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Q9R229

- BMP10_MOUSE

UniProt

Q9R229 - BMP10_MOUSE

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Protein

Bone morphogenetic protein 10

Gene

Bmp10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines By similarity.By similarity

GO - Molecular functioni

  1. receptor serine/threonine kinase binding Source: UniProtKB

GO - Biological processi

  1. activin receptor signaling pathway Source: Ensembl
  2. adult heart development Source: BHF-UCL
  3. atrial cardiac muscle tissue morphogenesis Source: BHF-UCL
  4. BMP signaling pathway Source: Ensembl
  5. cardiac muscle cell proliferation Source: UniProtKB
  6. cell adhesion Source: UniProtKB-KW
  7. heart development Source: MGI
  8. heart trabecula formation Source: BHF-UCL
  9. negative regulation of cardiac muscle hypertrophy Source: BHF-UCL
  10. negative regulation of cell growth Source: UniProtKB
  11. negative regulation of cell migration Source: UniProtKB
  12. negative regulation of endothelial cell migration Source: Ensembl
  13. pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  14. positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
  15. positive regulation of cardiac muscle hypertrophy Source: Ensembl
  16. positive regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
  17. positive regulation of gene expression Source: MGI
  18. positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
  19. positive regulation of sarcomere organization Source: Ensembl
  20. positive regulation of transcription, DNA-templated Source: Ensembl
  21. regulation of cardiac muscle contraction Source: Ensembl
  22. sarcomere organization Source: Ensembl
  23. ventricular cardiac muscle cell development Source: BHF-UCL
  24. ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_198998. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 10
Short name:
BMP-10
Gene namesi
Name:Bmp10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1338820. Bmp10.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
  3. Z disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice die in utero between E9.5 and E10.5. They appear normal at E8.5-E8.75 but display cardiac dysgenesis at E9.0-E9.5 with profound hypoplastic ventricular walls and absence of ventricular trabeculae and have a significantly lower heart rate than wild type embryos. Mutants show up-regulation of Cdkn1c/p57KIP throughout the ventricular wall while levels of Mef2c and Nkx2-5 are normal at E8.5-E8.75 but are down-regulated at E9.25-E9.5.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 313292Sequence AnalysisPRO_0000033890Add
BLAST
Chaini314 – 421108Bone morphogenetic protein 10PRO_0000033891Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi320 ↔ 386By similarity
Disulfide bondi349 ↔ 418By similarity
Disulfide bondi353 ↔ 420By similarity
Disulfide bondi385 – 385InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R229.
PRIDEiQ9R229.

PTM databases

PhosphoSiteiQ9R229.

Expressioni

Tissue specificityi

In the embryo, expressed exclusively in the ventricular trabecular myocardium of the developing heart from E9.0-E13.5. By E16.5-E18.5, only detectable in atria. Highly expressed in the adult heart where it is found in the right atrium but not in the left atrium. Lower levels in adult liver and lung.3 Publications

Developmental stagei

Down-regulation after E14.5 is critical for cardiomyocytes to undergo normal developmental hypertrophic growth in early postnatal life.1 Publication

Gene expression databases

BgeeiQ9R229.
CleanExiMM_BMP10.
GenevestigatoriQ9R229.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

IntActiQ9R229. 1 interaction.
MINTiMINT-4089291.

