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Q9R230

- Q9R230_RAT

UniProt

Q9R230 - Q9R230_RAT

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Protein
Submitted name: Fas receptor
Gene
Fas, Tnfrsf6
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. B cell mediated immunity Source: Ensembl
  2. activation-induced cell death of T cells Source: Ensembl
  3. cellular response to hyperoxia Source: Ensembl
  4. cellular response to lithium ion Source: Ensembl
  5. cellular response to mechanical stimulus Source: Ensembl
  6. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  7. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  8. gene expression Source: Ensembl
  9. immunoglobulin production Source: Ensembl
  10. inflammatory cell apoptotic process Source: Ensembl
  11. motor neuron apoptotic process Source: Ensembl
  12. negative regulation of B cell activation Source: Ensembl
  13. negative regulation of apoptotic process Source: Ensembl
  14. negative thymic T cell selection Source: Ensembl
  15. positive regulation of apoptotic process Source: Ensembl
  16. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  17. positive regulation of necrotic cell death Source: Ensembl
  18. positive regulation of protein homooligomerization Source: Ensembl
  19. protein homooligomerization Source: Ensembl
  20. regulation of lymphocyte differentiation Source: Ensembl
  21. regulation of myeloid cell differentiation Source: Ensembl
  22. renal system process Source: Ensembl
  23. response to glucocorticoid Source: Ensembl
  24. response to toxic substance Source: Ensembl
  25. spleen development Source: Ensembl
  26. transformed cell apoptotic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiREACT_198396. Regulation by c-FLIP.
REACT_202168. FasL/ CD95L signaling.
REACT_208401. Dimerization of procaspase-8.
REACT_222369. Caspase-8 activation.

Names & Taxonomyi

Protein namesi
Submitted name:
Fas receptorImported
Gene namesi
Name:FasImported
Synonyms:Tnfrsf6Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi619831. Fas.

Subcellular locationi

GO - Cellular componenti

  1. CD95 death-inducing signaling complex Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. external side of plasma membrane Source: Ensembl
  4. extracellular region Source: Ensembl
  5. membrane raft Source: Ensembl
  6. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ9R230.

Structurei

3D structure databases

ProteinModelPortaliQ9R230.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG004091.

Family and domain databases

InterProiIPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01680. TNFACTORR6.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9R230-1 [UniParc]FASTAAdd to Basket

« Hide

AVLPLVLAGP ELNVRMQGTD SISEGLELKR SVRETDNNCS EGLYQVGPFC    50
CQPCQPGERK VKDCTTSGGA PTCHPCTEGE EYTDRKHYSD KCRRCAFCDE 100
GHGLEVETNC TRTQNTKCRC KENFYCNASL CDHCYHCTSC GLEDILEPCT 150
Length:150
Mass (Da):16,645
Last modified:May 1, 2000 - v1
Checksum:i7DEC76EC40A6BA4F
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei150 – 1501Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF104034 mRNA. Translation: AAD20221.1.
UniGeneiRn.162521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF104034 mRNA. Translation: AAD20221.1 .
UniGenei Rn.162521.

3D structure databases

ProteinModelPortali Q9R230.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 619831. Fas.

Phylogenomic databases

HOVERGENi HBG004091.

Enzyme and pathway databases

Reactomei REACT_198396. Regulation by c-FLIP.
REACT_202168. FasL/ CD95L signaling.
REACT_208401. Dimerization of procaspase-8.
REACT_222369. Caspase-8 activation.

Gene expression databases

Genevestigatori Q9R230.

Family and domain databases

InterProi IPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view ]
Pfami PF00020. TNFR_c6. 2 hits.
[Graphical view ]
PRINTSi PR01680. TNFACTORR6.
SMARTi SM00208. TNFR. 2 hits.
[Graphical view ]
PROSITEi PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of Fas and Fas Ligand in the apoptotic rat corpus luteum."
    Lareu R.R., Dharmarajan A.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WistarImported.
    Tissue: Corpus luteumImported.

Entry informationi

Entry nameiQ9R230_RAT
AccessioniPrimary (citable) accession number: Q9R230
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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