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Protein
Submitted name:

Transforming growth factor beta-1

Gene

Tgfb1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. antigen binding Source: Ensembl

GO - Biological processi

  1. adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains Source: Ensembl
  2. ATP biosynthetic process Source: Ensembl
  3. branch elongation involved in mammary gland duct branching Source: Ensembl
  4. cell-cell junction organization Source: Ensembl
  5. cell cycle arrest Source: Ensembl
  6. cellular calcium ion homeostasis Source: Ensembl
  7. cellular response to organic cyclic compound Source: Ensembl
  8. chondrocyte differentiation Source: Ensembl
  9. common-partner SMAD protein phosphorylation Source: Ensembl
  10. endoderm development Source: Ensembl
  11. epidermal growth factor receptor signaling pathway Source: Ensembl
  12. evasion or tolerance of host defenses by virus Source: Ensembl
  13. extracellular matrix assembly Source: Ensembl
  14. extrinsic apoptotic signaling pathway Source: Ensembl
  15. face morphogenesis Source: Ensembl
  16. germ cell migration Source: Ensembl
  17. hematopoietic progenitor cell differentiation Source: Ensembl
  18. hyaluronan catabolic process Source: Ensembl
  19. inflammatory response Source: Ensembl
  20. lens fiber cell differentiation Source: Ensembl
  21. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  22. lymph node development Source: Ensembl
  23. mammary gland branching involved in thelarche Source: Ensembl
  24. MAPK cascade Source: Ensembl
  25. mitotic cell cycle checkpoint Source: Ensembl
  26. mononuclear cell proliferation Source: Ensembl
  27. myeloid dendritic cell differentiation Source: Ensembl
  28. negative regulation of blood vessel endothelial cell migration Source: Ensembl
  29. negative regulation of cell-cell adhesion Source: Ensembl
  30. negative regulation of cell growth Source: Ensembl
  31. negative regulation of DNA replication Source: Ensembl
  32. negative regulation of epithelial cell proliferation Source: Ensembl
  33. negative regulation of fat cell differentiation Source: Ensembl
  34. negative regulation of hyaluronan biosynthetic process Source: Ensembl
  35. negative regulation of macrophage cytokine production Source: Ensembl
  36. negative regulation of myoblast differentiation Source: Ensembl
  37. negative regulation of ossification Source: Ensembl
  38. negative regulation of protein phosphorylation Source: Ensembl
  39. negative regulation of skeletal muscle tissue development Source: Ensembl
  40. negative regulation of T cell proliferation Source: Ensembl
  41. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  42. ossification involved in bone remodeling Source: Ensembl
  43. pathway-restricted SMAD protein phosphorylation Source: Ensembl
  44. positive regulation of blood vessel endothelial cell migration Source: Ensembl
  45. positive regulation of bone mineralization Source: Ensembl
  46. positive regulation of cell cycle arrest Source: Ensembl
  47. positive regulation of cell proliferation Source: Ensembl
  48. positive regulation of chemotaxis Source: Ensembl
  49. positive regulation of collagen biosynthetic process Source: Ensembl
  50. positive regulation of epithelial to mesenchymal transition Source: Ensembl
  51. positive regulation of fibroblast migration Source: Ensembl
  52. positive regulation of histone acetylation Source: Ensembl
  53. positive regulation of histone deacetylation Source: Ensembl
  54. positive regulation of interleukin-17 production Source: Ensembl
  55. positive regulation of isotype switching to IgA isotypes Source: Ensembl
  56. positive regulation of MAP kinase activity Source: Ensembl
  57. positive regulation of NAD+ ADP-ribosyltransferase activity Source: Ensembl
  58. positive regulation of odontogenesis Source: Ensembl
  59. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  60. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  61. positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
  62. positive regulation of phosphatidylinositol 3-kinase activity Source: Ensembl
  63. positive regulation of protein complex assembly Source: Ensembl
  64. positive regulation of protein dephosphorylation Source: Ensembl
  65. positive regulation of protein kinase B signaling Source: Ensembl
  66. positive regulation of protein secretion Source: Ensembl
  67. positive regulation of SMAD protein import into nucleus Source: Ensembl
  68. positive regulation of superoxide anion generation Source: Ensembl
  69. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  70. positive regulation of transcription regulatory region DNA binding Source: Ensembl
  71. protein export from nucleus Source: Ensembl
  72. protein import into nucleus, translocation Source: Ensembl
  73. protein kinase B signaling Source: Ensembl
  74. receptor catabolic process Source: Ensembl
  75. regulation of actin cytoskeleton reorganization Source: Ensembl
  76. regulation of branching involved in mammary gland duct morphogenesis Source: Ensembl
  77. regulation of cartilage development Source: Ensembl
  78. regulation of miRNA metabolic process Source: Ensembl
  79. regulation of sodium ion transport Source: Ensembl
  80. regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  81. regulatory T cell differentiation Source: Ensembl
  82. response to cholesterol Source: Ensembl
  83. response to estradiol Source: Ensembl
  84. response to progesterone Source: Ensembl
  85. response to wounding Source: Ensembl
  86. salivary gland morphogenesis Source: Ensembl
  87. SMAD protein complex assembly Source: Ensembl
  88. SMAD protein import into nucleus Source: Ensembl
  89. T cell homeostasis Source: Ensembl
  90. tolerance induction to self antigen Source: Ensembl
  91. transforming growth factor beta receptor signaling pathway Source: Ensembl
  92. ureteric bud development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Transforming growth factor beta-1Imported
Gene namesi
Name:Tgfb1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi69051. Tgfb1.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: Ensembl
  2. cell surface Source: Ensembl
  3. cytoplasm Source: Ensembl
  4. microvillus Source: Ensembl
  5. nucleus Source: Ensembl
  6. proteinaceous extracellular matrix Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ9R231. baseline and differential.
GenevestigatoriQ9R231.

Sequencei

Sequence statusi: Fragment.

Q9R231-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20 
MPPSGLRLLP LLLPLPWLLV LTP
Length:23
Mass (Da):2,550
Last modified:May 1, 2000 - v1
Checksum:i26AA10E5D88E68F4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei23 – 231Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105069 Genomic DNA. Translation: AAD20222.1.
UniGeneiRn.40136.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105069 Genomic DNA. Translation: AAD20222.1.
UniGeneiRn.40136.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi69051. Tgfb1.

Gene expression databases

ExpressionAtlasiQ9R231. baseline and differential.
GenevestigatoriQ9R231.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Identification of the start sites for the 1.9- and 1.4-kb rat transforming growth factor-beta1 transcripts and their effect on translational efficiency."
    Yang Y., Mumy M., Romeo D., Wakefield L.M.
    Gene 219:81-89(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: FisherImported.

Entry informationi

Entry nameiQ9R231_RAT
AccessioniPrimary (citable) accession number: Q9R231
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.