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Q9R244

- TRPC2_MOUSE

UniProt

Q9R244 - TRPC2_MOUSE

Protein

Short transient receptor potential channel 2

Gene

Trpc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (23 Mar 2010)
      Previous versions | rss
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    Functioni

    Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. May also be activated by intracellular calcium store depletion. Plays a role in mediating responsivity to pheromones that elicit aggressive and mating behaviors. Required for response to the Esp1 pheromone which enhances female sexual receptive behavior and to the Esp22 pheromone which inhibits adult male mating behavior.4 Publications

    GO - Molecular functioni

    1. calmodulin binding Source: MGI
    2. damaged DNA binding Source: InterPro
    3. diacylglycerol binding Source: MGI
    4. inositol 1,4,5 trisphosphate binding Source: BHF-UCL
    5. protein binding Source: BHF-UCL
    6. store-operated calcium channel activity Source: MGI

    GO - Biological processi

    1. acrosome reaction Source: MGI
    2. calcium ion transport Source: MGI
    3. female courtship behavior Source: MGI
    4. inter-male aggressive behavior Source: MGI
    5. mating behavior, sex discrimination Source: MGI
    6. negative regulation of male mating behavior Source: MGI
    7. positive regulation of cytosolic calcium ion concentration Source: MGI
    8. regulation of gene expression Source: MGI
    9. response to pheromone Source: MGI
    10. single strand break repair Source: InterPro
    11. territorial aggressive behavior Source: MGI

    Keywords - Molecular functioni

    Calcium channel, Ion channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Short transient receptor potential channel 2
    Short name:
    TrpC2
    Alternative name(s):
    Transient receptor protein 2
    Short name:
    TRP-2
    Short name:
    mTrp2
    Gene namesi
    Name:Trpc2
    Synonyms:Trp2, Trrp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:109527. Trpc2.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite membrane Source: MGI
    2. endomembrane system Source: MGI
    3. endoplasmic reticulum membrane Source: MGI
    4. Golgi membrane Source: MGI
    5. integral component of membrane Source: UniProtKB-KW
    6. nuclear envelope Source: MGI
    7. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Reduced electrophysiological response to pheromone mixtures in the vomeronasal organ. Mutant males and nursing females are docile and fail to initiate aggressive attacks on intruder males. Males display normal mating behavior towards females but display increased sexual behavior towards prepubescent females even when presented simultaneously with adult estrus females and also show increased sexual behavior towards juvenile and adult males. Lack of response to Esp1.4 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11721172Short transient receptor potential channel 2PRO_0000215307Add
    BLAST

    Proteomic databases

    PaxDbiQ9R244.
    PRIDEiQ9R244.

    PTM databases

    PhosphoSiteiQ9R244.

    Expressioni

    Tissue specificityi

    Isoform 3 is ubiquitously expressed at low levels. Isoform 4 is expressed exclusively in vomeronasal organ.

    Gene expression databases

    BgeeiQ9R244.
    GenevestigatoriQ9R244.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000081903.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R244.
    SMRiQ9R244. Positions 2-60, 305-457, 785-940.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 659659CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini681 – 70222ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini724 – 73815CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini760 – 78930ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini811 – 83323CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini855 – 89945ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini921 – 1172252CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei660 – 68021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei703 – 72321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei739 – 75921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei790 – 81021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei834 – 85421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei900 – 92021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati301 – 33030ANK 1Add
    BLAST
    Repeati377 – 40630ANK 2Add
    BLAST
    Repeati430 – 45930ANK 3Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1140 – 11434Poly-Ser

    Sequence similaritiesi

    Contains 3 ANK repeats.Curated

    Keywords - Domaini

    ANK repeat, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257288.
    GeneTreeiENSGT00680000099764.
    HOGENOMiHOG000137678.
    HOVERGENiHBG101351.
    InParanoidiQ9R244.
    KOiK04965.
    OrthoDBiEOG76X5ZD.
    PhylomeDBiQ9R244.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    2.60.120.260. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR008979. Galactose-bd-like.
    IPR005821. Ion_trans_dom.
    IPR013555. TRP_dom.
    IPR005458. TRPC2_channel.
    IPR002153. TRPC_channel.
    IPR002706. Xrcc1_N.
    [Graphical view]
    PANTHERiPTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF6. PTHR10117:SF6. 1 hit.
    PfamiPF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    PF01834. XRCC1_N. 1 hit.
    [Graphical view]
    PRINTSiPR01097. TRNSRECEPTRP.
    PR01643. TRPCHANNEL2.
    SMARTiSM00248. ANK. 2 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF49785. SSF49785. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9R244-1) [UniParc]FASTAAdd to Basket

    Also known as: A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLMSRTDSKS GKNRSGVRMF KDGDFLTPAS GESWDRLRLT CSQPFTRHQS     50
    FGLAFLRVRS SLGSLADPVV DPSAPGSSGL NQNSTDVLES DPRPWLTNPS 100
    IRRTFFPDPQ TSTKEISELK GMLKQLQPGP LGRAARMVLS AARKAPPASV 150
    VSPNNSHGEP GPSRAESAEP RAEEPNRKTA VGRRKRRKVQ EPRRSLSNSS 200
    SQPNRRTGRT RQRQHRPQTK SDDGGVQAAG QCPICAGFFS IETLPQHAAT 250
    CGESPPPQPA SPASLSSSES VLRRHHVALT PVPLVPKPQP NWTEIVNKKL 300
    KFPPTLLRAI QEGQLGLVQQ LLESSSDASG AGPGGPLRNV EESEDRSWRE 350
    ALNLAIRLGH EVITDVLLAN VKFDFRQIHE ALLVAVDTNQ PAVVRRLLAR 400
    LEREKGRKVD TKSFSLAFFD SSIDGSRFAP GVTPLTLACQ KDLYEIAQLL 450
    MDQGHTIARP HPVSCACLEC SNARRYDLLK FSLSRINTYR GIASRAHLSL 500
    ASEDAMLAAF QLSRELRRLA RKEPEFKPQY IALESLCQDY GFELLGMCRN 550
    QSEVTAVLND LGEDSETEPE AEGLGQAFEE GIPNLARLRL AVNYNQKQFV 600
    AHPICQQVLS SIWCGNLAGW RGSTTIWKLF VAFLIFLTMP FLCIGYWLAP 650
    KSQLGRLLKI PVLKFLLHSA SYLWFLIFLL GESLVMETQL STFKGRSQSV 700
    WETSLHMIWV TGFLWFECKE VWIEGLRSYL LDWWNFLDVV ILSLYLASFA 750
    LRLLLAGLAY MHCRDASDST TCRYFTTAER SEWRTEDPQF LAEVLFAVTS 800
    MLSFTRLAYI LPAHESLGTL QISIGKMIDD MIRFMFILMI ILTAFLCGLN 850
    NIYVPYQESE KLGNFNETFQ FLFWTMFGME EHTVVDMPQF LVPEFVGRAM 900
    YGIFTIVMVI VLLNMLIAMI TNSFQKIEDD ADVEWKFARS KLYLSYFREG 950
    LTLPVPFNIL PSPKAAFYLV RRIFRFLCCG SSCCKAKKSD YPPIGTFTNP 1000
    GARAGSAGEG ERVSYRLRVI KALVQRYIET ARREFEETRR KDLGNRLTEL 1050
    TKTVSRLQSE VASVQKNLAA GGAPRPPDGA SILSRYITRV RNSFQNLGPP 1100
    TSDTPAELTM PGIVETEVSL GDGLDGTGEA GAPAPGEPGS SSSAHVLVHR 1150
    EQEAEGSGDL LLEGDLETKG ES 1172
    Length:1,172
    Mass (Da):130,531
    Last modified:March 23, 2010 - v2
    Checksum:iD9A9A9FEE01D1536
    GO
    Isoform 2 (identifier: Q9R244-2) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         1-111: MLMSRTDSKS...RRTFFPDPQT → MGTKTHPVVPW

    Show »
    Length:1,072
    Mass (Da):119,508
    Checksum:i0566C84794F190C6
    GO
    Isoform 3 (identifier: Q9R244-3) [UniParc]FASTAAdd to Basket

    Also known as: Alpha

    The sequence of this isoform differs from the canonical sequence as follows:
         2-287: Missing.

    Show »
    Length:886
    Mass (Da):99,545
    Checksum:i19A4673B0B861E56
    GO
    Isoform 4 (identifier: Q9R244-4) [UniParc]FASTAAdd to Basket

    Also known as: Beta

    The sequence of this isoform differs from the canonical sequence as follows:
         2-283: Missing.
         284-287: LVPK → DPLS

    Show »
    Length:890
    Mass (Da):99,957
    Checksum:i50791C101A98C5B8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti628 – 6281K → R in AAD17195. (PubMed:10051594)Curated
    Sequence conflicti628 – 6281K → R in AAD17196. (PubMed:10051594)Curated
    Sequence conflicti633 – 6331F → S in AAD17195. (PubMed:10051594)Curated
    Sequence conflicti633 – 6331F → S in AAD17196. (PubMed:10051594)Curated
    Sequence conflicti653 – 6531Q → R in AAG29951. (PubMed:10998353)Curated
    Sequence conflicti653 – 6531Q → R in AAG29950. (PubMed:10998353)Curated
    Sequence conflicti774 – 7741Y → C in AAD17195. (PubMed:10051594)Curated
    Sequence conflicti774 – 7741Y → C in AAD17196. (PubMed:10051594)Curated
    Sequence conflicti797 – 7971A → T in AAD17195. (PubMed:10051594)Curated
    Sequence conflicti797 – 7971A → T in AAD17196. (PubMed:10051594)Curated
    Sequence conflicti1161 – 11611L → P in AAG29951. (PubMed:10998353)Curated
    Sequence conflicti1161 – 11611L → P in AAG29950. (PubMed:10998353)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 111111MLMSR…PDPQT → MGTKTHPVVPW in isoform 2. 1 PublicationVSP_006562Add
    BLAST
    Alternative sequencei2 – 287286Missing in isoform 3. 1 PublicationVSP_006564Add
    BLAST
    Alternative sequencei2 – 283282Missing in isoform 4. 1 PublicationVSP_006563Add
    BLAST
    Alternative sequencei284 – 2874LVPK → DPLS in isoform 4. 1 PublicationVSP_006565

