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Protein

Multidrug resistance-associated protein 5

Gene

Abcc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a multispecific organic anion pump which can transport nucleotide analogs.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi595 – 602ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1226 – 1233ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2142850. Hyaluronan biosynthesis and export.
R-MMU-382556. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 5
Alternative name(s):
ATP-binding cassette sub-family C member 5
Multi-specific organic anion transporter C
Short name:
MOAT-C
SMRP
Gene namesi
Name:Abcc5
Synonyms:Abcc5a, Mrp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1351644. Abcc5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei179 – 199HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei219 – 239HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei296 – 316HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei317 – 337HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei400 – 420HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei426 – 446HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei608 – 628HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei847 – 867HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei916 – 936HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei996 – 1016HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1017 – 1037HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1101 – 1121HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1126 – 1146HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933641 – 1436Multidrug resistance-associated protein 5Add BLAST1436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Modified residuei43PhosphoserineCombined sources1
Modified residuei60PhosphoserineBy similarity1
Glycosylationi494N-linked (GlcNAc...)Sequence analysis1
Modified residuei505PhosphoserineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei513PhosphothreonineCombined sources1
Glycosylationi636N-linked (GlcNAc...)Sequence analysis1
Glycosylationi684N-linked (GlcNAc...)Sequence analysis1
Glycosylationi889N-linked (GlcNAc...)Sequence analysis1
Glycosylationi896N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1043N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1328N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1416N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9R1X5.
PaxDbiQ9R1X5.
PeptideAtlasiQ9R1X5.
PRIDEiQ9R1X5.

PTM databases

iPTMnetiQ9R1X5.
PhosphoSitePlusiQ9R1X5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022822.
ExpressionAtlasiQ9R1X5. baseline and differential.
GenevisibleiQ9R1X5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078158.

Structurei

3D structure databases

ProteinModelPortaliQ9R1X5.
SMRiQ9R1X5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini179 – 459ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST281
Domaini562 – 783ABC transporter 1PROSITE-ProRule annotationAdd BLAST222
Domaini858 – 1154ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST297
Domaini1192 – 1426ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133722.
HOVERGENiHBG108314.
InParanoidiQ9R1X5.
KOiK05668.
OMAiKHIHLGS.
OrthoDBiEOG091G01TC.
TreeFamiTF105202.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030238. ABCC5.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF196. PTHR24223:SF196. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDIDMGKEY IIPSPGYRSD RDRSAVPGQH RDPEEPRFRR TRSLECQDAL
60 70 80 90 100
ETAARVEGLS LDISVHSHLQ ILDEEHSKGK YHHGLSVLKP FRTTTKHQHP
110 120 130 140 150
VDNAGLFSYM TFSWLSPLAR VVHKKGELLM EDVWPLSKYE SSDVNSRRLE
160 170 180 190 200
RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPAFV
210 220 230 240 250
VKHLLEYTQA TESNLQYSLL LVLGLLLTEV VRSWSLALTW ALNYRTGVRL
260 270 280 290 300
RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG
310 320 330 340 350
PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFVSRLT AYFRRKCVAA
360 370 380 390 400
TDDRVQKMNE VLTYIKFIKM YAWVKAFSQC VQKIREEERR ILEKAGYFQS
410 420 430 440 450
ITVGVAPIVV VIASVVTFSV HMTLGFHLTA AQAFTVVTVF NSMTFALKVT
460 470 480 490 500
PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK NKPASPHIKI EMKNATLAWD
510 520 530 540 550
SSHSSIQNSP KLTPKMKKDK RATRGKKEKS RQLQHTEHQA VLAEQKGHLL
560 570 580 590 600
LDSDERPSPE EEEGKQIHTG SLRLQRTLYN IDLEIEEGKL VGICGSVGSG
610 620 630 640 650
KTSLVSAILG QMTLLEGSIA VSGTFAYVAQ QAWILNATLR DNILFGKEFD
660 670 680 690 700
EERYNSVLNS CCLRPDLAIL PNSDLTEIGE RGANLSGGQR QRISLARALY
710 720 730 740 750
SDRSIYILDD PLSALDAHVG NHIFNSAIRK RLKSKTVLFV THQLQYLVDC
760 770 780 790 800
DEVIFMKEGC ITERGTHEEL MNLNGDYATI FNNLLLGETP PVEINSKKEA
810 820 830 840 850
TGSQKSQDKG PKPGSVKKEK AVKSEEGQLV QVEEKGQGSV PWSVYWVYIQ
860 870 880 890 900
AAGGPLAFLV IMVLFMLNVG STAFSTWWLS YWIKQGSGNS TVYQGNRSFV
910 920 930 940 950
SDSMKDNPFM QYYASIYALS MAVMLILKAI RGVVFVKGTL RASSRLHDEL
960 970 980 990 1000
FRRILRSPMK FFDTTPTGRI LNRFSKDMDE VDVRLPFQAE MFIQNVILVF
1010 1020 1030 1040 1050
FCVGMIAGVF PWFLVAVGPL LILFSLLHIV SRVLIRELKR LDNITQSPFL
1060 1070 1080 1090 1100
SHITSSIQGL ATIHAYNKRQ EFLHRYQELL DDNQAPFFLF TCAMRWLAVR
1110 1120 1130 1140 1150
LDLISIALIT TTGLMIVLMH GQIPSAYAGL AISYAVQLTG LFQFTVRLAS
1160 1170 1180 1190 1200
ETEARFTSVE RINHYIKTLS LEAPARIKNK APPHDWPQEG EVTFENAEMR
1210 1220 1230 1240 1250
YRENLPLVLK KVSFTIKPKE KIGIVGRTGS GKSSLGMALF RLVELSGGCI
1260 1270 1280 1290 1300
KIDGIRISDI GLADLRSKLA IIPQEPVLFS GTVRSNLDPF NQYTEDQIWD
1310 1320 1330 1340 1350
ALERTHMKEC IAQLPLKLES EVMENGDNFS VGERQLLCIA RALLRHCKIL
1360 1370 1380 1390 1400
ILDEATAAMD TETDLLIQET IREAFADCTM LTIAHRLHTV LGSDRIMVLA
1410 1420 1430
QGQVVEFDTP SVLLSNDSSR FYAMFAAAEN KVAVKG
Length:1,436
Mass (Da):161,125
Last modified:June 28, 2011 - v2
Checksum:i6B40BA516D8BE87D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146S → C in BAA76609 (PubMed:10721709).Curated1
Sequence conflicti200V → M in BAA76609 (PubMed:10721709).Curated1
Sequence conflicti217Y → C in BAA76609 (PubMed:10721709).Curated1
Sequence conflicti230V → I in BAA76609 (PubMed:10721709).Curated1
Sequence conflicti347C → R in BAA76609 (PubMed:10721709).Curated1
Sequence conflicti1098A → P in BAA76609 (PubMed:10721709).Curated1
Sequence conflicti1103L → I in BAA76609 (PubMed:10721709).Curated1
Sequence conflicti1111T → S in BAA76609 (PubMed:10721709).Curated1
Sequence conflicti1118 – 1124LMHGQIP → SGMARSL in BAA76609 (PubMed:10721709).Curated7
Sequence conflicti1139T → I in BAA76609 (PubMed:10721709).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019003 mRNA. Translation: BAA76609.1.
AB012090 mRNA. Translation: BAA32782.1.
CH466521 Genomic DNA. Translation: EDK97565.1.
BC090629 mRNA. Translation: AAH90629.1.
CCDSiCCDS28045.1.
RefSeqiNP_038818.2. NM_013790.2.
XP_006522271.1. XM_006522208.3.
UniGeneiMm.20845.

