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Protein

Protein BEX1

Gene

Bex1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX1
Alternative name(s):
Brain-expressed X-linked protein 1 homolog
Reduced expression protein 3
Short name:
REX-3
Gene namesi
Name:Bex1
Synonyms:Rex3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1328321. Bex1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297741 – 128Protein BEX1Add BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50Omega-N-methylarginineBy similarity1
Modified residuei105PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation of Ser-105 protects it from the proteasome (By similarity).By similarity
Ubiquitinated. Degraded by the proteasome (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9R224.
PaxDbiQ9R224.
PeptideAtlasiQ9R224.
PRIDEiQ9R224.

PTM databases

iPTMnetiQ9R224.
PhosphoSitePlusiQ9R224.

Expressioni

Tissue specificityi

Primarily localized to neuronal cells within several regions of the brain, including the olfactory epithelium, bulb, peri/paraventricular nuclei, suprachiasmatic nucleus, arcuate nucleus, median eminence, lateral hypothalamic area, thalamus, hippocampus and cerebellum (at protein level). Expressed in brain, mid term embryos and to a lesser extent in ovary. In testis, it is expressed in the pachytene spermatocytes and spermatids but not in spermatogonia.4 Publications

Inductioni

Down-regulated following RA treatment. Up-regulated in parthenogenetic embryos.1 Publication

Gene expression databases

BgeeiENSMUSG00000050071.
CleanExiMM_BEX1.
GenevisibleiQ9R224. MM.

Interactioni

Subunit structurei

Interacts with neurotrophin receptor p75NTR/NGFR (By similarity). Interacts with OMP.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
OmpQ642883EBI-6991413,EBI-6991436

Protein-protein interaction databases

BioGridi202868. 1 interactor.
IntActiQ9R224. 1 interactor.
MINTiMINT-272048.
STRINGi10090.ENSMUSP00000060005.

Family & Domainsi

Sequence similaritiesi

Belongs to the BEX family.Curated

Phylogenomic databases

eggNOGiENOG410JBJY. Eukaryota.
ENOG4111DNW. LUCA.
GeneTreeiENSGT00810000125540.
HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ9R224.
OMAiEAGKNCA.
OrthoDBiEOG091G0ZN3.
PhylomeDBiQ9R224.
TreeFamiTF337909.

Family and domain databases

InterProiView protein in InterPro
IPR007623. BEX.
IPR021156. TF_A-like/BEX.
PfamiView protein in Pfam
PF04538. BEX. 1 hit.
PIRSFiPIRSF008633. BEX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9R224-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKDQGVKN LNMENDHQKK EEKEEKPQDT IRREPAVALT SEAGKNCAPR
60 70 80 90 100
GGRRRFRVRQ PIAHYRWDLM QRVGEPQGRM REENVQRFGG DVRQLMEKLR
110 120
ERQLSHSLRA VSTDPPHHDH HDEFCLMP
Length:128
Mass (Da):15,119
Last modified:April 4, 2006 - v2
Checksum:i6C8897FFA9C987C9
GO

Sequence cautioni

The sequence AAC61929 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40T → I in AAC61929 (PubMed:10072429).Curated1
Sequence conflicti40T → I in AAD24429 (PubMed:9806360).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097437 Genomic DNA. Translation: AAD47168.1.
AF097438 mRNA. Translation: AAD24429.1.
AF051347 mRNA. Translation: AAC61929.1. Different initiation.
AL671493 Genomic DNA. Translation: CAM45858.1.
CH466616 Genomic DNA. Translation: EDL23851.1.
BC061179 mRNA. Translation: AAH61179.1.
BC089464 mRNA. Translation: AAH89464.1.
CCDSiCCDS30417.1.
RefSeqiNP_033078.2. NM_009052.2.
UniGeneiMm.422943.

Genome annotation databases

EnsembliENSMUST00000058125; ENSMUSP00000060005; ENSMUSG00000050071.
ENSMUST00000113118; ENSMUSP00000108743; ENSMUSG00000050071.
ENSMUST00000113120; ENSMUSP00000108745; ENSMUSG00000050071.
GeneIDi19716.
KEGGimmu:19716.
UCSCiuc009uig.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiBEX1_MOUSE
AccessioniPrimary (citable) accession number: Q9R224
Secondary accession number(s): A3KGA2, O88858, Q9R1J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: September 27, 2017
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families