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Protein

Vinexin

Gene

Sorbs3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes up-regulation of actin stress fiber formation.

GO - Molecular functioni

  • transcription factor binding Source: MGI
  • vinculin binding Source: MGI

GO - Biological processi

  • actin filament organization Source: InterPro
  • cell-substrate adhesion Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of MAPK cascade Source: MGI
  • positive regulation of stress fiber assembly Source: MGI

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-445355 Smooth Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Vinexin
Alternative name(s):
SH3 domain-containing protein SH3P3
SH3-containing adapter molecule 1
Short name:
SCAM-1
Sorbin and SH3 domain-containing protein 3
Gene namesi
Name:Sorbs3
Synonyms:Scam1, Sh3d4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:700013 Sorbs3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000658311 – 733VinexinAdd BLAST733

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei412PhosphoserineCombined sources1
Modified residuei459PhosphoserineCombined sources1
Modified residuei594Phosphoserine; by MAPK11 Publication1
Modified residuei607PhosphoserineBy similarity1
Modified residuei610PhosphoserineBy similarity1
Modified residuei624PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated at Ser-594 by MAPK1/ERK2 during cell spreading.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9R1Z8
PaxDbiQ9R1Z8
PRIDEiQ9R1Z8

PTM databases

iPTMnetiQ9R1Z8
PhosphoSitePlusiQ9R1Z8

Expressioni

Gene expression databases

BgeeiENSMUSG00000022091
CleanExiMM_SORBS3
GenevisibleiQ9R1Z8 MM

Interactioni

Subunit structurei

Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC), through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with SAFB2, INPPL1/SHIP2 and SRCIN1 (By similarity). Interacts with DLG5 through its third SH3 domain. Interacts with SOCS7 and MAPK1/ERK2. Interacts with FASLG (By similarity).By similarity

GO - Molecular functioni

  • transcription factor binding Source: MGI
  • vinculin binding Source: MGI

Protein-protein interaction databases

BioGridi203212, 4 interactors
ELMiQ9R1Z8
IntActiQ9R1Z8, 5 interactors
MINTiQ9R1Z8
STRINGi10090.ENSMUSP00000022682

Structurei

3D structure databases

ProteinModelPortaliQ9R1Z8
SMRiQ9R1Z8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini164 – 232SoHoPROSITE-ProRule annotationAdd BLAST69
Domaini444 – 503SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini518 – 579SH3 2PROSITE-ProRule annotationAdd BLAST62
Domaini674 – 733SH3 3PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni444 – 579Binds to vinculinAdd BLAST136
Regioni674 – 733Binds to SOSBy similarityAdd BLAST60

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410KCZS Eukaryota
ENOG410XP8Q LUCA
GeneTreeiENSGT00760000119190
HOGENOMiHOG000294090
HOVERGENiHBG054842
InParanoidiQ9R1Z8
OMAiNTLNFQF
OrthoDBiEOG091G039F
PhylomeDBiQ9R1Z8
TreeFamiTF320680

Family and domain databases

CDDicd11921 SH3_Vinexin_1, 1 hit
cd11924 SH3_Vinexin_2, 1 hit
cd11918 SH3_Vinexin_3, 1 hit
InterProiView protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR003127 SoHo_dom
IPR028510 Vinexin
IPR035609 Vinexin_SH3_1
IPR035608 Vinexin_SH3_2
IPR035607 Vinexin_SH3_3
PANTHERiPTHR44972 PTHR44972, 1 hit
PfamiView protein in Pfam
PF00018 SH3_1, 1 hit
PF14604 SH3_9, 2 hits
PF02208 Sorb, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00326 SH3, 3 hits
SM00459 Sorb, 1 hit
SUPFAMiSSF50044 SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50002 SH3, 3 hits
PS50831 SOHO, 1 hit

Sequencei

Sequence statusi: Complete.

Q9R1Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARILGVGRS SASSLNNKED NESDVALLSP KDPNRVHTKE QLAHPASSNL
60 70 80 90 100
DPSMQGLPAG LSLDDFIPGH LRTHIGSSSR GTRVPVIRNG GSNTLNFQFH
110 120 130 140 150
DPAPRTVCNG CPPPRRDGSL NPDPAWYQTW PGPGSRPSMS PKPPASQHAQ
160 170 180 190 200
NWSATWTKDS KRQDKRWVKY EGIGPVDESG MPIAPRSSVD SPRDWYRRMF
210 220 230 240 250
QQIHRKMPDL QLDWTLEDPP KVVSARASSA EPRHLGTLQR PASRPGTTET
260 270 280 290 300
SSGRNWNHSE ETSRNTFNYN FRPSSSGLHP PNQVPRHREK VENVWTEDSW
310 320 330 340 350
NQFLHELETG HKPKKPLVDD PVEKPAQPIE VLLERELAKL SAELDKDLRA
360 370 380 390 400
IETRLPSPKN SQAPRRPLEQ PGLEQQPSAR LSSAWRPNSP HAPYFSSSRP
410 420 430 440 450
LSPHRMADGG GSPFLGRRDF VYPSSAREPS ASERGSSPSR KEEKKRKAAR
460 470 480 490 500
LKFDFQAQSP KELSLQKGDI VYIHKEVDKN WLEGEHHGRL GIFPANYVEV
510 520 530 540 550
LPADEIPKPI KPPTYQVLEY GDAVAQYTFK GDLEVELSFR KGERICLIRK
560 570 580 590 600
VNEHWYEGRI TGTGRQGIFP ASYVQINREP RLRLCDDGPQ LPASPNPTTT
610 620 630 640 650
AHLSSHSHPS SIPVDPTDWG GRTSPRRSAF PFPITLQEPR SQTQSLNTPG
660 670 680 690 700
PTLSHPRATS RPINLGPSSP NTEIHWTPYR AMYQYRPQNE DELELREGDR
710 720 730
VDVMQQCDDG WFVGVSRRTQ KFGTFPGNYV APV
Length:733
Mass (Da):82,349
Last modified:May 1, 2000 - v1
Checksum:iD7716FA1D4F0E3CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064806 mRNA Translation: AAD32303.1
U58889 mRNA Translation: AAC52642.1
CCDSiCCDS27249.1
RefSeqiNP_035496.1, NM_011366.3
UniGeneiMm.5068

Genome annotation databases

EnsembliENSMUST00000022682; ENSMUSP00000022682; ENSMUSG00000022091
GeneIDi20410
KEGGimmu:20410
UCSCiuc007unk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiVINEX_MOUSE
AccessioniPrimary (citable) accession number: Q9R1Z8
Secondary accession number(s): Q62423
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health