Genome annotation databases

EnsembliENSMUST00000079158; ENSMUSP00000078158; ENSMUSG00000022822.
ENSMUST00000115547; ENSMUSP00000111209; ENSMUSG00000022822.
GeneIDi27416.
KEGGimmu:27416.
UCSCiuc007ypp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019003 mRNA. Translation: BAA76609.1.
AB012090 mRNA. Translation: BAA32782.1.
CH466521 Genomic DNA. Translation: EDK97565.1.
BC090629 mRNA. Translation: AAH90629.1.
CCDSiCCDS28045.1.
RefSeqiNP_038818.2. NM_013790.2.
XP_006522271.1. XM_006522208.3.
UniGeneiMm.20845.

3D structure databases

ProteinModelPortaliQ9R1X5.
SMRiQ9R1X5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078158.

PTM databases

iPTMnetiQ9R1X5.
PhosphoSitePlusiQ9R1X5.

Proteomic databases

MaxQBiQ9R1X5.
PaxDbiQ9R1X5.
PeptideAtlasiQ9R1X5.
PRIDEiQ9R1X5.

Protocols and materials databases

DNASUi27416.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079158; ENSMUSP00000078158; ENSMUSG00000022822.
ENSMUST00000115547; ENSMUSP00000111209; ENSMUSG00000022822.
GeneIDi27416.
KEGGimmu:27416.
UCSCiuc007ypp.1. mouse.

Organism-specific databases

CTDi10057.
MGIiMGI:1351644. Abcc5.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133722.
HOVERGENiHBG108314.
InParanoidiQ9R1X5.
KOiK05668.
OMAiKHIHLGS.
OrthoDBiEOG091G01TC.
TreeFamiTF105202.

Enzyme and pathway databases

ReactomeiR-MMU-2142850. Hyaluronan biosynthesis and export.
R-MMU-382556. ABC-family proteins mediated transport.

Miscellaneous databases

ChiTaRSiAbcc5. mouse.
PROiQ9R1X5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022822.
ExpressionAtlasiQ9R1X5. baseline and differential.
GenevisibleiQ9R1X5. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030238. ABCC5.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF196. PTHR24223:SF196. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRP5_MOUSE
AccessioniPrimary (citable) accession number: Q9R1X5
Secondary accession number(s): O88284, Q5CZY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 28, 2011
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.