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Q9R244

- TRPC2_MOUSE

UniProt

Q9R244 - TRPC2_MOUSE

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Protein

Short transient receptor potential channel 2

Gene

Trpc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. May also be activated by intracellular calcium store depletion. Plays a role in mediating responsivity to pheromones that elicit aggressive and mating behaviors. Required for response to the Esp1 pheromone which enhances female sexual receptive behavior and to the Esp22 pheromone which inhibits adult male mating behavior.4 Publications

GO - Molecular functioni

  1. calmodulin binding Source: MGI
  2. damaged DNA binding Source: InterPro
  3. diacylglycerol binding Source: MGI
  4. inositol 1,4,5 trisphosphate binding Source: BHF-UCL
  5. store-operated calcium channel activity Source: MGI

GO - Biological processi

  1. acrosome reaction Source: MGI
  2. calcium ion transport Source: MGI
  3. female courtship behavior Source: MGI
  4. inter-male aggressive behavior Source: MGI
  5. mating behavior, sex discrimination Source: MGI
  6. negative regulation of male mating behavior Source: MGI
  7. positive regulation of cytosolic calcium ion concentration Source: MGI
  8. regulation of gene expression Source: MGI
  9. response to pheromone Source: MGI
  10. single strand break repair Source: InterPro
  11. territorial aggressive behavior Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 2
Short name:
TrpC2
Alternative name(s):
Transient receptor protein 2
Short name:
TRP-2
Short name:
mTrp2
Gene namesi
Name:Trpc2
Synonyms:Trp2, Trrp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:109527. Trpc2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 659659CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei660 – 68021HelicalSequence AnalysisAdd
BLAST
Topological domaini681 – 70222ExtracellularSequence AnalysisAdd
BLAST
Transmembranei703 – 72321HelicalSequence AnalysisAdd
BLAST
Topological domaini724 – 73815CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei739 – 75921HelicalSequence AnalysisAdd
BLAST
Topological domaini760 – 78930ExtracellularSequence AnalysisAdd
BLAST
Transmembranei790 – 81021HelicalSequence AnalysisAdd
BLAST
Topological domaini811 – 83323CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei834 – 85421HelicalSequence AnalysisAdd
BLAST
Topological domaini855 – 89945ExtracellularSequence AnalysisAdd
BLAST
Transmembranei900 – 92021HelicalSequence AnalysisAdd
BLAST
Topological domaini921 – 1172252CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. dendrite membrane Source: MGI
  2. endomembrane system Source: MGI
  3. endoplasmic reticulum membrane Source: MGI
  4. Golgi membrane Source: MGI
  5. integral component of membrane Source: UniProtKB-KW
  6. nuclear envelope Source: MGI
  7. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Reduced electrophysiological response to pheromone mixtures in the vomeronasal organ. Mutant males and nursing females are docile and fail to initiate aggressive attacks on intruder males. Males display normal mating behavior towards females but display increased sexual behavior towards prepubescent females even when presented simultaneously with adult estrus females and also show increased sexual behavior towards juvenile and adult males. Lack of response to Esp1.4 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11721172Short transient receptor potential channel 2PRO_0000215307Add
BLAST

Proteomic databases

PaxDbiQ9R244.
PRIDEiQ9R244.

PTM databases

PhosphoSiteiQ9R244.

Expressioni

Tissue specificityi

Isoform 3 is ubiquitously expressed at low levels. Isoform 4 is expressed exclusively in vomeronasal organ.

Gene expression databases

BgeeiQ9R244.
ExpressionAtlasiQ9R244. baseline.
GenevestigatoriQ9R244.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081903.

Structurei

3D structure databases

ProteinModelPortaliQ9R244.
SMRiQ9R244. Positions 2-60, 305-462, 785-940.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati301 – 33030ANK 1Add
BLAST
Repeati377 – 40630ANK 2Add
BLAST
Repeati430 – 45930ANK 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1140 – 11434Poly-Ser

