGHTIARPH PVSCACLECS NARRYDLLKF SLSRINTYRG IASRAHLSLA 500
    SEDAMLAAFQ LSRELRRLAR KEPEFKPQYI ALESLCQDYG FELLGMCRNQ 550
    SEVTAVLNDL GEDSETEPEA EGLGQAFEEG IPNLARLRLA VNYNQKQFVA 600
    HPICQQVLSS IWCGNLAGWR GSTTIWKLFV AFLIFLTMPF LCIGYWLAPK 650
    SRLGRLLKIP VLKFLLHSAS YLWFLIFLLG ESLVMETQLS TFKGRSQSVW 700
    ETSLHMIWVT GFLWFECKEV WIEGLRSYLL DWWNFLDVVI LSLYLASFAL 750
    RLLLAGLAYM HCRDASDSST CRYFTTAERS EWRTEDPQFL AEVLFAVTSM 800
    LSFTRLAYIL PAHESLGTLQ ISIGKMIDDM IRFMFILMII LTAFLCGLNN 850
    IYVPYQETEK LGNFNETFQF LFWTMFGMEE HSVVDMPQFL VPEFVGRAMY 900
    GIFTIVMVIV LLNMLIAMIT NSFQKIEDDA DVEWKFARSK LYLSYFREGL 950
    TLPVPFNILP SPKAAFYLLR RIFRFICCGS SCCKAKKSDY PPIPTFTNPG 1000
    ARAGPGEGEH VSYRLRVIKA LVQRYIETAR REFEETRRKD LGNRLTELTK 1050
    TVSRLQSEVA SVQKTVAAGG ALRPPDGASI LSRYITRVRN SFQNLGPPAP 1100
    DTPAELTMPG IVETEVSLED SLDATGEAGT PASGESSSSS SAHVLVHREQ 1150
    EAEGAGDLPL GEDLETKGES 1170

    Note: No experimental confirmation available. Inferred from mouse sequence.

    Length:1,170
    Mass (Da):130,467
    Last modified:May 5, 2009 - v2
    Checksum:iBDF876A83B28CA5C
    GO
    Isoform 2 (identifier: Q9R283-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-283: Missing.
         284-288: PLIPK → MDPLS

    Note: No experimental confirmation available.

    Show »
    Length:887
    Mass (Da):99,809
    Checksum:iF8A516AEB39F3A50
    GO
    Isoform 3 (identifier: Q9R283-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MAPVKISHVV...PFVTLLPATM
         274-315: RCLHVALTPV...LRAIQEGQLG → WVSSPESSPP...ASVCGEVFPA
         316-1170: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:407
    Mass (Da):44,359
    Checksum:i3C1FAF331F007681
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1010 – 10101H → R in AAD31453. (PubMed:10318963)Curated
    Sequence conflicti1069 – 10702Missing in AAD31453. (PubMed:10318963)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 283283Missing in isoform 2. 1 PublicationVSP_037236Add
    BLAST
    Alternative sequencei1 – 11M → MAPVKISHVVSFSSQDPKYP VENLLNPDSHKGPWLSCPRD KTGQLKVEFQLERAVPISYI DVGNCGCAFLQIDVGRSSWP LDRPFVTLLPATM in isoform 3. 1 PublicationVSP_038807
    Alternative sequencei274 – 31542RCLHV…EGQLG → WVSSPESSPPPSSWVQCPIC ELQFSAREIEEHASVCGEVF PA in isoform 3. 1 PublicationVSP_037238Add
    BLAST
    Alternative sequencei284 – 2885PLIPK → MDPLS in isoform 2. 1 PublicationVSP_037237
    Alternative sequencei316 – 1170855Missing in isoform 3. 1 PublicationVSP_037239Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF136401 mRNA. Translation: AAD31453.1.
    AABR03002379 Genomic DNA. No translation available.
    AABR03010502 Genomic DNA. No translation available.
    AABR03010734 Genomic DNA. No translation available.
    AABR03001253 Genomic DNA. No translation available.
    BC169022 mRNA. Translation: AAI69022.1.
    AF061874 mRNA. Translation: AAC16726.1.
    RefSeqiXP_006223494.1. XM_006223432.1. [Q9R283-3]
    XP_006223495.1. XM_006223433.1. [Q9R283-3]
    XP_006229965.1. XM_006229903.1. [Q9R283-3]
    XP_006229966.1. XM_006229904.1. [Q9R283-3]
    UniGeneiRn.48766.

    Genome annotation databases

    EnsembliENSRNOT00000027358; ENSRNOP00000027358; ENSRNOG00000020188. [Q9R283-3]
    ENSRNOT00000045726; ENSRNOP00000042378; ENSRNOG00000020188. [Q9R283-2]
    ENSRNOT00000048172; ENSRNOP00000047354; ENSRNOG00000020188. [Q9R283-1]
    GeneIDi102549471.
    KEGGirno:102549471.
    UCSCiRGD:628819. rat. [Q9R283-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF136401 mRNA. Translation: AAD31453.1 .
    AABR03002379 Genomic DNA. No translation available.
    AABR03010502 Genomic DNA. No translation available.
    AABR03010734 Genomic DNA. No translation available.
    AABR03001253 Genomic DNA. No translation available.
    BC169022 mRNA. Translation: AAI69022.1 .
    AF061874 mRNA. Translation: AAC16726.1 .
    RefSeqi XP_006223494.1. XM_006223432.1. [Q9R283-3 ]
    XP_006223495.1. XM_006223433.1. [Q9R283-3 ]
    XP_006229965.1. XM_006229903.1. [Q9R283-3 ]
    XP_006229966.1. XM_006229904.1. [Q9R283-3 ]
    UniGenei Rn.48766.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000027391.

    Proteomic databases

    PaxDbi Q9R283.
    PRIDEi Q9R283.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000027358 ; ENSRNOP00000027358 ; ENSRNOG00000020188 . [Q9R283-3 ]
    ENSRNOT00000045726 ; ENSRNOP00000042378 ; ENSRNOG00000020188 . [Q9R283-2 ]
    ENSRNOT00000048172 ; ENSRNOP00000047354 ; ENSRNOG00000020188 . [Q9R283-1 ]
    GeneIDi 102549471.
    KEGGi rno:102549471.
    UCSCi RGD:628819. rat. [Q9R283-1 ]

    Organism-specific databases

    RGDi 628819. Trpc2.

    Phylogenomic databases

    eggNOGi NOG257288.
    GeneTreei ENSGT00680000099764.
    HOGENOMi HOG000137678.
    HOVERGENi HBG061894.
    InParanoidi O70485.
    OMAi RKDLGNR.
    OrthoDBi EOG76X5ZD.
    PhylomeDBi Q9R283.

    Miscellaneous databases

    PROi Q9R283.

    Gene expression databases

    Genevestigatori Q9R283.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    2.60.120.260. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR008979. Galactose-bd-like.
    IPR005821. Ion_trans_dom.
    IPR013555. TRP_dom.
    IPR005458. TRPC2_channel.
    IPR002153. TRPC_channel.
    IPR002706. Xrcc1_N.
    [Graphical view ]
    PANTHERi PTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF6. PTHR10117:SF6. 1 hit.
    Pfami PF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    PF01834. XRCC1_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01097. TRNSRECEPTRP.
    PR01643. TRPCHANNEL2.
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF49785. SSF49785. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "TRP2: a candidate transduction channel for mammalian pheromone sensory signaling."
      Liman E.R., Corey D.P., Dulac C.
      Proc. Natl. Acad. Sci. U.S.A. 96:5791-5796(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Embryo.
    4. "Expression patterns of mammalian trp homologues in rat excitable cells."
      Koizumi S., Ripley S.J., Bootman M.D., Lipp P., Berridge M.J., Bobanovic L.K.
      Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 867-930 (ISOFORM 1/2).
      Strain: Wistar.
      Tissue: Heart.

    Entry informationi

    Entry nameiTRPC2_RAT
    AccessioniPrimary (citable) accession number: Q9R283
    Secondary accession number(s): B5DFD7, O70485
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3