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Q9R231

- Q9R231_RAT

UniProt

Q9R231 - Q9R231_RAT

Protein
Submitted name:

Transforming growth factor beta-1

Gene

Tgfb1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    GO - Biological processi

    1. adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains Source: Ensembl
    2. ATP biosynthetic process Source: Ensembl
    3. branch elongation involved in mammary gland duct branching Source: Ensembl
    4. cell-cell junction organization Source: Ensembl
    5. cell cycle arrest Source: Ensembl
    6. cellular calcium ion homeostasis Source: Ensembl
    7. cellular response to organic cyclic compound Source: Ensembl
    8. chondrocyte differentiation Source: Ensembl
    9. common-partner SMAD protein phosphorylation Source: Ensembl
    10. endoderm development Source: Ensembl
    11. epidermal growth factor receptor signaling pathway Source: Ensembl
    12. evasion or tolerance of host defenses by virus Source: Ensembl
    13. extracellular matrix assembly Source: Ensembl
    14. extrinsic apoptotic signaling pathway Source: Ensembl
    15. face morphogenesis Source: Ensembl
    16. germ cell migration Source: Ensembl
    17. hematopoietic progenitor cell differentiation Source: Ensembl
    18. hyaluronan catabolic process Source: Ensembl
    19. inflammatory response Source: Ensembl
    20. lens fiber cell differentiation Source: Ensembl
    21. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    22. lymph node development Source: Ensembl
    23. mammary gland branching involved in thelarche Source: Ensembl
    24. MAPK cascade Source: Ensembl
    25. mitotic cell cycle checkpoint Source: Ensembl
    26. mononuclear cell proliferation Source: Ensembl
    27. myeloid dendritic cell differentiation Source: Ensembl
    28. negative regulation of blood vessel endothelial cell migration Source: Ensembl
    29. negative regulation of cell-cell adhesion Source: Ensembl
    30. negative regulation of cell growth Source: Ensembl
    31. negative regulation of DNA replication Source: Ensembl
    32. negative regulation of epithelial cell proliferation Source: Ensembl
    33. negative regulation of fat cell differentiation Source: Ensembl
    34. negative regulation of hyaluronan biosynthetic process Source: Ensembl
    35. negative regulation of macrophage cytokine production Source: Ensembl
    36. negative regulation of mitotic cell cycle Source: Ensembl
    37. negative regulation of myoblast differentiation Source: Ensembl
    38. negative regulation of ossification Source: Ensembl
    39. negative regulation of protein phosphorylation Source: Ensembl
    40. negative regulation of skeletal muscle tissue development Source: Ensembl
    41. negative regulation of T cell proliferation Source: Ensembl
    42. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    43. ossification involved in bone remodeling Source: Ensembl
    44. pathway-restricted SMAD protein phosphorylation Source: Ensembl
    45. positive regulation of blood vessel endothelial cell migration Source: Ensembl
    46. positive regulation of bone mineralization Source: Ensembl
    47. positive regulation of cell cycle arrest Source: Ensembl
    48. positive regulation of cell proliferation Source: Ensembl
    49. positive regulation of chemotaxis Source: Ensembl
    50. positive regulation of collagen biosynthetic process Source: Ensembl
    51. positive regulation of epithelial to mesenchymal transition Source: Ensembl
    52. positive regulation of fibroblast migration Source: Ensembl
    53. positive regulation of histone acetylation Source: Ensembl
    54. positive regulation of histone deacetylation Source: Ensembl
    55. positive regulation of interleukin-17 production Source: Ensembl
    56. positive regulation of isotype switching to IgA isotypes Source: Ensembl
    57. positive regulation of MAP kinase activity Source: Ensembl
    58. positive regulation of NAD+ ADP-ribosyltransferase activity Source: Ensembl
    59. positive regulation of odontogenesis Source: Ensembl
    60. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    61. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    62. positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
    63. positive regulation of phosphatidylinositol 3-kinase activity Source: Ensembl
    64. positive regulation of protein complex assembly Source: Ensembl
    65. positive regulation of protein dephosphorylation Source: Ensembl
    66. positive regulation of protein kinase B signaling Source: Ensembl
    67. positive regulation of protein secretion Source: Ensembl
    68. positive regulation of SMAD protein import into nucleus Source: Ensembl
    69. positive regulation of superoxide anion generation Source: Ensembl
    70. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    71. positive regulation of transcription regulatory region DNA binding Source: Ensembl
    72. protein export from nucleus Source: Ensembl
    73. protein import into nucleus, translocation Source: Ensembl
    74. protein kinase B signaling Source: Ensembl
    75. receptor catabolic process Source: Ensembl
    76. regulation of branching involved in mammary gland duct morphogenesis Source: Ensembl
    77. regulation of cartilage development Source: Ensembl
    78. regulation of sodium ion transport Source: Ensembl
    79. regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    80. regulatory T cell differentiation Source: Ensembl
    81. response to cholesterol Source: Ensembl
    82. response to estradiol Source: Ensembl
    83. response to progesterone Source: Ensembl
    84. salivary gland morphogenesis Source: Ensembl
    85. SMAD protein complex assembly Source: Ensembl
    86. SMAD protein import into nucleus Source: Ensembl
    87. T cell homeostasis Source: Ensembl
    88. tolerance induction to self antigen Source: Ensembl
    89. transforming growth factor beta receptor signaling pathway Source: Ensembl
    90. ureteric bud development Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Transforming growth factor beta-1Imported
    Gene namesi
    Name:Tgfb1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi69051. Tgfb1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. extracellular space Source: Ensembl
    4. microvillus Source: Ensembl
    5. nucleus Source: Ensembl
    6. proteinaceous extracellular matrix Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ9R231.
    GenevestigatoriQ9R231.

    Family & Domainsi

    Phylogenomic databases

    InParanoidiQ9R231.

    Sequencei

    Sequence statusi: Fragment.

    Q9R231-1 [UniParc]FASTAAdd to Basket

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    MPPSGLRLLP LLLPLPWLLV LTP                                23
    Length:23
    Mass (Da):2,550
    Last modified:May 1, 2000 - v1
    Checksum:i26AA10E5D88E68F4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei23 – 231Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF105069 Genomic DNA. Translation: AAD20222.1.
    UniGeneiRn.40136.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF105069 Genomic DNA. Translation: AAD20222.1 .
    UniGenei Rn.40136.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 69051. Tgfb1.

    Phylogenomic databases

    InParanoidi Q9R231.

    Gene expression databases

    ArrayExpressi Q9R231.
    Genevestigatori Q9R231.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Identification of the start sites for the 1.9- and 1.4-kb rat transforming growth factor-beta1 transcripts and their effect on translational efficiency."
      Yang Y., Mumy M., Romeo D., Wakefield L.M.
      Gene 219:81-89(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: FisherImported.

    Entry informationi

    Entry nameiQ9R231_RAT
    AccessioniPrimary (citable) accession number: Q9R231
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)