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Protein

Heme-binding protein 1

Gene

Hebp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities.2 Publications

GO - Molecular functioni

  • heme binding Source: UniProtKB

GO - Biological processi

  • heme metabolic process Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Heme-binding protein 1
Alternative name(s):
p22HBP
Gene namesi
Name:Hebp1
Synonyms:Hbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1333880. Hebp1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • extracellular exosome Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001168981 – 190Heme-binding protein 1Add BLAST190

Proteomic databases

MaxQBiQ9R257.
PaxDbiQ9R257.
PeptideAtlasiQ9R257.
PRIDEiQ9R257.

PTM databases

iPTMnetiQ9R257.
PhosphoSitePlusiQ9R257.
SwissPalmiQ9R257.

Expressioni

Tissue specificityi

Ubiquitously expressed. Extremely abundant in liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000042770.
CleanExiMM_HEBP1.

Interactioni

Subunit structurei

Monomer.3 Publications

Protein-protein interaction databases

BioGridi200269. 1 interactor.
IntActiQ9R257. 5 interactors.
MINTiMINT-1845080.
STRINGi10090.ENSMUSP00000042232.

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 12Combined sources3
Beta strandi19 – 23Combined sources5
Beta strandi27 – 29Combined sources3
Beta strandi31 – 35Combined sources5
Beta strandi40 – 49Combined sources10
Helixi51 – 67Combined sources17
Beta strandi70 – 72Combined sources3
Beta strandi82 – 88Combined sources7
Beta strandi94 – 102Combined sources9
Helixi106 – 110Combined sources5
Beta strandi117 – 119Combined sources3
Beta strandi121 – 124Combined sources4
Beta strandi129 – 137Combined sources9
Helixi141 – 154Combined sources14
Turni155 – 157Combined sources3
Beta strandi162 – 173Combined sources12
Beta strandi176 – 179Combined sources4
Beta strandi182 – 189Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GOVNMR-A7-190[»]
2HVANMR-A1-190[»]
4A1MNMR-A7-190[»]
ProteinModelPortaliQ9R257.
SMRiQ9R257.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9R257.

Family & Domainsi

Domaini

Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel. Porphyrins are expected to bind to a hydrophobic patch on the outer surface of the beta-barrel structure.2 Publications

Sequence similaritiesi

Belongs to the HEBP family.Curated

Phylogenomic databases

eggNOGiENOG410IKQ6. Eukaryota.
ENOG4111HGX. LUCA.
HOGENOMiHOG000237638.
HOVERGENiHBG053223.
InParanoidiQ9R257.
TreeFamiTF328887.

Family and domain databases

InterProiIPR011256. Reg_factor_effector_dom.
IPR006917. SOUL_haem-bd.
[Graphical view]
PANTHERiPTHR11220. PTHR11220. 1 hit.
PfamiPF04832. SOUL. 1 hit.
[Graphical view]
SUPFAMiSSF55136. SSF55136. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9R257-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGMIRNSLF GSVETWPWQV LSTGGKEDVS YEERACEGGK FATVEVTDKP
60 70 80 90 100
VDEALREAMP KIMKYVGGTN DKGVGMGMTV PVSFALFPNE DGSLQKKLKV
110 120 130 140 150
WFRIPNQFQG SPPAPSDESV KIEEREGITV YSTQFGGYAK EADYVAHATQ
160 170 180 190
LRTTLEGTPA TYQGDVYYCA GYDPPMKPYG RRNEVWLVKA
Length:190
Mass (Da):21,067
Last modified:October 3, 2012 - v2
Checksum:iC1EA42E1798931DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86L → V in BAA33770 (PubMed:9813049).Curated1
Sequence conflicti86L → V in AAD32096 (PubMed:10640688).Curated1
Sequence conflicti86L → V in CAJ18470 (Ref. 4) Curated1
Sequence conflicti86L → V in AAH12654 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013095 mRNA. Translation: BAA33770.1.
AF117613 mRNA. Translation: AAD32096.1.
CT010262 mRNA. Translation: CAJ18470.1.
AC131718 Genomic DNA. No translation available.
BC012654 mRNA. Translation: AAH12654.1.
CCDSiCCDS20645.1.
RefSeqiNP_038574.3. NM_013546.3.
UniGeneiMm.378937.

Genome annotation databases

GeneIDi15199.
KEGGimmu:15199.
UCSCiuc009elh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013095 mRNA. Translation: BAA33770.1.
AF117613 mRNA. Translation: AAD32096.1.
CT010262 mRNA. Translation: CAJ18470.1.
AC131718 Genomic DNA. No translation available.
BC012654 mRNA. Translation: AAH12654.1.
CCDSiCCDS20645.1.
RefSeqiNP_038574.3. NM_013546.3.
UniGeneiMm.378937.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GOVNMR-A7-190[»]
2HVANMR-A1-190[»]
4A1MNMR-A7-190[»]
ProteinModelPortaliQ9R257.
SMRiQ9R257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200269. 1 interactor.
IntActiQ9R257. 5 interactors.
MINTiMINT-1845080.
STRINGi10090.ENSMUSP00000042232.

PTM databases

iPTMnetiQ9R257.
PhosphoSitePlusiQ9R257.
SwissPalmiQ9R257.

Proteomic databases

MaxQBiQ9R257.
PaxDbiQ9R257.
PeptideAtlasiQ9R257.
PRIDEiQ9R257.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15199.
KEGGimmu:15199.
UCSCiuc009elh.1. mouse.

Organism-specific databases

CTDi50865.
MGIiMGI:1333880. Hebp1.

Phylogenomic databases

eggNOGiENOG410IKQ6. Eukaryota.
ENOG4111HGX. LUCA.
HOGENOMiHOG000237638.
HOVERGENiHBG053223.
InParanoidiQ9R257.
TreeFamiTF328887.

Miscellaneous databases

EvolutionaryTraceiQ9R257.
PROiQ9R257.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042770.
CleanExiMM_HEBP1.

Family and domain databases

InterProiIPR011256. Reg_factor_effector_dom.
IPR006917. SOUL_haem-bd.
[Graphical view]
PANTHERiPTHR11220. PTHR11220. 1 hit.
PfamiPF04832. SOUL. 1 hit.
[Graphical view]
SUPFAMiSSF55136. SSF55136. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHEBP1_MOUSE
AccessioniPrimary (citable) accession number: Q9R257
Secondary accession number(s): O88814
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.