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Q9R1X5

- MRP5_MOUSE

UniProt

Q9R1X5 - MRP5_MOUSE

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Protein

Multidrug resistance-associated protein 5

Gene

Abcc5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a multispecific organic anion pump which can transport nucleotide analogs.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi595 – 6028ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1226 – 12338ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196552. Hyaluronan biosynthesis and export.
REACT_237882. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 5
Alternative name(s):
ATP-binding cassette sub-family C member 5
Multi-specific organic anion transporter C
Short name:
MOAT-C
SMRP
Gene namesi
Name:Abcc5
Synonyms:Abcc5a, Mrp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1351644. Abcc5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei179 – 19921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei219 – 23921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei296 – 31621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei317 – 33721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei400 – 42021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei426 – 44621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei608 – 62821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei847 – 86721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei916 – 93621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei996 – 101621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei1017 – 103721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei1101 – 112121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei1126 – 114621HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14361436Multidrug resistance-associated protein 5PRO_0000093364Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431Phosphoserine1 Publication
Glycosylationi494 – 4941N-linked (GlcNAc...)Sequence Analysis
Modified residuei509 – 5091PhosphoserineBy similarity
Modified residuei513 – 5131PhosphothreonineBy similarity
Glycosylationi636 – 6361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi684 – 6841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi889 – 8891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi896 – 8961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1043 – 10431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1328 – 13281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1416 – 14161N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9R1X5.
PaxDbiQ9R1X5.
PRIDEiQ9R1X5.

PTM databases

PhosphoSiteiQ9R1X5.

Expressioni

Gene expression databases

BgeeiQ9R1X5.
ExpressionAtlasiQ9R1X5. baseline and differential.
GenevestigatoriQ9R1X5.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078158.

Structurei

3D structure databases

ProteinModelPortaliQ9R1X5.
SMRiQ9R1X5. Positions 520-842, 909-1427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini179 – 459281ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini562 – 783222ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini858 – 1154297ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1192 – 1426235ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00770000120514.
HOVERGENiHBG108314.
InParanoidiQ9R1X5.
KOiK05668.
OMAiMNAERYY.
OrthoDBiEOG7MWGW0.
TreeFamiTF105202.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1X5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDIDMGKEY IIPSPGYRSD RDRSAVPGQH RDPEEPRFRR TRSLECQDAL
60 70 80 90 100
ETAARVEGLS LDISVHSHLQ ILDEEHSKGK YHHGLSVLKP FRTTTKHQHP
110 120 130 140 150
VDNAGLFSYM TFSWLSPLAR VVHKKGELLM EDVWPLSKYE SSDVNSRRLE
160 170 180 190 200
RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPAFV
210 220 230 240 250
VKHLLEYTQA TESNLQYSLL LVLGLLLTEV VRSWSLALTW ALNYRTGVRL
260 270 280 290 300
RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG
310 320 330 340 350
PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFVSRLT AYFRRKCVAA
360 370 380 390 400
TDDRVQKMNE VLTYIKFIKM YAWVKAFSQC VQKIREEERR ILEKAGYFQS
410 420 430 440 450
ITVGVAPIVV VIASVVTFSV HMTLGFHLTA AQAFTVVTVF NSMTFALKVT
460 470 480 490 500
PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK NKPASPHIKI EMKNATLAWD
510 520 530 540 550
SSHSSIQNSP KLTPKMKKDK RATRGKKEKS RQLQHTEHQA VLAEQKGHLL
560 570 580 590 600
LDSDERPSPE EEEGKQIHTG SLRLQRTLYN IDLEIEEGKL VGICGSVGSG
610 620 630 640 650
KTSLVSAILG QMTLLEGSIA VSGTFAYVAQ QAWILNATLR DNILFGKEFD
660 670 680 690 700
EERYNSVLNS CCLRPDLAIL PNSDLTEIGE RGANLSGGQR QRISLARALY
710 720 730 740 750
SDRSIYILDD PLSALDAHVG NHIFNSAIRK RLKSKTVLFV THQLQYLVDC
760 770 780 790 800
DEVIFMKEGC ITERGTHEEL MNLNGDYATI FNNLLLGETP PVEINSKKEA
810 820 830 840 850
TGSQKSQDKG PKPGSVKKEK AVKSEEGQLV QVEEKGQGSV PWSVYWVYIQ
860 870 880 890 900
AAGGPLAFLV IMVLFMLNVG STAFSTWWLS YWIKQGSGNS TVYQGNRSFV
910 920 930 940 950
SDSMKDNPFM QYYASIYALS MAVMLILKAI RGVVFVKGTL RASSRLHDEL
960 970 980 990 1000
FRRILRSPMK FFDTTPTGRI LNRFSKDMDE VDVRLPFQAE MFIQNVILVF
1010 1020 1030 1040 1050
FCVGMIAGVF PWFLVAVGPL LILFSLLHIV SRVLIRELKR LDNITQSPFL
1060 1070 1080 1090 1100
SHITSSIQGL ATIHAYNKRQ EFLHRYQELL DDNQAPFFLF TCAMRWLAVR
1110 1120 1130 1140 1150
LDLISIALIT TTGLMIVLMH GQIPSAYAGL AISYAVQLTG LFQFTVRLAS
1160 1170 1180 1190 1200
ETEARFTSVE RINHYIKTLS LEAPARIKNK APPHDWPQEG EVTFENAEMR
1210 1220 1230 1240 1250
YRENLPLVLK KVSFTIKPKE KIGIVGRTGS GKSSLGMALF RLVELSGGCI
1260 1270 1280 1290 1300
KIDGIRISDI GLADLRSKLA IIPQEPVLFS GTVRSNLDPF NQYTEDQIWD
1310 1320 1330 1340 1350
ALERTHMKEC IAQLPLKLES EVMENGDNFS VGERQLLCIA RALLRHCKIL
1360 1370 1380 1390 1400
ILDEATAAMD TETDLLIQET IREAFADCTM LTIAHRLHTV LGSDRIMVLA
1410 1420 1430
QGQVVEFDTP SVLLSNDSSR FYAMFAAAEN KVAVKG
Length:1,436
Mass (Da):161,125
Last modified:June 28, 2011 - v2
Checksum:i6B40BA516D8BE87D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1461S → C in BAA76609. (PubMed:10721709)Curated
Sequence conflicti200 – 2001V → M in BAA76609. (PubMed:10721709)Curated
Sequence conflicti217 – 2171Y → C in BAA76609. (PubMed:10721709)Curated
Sequence conflicti230 – 2301V → I in BAA76609. (PubMed:10721709)Curated
Sequence conflicti347 – 3471C → R in BAA76609. (PubMed:10721709)Curated
Sequence conflicti1098 – 10981A → P in BAA76609. (PubMed:10721709)Curated
Sequence conflicti1103 – 11031L → I in BAA76609. (PubMed:10721709)Curated
Sequence conflicti1111 – 11111T → S in BAA76609. (PubMed:10721709)Curated
Sequence conflicti1118 – 11247LMHGQIP → SGMARSL in BAA76609. (PubMed:10721709)Curated
Sequence conflicti1139 – 11391T → I in BAA76609. (PubMed:10721709)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019003 mRNA. Translation: BAA76609.1.
AB012090 mRNA. Translation: BAA32782.1.
CH466521 Genomic DNA. Translation: EDK97565.1.
BC090629 mRNA. Translation: AAH90629.1.
CCDSiCCDS28045.1.
RefSeqiNP_038818.2. NM_013790.2.
XP_006522271.1. XM_006522208.1.
UniGeneiMm.20845.

