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Protein

Protein BEX1

Gene

Bex1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX1
Alternative name(s):
Brain-expressed X-linked protein 1 homolog
Reduced expression protein 3
Short name:
REX-3
Gene namesi
Name:Bex1
Synonyms:Rex3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1328321. Bex1.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

  • Note: Shuttles between the cytoplasm and the nucleus.

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128Protein BEX1PRO_0000229774Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated. Phosphorylation of Ser-105 protects it from the proteasome (By similarity).By similarity
Ubiquitinated. Degraded by the proteasome (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9R224.
MaxQBiQ9R224.
PaxDbiQ9R224.
PRIDEiQ9R224.

PTM databases

iPTMnetiQ9R224.
PhosphoSiteiQ9R224.

Expressioni

Tissue specificityi

Primarily localized to neuronal cells within several regions of the brain, including the olfactory epithelium, bulb, peri/paraventricular nuclei, suprachiasmatic nucleus, arcuate nucleus, median eminence, lateral hypothalamic area, thalamus, hippocampus and cerebellum (at protein level). Expressed in brain, mid term embryos and to a lesser extent in ovary. In testis, it is expressed in the pachytene spermatocytes and spermatids but not in spermatogonia.4 Publications

Inductioni

Down-regulated following RA treatment. Up-regulated in parthenogenetic embryos.1 Publication

Gene expression databases

BgeeiQ9R224.
CleanExiMM_BEX1.
GenevisibleiQ9R224. MM.

Interactioni

Subunit structurei

Interacts with neurotrophin receptor p75NTR/NGFR (By similarity). Interacts with OMP.By similarity3 Publications

Protein-protein interaction databases

BioGridi202868. 1 interaction.
MINTiMINT-272048.
STRINGi10090.ENSMUSP00000060005.

Family & Domainsi

Sequence similaritiesi

Belongs to the BEX family.Curated

Phylogenomic databases

eggNOGiENOG410JBJY. Eukaryota.
ENOG4111DNW. LUCA.
GeneTreeiENSGT00810000125540.
HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ9R224.
OMAiEAGKNCA.
OrthoDBiEOG7ZSHWF.
PhylomeDBiQ9R224.
TreeFamiTF337909.

Family and domain databases

InterProiIPR007623. BEX.
IPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
PIRSFiPIRSF008633. BEX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9R224-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKDQGVKN LNMENDHQKK EEKEEKPQDT IRREPAVALT SEAGKNCAPR
60 70 80 90 100
GGRRRFRVRQ PIAHYRWDLM QRVGEPQGRM REENVQRFGG DVRQLMEKLR
110 120
ERQLSHSLRA VSTDPPHHDH HDEFCLMP
Length:128
Mass (Da):15,119
Last modified:April 4, 2006 - v2
Checksum:i6C8897FFA9C987C9
GO

Sequence cautioni

The sequence AAC61929.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401T → I in AAC61929 (PubMed:10072429).Curated
Sequence conflicti40 – 401T → I in AAD24429 (PubMed:9806360).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097437 Genomic DNA. Translation: AAD47168.1.
AF097438 mRNA. Translation: AAD24429.1.
AF051347 mRNA. Translation: AAC61929.1. Different initiation.
AL671493 Genomic DNA. Translation: CAM45858.1.
CH466616 Genomic DNA. Translation: EDL23851.1.
BC061179 mRNA. Translation: AAH61179.1.
BC089464 mRNA. Translation: AAH89464.1.
CCDSiCCDS30417.1.
RefSeqiNP_033078.2. NM_009052.2.
UniGeneiMm.422943.

