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Q9R216

- FZD9_MOUSE

UniProt

Q9R216 - FZD9_MOUSE

Protein

Frizzled-9

Gene

Fzd9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. PDZ domain binding Source: RefGenome
    3. Wnt-activated receptor activity Source: RefGenome
    4. Wnt-protein binding Source: RefGenome

    GO - Biological processi

    1. B cell differentiation Source: MGI
    2. brain development Source: RefGenome
    3. canonical Wnt signaling pathway Source: RefGenome
    4. gonad development Source: RefGenome
    5. learning or memory Source: MGI
    6. neuroblast proliferation Source: MGI
    7. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    8. vasculature development Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Wnt signaling pathway

    Protein family/group databases

    MEROPSiI93.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Frizzled-9
    Short name:
    Fz-9
    Short name:
    mFz3
    Short name:
    mFz9
    Alternative name(s):
    CD_antigen: CD349
    Gene namesi
    Name:Fzd9
    Synonyms:Fzd3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1313278. Fzd9.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. filopodium membrane Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. perinuclear region of cytoplasm Source: MGI
    5. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 592569Frizzled-9PRO_0000013004Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi40 ↔ 101PROSITE-ProRule annotation
    Disulfide bondi48 ↔ 94PROSITE-ProRule annotation
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi85 ↔ 123PROSITE-ProRule annotation
    Disulfide bondi112 ↔ 153PROSITE-ProRule annotation
    Disulfide bondi116 ↔ 140PROSITE-ProRule annotation
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ9R216.

    PTM databases

    PhosphoSiteiQ9R216.

    Expressioni

    Tissue specificityi

    In the embryo, found in the neural tube, trunk skeletal muscle precursors (myotomes), limb skeletal anlagen, craniofacial regions and nephric ducts. In the adult, expression is abundant in heart, brain, testis and skeletal muscle. In the testis, expressed in all spermatogenic cell types. Lower levels in adult lung, liver and kidney. Barely detectable in spleen. Expressed also in chondrocytes.

    Developmental stagei

    Not detected at embryonic day 7 (E7), weakly at E11 and strongly at E15 and E17. Expression covers the entire neural tube at 9.5 dpc, decreases at 10.5 dpc and becomes detectable only in the lumbar to tail regions at 11.5 dpc. In the somites, expression begins at 10.5 dpc to become up-regulated all along the rostrocaudal trunk axis at 11.5 dpc. In craniofacial territories, expression is first detected at 11.5 dpc in restricted areas of the nose, the maxillar mandibular and second branchial arch anlagen. At 11.5 dpc, predominantly expressed in restricted areas of the nose, dorsally to the eye and in the caudal pharyngeal region.1 Publication

    Gene expression databases

    BgeeiQ9R216.
    CleanExiMM_FZD3.
    MM_FZD9.
    GenevestigatoriQ9R216.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000053551.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R216.
    SMRiQ9R216. Positions 40-156, 198-429.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 230207ExtracellularAdd
    BLAST
    Topological domaini252 – 26716CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini289 – 31628ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini338 – 35619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini378 – 40124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini423 – 44826CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini470 – 50940ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini531 – 59262CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei231 – 25121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei317 – 33721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei357 – 37721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei402 – 42221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei449 – 46921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei510 – 53021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 156122FZPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi533 – 5386Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity

    Domaini

    Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
    The FZ domain is involved in binding with Wnt ligands.By similarity

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257258.
    GeneTreeiENSGT00750000117488.
    HOGENOMiHOG000233236.
    HOVERGENiHBG006977.
    InParanoidiQ9R216.
    KOiK02842.
    OMAiNALCMEA.
    OrthoDBiEOG7M3J01.
    PhylomeDBiQ9R216.
    TreeFamiTF317907.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR017981. GPCR_2-like.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9R216-1 [UniParc]FASTAAdd to Basket

