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Q9R230

- Q9R230_RAT

UniProt

Q9R230 - Q9R230_RAT

Protein
Submitted name:

Fas receptor

Gene

Fas

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. transmembrane signaling receptor activity Source: InterPro

    GO - Biological processi

    1. activation-induced cell death of T cells Source: Ensembl
    2. B cell mediated immunity Source: Ensembl
    3. cellular response to hyperoxia Source: Ensembl
    4. cellular response to lithium ion Source: Ensembl
    5. cellular response to mechanical stimulus Source: Ensembl
    6. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    7. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    8. gene expression Source: Ensembl
    9. immunoglobulin production Source: Ensembl
    10. inflammatory cell apoptotic process Source: Ensembl
    11. motor neuron apoptotic process Source: Ensembl
    12. negative regulation of apoptotic process Source: Ensembl
    13. negative regulation of B cell activation Source: Ensembl
    14. negative thymic T cell selection Source: Ensembl
    15. positive regulation of apoptotic process Source: Ensembl
    16. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    17. positive regulation of necrotic cell death Source: Ensembl
    18. positive regulation of protein homooligomerization Source: Ensembl
    19. protein homooligomerization Source: Ensembl
    20. regulation of lymphocyte differentiation Source: Ensembl
    21. regulation of myeloid cell differentiation Source: Ensembl
    22. renal system process Source: Ensembl
    23. response to glucocorticoid Source: Ensembl
    24. response to toxic substance Source: Ensembl
    25. spleen development Source: Ensembl
    26. transformed cell apoptotic process Source: Ensembl

    Keywords - Molecular functioni

    ReceptorImported

    Enzyme and pathway databases

    ReactomeiREACT_198396. Regulation by c-FLIP.
    REACT_202168. FasL/ CD95L signaling.
    REACT_208401. Dimerization of procaspase-8.
    REACT_222369. Caspase-8 activation.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Fas receptorImported
    Gene namesi
    Name:FasImported
    Synonyms:Tnfrsf6Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi619831. Fas.

    Subcellular locationi

    GO - Cellular componenti

    1. CD95 death-inducing signaling complex Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. external side of plasma membrane Source: Ensembl
    4. extracellular region Source: Ensembl
    5. membrane raft Source: Ensembl
    6. nucleus Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ9R230.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R230.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG004091.

    Family and domain databases

    InterProiIPR008063. Fas_rcpt.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    [Graphical view]
    PfamiPF00020. TNFR_c6. 2 hits.
    [Graphical view]
    PRINTSiPR01680. TNFACTORR6.
    SMARTiSM00208. TNFR. 2 hits.
    [Graphical view]
    PROSITEiPS50050. TNFR_NGFR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9R230-1 [UniParc]FASTAAdd to Basket

    « Hide

    AVLPLVLAGP ELNVRMQGTD SISEGLELKR SVRETDNNCS EGLYQVGPFC    50
    CQPCQPGERK VKDCTTSGGA PTCHPCTEGE EYTDRKHYSD KCRRCAFCDE 100
    GHGLEVETNC TRTQNTKCRC KENFYCNASL CDHCYHCTSC GLEDILEPCT 150
    Length:150
    Mass (Da):16,645
    Last modified:May 1, 2000 - v1
    Checksum:i7DEC76EC40A6BA4F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei150 – 1501Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF104034 mRNA. Translation: AAD20221.1.
    UniGeneiRn.162521.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF104034 mRNA. Translation: AAD20221.1 .
    UniGenei Rn.162521.

    3D structure databases

    ProteinModelPortali Q9R230.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 619831. Fas.

    Phylogenomic databases

    HOVERGENi HBG004091.

    Enzyme and pathway databases

    Reactomei REACT_198396. Regulation by c-FLIP.
    REACT_202168. FasL/ CD95L signaling.
    REACT_208401. Dimerization of procaspase-8.
    REACT_222369. Caspase-8 activation.

    Gene expression databases

    Genevestigatori Q9R230.

    Family and domain databases

    InterProi IPR008063. Fas_rcpt.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    [Graphical view ]
    Pfami PF00020. TNFR_c6. 2 hits.
    [Graphical view ]
    PRINTSi PR01680. TNFACTORR6.
    SMARTi SM00208. TNFR. 2 hits.
    [Graphical view ]
    PROSITEi PS50050. TNFR_NGFR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of Fas and Fas Ligand in the apoptotic rat corpus luteum."
      Lareu R.R., Dharmarajan A.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: WistarImported.
      Tissue: Corpus luteumImported.

    Entry informationi

    Entry nameiQ9R230_RAT
    AccessioniPrimary (citable) accession number: Q9R230
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)