Genome annotation databases

EnsembliENSMUST00000058125; ENSMUSP00000060005; ENSMUSG00000050071.
ENSMUST00000113118; ENSMUSP00000108743; ENSMUSG00000050071.
ENSMUST00000113120; ENSMUSP00000108745; ENSMUSG00000050071.
GeneIDi19716.
KEGGimmu:19716.
UCSCiuc009uig.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097437 Genomic DNA. Translation: AAD47168.1.
AF097438 mRNA. Translation: AAD24429.1.
AF051347 mRNA. Translation: AAC61929.1. Different initiation.
AL671493 Genomic DNA. Translation: CAM45858.1.
CH466616 Genomic DNA. Translation: EDL23851.1.
BC061179 mRNA. Translation: AAH61179.1.
BC089464 mRNA. Translation: AAH89464.1.
CCDSiCCDS30417.1.
RefSeqiNP_033078.2. NM_009052.2.
UniGeneiMm.422943.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202868. 1 interaction.
MINTiMINT-272048.
STRINGi10090.ENSMUSP00000060005.

PTM databases

iPTMnetiQ9R224.
PhosphoSiteiQ9R224.

Proteomic databases

EPDiQ9R224.
MaxQBiQ9R224.
PaxDbiQ9R224.
PRIDEiQ9R224.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058125; ENSMUSP00000060005; ENSMUSG00000050071.
ENSMUST00000113118; ENSMUSP00000108743; ENSMUSG00000050071.
ENSMUST00000113120; ENSMUSP00000108745; ENSMUSG00000050071.
GeneIDi19716.
KEGGimmu:19716.
UCSCiuc009uig.1. mouse.

Organism-specific databases

CTDi55859.
MGIiMGI:1328321. Bex1.

Phylogenomic databases

eggNOGiENOG410JBJY. Eukaryota.
ENOG4111DNW. LUCA.
GeneTreeiENSGT00810000125540.
HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ9R224.
OMAiEAGKNCA.
OrthoDBiEOG7ZSHWF.
PhylomeDBiQ9R224.
TreeFamiTF337909.

Miscellaneous databases

ChiTaRSiBex1. mouse.
NextBioi297112.
PROiQ9R224.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R224.
CleanExiMM_BEX1.
GenevisibleiQ9R224. MM.

Family and domain databases

InterProiIPR007623. BEX.
IPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
PIRSFiPIRSF008633. BEX. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bex1, a gene with increased expression in parthenogenetic embryos, is a member of a novel gene family on the mouse X chromosome."
    Brown A.L., Kay G.F.
    Hum. Mol. Genet. 8:611-619(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Tissue: Blastocyst.
  2. Erratum
    Brown A.L., Kay G.F.
    Hum. Mol. Genet. 8:943-943(1999)
  3. "Characterization of genes which exhibit reduced expression during the retinoic acid-induced differentiation of F9 teratocarcinoma cells: involvement of cyclin D3 in RA-mediated growth arrest."
    Faria T.N., LaRosa G.J., Wilen E., Liao J., Gudas L.J.
    Mol. Cell. Endocrinol. 143:155-166(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Cloning and expression pattern of a spermatogenesis-related gene, BEX1, mapped to chromosome Xq22."
    Yang Q.-S., Xia F., Gu S.-H., Yuan H.-L., Chen J.-Z., Yang Q.-S., Ying K., Xie Y., Mao Y.-M.
    Biochem. Genet. 40:1-12(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction."
    Baldisseri D.M., Margolis J.W., Weber D.J., Koo J.H., Margolis F.L.
    J. Mol. Biol. 319:823-837(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH OMP.
  9. "Identification of members of the Bex gene family as olfactory marker protein (OMP) binding partners."
    Behrens M., Margolis J.W., Margolis F.L.
    J. Neurochem. 86:1289-1296(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH OMP.
  10. "The interaction of Bex and OMP reveals a dimer of OMP with a short half-life."
    Koo J.H., Gill S., Pannell L.K., Menco B.P.M., Margolis J.W., Margolis F.L.
    J. Neurochem. 90:102-116(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH OMP.
  11. "Immunolocalization of Bex protein in the mouse brain and olfactory system."
    Koo J.H., Saraswati M., Margolis F.L.
    J. Comp. Neurol. 487:1-14(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiBEX1_MOUSE
AccessioniPrimary (citable) accession number: Q9R224
Secondary accession number(s): A3KGA2, O88858, Q9R1J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: May 11, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.