Genome annotation databases

EnsembliENSMUST00000079158; ENSMUSP00000078158; ENSMUSG00000022822.
ENSMUST00000115547; ENSMUSP00000111209; ENSMUSG00000022822.
GeneIDi27416.
KEGGimmu:27416.
UCSCiuc007ypp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019003 mRNA. Translation: BAA76609.1 .
AB012090 mRNA. Translation: BAA32782.1 .
CH466521 Genomic DNA. Translation: EDK97565.1 .
BC090629 mRNA. Translation: AAH90629.1 .
CCDSi CCDS28045.1.
RefSeqi NP_038818.2. NM_013790.2.
XP_006522271.1. XM_006522208.1.
UniGenei Mm.20845.

3D structure databases

ProteinModelPortali Q9R1X5.
SMRi Q9R1X5. Positions 520-842, 909-1427.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000078158.

PTM databases

PhosphoSitei Q9R1X5.

Proteomic databases

MaxQBi Q9R1X5.
PaxDbi Q9R1X5.
PRIDEi Q9R1X5.

Protocols and materials databases

DNASUi 27416.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000079158 ; ENSMUSP00000078158 ; ENSMUSG00000022822 .
ENSMUST00000115547 ; ENSMUSP00000111209 ; ENSMUSG00000022822 .
GeneIDi 27416.
KEGGi mmu:27416.
UCSCi uc007ypp.1. mouse.

Organism-specific databases

CTDi 10057.
MGIi MGI:1351644. Abcc5.

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00770000120514.
HOVERGENi HBG108314.
InParanoidi Q9R1X5.
KOi K05668.
OMAi MNAERYY.
OrthoDBi EOG7MWGW0.
TreeFami TF105202.

Enzyme and pathway databases

Reactomei REACT_196552. Hyaluronan biosynthesis and export.
REACT_237882. ABC-family proteins mediated transport.

Miscellaneous databases

ChiTaRSi Abcc5. mouse.
NextBioi 305450.
PROi Q9R1X5.
SOURCEi Search...

Gene expression databases

Bgeei Q9R1X5.
ExpressionAtlasi Q9R1X5. baseline and differential.
Genevestigatori Q9R1X5.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts."
    Suzuki T., Sasaki H., Kuh H.J., Agui M., Tatsumi Y., Tanabe S., Terada M., Saijo N., Nishio K.
    Gene 242:167-173(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 261-266, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  5. "Moleculer cloning of mouse homologue of SMRP/MRP5."
    Suzuki T., Kuh H., Nishio K.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1302-1436.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMRP5_MOUSE
AccessioniPrimary (citable) accession number: Q9R1X5
Secondary accession number(s): O88284, Q5CZY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 28, 2011
Last modified: November 26, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3