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    MAVPPLLRGA LLLWQLLATG GAALEIGRFD PERGRGPAPC QAMEIPMCRG    50
    IGYNLTRMPN LLGHTSQGEA AAQLAEFSPL VQYGCHSHLR FFLCSLYAPM 100
    CTDQVSTPIP ACRPMCEQAR LRCAPIMEQF NFGWPDSLDC ARLPTRNDPH 150
    ALCMEAPENA TAGPTEPHKG LGMLPVAPRP ARPPGDSAPG PGSGGTCDNP 200
    EKFQYVEKSR SCAPRCGPGV EVFWSRRDKD FALVWMAVWS ALCFFSTAFT 250
    VFTFLLEPHR FQYPERPIIF LSMCYNVYSL AFLIRAVAGA QSVACDQEAG 300
    ALYVIQEGLE NTGCTLVFLL LYYFGMASSL WWVVLTLTWF LAAGKKWGHE 350
    AIEAHGSYFH MAAWGLPALK TIVVLTLRKV AGDELTGLCY VASMDPAALT 400
    GFVLVPLSCY LVLGTSFLLT GFVALFHIRK IMKTGGTNTE KLEKLMVKIG 450
    VFSILYTVPA TCVIVCYVYE RLNMDFWRLR ATEQPCTAAT VPGGRRDCSL 500
    PGGSVPTVAV FMLKIFMSLV VGITSGVWVW SSKTFQTWQS LCYRKMAAGR 550
    ARAKACRTPG GYGRGTHCHY KAPTVVLHMT KTDPSLENPT HL 592
    Length:592
    Mass (Da):64,995
    Last modified:May 1, 2000 - v1
    Checksum:i21B2D4F8CE232965
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661S → P in AAB87503. 1 PublicationCurated
    Sequence conflicti73 – 742QL → HC in BAB32311. (PubMed:16141072)Curated
    Sequence conflicti93 – 931L → F in BAB32311. (PubMed:16141072)Curated
    Sequence conflicti144 – 1441P → S in CAB44237. 1 PublicationCurated
    Sequence conflicti221 – 2211E → K in CAB44237. 1 PublicationCurated
    Sequence conflicti237 – 2371A → P in CAB44237. 1 PublicationCurated
    Sequence conflicti308 – 3081G → D in AAB87503. 1 PublicationCurated
    Sequence conflicti374 – 3741V → F in CAB44237. 1 PublicationCurated
    Sequence conflicti592 – 5921L → P in BAB32311. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF088850 Genomic DNA. Translation: AAD27789.1.
    AK021164 mRNA. Translation: BAB32311.1.
    AF033585 mRNA. Translation: AAB87503.2.
    Y17709 mRNA. Translation: CAB44237.1.
    CCDSiCCDS51661.1.
    RefSeqiNP_034376.1. NM_010246.1.
    UniGeneiMm.6256.

    Genome annotation databases

    EnsembliENSMUST00000062572; ENSMUSP00000053551; ENSMUSG00000049551.
    GeneIDi14371.
    KEGGimmu:14371.
    UCSCiuc008zya.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF088850 Genomic DNA. Translation: AAD27789.1 .
    AK021164 mRNA. Translation: BAB32311.1 .
    AF033585 mRNA. Translation: AAB87503.2 .
    Y17709 mRNA. Translation: CAB44237.1 .
    CCDSi CCDS51661.1.
    RefSeqi NP_034376.1. NM_010246.1.
    UniGenei Mm.6256.

    3D structure databases

    ProteinModelPortali Q9R216.
    SMRi Q9R216. Positions 40-156, 198-429.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000053551.

    Protein family/group databases

    MEROPSi I93.001.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9R216.

    Proteomic databases

    PRIDEi Q9R216.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000062572 ; ENSMUSP00000053551 ; ENSMUSG00000049551 .
    GeneIDi 14371.
    KEGGi mmu:14371.
    UCSCi uc008zya.2. mouse.

    Organism-specific databases

    CTDi 8326.
    MGIi MGI:1313278. Fzd9.

    Phylogenomic databases

    eggNOGi NOG257258.
    GeneTreei ENSGT00750000117488.
    HOGENOMi HOG000233236.
    HOVERGENi HBG006977.
    InParanoidi Q9R216.
    KOi K02842.
    OMAi NALCMEA.
    OrthoDBi EOG7M3J01.
    PhylomeDBi Q9R216.
    TreeFami TF317907.

    Miscellaneous databases

    NextBioi 285857.
    PROi Q9R216.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9R216.
    CleanExi MM_FZD3.
    MM_FZD9.
    Genevestigatori Q9R216.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR017981. GPCR_2-like.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome."
      Wang Y.-K., Spoerle R., Paperna T., Schughart K., Francke U.
      Genomics 57:235-248(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE.
      Strain: 129/SvJ.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryonic head.
    3. "A novel mouse frizzled gene expressed in early neural development."
      Van Raay T.J., Rasmussen J.T., Rao M.S.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 44-592.
    4. "Localization of the mouse frizzled gene mFZD3 in the olfactory epithelium and in the vomeronasal organ."
      Calo L., Mimmack M.L., Keverne E.B., Emson P.C.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 144-592.
      Strain: BALB/c.

    Entry informationi

    Entry nameiFZD9_MOUSE
    AccessioniPrimary (citable) accession number: Q9R216
    Secondary accession number(s): O35494, Q9CX16, Q9R2B3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Has been first described as FZD3 in literature.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3