Sequence similaritiesi

Contains 3 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257288.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000137678.
HOVERGENiHBG101351.
InParanoidiQ9R244.
KOiK04965.
OrthoDBiEOG76X5ZD.
PhylomeDBiQ9R244.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.120.260. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR008979. Galactose-bd-like.
IPR005821. Ion_trans_dom.
IPR013555. TRP_dom.
IPR005458. TRPC2_channel.
IPR002153. TRPC_channel.
IPR002706. Xrcc1_N.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF6. PTHR10117:SF6. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
PF01834. XRCC1_N. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01643. TRPCHANNEL2.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF49785. SSF49785. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9R244-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLMSRTDSKS GKNRSGVRMF KDGDFLTPAS GESWDRLRLT CSQPFTRHQS
60 70 80 90 100
FGLAFLRVRS SLGSLADPVV DPSAPGSSGL NQNSTDVLES DPRPWLTNPS
110 120 130 140 150
IRRTFFPDPQ TSTKEISELK GMLKQLQPGP LGRAARMVLS AARKAPPASV
160 170 180 190 200
VSPNNSHGEP GPSRAESAEP RAEEPNRKTA VGRRKRRKVQ EPRRSLSNSS
210 220 230 240 250
SQPNRRTGRT RQRQHRPQTK SDDGGVQAAG QCPICAGFFS IETLPQHAAT
260 270 280 290 300
CGESPPPQPA SPASLSSSES VLRRHHVALT PVPLVPKPQP NWTEIVNKKL
310 320 330 340 350
KFPPTLLRAI QEGQLGLVQQ LLESSSDASG AGPGGPLRNV EESEDRSWRE
360 370 380 390 400
ALNLAIRLGH EVITDVLLAN VKFDFRQIHE ALLVAVDTNQ PAVVRRLLAR
410 420 430 440 450
LEREKGRKVD TKSFSLAFFD SSIDGSRFAP GVTPLTLACQ KDLYEIAQLL
460 470 480 490 500
MDQGHTIARP HPVSCACLEC SNARRYDLLK FSLSRINTYR GIASRAHLSL
510 520 530 540 550
ASEDAMLAAF QLSRELRRLA RKEPEFKPQY IALESLCQDY GFELLGMCRN
560 570 580 590 600
QSEVTAVLND LGEDSETEPE AEGLGQAFEE GIPNLARLRL AVNYNQKQFV
610 620 630 640 650
AHPICQQVLS SIWCGNLAGW RGSTTIWKLF VAFLIFLTMP FLCIGYWLAP
660 670 680 690 700
KSQLGRLLKI PVLKFLLHSA SYLWFLIFLL GESLVMETQL STFKGRSQSV
710 720 730 740 750
WETSLHMIWV TGFLWFECKE VWIEGLRSYL LDWWNFLDVV ILSLYLASFA
760 770 780 790 800
LRLLLAGLAY MHCRDASDST TCRYFTTAER SEWRTEDPQF LAEVLFAVTS
810 820 830 840 850
MLSFTRLAYI LPAHESLGTL QISIGKMIDD MIRFMFILMI ILTAFLCGLN
860 870 880 890 900
NIYVPYQESE KLGNFNETFQ FLFWTMFGME EHTVVDMPQF LVPEFVGRAM
910 920 930 940 950
YGIFTIVMVI VLLNMLIAMI TNSFQKIEDD ADVEWKFARS KLYLSYFREG
960 970 980 990 1000
LTLPVPFNIL PSPKAAFYLV RRIFRFLCCG SSCCKAKKSD YPPIGTFTNP
1010 1020 1030 1040 1050
GARAGSAGEG ERVSYRLRVI KALVQRYIET ARREFEETRR KDLGNRLTEL
1060 1070 1080 1090 1100
TKTVSRLQSE VASVQKNLAA GGAPRPPDGA SILSRYITRV RNSFQNLGPP
1110 1120 1130 1140 1150
TSDTPAELTM PGIVETEVSL GDGLDGTGEA GAPAPGEPGS SSSAHVLVHR
1160 1170
EQEAEGSGDL LLEGDLETKG ES
Length:1,172
Mass (Da):130,531
Last modified:March 23, 2010 - v2
Checksum:iD9A9A9FEE01D1536
GO
Isoform 2 (identifier: Q9R244-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: MLMSRTDSKS...RRTFFPDPQT → MGTKTHPVVPW

Show »
Length:1,072
Mass (Da):119,508
Checksum:i0566C84794F190C6
GO
Isoform 3 (identifier: Q9R244-3) [UniParc]FASTAAdd to Basket

Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     2-287: Missing.

Show »
Length:886
Mass (Da):99,545
Checksum:i19A4673B0B861E56
GO
Isoform 4 (identifier: Q9R244-4) [UniParc]FASTAAdd to Basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     2-283: Missing.
     284-287: LVPK → DPLS

Show »
Length:890
Mass (Da):99,957
Checksum:i50791C101A98C5B8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti628 – 6281K → R in AAD17195. (PubMed:10051594)Curated
Sequence conflicti628 – 6281K → R in AAD17196. (PubMed:10051594)Curated
Sequence conflicti633 – 6331F → S in AAD17195. (PubMed:10051594)Curated
Sequence conflicti633 – 6331F → S in AAD17196. (PubMed:10051594)Curated
Sequence conflicti653 – 6531Q → R in AAG29951. (PubMed:10998353)Curated
Sequence conflicti653 – 6531Q → R in AAG29950. (PubMed:10998353)Curated
Sequence conflicti774 – 7741Y → C in AAD17195. (PubMed:10051594)Curated
Sequence conflicti774 – 7741Y → C in AAD17196. (PubMed:10051594)Curated
Sequence conflicti797 – 7971A → T in AAD17195. (PubMed:10051594)Curated
Sequence conflicti797 – 7971A → T in AAD17196. (PubMed:10051594)Curated
Sequence conflicti1161 – 11611L → P in AAG29951. (PubMed:10998353)Curated
Sequence conflicti1161 – 11611L → P in AAG29950. (PubMed:10998353)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 111111MLMSR…PDPQT → MGTKTHPVVPW in isoform 2. 1 PublicationVSP_006562Add
BLAST
Alternative sequencei2 – 287286Missing in isoform 3. 1 PublicationVSP_006564Add
BLAST
Alternative sequencei2 – 283282Missing in isoform 4. 1 PublicationVSP_006563Add
BLAST
Alternative sequencei284 – 2874LVPK → DPLS in isoform 4. 1 PublicationVSP_006565

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111108 mRNA. Translation: AAD17196.1.
AF111107 mRNA. Translation: AAD17195.1.
AF230803 mRNA. Translation: AAG29951.1.
AF230802 mRNA. Translation: AAG29950.1.
CCDSiCCDS52333.1. [Q9R244-4]
RefSeqiNP_001103367.1. NM_001109897.2. [Q9R244-4]
UniGeneiMm.292904.

