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Q9R1X5

- MRP5_MOUSE

UniProt

Q9R1X5 - MRP5_MOUSE

Protein

Multidrug resistance-associated protein 5

Gene

Abcc5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Acts as a multispecific organic anion pump which can transport nucleotide analogs.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi595 – 6028ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1226 – 12338ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196552. Hyaluronan biosynthesis and export.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug resistance-associated protein 5
    Alternative name(s):
    ATP-binding cassette sub-family C member 5
    Multi-specific organic anion transporter C
    Short name:
    MOAT-C
    SMRP
    Gene namesi
    Name:Abcc5
    Synonyms:Abcc5a, Mrp5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1351644. Abcc5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14361436Multidrug resistance-associated protein 5PRO_0000093364Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei43 – 431Phosphoserine1 Publication
    Glycosylationi494 – 4941N-linked (GlcNAc...)Sequence Analysis
    Modified residuei509 – 5091PhosphoserineBy similarity
    Modified residuei513 – 5131PhosphothreonineBy similarity
    Glycosylationi636 – 6361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi684 – 6841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi889 – 8891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi896 – 8961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1043 – 10431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1328 – 13281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1416 – 14161N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9R1X5.
    PRIDEiQ9R1X5.

    PTM databases

    PhosphoSiteiQ9R1X5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9R1X5.
    BgeeiQ9R1X5.
    GenevestigatoriQ9R1X5.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000078158.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R1X5.
    SMRiQ9R1X5. Positions 520-1432.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei179 – 19921HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei219 – 23921HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei296 – 31621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei317 – 33721HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei400 – 42021HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei426 – 44621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei608 – 62821HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei847 – 86721HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei916 – 93621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei996 – 101621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1017 – 103721HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1101 – 112121HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1126 – 114621HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini179 – 459281ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini562 – 783222ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini858 – 1154297ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1192 – 1426235ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    GeneTreeiENSGT00750000117379.
    HOVERGENiHBG108314.
    InParanoidiQ5CZY2.
    KOiK05668.
    OMAiMNAERYY.
    OrthoDBiEOG7MWGW0.
    TreeFamiTF105202.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEiPS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9R1X5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDIDMGKEY IIPSPGYRSD RDRSAVPGQH RDPEEPRFRR TRSLECQDAL     50
    ETAARVEGLS LDISVHSHLQ ILDEEHSKGK YHHGLSVLKP FRTTTKHQHP 100
    VDNAGLFSYM TFSWLSPLAR VVHKKGELLM EDVWPLSKYE SSDVNSRRLE 150
    RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPAFV 200
    VKHLLEYTQA TESNLQYSLL LVLGLLLTEV VRSWSLALTW ALNYRTGVRL 250
    RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG 300
    PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFVSRLT AYFRRKCVAA 350
    TDDRVQKMNE VLTYIKFIKM YAWVKAFSQC VQKIREEERR ILEKAGYFQS 400
    ITVGVAPIVV VIASVVTFSV HMTLGFHLTA AQAFTVVTVF NSMTFALKVT 450
    PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK NKPASPHIKI EMKNATLAWD 500
    SSHSSIQNSP KLTPKMKKDK RATRGKKEKS RQLQHTEHQA VLAEQKGHLL 550
    LDSDERPSPE EEEGKQIHTG SLRLQRTLYN IDLEIEEGKL VGICGSVGSG 600
    KTSLVSAILG QMTLLEGSIA VSGTFAYVAQ QAWILNATLR DNILFGKEFD 650
    EERYNSVLNS CCLRPDLAIL PNSDLTEIGE RGANLSGGQR QRISLARALY 700
    SDRSIYILDD PLSALDAHVG NHIFNSAIRK RLKSKTVLFV THQLQYLVDC 750
    DEVIFMKEGC ITERGTHEEL MNLNGDYATI FNNLLLGETP PVEINSKKEA 800
    TGSQKSQDKG PKPGSVKKEK AVKSEEGQLV QVEEKGQGSV PWSVYWVYIQ 850
    AAGGPLAFLV IMVLFMLNVG STAFSTWWLS YWIKQGSGNS TVYQGNRSFV 900
    SDSMKDNPFM QYYASIYALS MAVMLILKAI RGVVFVKGTL RASSRLHDEL 950
    FRRILRSPMK FFDTTPTGRI LNRFSKDMDE VDVRLPFQAE MFIQNVILVF 1000
    FCVGMIAGVF PWFLVAVGPL LILFSLLHIV SRVLIRELKR LDNITQSPFL 1050
    SHITSSIQGL ATIHAYNKRQ EFLHRYQELL DDNQAPFFLF TCAMRWLAVR 1100
    LDLISIALIT TTGLMIVLMH GQIPSAYAGL AISYAVQLTG LFQFTVRLAS 1150
    ETEARFTSVE RINHYIKTLS LEAPARIKNK APPHDWPQEG EVTFENAEMR 1200
    YRENLPLVLK KVSFTIKPKE KIGIVGRTGS GKSSLGMALF RLVELSGGCI 1250
    KIDGIRISDI GLADLRSKLA IIPQEPVLFS GTVRSNLDPF NQYTEDQIWD 1300
    ALERTHMKEC IAQLPLKLES EVMENGDNFS VGERQLLCIA RALLRHCKIL 1350
    ILDEATAAMD TETDLLIQET IREAFADCTM LTIAHRLHTV LGSDRIMVLA 1400
    QGQVVEFDTP SVLLSNDSSR FYAMFAAAEN KVAVKG 1436
    Length:1,436
    Mass (Da):161,125
    Last modified:June 28, 2011 - v2
    Checksum:i6B40BA516D8BE87D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti146 – 1461S → C in BAA76609. (PubMed:10721709)Curated
    Sequence conflicti200 – 2001V → M in BAA76609. (PubMed:10721709)Curated
    Sequence conflicti217 – 2171Y → C in BAA76609. (PubMed:10721709)Curated
    Sequence conflicti230 – 2301V → I in BAA76609. (PubMed:10721709)Curated
    Sequence conflicti347 – 3471C → R in BAA76609. (PubMed:10721709)Curated
    Sequence conflicti1098 – 10981A → P in BAA76609. (PubMed:10721709)Curated
    Sequence conflicti1103 – 11031L → I in BAA76609. (PubMed:10721709)Curated
    Sequence conflicti1111 – 11111T → S in BAA76609. (PubMed:10721709)Curated
    Sequence conflicti1118 – 11247LMHGQIP → SGMARSL in BAA76609. (PubMed:10721709)Curated
    Sequence conflicti1139 – 11391T → I in BAA76609. (PubMed:10721709)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019003 mRNA. Translation: BAA76609.1.
    AB012090 mRNA. Translation: BAA32782.1.
    CH466521 Genomic DNA. Translation: EDK97565.1.
    BC090629 mRNA. Translation: AAH90629.1.
    CCDSiCCDS28045.1.
    RefSeqiNP_038818.2. NM_013790.2.
    XP_006522271.1. XM_006522208.1.
    UniGeneiMm.20845.

