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Protein

Short transient receptor potential channel 2

Gene

Trpc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. May also be activated by intracellular calcium store depletion. Plays a role in mediating responsivity to pheromones that elicit aggressive and mating behaviors. Required for response to the Esp1 pheromone which enhances female sexual receptive behavior and to the Esp22 pheromone which inhibits adult male mating behavior.4 Publications

GO - Molecular functioni

  • calmodulin binding Source: MGI
  • damaged DNA binding Source: InterPro
  • diacylglycerol binding Source: MGI
  • inositol 1,4,5 trisphosphate binding Source: BHF-UCL
  • store-operated calcium channel activity Source: MGI

GO - Biological processi

  • acrosome reaction Source: MGI
  • calcium ion transport Source: MGI
  • female courtship behavior Source: MGI
  • inter-male aggressive behavior Source: MGI
  • manganese ion transport Source: GO_Central
  • mating behavior, sex discrimination Source: MGI
  • negative regulation of male mating behavior Source: MGI
  • positive regulation of cytosolic calcium ion concentration Source: MGI
  • regulation of gene expression Source: MGI
  • response to pheromone Source: MGI
  • single strand break repair Source: InterPro
  • territorial aggressive behavior Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 2
Short name:
TrpC2
Alternative name(s):
Transient receptor protein 2
Short name:
TRP-2
Short name:
mTrp2
Gene namesi
Name:Trpc2
Synonyms:Trp2, Trrp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:109527. Trpc2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 659CytoplasmicSequence analysisAdd BLAST659
Transmembranei660 – 680HelicalSequence analysisAdd BLAST21
Topological domaini681 – 702ExtracellularSequence analysisAdd BLAST22
Transmembranei703 – 723HelicalSequence analysisAdd BLAST21
Topological domaini724 – 738CytoplasmicSequence analysisAdd BLAST15
Transmembranei739 – 759HelicalSequence analysisAdd BLAST21
Topological domaini760 – 789ExtracellularSequence analysisAdd BLAST30
Transmembranei790 – 810HelicalSequence analysisAdd BLAST21
Topological domaini811 – 833CytoplasmicSequence analysisAdd BLAST23
Transmembranei834 – 854HelicalSequence analysisAdd BLAST21
Topological domaini855 – 899ExtracellularSequence analysisAdd BLAST45
Transmembranei900 – 920HelicalSequence analysisAdd BLAST21
Topological domaini921 – 1172CytoplasmicSequence analysisAdd BLAST252

GO - Cellular componenti

  • dendrite membrane Source: MGI
  • endomembrane system Source: MGI
  • endoplasmic reticulum membrane Source: MGI
  • Golgi membrane Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • nuclear envelope Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Reduced electrophysiological response to pheromone mixtures in the vomeronasal organ. Mutant males and nursing females are docile and fail to initiate aggressive attacks on intruder males. Males display normal mating behavior towards females but display increased sexual behavior towards prepubescent females even when presented simultaneously with adult estrus females and also show increased sexual behavior towards juvenile and adult males. Lack of response to Esp1.4 Publications

Chemistry databases

GuidetoPHARMACOLOGYi487.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153071 – 1172Short transient receptor potential channel 2Add BLAST1172

Proteomic databases

PaxDbiQ9R244.
PRIDEiQ9R244.

PTM databases

iPTMnetiQ9R244.
PhosphoSitePlusiQ9R244.

Expressioni

Tissue specificityi

Isoform 3 is ubiquitously expressed at low levels. Isoform 4 is expressed exclusively in vomeronasal organ.

Gene expression databases

BgeeiENSMUSG00000070425.
GenevisibleiQ9R244. MM.

Interactioni

GO - Molecular functioni

  • calmodulin binding Source: MGI

Protein-protein interaction databases

DIPiDIP-61090N.
STRINGi10090.ENSMUSP00000081903.

Structurei

3D structure databases

ProteinModelPortaliQ9R244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati301 – 330ANK 1Add BLAST30
Repeati377 – 406ANK 2Add BLAST30
Repeati430 – 459ANK 3Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1140 – 1143Poly-Ser4

