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Q9R1X5 (MRP5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multidrug resistance-associated protein 5
Alternative name(s):
ATP-binding cassette sub-family C member 5
Multi-specific organic anion transporter C
Short name=MOAT-C
SMRP
Gene names
Name:Abcc5
Synonyms:Abcc5a, Mrp5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1436 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a multispecific organic anion pump which can transport nucleotide analogs By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14361436Multidrug resistance-associated protein 5
PRO_0000093364

Regions

Transmembrane179 – 19921Helical; Potential
Transmembrane219 – 23921Helical; Potential
Transmembrane296 – 31621Helical; Potential
Transmembrane317 – 33721Helical; Potential
Transmembrane400 – 42021Helical; Potential
Transmembrane426 – 44621Helical; Potential
Transmembrane608 – 62821Helical; Potential
Transmembrane847 – 86721Helical; Potential
Transmembrane916 – 93621Helical; Potential
Transmembrane996 – 101621Helical; Potential
Transmembrane1017 – 103721Helical; Potential
Transmembrane1101 – 112121Helical; Potential
Transmembrane1126 – 114621Helical; Potential
Domain179 – 459281ABC transmembrane type-1 1
Domain562 – 783222ABC transporter 1
Domain858 – 1154297ABC transmembrane type-1 2
Domain1192 – 1426235ABC transporter 2
Nucleotide binding595 – 6028ATP 1 Potential
Nucleotide binding1226 – 12338ATP 2 Potential

Amino acid modifications

Modified residue431Phosphoserine Ref.6
Modified residue5091Phosphoserine By similarity
Modified residue5131Phosphothreonine By similarity
Glycosylation4941N-linked (GlcNAc...) Potential
Glycosylation6361N-linked (GlcNAc...) Potential
Glycosylation6841N-linked (GlcNAc...) Potential
Glycosylation8891N-linked (GlcNAc...) Potential
Glycosylation8961N-linked (GlcNAc...) Potential
Glycosylation10431N-linked (GlcNAc...) Potential
Glycosylation13281N-linked (GlcNAc...) Potential
Glycosylation14161N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1461S → C in BAA76609. Ref.1
Sequence conflict2001V → M in BAA76609. Ref.1
Sequence conflict2171Y → C in BAA76609. Ref.1
Sequence conflict2301V → I in BAA76609. Ref.1
Sequence conflict3471C → R in BAA76609. Ref.1
Sequence conflict10981A → P in BAA76609. Ref.1
Sequence conflict11031L → I in BAA76609. Ref.1
Sequence conflict11111T → S in BAA76609. Ref.1
Sequence conflict1118 – 11247LMHGQIP → SGMARSL in BAA76609. Ref.1
Sequence conflict11391T → I in BAA76609. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9R1X5 [UniParc].

Last modified June 28, 2011. Version 2.
Checksum: 6B40BA516D8BE87D

FASTA1,436161,125
        10         20         30         40         50         60 
MKDIDMGKEY IIPSPGYRSD RDRSAVPGQH RDPEEPRFRR TRSLECQDAL ETAARVEGLS 

        70         80         90        100        110        120 
LDISVHSHLQ ILDEEHSKGK YHHGLSVLKP FRTTTKHQHP VDNAGLFSYM TFSWLSPLAR 

       130        140        150        160        170        180 
VVHKKGELLM EDVWPLSKYE SSDVNSRRLE RLWQEELNEV GPDAASLRRV VWIFCRTRLI 

       190        200        210        220        230        240 
LSIVCLMITQ LAGFSGPAFV VKHLLEYTQA TESNLQYSLL LVLGLLLTEV VRSWSLALTW 

       250        260        270        280        290        300 
ALNYRTGVRL RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG 

       310        320        330        340        350        360 
PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFVSRLT AYFRRKCVAA TDDRVQKMNE 

       370        380        390        400        410        420 
VLTYIKFIKM YAWVKAFSQC VQKIREEERR ILEKAGYFQS ITVGVAPIVV VIASVVTFSV 

       430        440        450        460        470        480 
HMTLGFHLTA AQAFTVVTVF NSMTFALKVT PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK 

       490        500        510        520        530        540 
NKPASPHIKI EMKNATLAWD SSHSSIQNSP KLTPKMKKDK RATRGKKEKS RQLQHTEHQA 

       550        560        570        580        590        600 
VLAEQKGHLL LDSDERPSPE EEEGKQIHTG SLRLQRTLYN IDLEIEEGKL VGICGSVGSG 

       610        620        630        640        650        660 
KTSLVSAILG QMTLLEGSIA VSGTFAYVAQ QAWILNATLR DNILFGKEFD EERYNSVLNS 