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF111108 mRNA. Translation: AAD17196.1.
    AF111107 mRNA. Translation: AAD17195.1.
    AF230803 mRNA. Translation: AAG29951.1.
    AF230802 mRNA. Translation: AAG29950.1.
    CCDSiCCDS52333.1. [Q9R244-4]
    RefSeqiNP_001103367.1. NM_001109897.2. [Q9R244-4]
    UniGeneiMm.292904.

    Genome annotation databases

    EnsembliENSMUST00000106943; ENSMUSP00000102556; ENSMUSG00000070425. [Q9R244-4]
    GeneIDi22064.
    KEGGimmu:22064.
    UCSCiuc009iqm.1. mouse. [Q9R244-3]
    uc009iqn.1. mouse. [Q9R244-2]
    uc012fqr.1. mouse. [Q9R244-1]
    uc012fqs.1. mouse. [Q9R244-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF111108 mRNA. Translation: AAD17196.1 .
    AF111107 mRNA. Translation: AAD17195.1 .
    AF230803 mRNA. Translation: AAG29951.1 .
    AF230802 mRNA. Translation: AAG29950.1 .
    CCDSi CCDS52333.1. [Q9R244-4 ]
    RefSeqi NP_001103367.1. NM_001109897.2. [Q9R244-4 ]
    UniGenei Mm.292904.

    3D structure databases

    ProteinModelPortali Q9R244.
    SMRi Q9R244. Positions 2-60, 305-457, 785-940.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000081903.

    Chemistry

    GuidetoPHARMACOLOGYi 487.

    PTM databases

    PhosphoSitei Q9R244.

    Proteomic databases

    PaxDbi Q9R244.
    PRIDEi Q9R244.

    Protocols and materials databases

    DNASUi 22064.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000106943 ; ENSMUSP00000102556 ; ENSMUSG00000070425 . [Q9R244-4 ]
    GeneIDi 22064.
    KEGGi mmu:22064.
    UCSCi uc009iqm.1. mouse. [Q9R244-3 ]
    uc009iqn.1. mouse. [Q9R244-2 ]
    uc012fqr.1. mouse. [Q9R244-1 ]
    uc012fqs.1. mouse. [Q9R244-4 ]

    Organism-specific databases

    CTDi 7221.
    MGIi MGI:109527. Trpc2.

    Phylogenomic databases

    eggNOGi NOG257288.
    GeneTreei ENSGT00680000099764.
    HOGENOMi HOG000137678.
    HOVERGENi HBG101351.
    InParanoidi Q9R244.
    KOi K04965.
    OrthoDBi EOG76X5ZD.
    PhylomeDBi Q9R244.

    Miscellaneous databases

    NextBioi 301876.
    PROi Q9R244.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9R244.
    Genevestigatori Q9R244.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    2.60.120.260. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR008979. Galactose-bd-like.
    IPR005821. Ion_trans_dom.
    IPR013555. TRP_dom.
    IPR005458. TRPC2_channel.
    IPR002153. TRPC_channel.
    IPR002706. Xrcc1_N.
    [Graphical view ]
    PANTHERi PTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF6. PTHR10117:SF6. 1 hit.
    Pfami PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    PF01834. XRCC1_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01097. TRNSRECEPTRP.
    PR01643. TRPCHANNEL2.
    SMARTi SM00248. ANK. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF49785. SSF49785. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel."
      Vannier B., Peyton M., Boulay G., Brown D., Qin N., Jiang M., Zhu X., Birnbaumer L.
      Proc. Natl. Acad. Sci. U.S.A. 96:2060-2064(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Testis.
    2. "Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2."
      Hofmann T., Schaefer M., Schultz G., Gudermann T.
      Biochem. J. 351:115-122(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
    3. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    4. "Loss of sex discrimination and male-male aggression in mice deficient for TRP2."
      Stowers L., Holy T.E., Meister M., Dulac C., Koentges G.
      Science 295:1493-1500(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    5. "The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor."
      Haga S., Hattori T., Sato T., Sato K., Matsuda S., Kobayakawa R., Sakano H., Yoshihara Y., Kikusui T., Touhara K.
      Nature 466:118-122(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    6. "A juvenile mouse pheromone inhibits sexual behaviour through the vomeronasal system."
      Ferrero D.M., Moeller L.M., Osakada T., Horio N., Li Q., Roy D.S., Cichy A., Spehr M., Touhara K., Liberles S.D.
      Nature 502:368-371(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiTRPC2_MOUSE
    AccessioniPrimary (citable) accession number: Q9R244
    Secondary accession number(s): Q9ES59, Q9ES60, Q9R243
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: March 23, 2010
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3