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Protein

Prostaglandin D2 receptor

Gene

Ptgdr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor
Short name:
PGD receptor
Short name:
PGD2 receptor
Alternative name(s):
Prostanoid DP receptor
Gene namesi
Name:Ptgdr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1565108. Ptgdr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020ExtracellularSequence analysisAdd
BLAST
Transmembranei21 – 4121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini42 – 5716CytoplasmicSequence analysisAdd
BLAST
Transmembranei58 – 7821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini79 – 10628ExtracellularSequence analysisAdd
BLAST
Transmembranei107 – 12721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini128 – 14922CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 17021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini171 – 19424ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini216 – 26146CytoplasmicSequence analysisAdd
BLAST
Transmembranei262 – 28221Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini283 – 30624ExtracellularSequence analysisAdd
BLAST
Transmembranei307 – 32721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini328 – 35730CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi338.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Prostaglandin D2 receptorPRO_0000370711Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence analysis
Disulfide bondi104 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R261.

Expressioni

Tissue specificityi

Strongly expressed in eye and gastrointestinal tract (GIT), moderately in the brain and oviduct and weakly in the epididymis. In the eye, expressed in the epithelium of the iris and ciliary body and in photoreceptor cells of the retina. In the brain, expressed in leptomeninges, choroid plexus and spinal cord (sensory and motor neurons of the dorsal and ventral horns). In the stomach, expressed in the mucous-secreting goblet cells and the columnar epithelium. Expressed in platelets.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048101.

Chemistry

BindingDBiQ9R261.

Structurei

3D structure databases

ProteinModelPortaliQ9R261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
InParanoidiQ9R261.
KOiK04332.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNESYRCQAA TWVERGSSAT MGGVAFSAGL LGNLLALVLL ARSGLGSCRP
60 70 80 90 100
GPLHPPPSVF YVLVCGLTVT DLLGKCLISP MVLAAYAQNR SLKELLPASG
110 120 130 140 150
NQLCEAFAFL MSFFGLASTL QLLAMALECW LSLGHPFFYQ RHITARRGVL
160 170 180 190 200
VAPVAGAFSL AFCALPFAGF GKFVQYCPGT WCFIQMIHKK RSFSVIGFSV
210 220 230 240 250
LYSSLMALLV LATVVCNLGA MSNLYAMHRR QRHHPRRCSR DRAQSGSDYR
260 270 280 290 300
HGSPNPLEEL DHFVLLALTT VLFTMCSLPL IYRAYYGAFK LVDRADGDSE
310 320 330 340 350
DLQALRFLSV ISIVDPWIFI IFRTSVFRML FHKTFTRPLI YRNWCSHSWQ

TNMESTL
Length:357
Mass (Da):39,769
Last modified:May 1, 2000 - v1
Checksum:iA65E1355E52E8286
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120101 mRNA. Translation: AAD23564.1.
RefSeqiNP_001128636.1. NM_001135164.1.
UniGeneiRn.57393.

Genome annotation databases

GeneIDi498475.
KEGGirno:498475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120101 mRNA. Translation: AAD23564.1.
RefSeqiNP_001128636.1. NM_001135164.1.
UniGeneiRn.57393.

3D structure databases

ProteinModelPortaliQ9R261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000048101.

Chemistry

BindingDBiQ9R261.
GuidetoPHARMACOLOGYi338.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9R261.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi498475.
KEGGirno:498475.

Organism-specific databases

CTDi5729.
RGDi1565108. Ptgdr.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
InParanoidiQ9R261.
KOiK04332.

Miscellaneous databases

PROiQ9R261.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel biological role for prostaglandin D2 is suggested by distribution studies of the rat DP prostanoid receptor."
    Wright D.H., Nantel F., Metters K.M., Ford-Hutchinson A.W.
    Eur. J. Pharmacol. 377:101-115(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
  2. "Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors."
    Town M.H., Casals-Stenzel J., Schillinger E.
    Prostaglandins 25:13-28(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPD2R_RAT
AccessioniPrimary (citable) accession number: Q9R261
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.