Reviewed,
UniProtKB/Swiss-Prot Q9R244 (TRPC2_MOUSE)
Last modified
June 16, 2009.
Version 75.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Short transient receptor potential channel 2 Short name=TrpC2 Alternative name(s): Transient receptor protein 2 Short name=TRP-2 Short name=mTrp2 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 1172 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. May also be activated by intracellular calcium store depletion. |
| Subcellular location | Membrane; Multi-pass membrane protein Probable. |
| Tissue specificity | Isoform 3 is ubiquitously expressed at low levels. Isoform 4 is expressed exclusively in vomeronasal organ. |
| Sequence similarities | Belongs to the transient receptor family. STrpC subfamily. Contains 3 ANK repeats. |
Ontologies
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9R244-1) Also known as: A; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9R244-2) Also known as: B; The sequence of this isoform differs from the canonical sequence as follows: 1-111: MLMSRTDSKS...RRTFFPDPQT → MGTKTHPVVPW | ||||||
| Isoform 3 (identifier: Q9R244-3) Also known as: Alpha; The sequence of this isoform differs from the canonical sequence as follows: 2-287: Missing. | ||||||
| Isoform 4 (identifier: Q9R244-4) Also known as: Beta; The sequence of this isoform differs from the canonical sequence as follows: 2-283: Missing. 284-287: LVPK → DPLS |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1172 | 1172 | Short transient receptor potential channel 2 | PRO_0000215307 | |||||
Regions | |||||||||
| Topological domain | 1 – 659 | 659 | Cytoplasmic Potential | ||||||
| Transmembrane | 660 – 680 | 21 | Potential | ||||||
| Topological domain | 681 – 702 | 22 | Extracellular Potential | ||||||
| Transmembrane | 703 – 723 | 21 | Potential | ||||||
| Topological domain | 724 – 738 | 15 | Cytoplasmic Potential | ||||||
| Transmembrane | 739 – 759 | 21 | Potential | ||||||
| Topological domain | 760 – 789 | 30 | Extracellular Potential | ||||||
| Transmembrane | 790 – 810 | 21 | Potential | ||||||
| Topological domain | 811 – 833 | 23 | Cytoplasmic Potential | ||||||
| Transmembrane | 834 – 854 | 21 | Potential | ||||||
| Topological domain | 855 – 899 | 45 | Extracellular Potential | ||||||
| Transmembrane | 900 – 920 | 21 | Potential | ||||||
| Topological domain | 921 – 1172 | 252 | Cytoplasmic Potential | ||||||
| Repeat | 301 – 330 | 30 | ANK 1 | ||||||
| Repeat | 377 – 406 | 30 | ANK 2 | ||||||
| Repeat | 430 – 459 | 30 | ANK 3 | ||||||
| Compositional bias | 1140 – 1143 | 4 | Poly-Ser | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 111 | 111 | MLMSR…PDPQT → MGTKTHPVVPW in isoform 2. | VSP_006562 | |||||
| Alternative sequence | 2 – 287 | 286 | Missing in isoform 3. | VSP_006564 | |||||
| Alternative sequence | 2 – 283 | 282 | Missing in isoform 4. | VSP_006563 | |||||
| Alternative sequence | 284 – 287 | 4 | LVPK → DPLS in isoform 4. | VSP_006565 | |||||
Experimental info | |||||||||
| Sequence conflict | 628 | 1 | R → K in AAG29951. Ref.2 | ||||||
| Sequence conflict | 628 | 1 | R → K in AAG29950. Ref.2 | ||||||
| Sequence conflict | 633 | 1 | S → F in AAG29951. Ref.2 | ||||||
| Sequence conflict | 633 | 1 | S → F in AAG29950. Ref.2 | ||||||
| Sequence conflict | 653 | 1 | Q → R in AAG29951. Ref.2 | ||||||
| Sequence conflict | 653 | 1 | Q → R in AAG29950. Ref.2 | ||||||
| Sequence conflict | 774 | 1 | C → Y in AAG29951. Ref.2 | ||||||
| Sequence conflict | 774 | 1 | C → Y in AAG29950. Ref.2 | ||||||
| Sequence conflict | 797 | 1 | T → A in AAG29951. Ref.2 | ||||||
| Sequence conflict | 797 | 1 | T → A in AAG29950. Ref.2 | ||||||
| Sequence conflict | 1161 | 1 | L → P in AAG29951. Ref.2 | ||||||
| Sequence conflict | 1161 | 1 | L → P in AAG29950. Ref.2 | ||||||
Sequences
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References
| [1] | "Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel." Vannier B., Peyton M., Boulay G., Brown D., Qin N., Jiang M., Zhu X., Birnbaumer L. Proc. Natl. Acad. Sci. U.S.A. 96:2060-2064(1999) [PubMed: 10051594] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Testis. |
| [2] | "Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2." Hofmann T., Schaefer M., Schultz G., Gudermann T. Biochem. J. 351:115-122(2000) [PubMed: 10998353] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4). |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF111108 mRNA. Translation: AAD17196.1. AF111107 mRNA. Translation: AAD17195.1. AF230803 mRNA. Translation: AAG29951.1. AF230802 mRNA. Translation: AAG29950.1. | |
| IPI | IPI00129142. IPI00230561. IPI00230562. IPI00230563. |
| RefSeq | NP_001103367.1. NP_035774.2. |
| UniGene | Mm.292904 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1XNA based on UniProtKB P18887. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUSG00000070425. Mus musculus. [Contig view] |
| GeneID | 22064. |
| KEGG | mmu:22064. |
Organism-specific databases | |
| MGI | MGI:109527. Trpc2. |
Phylogenomic databases | |
| HOGENOM | Q9R244. |
| HOVERGEN | Q9R244. |
Gene expression databases | |
| ArrayExpress | Q9R244. |
| Bgee | Q9R244. |
| GermOnline | ENSMUSG00000070425. Mus musculus. |
Family and domain databases | |
| InterPro | IPR002110. ANK. IPR005821. Ion_trans. IPR002153. Trans_rcpt. IPR013555. TRP_2. IPR005458. TRP_channel2. IPR002706. Xrcc1_N. [Graphical view] |
| Gene3D | G3DSA:1.25.40.20. ANK. 1 hit. |
| Pfam | PF00520. Ion_trans. 1 hit. PF08344. TRP_2. 1 hit. PF01834. XRCC1_N. 1 hit. [Graphical view] |
| PRINTS | PR01097. TRNSRECEPTRP. PR01643. TRPCHANNEL2. |
| ProDom | PD023136. Xrcc1_N. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00248. ANK. 2 hits. [Graphical view] |
| PROSITE | PS50297. ANK_REP_REGION. False negative. PS50088. ANK_REPEAT. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 301876. |
| SOURCE | Search... |
Entry information
| Entry name | TRPC2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9R244 Secondary accession number(s): Q9ES59, Q9ES60, Q9R243 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


