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Q9R229

- BMP10_MOUSE

UniProt

Q9R229 - BMP10_MOUSE

Protein

Bone morphogenetic protein 10

Gene

Bmp10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines By similarity.By similarity

    GO - Molecular functioni

    1. receptor serine/threonine kinase binding Source: UniProtKB

    GO - Biological processi

    1. activin receptor signaling pathway Source: Ensembl
    2. adult heart development Source: BHF-UCL
    3. atrial cardiac muscle tissue morphogenesis Source: BHF-UCL
    4. BMP signaling pathway Source: Ensembl
    5. cardiac muscle cell proliferation Source: UniProtKB
    6. cell adhesion Source: UniProtKB-KW
    7. heart development Source: MGI
    8. heart trabecula formation Source: BHF-UCL
    9. negative regulation of cardiac muscle hypertrophy Source: BHF-UCL
    10. negative regulation of cell growth Source: UniProtKB
    11. negative regulation of cell migration Source: UniProtKB
    12. negative regulation of endothelial cell migration Source: Ensembl
    13. pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
    14. positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
    15. positive regulation of cardiac muscle hypertrophy Source: Ensembl
    16. positive regulation of cell proliferation involved in heart morphogenesis Source: BHF-UCL
    17. positive regulation of gene expression Source: MGI
    18. positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
    19. positive regulation of sarcomere organization Source: Ensembl
    20. positive regulation of transcription, DNA-templated Source: Ensembl
    21. regulation of cardiac muscle contraction Source: Ensembl
    22. sarcomere organization Source: Ensembl
    23. ventricular cardiac muscle cell development Source: BHF-UCL
    24. ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_198998. Molecules associated with elastic fibres.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 10
    Short name:
    BMP-10
    Gene namesi
    Name:Bmp10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1338820. Bmp10.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular space Source: UniProtKB-KW
    3. Z disc Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Disruption phenotypei

    Mice die in utero between E9.5 and E10.5. They appear normal at E8.5-E8.75 but display cardiac dysgenesis at E9.0-E9.5 with profound hypoplastic ventricular walls and absence of ventricular trabeculae and have a significantly lower heart rate than wild type embryos. Mutants show up-regulation of Cdkn1c/p57KIP throughout the ventricular wall while levels of Mef2c and Nkx2-5 are normal at E8.5-E8.75 but are down-regulated at E9.25-E9.5.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 313292Sequence AnalysisPRO_0000033890Add
    BLAST
    Chaini314 – 421108Bone morphogenetic protein 10PRO_0000033891Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi320 ↔ 386By similarity
    Disulfide bondi349 ↔ 418By similarity
    Disulfide bondi353 ↔ 420By similarity
    Disulfide bondi385 – 385InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9R229.
    PRIDEiQ9R229.

    PTM databases

    PhosphoSiteiQ9R229.

    Expressioni

    Tissue specificityi

    In the embryo, expressed exclusively in the ventricular trabecular myocardium of the developing heart from E9.0-E13.5. By E16.5-E18.5, only detectable in atria. Highly expressed in the adult heart where it is found in the right atrium but not in the left atrium. Lower levels in adult liver and lung.3 Publications

    Developmental stagei

    Down-regulation after E14.5 is critical for cardiomyocytes to undergo normal developmental hypertrophic growth in early postnatal life.1 Publication

