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Q9R1X5

- MRP5_MOUSE

UniProt

Q9R1X5 - MRP5_MOUSE

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Protein
Multidrug resistance-associated protein 5
Gene
Abcc5, Abcc5a, Mrp5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a multispecific organic anion pump which can transport nucleotide analogs By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi595 – 6028ATP 1 Reviewed prediction
Nucleotide bindingi1226 – 12338ATP 2 Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196552. Hyaluronan biosynthesis and export.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 5
Alternative name(s):
ATP-binding cassette sub-family C member 5
Multi-specific organic anion transporter C
Short name:
MOAT-C
SMRP
Gene namesi
Name:Abcc5
Synonyms:Abcc5a, Mrp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1351644. Abcc5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei179 – 19921Helical; Reviewed prediction
Add
BLAST
Transmembranei219 – 23921Helical; Reviewed prediction
Add
BLAST
Transmembranei296 – 31621Helical; Reviewed prediction
Add
BLAST
Transmembranei317 – 33721Helical; Reviewed prediction
Add
BLAST
Transmembranei400 – 42021Helical; Reviewed prediction
Add
BLAST
Transmembranei426 – 44621Helical; Reviewed prediction
Add
BLAST
Transmembranei608 – 62821Helical; Reviewed prediction
Add
BLAST
Transmembranei847 – 86721Helical; Reviewed prediction
Add
BLAST
Transmembranei916 – 93621Helical; Reviewed prediction
Add
BLAST
Transmembranei996 – 101621Helical; Reviewed prediction
Add
BLAST
Transmembranei1017 – 103721Helical; Reviewed prediction
Add
BLAST
Transmembranei1101 – 112121Helical; Reviewed prediction
Add
BLAST
Transmembranei1126 – 114621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14361436Multidrug resistance-associated protein 5
PRO_0000093364Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431Phosphoserine1 Publication
Glycosylationi494 – 4941N-linked (GlcNAc...) Reviewed prediction
Modified residuei509 – 5091Phosphoserine By similarity
Modified residuei513 – 5131Phosphothreonine By similarity
Glycosylationi636 – 6361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi684 – 6841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi889 – 8891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi896 – 8961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1043 – 10431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1328 – 13281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1416 – 14161N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9R1X5.
PRIDEiQ9R1X5.

PTM databases

PhosphoSiteiQ9R1X5.

Expressioni

Gene expression databases

ArrayExpressiQ9R1X5.
BgeeiQ9R1X5.
GenevestigatoriQ9R1X5.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078158.

Structurei

3D structure databases

ProteinModelPortaliQ9R1X5.
SMRiQ9R1X5. Positions 520-1432.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini179 – 459281ABC transmembrane type-1 1
Add
BLAST
Domaini562 – 783222ABC transporter 1
Add
BLAST
Domaini858 – 1154297ABC transmembrane type-1 2
Add
BLAST
Domaini1192 – 1426235ABC transporter 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00750000117379.
HOVERGENiHBG108314.
InParanoidiQ5CZY2.
KOiK05668.
OMAiMNAERYY.
OrthoDBiEOG7MWGW0.
TreeFamiTF105202.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1X5-1 [UniParc]FASTAAdd to Basket