Sequence similaritiesi

Contains 3 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000137678.
HOVERGENiHBG101351.
InParanoidiQ9R244.
KOiK04965.
OrthoDBiEOG091G0KP0.
PhylomeDBiQ9R244.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.120.260. 1 hit.
InterProiIPR020683. Ankyrin_rpt-contain_dom.
IPR008979. Galactose-bd-like.
IPR005821. Ion_trans_dom.
IPR013555. TRP_dom.
IPR005458. TRPC2_channel.
IPR002153. TRPC_channel.
IPR002706. Xrcc1_N.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF6. PTHR10117:SF6. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
PF01834. XRCC1_N. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01643. TRPCHANNEL2.
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF49785. SSF49785. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9R244-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLMSRTDSKS GKNRSGVRMF KDGDFLTPAS GESWDRLRLT CSQPFTRHQS
60 70 80 90 100
FGLAFLRVRS SLGSLADPVV DPSAPGSSGL NQNSTDVLES DPRPWLTNPS
110 120 130 140 150
IRRTFFPDPQ TSTKEISELK GMLKQLQPGP LGRAARMVLS AARKAPPASV
160 170 180 190 200
VSPNNSHGEP GPSRAESAEP RAEEPNRKTA VGRRKRRKVQ EPRRSLSNSS
210 220 230 240 250
SQPNRRTGRT RQRQHRPQTK SDDGGVQAAG QCPICAGFFS IETLPQHAAT
260 270 280 290 300
CGESPPPQPA SPASLSSSES VLRRHHVALT PVPLVPKPQP NWTEIVNKKL
310 320 330 340 350
KFPPTLLRAI QEGQLGLVQQ LLESSSDASG AGPGGPLRNV EESEDRSWRE
360 370 380 390 400
ALNLAIRLGH EVITDVLLAN VKFDFRQIHE ALLVAVDTNQ PAVVRRLLAR
410 420 430 440 450
LEREKGRKVD TKSFSLAFFD SSIDGSRFAP GVTPLTLACQ KDLYEIAQLL
460 470 480 490 500
MDQGHTIARP HPVSCACLEC SNARRYDLLK FSLSRINTYR GIASRAHLSL
510 520 530 540 550
ASEDAMLAAF QLSRELRRLA RKEPEFKPQY IALESLCQDY GFELLGMCRN
560 570 580 590 600
QSEVTAVLND LGEDSETEPE AEGLGQAFEE GIPNLARLRL AVNYNQKQFV
610 620 630 640 650
AHPICQQVLS SIWCGNLAGW RGSTTIWKLF VAFLIFLTMP FLCIGYWLAP
660 670 680 690 700
KSQLGRLLKI PVLKFLLHSA SYLWFLIFLL GESLVMETQL STFKGRSQSV
710 720 730 740 750
WETSLHMIWV TGFLWFECKE VWIEGLRSYL LDWWNFLDVV ILSLYLASFA
760 770 780 790 800
LRLLLAGLAY MHCRDASDST TCRYFTTAER SEWRTEDPQF LAEVLFAVTS
810 820 830 840 850
MLSFTRLAYI LPAHESLGTL QISIGKMIDD MIRFMFILMI ILTAFLCGLN
860 870 880 890 900
NIYVPYQESE KLGNFNETFQ FLFWTMFGME EHTVVDMPQF LVPEFVGRAM
910 920 930 940 950
YGIFTIVMVI VLLNMLIAMI TNSFQKIEDD ADVEWKFARS KLYLSYFREG
960 970 980 990 1000
LTLPVPFNIL PSPKAAFYLV RRIFRFLCCG SSCCKAKKSD YPPIGTFTNP
1010 1020 1030 1040 1050
GARAGSAGEG ERVSYRLRVI KALVQRYIET ARREFEETRR KDLGNRLTEL
1060 1070 1080 1090 1100
TKTVSRLQSE VASVQKNLAA GGAPRPPDGA SILSRYITRV RNSFQNLGPP
1110 1120 1130 1140 1150
TSDTPAELTM PGIVETEVSL GDGLDGTGEA GAPAPGEPGS SSSAHVLVHR
1160 1170
EQEAEGSGDL LLEGDLETKG ES
Length:1,172
Mass (Da):130,531
Last modified:March 23, 2010 - v2
Checksum:iD9A9A9FEE01D1536
GO
Isoform 2 (identifier: Q9R244-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: MLMSRTDSKS...RRTFFPDPQT → MGTKTHPVVPW

Show »
Length:1,072
Mass (Da):119,508
Checksum:i0566C84794F190C6
GO
Isoform 3 (identifier: Q9R244-3) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     2-287: Missing.

