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Protein

Interleukin-12 subunit beta

Gene

Il12b

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.UniRule annotation

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • cytokine receptor activity Source: UniProtKB-UniRule
  • interleukin-12 alpha subunit binding Source: RGD
  • protein heterodimerization activity Source: RGD

GO - Biological processi

  • natural killer cell activation involved in immune response Source: RGD
  • sensory perception of pain Source: RGD

Keywordsi

Molecular functionCytokineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-12 subunit betaUniRule annotation
Short name:
IL-12BUniRule annotation
Alternative name(s):
Cytotoxic lymphocyte maturation factor 40 kDa subunitUniRule annotation
IL-12 subunit p40UniRule annotation
Gene namesi
Name:Il12bImported
Synonyms:IL12BUniRule annotation
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi628704. Il12b.

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

  • extracellular space Source: RGD
  • interleukin-12 complex Source: RGD
  • membrane Source: InterPro

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22UniRule annotationAdd BLAST22
ChainiPRO_500936920923 – 335Interleukin-12 subunit betaUniRule annotationAdd BLAST313

Keywords - PTMi

GlycoproteinUniRule annotation

Proteomic databases

PaxDbiQ9R278.
PRIDEiQ9R278.

Expressioni

Gene expression databases

GenevisibleiQ9R278. RN.

Interactioni

Subunit structurei

Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.UniRule annotation

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • interleukin-12 alpha subunit binding Source: RGD
  • protein heterodimerization activity Source: RGD

Structurei

3D structure databases

ProteinModelPortaliQ9R278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 90Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST48

Sequence similaritiesi

Belongs to the type I cytokine receptor family. Type 3 subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainUniRule annotation, SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410IF5K. Eukaryota.
ENOG410YWXR. LUCA.
HOGENOMiHOG000113027.
HOVERGENiHBG052094.
KOiK05425.
PhylomeDBiQ9R278.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR015528. IL-12_beta.
IPR019482. IL-12_beta_cen-dom.
PANTHERiPTHR10078:SF37. PTHR10078:SF37. 1 hit.
PfamiView protein in Pfam
PF10420. IL12p40_C. 1 hit.
PIRSFiPIRSF038007. IL_12_beta. 1 hit.
PRINTSiPR01928. INTRLEUKN12B.
SMARTiView protein in SMART
SM00408. IGc2. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
PROSITEiView protein in PROSITE
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9R278-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHQKLTFSW FAMVLLVSPL MAMWELEKDV YVVEVDWRPD APGETVTLTC
60 70 80 90 100
DSPEEDDITW TSDQRRGVIG SGKTLTITVR EFLDAGQYTC HRGGETLSHS
110 120 130 140 150
HLLLHKKENG IWSTEILKNF KNKTFLKCEA PNYSGRFTCS WLVHRNTDLK
160 170 180 190 200
FNIKSSSSSP ESRAVTCGRA SLSAEKVTLN QRDYEKYSVA CQEDVTCPTA
210 220 230 240 250
EETLPIELVV EAQQQNKYEN YSTSFFIRDI IKPDPPKNLQ VKPLKNSQVE
260 270 280 290 300
VSWEYPDSWS TPHSYFSLKF FVRIQRKKEK TKETEEECNQ KGAFLVEKTS
310 320 330
AEVQCKGANI CVQAQDRYYN SSCSKWTCVP CRGRS
Length:335
Mass (Da):38,413
Last modified:May 1, 2000 - v1
Checksum:i39BF5B49AF191007
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133197 mRNA. Translation: AAD24190.1.
RefSeqiNP_072133.1. NM_022611.1.
UniGeneiRn.48686.

Genome annotation databases

GeneIDi64546.
KEGGirno:64546.
UCSCiRGD:628704. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ9R278_RAT
AccessioniPrimary (citable) accession number: Q9R278
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 5, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)