       670        680        690        700        710        720 
CCLRPDLAIL PNSDLTEIGE RGANLSGGQR QRISLARALY SDRSIYILDD PLSALDAHVG 

       730        740        750        760        770        780 
NHIFNSAIRK RLKSKTVLFV THQLQYLVDC DEVIFMKEGC ITERGTHEEL MNLNGDYATI 

       790        800        810        820        830        840 
FNNLLLGETP PVEINSKKEA TGSQKSQDKG PKPGSVKKEK AVKSEEGQLV QVEEKGQGSV 

       850        860        870        880        890        900 
PWSVYWVYIQ AAGGPLAFLV IMVLFMLNVG STAFSTWWLS YWIKQGSGNS TVYQGNRSFV 

       910        920        930        940        950        960 
SDSMKDNPFM QYYASIYALS MAVMLILKAI RGVVFVKGTL RASSRLHDEL FRRILRSPMK 

       970        980        990       1000       1010       1020 
FFDTTPTGRI LNRFSKDMDE VDVRLPFQAE MFIQNVILVF FCVGMIAGVF PWFLVAVGPL 

      1030       1040       1050       1060       1070       1080 
LILFSLLHIV SRVLIRELKR LDNITQSPFL SHITSSIQGL ATIHAYNKRQ EFLHRYQELL 

      1090       1100       1110       1120       1130       1140 
DDNQAPFFLF TCAMRWLAVR LDLISIALIT TTGLMIVLMH GQIPSAYAGL AISYAVQLTG 

      1150       1160       1170       1180       1190       1200 
LFQFTVRLAS ETEARFTSVE RINHYIKTLS LEAPARIKNK APPHDWPQEG EVTFENAEMR 

      1210       1220       1230       1240       1250       1260 
YRENLPLVLK KVSFTIKPKE KIGIVGRTGS GKSSLGMALF RLVELSGGCI KIDGIRISDI 

      1270       1280       1290       1300       1310       1320 
GLADLRSKLA IIPQEPVLFS GTVRSNLDPF NQYTEDQIWD ALERTHMKEC IAQLPLKLES 

      1330       1340       1350       1360       1370       1380 
EVMENGDNFS VGERQLLCIA RALLRHCKIL ILDEATAAMD TETDLLIQET IREAFADCTM 

      1390       1400       1410       1420       1430 
LTIAHRLHTV LGSDRIMVLA QGQVVEFDTP SVLLSNDSSR FYAMFAAAEN KVAVKG 

« Hide

References

« Hide 'large scale' references
[1]"Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts."
Suzuki T., Sasaki H., Kuh H.J., Agui M., Tatsumi Y., Tanabe S., Terada M., Saijo N., Nishio K.
Gene 242:167-173(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[4]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 261-266, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
[5]"Moleculer cloning of mouse homologue of SMRP/MRP5."
Suzuki T., Kuh H., Nishio K.
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1302-1436.
[6]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB019003 mRNA. Translation: BAA76609.1.
AB012090 mRNA. Translation: BAA32782.1.
CH466521 Genomic DNA. Translation: EDK97565.1.
BC090629 mRNA. Translation: AAH90629.1.
RefSeqNP_038818.2. NM_013790.2.
XP_006522271.1. XM_006522208.1.
UniGeneMm.20845.

3D structure databases

ProteinModelPortalQ9R1X5.
SMRQ9R1X5. Positions 520-1431.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000078158.

PTM databases

PhosphoSiteQ9R1X5.

Proteomic databases

PaxDbQ9R1X5.
PRIDEQ9R1X5.

Protocols and materials databases

DNASU27416.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000079158; ENSMUSP00000078158; ENSMUSG00000022822.
ENSMUST00000115547; ENSMUSP00000111209; ENSMUSG00000022822.
GeneID27416.
KEGGmmu:27416.
UCSCuc007ypp.1. mouse.

Organism-specific databases

CTD10057.
MGIMGI:1351644. Abcc5.

Phylogenomic databases

eggNOGCOG1132.
GeneTreeENSGT00750000117379.
HOVERGENHBG108314.
InParanoidQ5CZY2.
KOK05668.
OMALFSVLHI.
OrthoDBEOG7MWGW0.
TreeFamTF105202.

Gene expression databases

ArrayExpressQ9R1X5.
BgeeQ9R1X5.
GenevestigatorQ9R1X5.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSABCC5. mouse.
NextBio305450.
PROQ9R1X5.
SOURCESearch...

Entry information

Entry nameMRP5_MOUSE
AccessionPrimary (citable) accession number: Q9R1X5
Secondary accession number(s): O88284, Q5CZY2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot