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Protein

Interleukin-12 subunit beta

Gene

Il12b

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.UniRule annotation

GO - Molecular functioni

  • cytokine receptor activity Source: InterPro
  • interleukin-12 alpha subunit binding Source: RGD
  • protein heterodimerization activity Source: RGD

GO - Biological processi

  • natural killer cell activation involved in immune response Source: RGD
  • sensory perception of pain Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

CytokineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-12 subunit betaUniRule annotation
Alternative name(s):
Cytotoxic lymphocyte maturation factor 40 kDa subunitUniRule annotation
IL-12 subunit p40UniRule annotation
Gene namesi
Name:Il12bImported
Synonyms:IL12BUniRule annotation
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi628704. Il12b.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • interleukin-12 complex Source: RGD
  • membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 335313Interleukin-12 subunit betaSequence analysisPRO_5004332834Add
BLAST

Keywords - PTMi

GlycoproteinUniRule annotation

Proteomic databases

PaxDbiQ9R278.
PRIDEiQ9R278.

Expressioni

Gene expression databases

GenevisibleiQ9R278. RN.

Interactioni

GO - Molecular functioni

  • interleukin-12 alpha subunit binding Source: RGD
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005898.

Structurei

3D structure databases

ProteinModelPortaliQ9R278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 9048Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the type I cytokine receptor family. Type 3 subfamily.UniRule annotation
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.UniRule annotation
Contains 1 fibronectin type-III domain.UniRule annotation

Keywords - Domaini

Immunoglobulin domainUniRule annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IF5K. Eukaryota.
ENOG410YWXR. LUCA.
HOGENOMiHOG000113027.
HOVERGENiHBG052094.
KOiK05425.
PhylomeDBiQ9R278.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR015528. IL-12_beta.
IPR019482. IL-12_beta_cen-dom.
[Graphical view]
PANTHERiPTHR11321. PTHR11321. 1 hit.
PfamiPF10420. IL12p40_C. 1 hit.
[Graphical view]
PIRSFiPIRSF038007. IL_12_beta. 1 hit.
PRINTSiPR01928. INTRLEUKN12B.
SMARTiSM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R278-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHQKLTFSW FAMVLLVSPL MAMWELEKDV YVVEVDWRPD APGETVTLTC
60 70 80 90 100
DSPEEDDITW TSDQRRGVIG SGKTLTITVR EFLDAGQYTC HRGGETLSHS
110 120 130 140 150
HLLLHKKENG IWSTEILKNF KNKTFLKCEA PNYSGRFTCS WLVHRNTDLK
160 170 180 190 200
FNIKSSSSSP ESRAVTCGRA SLSAEKVTLN QRDYEKYSVA CQEDVTCPTA
210 220 230 240 250
EETLPIELVV EAQQQNKYEN YSTSFFIRDI IKPDPPKNLQ VKPLKNSQVE
260 270 280 290 300
VSWEYPDSWS TPHSYFSLKF FVRIQRKKEK TKETEEECNQ KGAFLVEKTS
310 320 330
AEVQCKGANI CVQAQDRYYN SSCSKWTCVP CRGRS
Length:335
Mass (Da):38,413
Last modified:May 1, 2000 - v1
Checksum:i39BF5B49AF191007
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133197 mRNA. Translation: AAD24190.1.
RefSeqiNP_072133.1. NM_022611.1.
UniGeneiRn.48686.

Genome annotation databases

GeneIDi64546.
KEGGirno:64546.
UCSCiRGD:628704. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133197 mRNA. Translation: AAD24190.1.
RefSeqiNP_072133.1. NM_022611.1.
UniGeneiRn.48686.

3D structure databases

ProteinModelPortaliQ9R278.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005898.

Proteomic databases

PaxDbiQ9R278.
PRIDEiQ9R278.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64546.
KEGGirno:64546.
UCSCiRGD:628704. rat.

Organism-specific databases

CTDi3593.
RGDi628704. Il12b.

Phylogenomic databases

eggNOGiENOG410IF5K. Eukaryota.
ENOG410YWXR. LUCA.
HOGENOMiHOG000113027.
HOVERGENiHBG052094.
KOiK05425.
PhylomeDBiQ9R278.

Gene expression databases

GenevisibleiQ9R278. RN.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR015528. IL-12_beta.
IPR019482. IL-12_beta_cen-dom.
[Graphical view]
PANTHERiPTHR11321. PTHR11321. 1 hit.
PfamiPF10420. IL12p40_C. 1 hit.
[Graphical view]
PIRSFiPIRSF038007. IL_12_beta. 1 hit.
PRINTSiPR01928. INTRLEUKN12B.
SMARTiSM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiPS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9R278_RAT
AccessioniPrimary (citable) accession number: Q9R278
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.