    Gene expression databases

    BgeeiQ9R229.
    CleanExiMM_BMP10.
    GenevestigatoriQ9R229.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    IntActiQ9R229. 1 interaction.
    MINTiMINT-4089291.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R229.
    SMRiQ9R229. Positions 317-421.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG280573.
    GeneTreeiENSGT00740000115456.
    HOGENOMiHOG000249477.
    HOVERGENiHBG106648.
    InParanoidiQ9R229.
    KOiK05503.
    OMAiNVSIPHH.
    OrthoDBiEOG7ZD1V3.
    PhylomeDBiQ9R229.
    TreeFamiTF316134.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PRINTSiPR00669. INHIBINA.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9R229-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSLVLPLSA VFCLVAHSAS GSPIMGLEQS PLEEDMPFFD DIFTEQDGID    50
    FNTLLQSMKN EFLKTLNLSD IPVQDTGRVD PPEYMLELYN KFATDRTSMP 100
    SANIIRSFKN EDLFSQPVTF NGLRKYPLLF NVSIPHHEEV VMAELRLYTL 150
    VQRDRMMYDG VDRKITIFEV LESADGSEEE RSMLVLVSTE IYGTNSEWET 200
    FDVTDATRRW QKSGPSTHQL EIHIESRQNQ AEDTGRGQLE IDMSAQNKHD 250
    PLLVVFSDDQ SNDKEQKEEL NELITHEQDL DLDSDAFFSG PDEEALLQMR 300
    SNMIDDSSAR IRRNAKGNYC KKTPLYIDFK EIGWDSWIIA PPGYEAYECR 350
    GVCNYPLAEH LTPTKHAIIQ ALVHLKNSQK ASKACCVPTK LDPISILYLD 400
    KGVVTYKFKY EGMAVSECGC R 421
    Length:421
    Mass (Da):47,888
    Last modified:November 13, 2007 - v2
    Checksum:i770AF401A64C3F49
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti83 – 831E → K in AAC95357. (PubMed:10072785)Curated
    Sequence conflicti83 – 831E → K in AAC77461. 1 PublicationCurated
    Sequence conflicti112 – 1121Missing in AAC95357. (PubMed:10072785)Curated
    Sequence conflicti309 – 3091A → T in AAC95357. (PubMed:10072785)Curated
    Sequence conflicti309 – 3091A → T in AAC77461. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF101033 mRNA. Translation: AAC95357.1.
    AF101440, AF101439 Genomic DNA. Translation: AAC77461.1.
    BC145983 mRNA. Translation: AAI45984.1.
    CCDSiCCDS51838.1.
    RefSeqiNP_033886.2. NM_009756.2.
    UniGeneiMm.483321.

    Genome annotation databases

    EnsembliENSMUST00000032125; ENSMUSP00000032125; ENSMUSG00000030046.
    GeneIDi12154.
    KEGGimmu:12154.
    UCSCiuc012eol.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF101033 mRNA. Translation: AAC95357.1 .
    AF101440 , AF101439 Genomic DNA. Translation: AAC77461.1 .
    BC145983 mRNA. Translation: AAI45984.1 .
    CCDSi CCDS51838.1.
    RefSeqi NP_033886.2. NM_009756.2.
    UniGenei Mm.483321.

    3D structure databases

    ProteinModelPortali Q9R229.
    SMRi Q9R229. Positions 317-421.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9R229. 1 interaction.
    MINTi MINT-4089291.

    PTM databases

    PhosphoSitei Q9R229.

    Proteomic databases

    PaxDbi Q9R229.
    PRIDEi Q9R229.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032125 ; ENSMUSP00000032125 ; ENSMUSG00000030046 .
    GeneIDi 12154.
    KEGGi mmu:12154.
    UCSCi uc012eol.1. mouse.

    Organism-specific databases

    CTDi 27302.
    MGIi MGI:1338820. Bmp10.

    Phylogenomic databases

    eggNOGi NOG280573.
    GeneTreei ENSGT00740000115456.
    HOGENOMi HOG000249477.
    HOVERGENi HBG106648.
    InParanoidi Q9R229.
    KOi K05503.
    OMAi NVSIPHH.
    OrthoDBi EOG7ZD1V3.
    PhylomeDBi Q9R229.
    TreeFami TF316134.

    Enzyme and pathway databases

    Reactomei REACT_198998. Molecules associated with elastic fibres.

    Miscellaneous databases

    NextBioi 280491.
    PROi Q9R229.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9R229.
    CleanExi MM_BMP10.
    Genevestigatori Q9R229.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR00669. INHIBINA.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily."
      Neuhaus H., Rosen V., Thies R.S.
      Mech. Dev. 80:181-184(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: NIH Swiss.
      Tissue: Heart.
    2. "Mouse bone morphogenetic protein 10 (BMP-10) genomic sequence, full coding region of exon 2."
      Celeste A.J.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Nkx2-5 pathways and congenital heart disease: loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block."
      Pashmforoush M., Lu J.T., Chen H., Amand T.S., Kondo R., Pradervand S., Evans S.M., Clark B., Feramisco J.R., Giles W., Ho S.Y., Benson D.W., Silberbach M., Shou W., Chien K.R.
      Cell 117:373-386(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    5. Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    6. "Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth."
      Chen H., Yong W., Ren S., Shen W., He Y., Cox K.A., Zhu W., Li W., Soonpaa M., Payne R.M., Franco D., Field L.J., Rosen V., Wang Y., Shou W.
      J. Biol. Chem. 281:27481-27491(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiBMP10_MOUSE
    AccessioniPrimary (citable) accession number: Q9R229
    Secondary accession number(s): A6H6S5, Q9Z1V8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3