Genome annotation databases

EnsembliENSMUST00000124189; ENSMUSP00000116934; ENSMUSG00000100254. [Q9R244-4]
GeneIDi22064.
KEGGimmu:22064.
UCSCiuc009iqm.1. mouse. [Q9R244-3]
uc009iqn.1. mouse. [Q9R244-2]
uc012fqr.1. mouse. [Q9R244-1]
uc012fqs.1. mouse. [Q9R244-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111108 mRNA. Translation: AAD17196.1 .
AF111107 mRNA. Translation: AAD17195.1 .
AF230803 mRNA. Translation: AAG29951.1 .
AF230802 mRNA. Translation: AAG29950.1 .
CCDSi CCDS52333.1. [Q9R244-4 ]
RefSeqi NP_001103367.1. NM_001109897.2. [Q9R244-4 ]
UniGenei Mm.292904.

3D structure databases

ProteinModelPortali Q9R244.
SMRi Q9R244. Positions 2-60, 305-462, 785-940.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000081903.

Chemistry

GuidetoPHARMACOLOGYi 487.

PTM databases

PhosphoSitei Q9R244.

Proteomic databases

PaxDbi Q9R244.
PRIDEi Q9R244.

Protocols and materials databases

DNASUi 22064.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000124189 ; ENSMUSP00000116934 ; ENSMUSG00000100254 . [Q9R244-4 ]
GeneIDi 22064.
KEGGi mmu:22064.
UCSCi uc009iqm.1. mouse. [Q9R244-3 ]
uc009iqn.1. mouse. [Q9R244-2 ]
uc012fqr.1. mouse. [Q9R244-1 ]
uc012fqs.1. mouse. [Q9R244-4 ]

Organism-specific databases

CTDi 7221.
MGIi MGI:109527. Trpc2.

Phylogenomic databases

eggNOGi NOG257288.
GeneTreei ENSGT00760000119180.
HOGENOMi HOG000137678.
HOVERGENi HBG101351.
InParanoidi Q9R244.
KOi K04965.
OrthoDBi EOG76X5ZD.
PhylomeDBi Q9R244.

Miscellaneous databases

NextBioi 301876.
PROi Q9R244.
SOURCEi Search...

Gene expression databases

Bgeei Q9R244.
ExpressionAtlasi Q9R244. baseline.
Genevestigatori Q9R244.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
2.60.120.260. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR008979. Galactose-bd-like.
IPR005821. Ion_trans_dom.
IPR013555. TRP_dom.
IPR005458. TRPC2_channel.
IPR002153. TRPC_channel.
IPR002706. Xrcc1_N.
[Graphical view ]
PANTHERi PTHR10117. PTHR10117. 1 hit.
PTHR10117:SF6. PTHR10117:SF6. 1 hit.
Pfami PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
PF01834. XRCC1_N. 1 hit.
[Graphical view ]
PRINTSi PR01097. TRNSRECEPTRP.
PR01643. TRPCHANNEL2.
SMARTi SM00248. ANK. 2 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF49785. SSF49785. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel."
    Vannier B., Peyton M., Boulay G., Brown D., Qin N., Jiang M., Zhu X., Birnbaumer L.
    Proc. Natl. Acad. Sci. U.S.A. 96:2060-2064(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  2. "Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2."
    Hofmann T., Schaefer M., Schultz G., Gudermann T.
    Biochem. J. 351:115-122(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
  3. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  4. "Loss of sex discrimination and male-male aggression in mice deficient for TRP2."
    Stowers L., Holy T.E., Meister M., Dulac C., Koentges G.
    Science 295:1493-1500(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  5. "The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor."
    Haga S., Hattori T., Sato T., Sato K., Matsuda S., Kobayakawa R., Sakano H., Yoshihara Y., Kikusui T., Touhara K.
    Nature 466:118-122(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  6. "A juvenile mouse pheromone inhibits sexual behaviour through the vomeronasal system."
    Ferrero D.M., Moeller L.M., Osakada T., Horio N., Li Q., Roy D.S., Cichy A., Spehr M., Touhara K., Liberles S.D.
    Nature 502:368-371(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiTRPC2_MOUSE
AccessioniPrimary (citable) accession number: Q9R244
Secondary accession number(s): Q9ES59, Q9ES60, Q9R243
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 23, 2010
Last modified: November 26, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3