Show »
Length:886
Mass (Da):99,545
Checksum:i19A4673B0B861E56
GO
Isoform 4 (identifier: Q9R244-4) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     2-283: Missing.
     284-287: LVPK → DPLS

Show »
Length:890
Mass (Da):99,957
Checksum:i50791C101A98C5B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti628K → R in AAD17195 (PubMed:10051594).Curated1
Sequence conflicti628K → R in AAD17196 (PubMed:10051594).Curated1
Sequence conflicti633F → S in AAD17195 (PubMed:10051594).Curated1
Sequence conflicti633F → S in AAD17196 (PubMed:10051594).Curated1
Sequence conflicti653Q → R in AAG29951 (PubMed:10998353).Curated1
Sequence conflicti653Q → R in AAG29950 (PubMed:10998353).Curated1
Sequence conflicti774Y → C in AAD17195 (PubMed:10051594).Curated1
Sequence conflicti774Y → C in AAD17196 (PubMed:10051594).Curated1
Sequence conflicti797A → T in AAD17195 (PubMed:10051594).Curated1
Sequence conflicti797A → T in AAD17196 (PubMed:10051594).Curated1
Sequence conflicti1161L → P in AAG29951 (PubMed:10998353).Curated1
Sequence conflicti1161L → P in AAG29950 (PubMed:10998353).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0065621 – 111MLMSR…PDPQT → MGTKTHPVVPW in isoform 2. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_0065642 – 287Missing in isoform 3. 1 PublicationAdd BLAST286
Alternative sequenceiVSP_0065632 – 283Missing in isoform 4. 1 PublicationAdd BLAST282
Alternative sequenceiVSP_006565284 – 287LVPK → DPLS in isoform 4. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111108 mRNA. Translation: AAD17196.1.
AF111107 mRNA. Translation: AAD17195.1.
AF230803 mRNA. Translation: AAG29951.1.
AF230802 mRNA. Translation: AAG29950.1.
CCDSiCCDS52333.1. [Q9R244-4]
RefSeqiNP_001103367.1. NM_001109897.2. [Q9R244-4]
UniGeneiMm.292904.

Genome annotation databases

EnsembliENSMUST00000124189; ENSMUSP00000116934; ENSMUSG00000100254. [Q9R244-4]
GeneIDi22064.
KEGGimmu:22064.
UCSCiuc009iqm.2. mouse. [Q9R244-3]
uc009iqn.2. mouse. [Q9R244-2]
uc012fqr.2. mouse. [Q9R244-1]
uc012fqs.2. mouse. [Q9R244-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111108 mRNA. Translation: AAD17196.1.
AF111107 mRNA. Translation: AAD17195.1.
AF230803 mRNA. Translation: AAG29951.1.
AF230802 mRNA. Translation: AAG29950.1.
CCDSiCCDS52333.1. [Q9R244-4]
RefSeqiNP_001103367.1. NM_001109897.2. [Q9R244-4]
UniGeneiMm.292904.

3D structure databases

ProteinModelPortaliQ9R244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61090N.
STRINGi10090.ENSMUSP00000081903.

Chemistry databases

GuidetoPHARMACOLOGYi487.

PTM databases

iPTMnetiQ9R244.
PhosphoSitePlusiQ9R244.

Proteomic databases

PaxDbiQ9R244.
PRIDEiQ9R244.

Protocols and materials databases

DNASUi22064.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000124189; ENSMUSP00000116934; ENSMUSG00000100254. [Q9R244-4]
GeneIDi22064.
KEGGimmu:22064.
UCSCiuc009iqm.2. mouse. [Q9R244-3]
uc009iqn.2. mouse. [Q9R244-2]
uc012fqr.2. mouse. [Q9R244-1]
uc012fqs.2. mouse. [Q9R244-4]

Organism-specific databases

CTDi7221.
MGIiMGI:109527. Trpc2.

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000137678.
HOVERGENiHBG101351.
InParanoidiQ9R244.
KOiK04965.
OrthoDBiEOG091G0KP0.
PhylomeDBiQ9R244.

Miscellaneous databases

PROiQ9R244.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070425.
GenevisibleiQ9R244. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.120.260. 1 hit.
InterProiIPR020683. Ankyrin_rpt-contain_dom.
IPR008979. Galactose-bd-like.
IPR005821. Ion_trans_dom.
IPR013555. TRP_dom.
IPR005458. TRPC2_channel.
IPR002153. TRPC_channel.
IPR002706. Xrcc1_N.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF6. PTHR10117:SF6. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
PF01834. XRCC1_N. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01643. TRPCHANNEL2.
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF49785. SSF49785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPC2_MOUSE
AccessioniPrimary (citable) accession number: Q9R244
Secondary accession number(s): Q9ES59, Q9ES60, Q9R243
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 23, 2010
Last modified: November 2, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.