Structurei

3D structure databases

ProteinModelPortaliQ9R229.
SMRiQ9R229. Positions 317-421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG280573.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249477.
HOVERGENiHBG106648.
InParanoidiQ9R229.
KOiK05503.
OMAiNVSIPHH.
OrthoDBiEOG7ZD1V3.
PhylomeDBiQ9R229.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R229-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSLVLPLSA VFCLVAHSAS GSPIMGLEQS PLEEDMPFFD DIFTEQDGID
60 70 80 90 100
FNTLLQSMKN EFLKTLNLSD IPVQDTGRVD PPEYMLELYN KFATDRTSMP
110 120 130 140 150
SANIIRSFKN EDLFSQPVTF NGLRKYPLLF NVSIPHHEEV VMAELRLYTL
160 170 180 190 200
VQRDRMMYDG VDRKITIFEV LESADGSEEE RSMLVLVSTE IYGTNSEWET
210 220 230 240 250
FDVTDATRRW QKSGPSTHQL EIHIESRQNQ AEDTGRGQLE IDMSAQNKHD
260 270 280 290 300
PLLVVFSDDQ SNDKEQKEEL NELITHEQDL DLDSDAFFSG PDEEALLQMR
310 320 330 340 350
SNMIDDSSAR IRRNAKGNYC KKTPLYIDFK EIGWDSWIIA PPGYEAYECR
360 370 380 390 400
GVCNYPLAEH LTPTKHAIIQ ALVHLKNSQK ASKACCVPTK LDPISILYLD
410 420
KGVVTYKFKY EGMAVSECGC R
Length:421
Mass (Da):47,888
Last modified:November 13, 2007 - v2
Checksum:i770AF401A64C3F49
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831E → K in AAC95357. (PubMed:10072785)Curated
Sequence conflicti83 – 831E → K in AAC77461. 1 PublicationCurated
Sequence conflicti112 – 1121Missing in AAC95357. (PubMed:10072785)Curated
Sequence conflicti309 – 3091A → T in AAC95357. (PubMed:10072785)Curated
Sequence conflicti309 – 3091A → T in AAC77461. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF101033 mRNA. Translation: AAC95357.1.
AF101440, AF101439 Genomic DNA. Translation: AAC77461.1.
BC145983 mRNA. Translation: AAI45984.1.
CCDSiCCDS51838.1.
RefSeqiNP_033886.2. NM_009756.2.
UniGeneiMm.483321.

Genome annotation databases

EnsembliENSMUST00000032125; ENSMUSP00000032125; ENSMUSG00000030046.
GeneIDi12154.
KEGGimmu:12154.
UCSCiuc012eol.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF101033 mRNA. Translation: AAC95357.1 .
AF101440 , AF101439 Genomic DNA. Translation: AAC77461.1 .
BC145983 mRNA. Translation: AAI45984.1 .
CCDSi CCDS51838.1.
RefSeqi NP_033886.2. NM_009756.2.
UniGenei Mm.483321.

3D structure databases

ProteinModelPortali Q9R229.
SMRi Q9R229. Positions 317-421.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9R229. 1 interaction.
MINTi MINT-4089291.

PTM databases

PhosphoSitei Q9R229.

Proteomic databases

PaxDbi Q9R229.
PRIDEi Q9R229.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032125 ; ENSMUSP00000032125 ; ENSMUSG00000030046 .
GeneIDi 12154.
KEGGi mmu:12154.
UCSCi uc012eol.1. mouse.

Organism-specific databases

CTDi 27302.
MGIi MGI:1338820. Bmp10.

Phylogenomic databases

eggNOGi NOG280573.
GeneTreei ENSGT00760000118883.
HOGENOMi HOG000249477.
HOVERGENi HBG106648.
InParanoidi Q9R229.
KOi K05503.
OMAi NVSIPHH.
OrthoDBi EOG7ZD1V3.
PhylomeDBi Q9R229.
TreeFami TF316134.

Enzyme and pathway databases

Reactomei REACT_198998. Molecules associated with elastic fibres.

Miscellaneous databases

NextBioi 280491.
PROi Q9R229.
SOURCEi Search...

Gene expression databases

Bgeei Q9R229.
CleanExi MM_BMP10.
Genevestigatori Q9R229.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PRINTSi PR00669. INHIBINA.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily."
    Neuhaus H., Rosen V., Thies R.S.
    Mech. Dev. 80:181-184(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: NIH Swiss.
    Tissue: Heart.
  2. "Mouse bone morphogenetic protein 10 (BMP-10) genomic sequence, full coding region of exon 2."
    Celeste A.J.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Nkx2-5 pathways and congenital heart disease: loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block."
    Pashmforoush M., Lu J.T., Chen H., Amand T.S., Kondo R., Pradervand S., Evans S.M., Clark B., Feramisco J.R., Giles W., Ho S.Y., Benson D.W., Silberbach M., Shou W., Chien K.R.
    Cell 117:373-386(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  5. Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  6. "Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth."
    Chen H., Yong W., Ren S., Shen W., He Y., Cox K.A., Zhu W., Li W., Soonpaa M., Payne R.M., Franco D., Field L.J., Rosen V., Wang Y., Shou W.
    J. Biol. Chem. 281:27481-27491(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiBMP10_MOUSE
AccessioniPrimary (citable) accession number: Q9R229
Secondary accession number(s): A6H6S5, Q9Z1V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3