    Genome annotation databases

    EnsembliENSMUST00000079158; ENSMUSP00000078158; ENSMUSG00000022822.
    ENSMUST00000115547; ENSMUSP00000111209; ENSMUSG00000022822.
    GeneIDi27416.
    KEGGimmu:27416.
    UCSCiuc007ypp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019003 mRNA. Translation: BAA76609.1 .
    AB012090 mRNA. Translation: BAA32782.1 .
    CH466521 Genomic DNA. Translation: EDK97565.1 .
    BC090629 mRNA. Translation: AAH90629.1 .
    CCDSi CCDS28045.1.
    RefSeqi NP_038818.2. NM_013790.2.
    XP_006522271.1. XM_006522208.1.
    UniGenei Mm.20845.

    3D structure databases

    ProteinModelPortali Q9R1X5.
    SMRi Q9R1X5. Positions 520-1432.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000078158.

    PTM databases

    PhosphoSitei Q9R1X5.

    Proteomic databases

    PaxDbi Q9R1X5.
    PRIDEi Q9R1X5.

    Protocols and materials databases

    DNASUi 27416.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000079158 ; ENSMUSP00000078158 ; ENSMUSG00000022822 .
    ENSMUST00000115547 ; ENSMUSP00000111209 ; ENSMUSG00000022822 .
    GeneIDi 27416.
    KEGGi mmu:27416.
    UCSCi uc007ypp.1. mouse.

    Organism-specific databases

    CTDi 10057.
    MGIi MGI:1351644. Abcc5.

    Phylogenomic databases

    eggNOGi COG1132.
    GeneTreei ENSGT00750000117379.
    HOVERGENi HBG108314.
    InParanoidi Q5CZY2.
    KOi K05668.
    OMAi MNAERYY.
    OrthoDBi EOG7MWGW0.
    TreeFami TF105202.

    Enzyme and pathway databases

    Reactomei REACT_196552. Hyaluronan biosynthesis and export.

    Miscellaneous databases

    ChiTaRSi ABCC5. mouse.
    NextBioi 305450.
    PROi Q9R1X5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9R1X5.
    Bgeei Q9R1X5.
    Genevestigatori Q9R1X5.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEi PS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts."
      Suzuki T., Sasaki H., Kuh H.J., Agui M., Tatsumi Y., Tanabe S., Terada M., Saijo N., Nishio K.
      Gene 242:167-173(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    4. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 261-266, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    5. "Moleculer cloning of mouse homologue of SMRP/MRP5."
      Suzuki T., Kuh H., Nishio K.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1302-1436.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMRP5_MOUSE
    AccessioniPrimary (citable) accession number: Q9R1X5
    Secondary accession number(s): O88284, Q5CZY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3