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Q9R230

- Q9R230_RAT

UniProt

Q9R230 - Q9R230_RAT

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Protein
Submitted name:

Fas receptor

Gene

Fas

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. activation-induced cell death of T cells Source: Ensembl
  2. B cell mediated immunity Source: Ensembl
  3. cellular response to hyperoxia Source: Ensembl
  4. cellular response to lithium ion Source: Ensembl
  5. cellular response to mechanical stimulus Source: Ensembl
  6. circadian rhythm Source: Ensembl
  7. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  8. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  9. gene expression Source: Ensembl
  10. immunoglobulin production Source: Ensembl
  11. inflammatory cell apoptotic process Source: Ensembl
  12. motor neuron apoptotic process Source: Ensembl
  13. necroptotic signaling pathway Source: Ensembl
  14. negative regulation of apoptotic process Source: Ensembl
  15. negative regulation of B cell activation Source: Ensembl
  16. negative thymic T cell selection Source: Ensembl
  17. positive regulation of apoptotic process Source: Ensembl
  18. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  19. positive regulation of protein homooligomerization Source: Ensembl
  20. protein homooligomerization Source: Ensembl
  21. regulation of lymphocyte differentiation Source: Ensembl
  22. regulation of myeloid cell differentiation Source: Ensembl
  23. renal system process Source: Ensembl
  24. response to glucocorticoid Source: Ensembl
  25. response to toxic substance Source: Ensembl
  26. spleen development Source: Ensembl
  27. transformed cell apoptotic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiREACT_198396. Regulation by c-FLIP.
REACT_202168. FasL/ CD95L signaling.
REACT_208401. Dimerization of procaspase-8.
REACT_222369. Caspase-8 activation.

Names & Taxonomyi

Protein namesi
Submitted name:
Fas receptorImported
Gene namesi
Name:FasImported
Synonyms:Tnfrsf6Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi619831. Fas.

Subcellular locationi

GO - Cellular componenti

  1. CD95 death-inducing signaling complex Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. external side of plasma membrane Source: Ensembl
  4. extracellular vesicular exosome Source: Ensembl
  5. membrane raft Source: Ensembl
  6. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ9R230. baseline and differential.
GenevestigatoriQ9R230.

Structurei

3D structure databases

ProteinModelPortaliQ9R230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG004091.

Family and domain databases

InterProiIPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01680. TNFACTORR6.
SMARTiSM00208. TNFR. 2 hits.
[Graphical view]
PROSITEiPS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9R230-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
AVLPLVLAGP ELNVRMQGTD SISEGLELKR SVRETDNNCS EGLYQVGPFC
60 70 80 90 100
CQPCQPGERK VKDCTTSGGA PTCHPCTEGE EYTDRKHYSD KCRRCAFCDE
110 120 130 140 150
GHGLEVETNC TRTQNTKCRC KENFYCNASL CDHCYHCTSC GLEDILEPCT
Length:150
Mass (Da):16,645
Last modified:May 1, 2000 - v1
Checksum:i7DEC76EC40A6BA4F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei150 – 1501Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF104034 mRNA. Translation: AAD20221.1.
UniGeneiRn.162521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF104034 mRNA. Translation: AAD20221.1 .
UniGenei Rn.162521.

3D structure databases

ProteinModelPortali Q9R230.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 619831. Fas.

Phylogenomic databases

HOVERGENi HBG004091.

Enzyme and pathway databases

Reactomei REACT_198396. Regulation by c-FLIP.
REACT_202168. FasL/ CD95L signaling.
REACT_208401. Dimerization of procaspase-8.
REACT_222369. Caspase-8 activation.

Gene expression databases

ExpressionAtlasi Q9R230. baseline and differential.
Genevestigatori Q9R230.

Family and domain databases

InterProi IPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view ]
Pfami PF00020. TNFR_c6. 2 hits.
[Graphical view ]
PRINTSi PR01680. TNFACTORR6.
SMARTi SM00208. TNFR. 2 hits.
[Graphical view ]
PROSITEi PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of Fas and Fas Ligand in the apoptotic rat corpus luteum."
    Lareu R.R., Dharmarajan A.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WistarImported.
    Tissue: Corpus luteumImported.

Entry informationi

Entry nameiQ9R230_RAT
AccessioniPrimary (citable) accession number: Q9R230
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)