« Hide

MKDIDMGKEY IIPSPGYRSD RDRSAVPGQH RDPEEPRFRR TRSLECQDAL     50
ETAARVEGLS LDISVHSHLQ ILDEEHSKGK YHHGLSVLKP FRTTTKHQHP 100
VDNAGLFSYM TFSWLSPLAR VVHKKGELLM EDVWPLSKYE SSDVNSRRLE 150
RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPAFV 200
VKHLLEYTQA TESNLQYSLL LVLGLLLTEV VRSWSLALTW ALNYRTGVRL 250
RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG 300
PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFVSRLT AYFRRKCVAA 350
TDDRVQKMNE VLTYIKFIKM YAWVKAFSQC VQKIREEERR ILEKAGYFQS 400
ITVGVAPIVV VIASVVTFSV HMTLGFHLTA AQAFTVVTVF NSMTFALKVT 450
PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK NKPASPHIKI EMKNATLAWD 500
SSHSSIQNSP KLTPKMKKDK RATRGKKEKS RQLQHTEHQA VLAEQKGHLL 550
LDSDERPSPE EEEGKQIHTG SLRLQRTLYN IDLEIEEGKL VGICGSVGSG 600
KTSLVSAILG QMTLLEGSIA VSGTFAYVAQ QAWILNATLR DNILFGKEFD 650
EERYNSVLNS CCLRPDLAIL PNSDLTEIGE RGANLSGGQR QRISLARALY 700
SDRSIYILDD PLSALDAHVG NHIFNSAIRK RLKSKTVLFV THQLQYLVDC 750
DEVIFMKEGC ITERGTHEEL MNLNGDYATI FNNLLLGETP PVEINSKKEA 800
TGSQKSQDKG PKPGSVKKEK AVKSEEGQLV QVEEKGQGSV PWSVYWVYIQ 850
AAGGPLAFLV IMVLFMLNVG STAFSTWWLS YWIKQGSGNS TVYQGNRSFV 900
SDSMKDNPFM QYYASIYALS MAVMLILKAI RGVVFVKGTL RASSRLHDEL 950
FRRILRSPMK FFDTTPTGRI LNRFSKDMDE VDVRLPFQAE MFIQNVILVF 1000
FCVGMIAGVF PWFLVAVGPL LILFSLLHIV SRVLIRELKR LDNITQSPFL 1050
SHITSSIQGL ATIHAYNKRQ EFLHRYQELL DDNQAPFFLF TCAMRWLAVR 1100
LDLISIALIT TTGLMIVLMH GQIPSAYAGL AISYAVQLTG LFQFTVRLAS 1150
ETEARFTSVE RINHYIKTLS LEAPARIKNK APPHDWPQEG EVTFENAEMR 1200
YRENLPLVLK KVSFTIKPKE KIGIVGRTGS GKSSLGMALF RLVELSGGCI 1250
KIDGIRISDI GLADLRSKLA IIPQEPVLFS GTVRSNLDPF NQYTEDQIWD 1300
ALERTHMKEC IAQLPLKLES EVMENGDNFS VGERQLLCIA RALLRHCKIL 1350
ILDEATAAMD TETDLLIQET IREAFADCTM LTIAHRLHTV LGSDRIMVLA 1400
QGQVVEFDTP SVLLSNDSSR FYAMFAAAEN KVAVKG 1436
Length:1,436
Mass (Da):161,125
Last modified:June 28, 2011 - v2
Checksum:i6B40BA516D8BE87D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1461S → C in BAA76609. 1 Publication
Sequence conflicti200 – 2001V → M in BAA76609. 1 Publication
Sequence conflicti217 – 2171Y → C in BAA76609. 1 Publication
Sequence conflicti230 – 2301V → I in BAA76609. 1 Publication
Sequence conflicti347 – 3471C → R in BAA76609. 1 Publication
Sequence conflicti1098 – 10981A → P in BAA76609. 1 Publication
Sequence conflicti1103 – 11031L → I in BAA76609. 1 Publication
Sequence conflicti1111 – 11111T → S in BAA76609. 1 Publication
Sequence conflicti1118 – 11247LMHGQIP → SGMARSL in BAA76609. 1 Publication
Sequence conflicti1139 – 11391T → I in BAA76609. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB019003 mRNA. Translation: BAA76609.1.
AB012090 mRNA. Translation: BAA32782.1.
CH466521 Genomic DNA. Translation: EDK97565.1.
BC090629 mRNA. Translation: AAH90629.1.
CCDSiCCDS28045.1.
RefSeqiNP_038818.2. NM_013790.2.
XP_006522271.1. XM_006522208.1.
UniGeneiMm.20845.

Genome annotation databases

EnsembliENSMUST00000079158; ENSMUSP00000078158; ENSMUSG00000022822.
ENSMUST00000115547; ENSMUSP00000111209; ENSMUSG00000022822.
GeneIDi27416.
KEGGimmu:27416.
UCSCiuc007ypp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB019003 mRNA. Translation: BAA76609.1 .
AB012090 mRNA. Translation: BAA32782.1 .
CH466521 Genomic DNA. Translation: EDK97565.1 .
BC090629 mRNA. Translation: AAH90629.1 .
CCDSi CCDS28045.1.
RefSeqi NP_038818.2. NM_013790.2.
XP_006522271.1. XM_006522208.1.
UniGenei Mm.20845.

3D structure databases

ProteinModelPortali Q9R1X5.
SMRi Q9R1X5. Positions 520-1432.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000078158.

PTM databases

PhosphoSitei Q9R1X5.

Proteomic databases

PaxDbi Q9R1X5.
PRIDEi Q9R1X5.

Protocols and materials databases

DNASUi 27416.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000079158 ; ENSMUSP00000078158 ; ENSMUSG00000022822 .
ENSMUST00000115547 ; ENSMUSP00000111209 ; ENSMUSG00000022822 .
GeneIDi 27416.
KEGGi mmu:27416.
UCSCi uc007ypp.1. mouse.

Organism-specific databases

CTDi 10057.
MGIi MGI:1351644. Abcc5.

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00750000117379.
HOVERGENi HBG108314.
InParanoidi Q5CZY2.
KOi K05668.
OMAi MNAERYY.
OrthoDBi EOG7MWGW0.
TreeFami TF105202.

Enzyme and pathway databases

Reactomei REACT_196552. Hyaluronan biosynthesis and export.

Miscellaneous databases

ChiTaRSi ABCC5. mouse.
NextBioi 305450.
PROi Q9R1X5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9R1X5.
Bgeei Q9R1X5.
Genevestigatori Q9R1X5.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts."
    Suzuki T., Sasaki H., Kuh H.J., Agui M., Tatsumi Y., Tanabe S., Terada M., Saijo N., Nishio K.
    Gene 242:167-173(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 261-266, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  5. "Moleculer cloning of mouse homologue of SMRP/MRP5."
    Suzuki T., Kuh H., Nishio K.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1302-1436.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMRP5_MOUSE
AccessioniPrimary (citable) accession number: Q9R1X5
Secondary accession number(s): O88284, Q5CZY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi