Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein timeless homolog

Gene

Timeless

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.5 Publications

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: MGI

GO - Biological processi

  • branching involved in ureteric bud morphogenesis Source: MGI
  • branching morphogenesis of an epithelial tube Source: MGI
  • cell cycle phase transition Source: MGI
  • cell division Source: UniProtKB-KW
  • cellular response to DNA damage stimulus Source: UniProtKB
  • circadian rhythm Source: UniProtKB
  • lung development Source: MGI
  • mitotic nuclear division Source: UniProtKB-KW
  • morphogenesis of an epithelium Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of circadian rhythm Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Biological rhythms, Cell cycle, Cell division, DNA damage, Mitosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-5693607. Processing of DNA double-strand break ends.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein timeless homolog
Short name:
mTim
Gene namesi
Name:TimelessImported
Synonyms:Tim1Imported, Timeless11 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1321393. Timeless.

Subcellular locationi

GO - Cellular componenti

  • microtubule cytoskeleton Source: MGI
  • nuclear chromatin Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11971197Protein timeless homologPRO_0000072539Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1165 – 11651PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9R1X4.
MaxQBiQ9R1X4.
PaxDbiQ9R1X4.
PRIDEiQ9R1X4.

PTM databases

iPTMnetiQ9R1X4.
PhosphoSiteiQ9R1X4.

Expressioni

Tissue specificityi

Predominantly and robustly expressed in proliferative organs (spleen, thymus, intestine and testis) compared to those more differentiated such as kidney and liver (at protein level). Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Strongly expressed in the suprachiasmatic nucleus (SCN) and pars tuberalis, moderately in the cingulate cortex, pyrimidal cell layer of the piriform cortex, periventricular part of the caudate putamen, and granular layer of the cerebellum, and weakly in the cerebral cortex, gyrus dentatus, hippocampus and thalamic nuclei. In embryonic kidney, expression is highest in regions of active ureteric bud cell branching.7 Publications

Developmental stagei

Expression is highest in whole embryos at E11 and gradually decreases as embryonic development progresses. At E7.5, expressed in germ cell layers. At E14.5, expressed at highest levels in thymus, liver, gastrointestinal tract, lung and the rapidly proliferating ventricular zone of the brain.4 Publications

Inductioni

In retina, expression exhibits a circadian rhythm in the presence of light/dark cycles. In the suprachiasmatic nucleus (SCN), isoform 1 exhibited 24 hours oscillation, isoform 4 is constitutively expressed. Shows a circadian expression pattern in the intestine with peaks at ZT4 and ZT8.4 Publications

Gene expression databases

BgeeiQ9R1X4.
CleanExiMM_TIMELESS.
ExpressionAtlasiQ9R1X4. baseline and differential.
GenevisibleiQ9R1X4. MM.

Interactioni

Subunit structurei

Homodimer or homomultimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSKN1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with PER1, PER2 and PER3; the interaction with PER2 is via its second PAS domain. Interacts with CRY1, CRY2, CHEK1, ATR and ATRIP. Interacts with CLSPN and TIPIN.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Per1O359733EBI-1793117,EBI-1266764

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi204198. 35 interactions.
IntActiQ9R1X4. 26 interactions.
STRINGi10090.ENSMUSP00000058021.

Structurei

3D structure databases

ProteinModelPortaliQ9R1X4.
SMRiQ9R1X4. Positions 1013-1095.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 309309Required for homodimerization and for interaction with CRY1 and CHEK1Add
BLAST
Regioni1079 – 1197119Required for nuclear localizationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi655 – 68733Glu-richAdd
BLAST
Compositional biasi964 – 1172209Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the timeless family.Curated

Phylogenomic databases

eggNOGiKOG1974. Eukaryota.
ENOG410XQM6. LUCA.
GeneTreeiENSGT00390000015124.
HOVERGENiHBG079258.
InParanoidiQ9R1X4.
KOiK03155.
OMAiRKGTQIV.
OrthoDBiEOG7WDN1T.
PhylomeDBiQ9R1X4.
TreeFamiTF312802.

Family and domain databases

InterProiIPR006906. Timeless.
IPR007725. TIMELESS_C.
[Graphical view]
PfamiPF04821. TIMELESS. 1 hit.
PF05029. TIMELESS_C. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 14 Publications (identifier: Q9R1X4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLYMMNCEL LATCSALGYL EGGTYHKEPD CLESVKDLIR YLRHEDETRD
60 70 80 90 100
VRQQLGAAQI LQSDLLPILT QHRQDKPLFD AVIRLMVNLT QPALLCFGSV
110 120 130 140 150
PKDSSVRHHF LQVLTYLQAY KEAFASEKAF GVLSETLYEL LQLGWEDRQE
160 170 180 190 200
EDNLLIERIL LLVRNILHVP ANLEQEKSID DDASIHDRLL WAIHLSGMDD
210 220 230 240 250
LLLFLSSSSA EQQWSLHVLE IISLMFRDQT PEQLAGVGQG RLAQERSTDV
260 270 280 290 300
AELEVLRQRE MAEKRARALQ RGNRHSRFGG SYIVQGLKSI GEKDVVFHKG
310 320 330 340 350
LHNLQNYSSD LGKQPRRVPK RRQAAQELSV HRRSVLNVRL FLRDFCSEFL
360 370 380 390 400
ENCYNPLMGA VKDHLLRERA QQHDETYYMW AMAFFMAFNR AATFRPGLVS
410 420 430 440 450
ETLSIRTFHF VEQNLTNYYE MMLTDRKEAA SWARRMHLAL KAYQELLATV
460 470 480 490 500
NEMDMCPDEA VRESSRIIKN NIFYMMEYRE LFLALFRKFD ERYHPRSFLR
510 520 530 540 550
DLVETTHLFL KMLERFCRSR GNLMVQNKRK KRKKKKKVQD QGVAFSQSPG
560 570 580 590 600
ELEAMWPALA EQLLQCAQDP ELSVDPVVPF DAASEVPVEE QRVEAMVRIQ
610 620 630 640 650
DCLTAGQAPQ ALALLRSARE VWPEGNAFGS PVISPGEEMQ LLKQILSTPL
660 670 680 690 700
PRQQEPEEGD AEEEEEEEEE EELQVVQVSE KEFNFLEYLK RFASSTIVRA
710 720 730 740 750
YVLLLRSYRQ NSAHTNHCIA KMLHRLAHGL GMEALLFQLS LFCLFNRLLS
760 770 780 790 800
DPAAAAYKEL VTFAKYIIGK FFALAAVNQK AFVELLFWKN TAVVREMTQG
810 820 830 840 850
YGSLDSGSSS HRAPLWSPEE EAQLQELYLA HKDVEGQDVV ETILAHLKVV
860 870 880 890 900
PRTRKQVIHH LVRMGLADSV KEFQKRKGTQ IVLWTEDQEL ELQRLFEEFR
910 920 930 940 950
DSDDVLGQIM KNITAKRSRA RVVDKLLALG LVSERRQLYK KRRKKLAPSC
960 970 980 990 1000
MQNGEKSPRD PWQEDPEEED EHLPEDESED EESEEGLPSG QGQGSSSLSA
1010 1020 1030 1040 1050
ENLGESLRQE GLSAPLLWLQ SSLIRAANDR EEDGCSQAIP LVPLTEENEE
1060 1070 1080 1090 1100
AMENEQFQHL LRKLGIRPPS SGQETFWRIP AKLSSTQLRR VAASLSQQEN
1110 1120 1130 1140 1150
EEEREEEPEP GVPGEQGPSE EHRTEALRAL LSARKRKAGL GPTEEEATGE
1160 1170 1180 1190
EEWNSAPKKR QLLDSDEEED DEGRRQAVSG TPRVHRKKRF QIEDEDD
Length:1,197
Mass (Da):137,503
Last modified:March 15, 2005 - v3
Checksum:iDB24B7F0F3D05787
GO
Isoform 2Curated (identifier: Q9R1X4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     952-952: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,196
Mass (Da):137,375
Checksum:iF96561FD89D5941B
GO
Isoform 3Curated (identifier: Q9R1X4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     952-952: Missing.
     967-1104: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,058
Mass (Da):122,007
Checksum:i1132EA312EEF49AD
GO
Isoform 41 Publication (identifier: Q9R1X4-4) [UniParc]FASTAAdd to basket

Also known as: TIM-s

The sequence of this isoform differs from the canonical sequence as follows:
     1-721: Missing.
     952-952: Missing.

Show »
Length:475
Mass (Da):53,886
Checksum:i56706A9F906EF3B1
GO
Isoform 5Curated (identifier: Q9R1X4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-721: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:476
Mass (Da):54,014
Checksum:i3B6BA2FB91C9ECE0
GO
Isoform 61 Publication (identifier: Q9R1X4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1177-1177: Missing.

Show »
Length:1,196
Mass (Da):137,432
Checksum:iED8B120D87B20E44
GO

Sequence cautioni

The sequence AAH52884.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH64788.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791I → V in AAH64788 (PubMed:15489334).Curated
Sequence conflicti298 – 2981H → R in AAH64788 (PubMed:15489334).Curated
Sequence conflicti317 – 3171R → G in AAH64788 (PubMed:15489334).Curated
Sequence conflicti583 – 5831A → V in BAA76390 (PubMed:10231394).Curated
Sequence conflicti744 – 7441L → H in AAD24467 (PubMed:10963667).Curated
Sequence conflicti846 – 8461H → Y in AAD24467 (PubMed:10963667).Curated
Sequence conflicti956 – 9561K → R in AAD24467 (PubMed:10963667).Curated
Sequence conflicti1068 – 10681P → L in AAD24467 (PubMed:10963667).Curated
Sequence conflicti1190 – 11901F → L in BAA76390 (PubMed:10231394).Curated
Sequence conflicti1196 – 11961D → G in BAA76390 (PubMed:10231394).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 721721Missing in isoform 4 and isoform 5. 2 PublicationsVSP_051694Add
BLAST
Alternative sequencei952 – 9521Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsVSP_051695
Alternative sequencei967 – 1104138Missing in isoform 3. 1 PublicationVSP_051696Add
BLAST
Alternative sequencei1177 – 11771Missing in isoform 6. 1 PublicationVSP_051697

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015598 mRNA. Translation: BAA36500.1.
AF098161 mRNA. Translation: AAC80010.1.
AF071506 mRNA. Translation: AAC79687.1.
AB019001 mRNA. Translation: BAA76390.2.
AF126480 mRNA. Translation: AAD24467.1.
BC026526 mRNA. Translation: AAH26526.1.
BC052884 mRNA. Translation: AAH52884.1. Sequence problems.
BC058641 mRNA. Translation: AAH58641.1.
BC064788 mRNA. Translation: AAH64788.1. Sequence problems.
BC082770 mRNA. Translation: AAH82770.1.
CCDSiCCDS24266.1. [Q9R1X4-1]
CCDS48724.1. [Q9R1X4-6]
CCDS48725.1. [Q9R1X4-2]
PIRiT13956.
RefSeqiNP_001129554.1. NM_001136082.2. [Q9R1X4-2]
NP_001157552.1. NM_001164080.1. [Q9R1X4-6]
NP_001157553.1. NM_001164081.1. [Q9R1X4-1]
NP_035719.1. NM_011589.2. [Q9R1X4-1]
XP_006513646.1. XM_006513583.2. [Q9R1X4-1]
UniGeneiMm.6458.

Genome annotation databases

EnsembliENSMUST00000055539; ENSMUSP00000058021; ENSMUSG00000039994. [Q9R1X4-1]
ENSMUST00000105242; ENSMUSP00000100876; ENSMUSG00000039994. [Q9R1X4-2]
ENSMUST00000105244; ENSMUSP00000100878; ENSMUSG00000039994. [Q9R1X4-6]
ENSMUST00000105245; ENSMUSP00000100879; ENSMUSG00000039994. [Q9R1X4-1]
GeneIDi21853.
KEGGimmu:21853.
UCSCiuc007hlv.2. mouse. [Q9R1X4-1]
uc007hlw.2. mouse. [Q9R1X4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015598 mRNA. Translation: BAA36500.1.
AF098161 mRNA. Translation: AAC80010.1.
AF071506 mRNA. Translation: AAC79687.1.
AB019001 mRNA. Translation: BAA76390.2.
AF126480 mRNA. Translation: AAD24467.1.
BC026526 mRNA. Translation: AAH26526.1.
BC052884 mRNA. Translation: AAH52884.1. Sequence problems.
BC058641 mRNA. Translation: AAH58641.1.
BC064788 mRNA. Translation: AAH64788.1. Sequence problems.
BC082770 mRNA. Translation: AAH82770.1.
CCDSiCCDS24266.1. [Q9R1X4-1]
CCDS48724.1. [Q9R1X4-6]
CCDS48725.1. [Q9R1X4-2]
PIRiT13956.
RefSeqiNP_001129554.1. NM_001136082.2. [Q9R1X4-2]
NP_001157552.1. NM_001164080.1. [Q9R1X4-6]
NP_001157553.1. NM_001164081.1. [Q9R1X4-1]
NP_035719.1. NM_011589.2. [Q9R1X4-1]
XP_006513646.1. XM_006513583.2. [Q9R1X4-1]
UniGeneiMm.6458.

3D structure databases

ProteinModelPortaliQ9R1X4.
SMRiQ9R1X4. Positions 1013-1095.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204198. 35 interactions.
IntActiQ9R1X4. 26 interactions.
STRINGi10090.ENSMUSP00000058021.

PTM databases

iPTMnetiQ9R1X4.
PhosphoSiteiQ9R1X4.

Proteomic databases

EPDiQ9R1X4.
MaxQBiQ9R1X4.
PaxDbiQ9R1X4.
PRIDEiQ9R1X4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055539; ENSMUSP00000058021; ENSMUSG00000039994. [Q9R1X4-1]
ENSMUST00000105242; ENSMUSP00000100876; ENSMUSG00000039994. [Q9R1X4-2]
ENSMUST00000105244; ENSMUSP00000100878; ENSMUSG00000039994. [Q9R1X4-6]
ENSMUST00000105245; ENSMUSP00000100879; ENSMUSG00000039994. [Q9R1X4-1]
GeneIDi21853.
KEGGimmu:21853.
UCSCiuc007hlv.2. mouse. [Q9R1X4-1]
uc007hlw.2. mouse. [Q9R1X4-2]

Organism-specific databases

CTDi8914.
MGIiMGI:1321393. Timeless.

Phylogenomic databases

eggNOGiKOG1974. Eukaryota.
ENOG410XQM6. LUCA.
GeneTreeiENSGT00390000015124.
HOVERGENiHBG079258.
InParanoidiQ9R1X4.
KOiK03155.
OMAiRKGTQIV.
OrthoDBiEOG7WDN1T.
PhylomeDBiQ9R1X4.
TreeFamiTF312802.

Enzyme and pathway databases

ReactomeiR-MMU-5693607. Processing of DNA double-strand break ends.

Miscellaneous databases

NextBioi301334.
PROiQ9R1X4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R1X4.
CleanExiMM_TIMELESS.
ExpressionAtlasiQ9R1X4. baseline and differential.
GenevisibleiQ9R1X4. MM.

Family and domain databases

InterProiIPR006906. Timeless.
IPR007725. TIMELESS_C.
[Graphical view]
PfamiPF04821. TIMELESS. 1 hit.
PF05029. TIMELESS_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1."
    Koike N., Hida A., Numano R., Hirose M., Sakaki Y., Tei H.
    FEBS Lett. 441:427-431(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/cJImported.
    Tissue: Brain1 Publication.
  2. "Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-ARTNL/BMAL1-induced transcription."
    Sangoram A.M., Saez L., Antoch M.P., Gekakis N., Staknis D., Whiteley A., Fruechte E.M., Vitaterna M.H., Shimomura K., King D.P., Young M.W., Weitz C.J., Takahashi J.S.
    Neuron 21:1101-1113(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 6), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, FUNCTION, INTERACTION WITH PER1 AND PER2.
    Tissue: Embryo1 Publication.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Strain: C57BL/6J1 Publication.
    Tissue: Brain1 Publication.
  4. "A mammalian ortholog of Drosophila timeless, highly expressed in SCN and retina, forms a complex with mPER1."
    Takumi T., Nagamine Y., Miyake S., Matsubara C., Taguchi K., Takekida S., Sakakida Y., Nishikawa K., Kishimoto T., Niwa S., Okumura K., Okamura H.
    Genes Cells 4:67-75(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, INTERACTION WITH PER1.
    Strain: BALB/cJ1 Publication.
    Tissue: Brain1 Publication.
  5. "A role for Timeless in epithelial morphogenesis during kidney development."
    Li Z., Stuart R.O., Qiao J., Pavlova A., Bush K.T., Pohl M., Sakurai H., Nigam S.K.
    Proc. Natl. Acad. Sci. U.S.A. 97:10038-10043(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: HeartImported and Kidney1 Publication.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 5).
    Strain: C57BL/6JImported and FVB/NImported.
    Tissue: BrainImported, EggImported, Olfactory epitheliumImported and Salivary glandImported.
  7. "mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop."
    Kume K., Zylka M.J., Sriram S., Shearman L.P., Weaver D.R., Jin X., Maywood E.S., Hastings M.H., Reppert S.M.
    Cell 98:193-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CRY1 AND CRY2, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
  8. "Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association."
    Gotter A.L.
    J. Mol. Biol. 331:167-176(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TIPIN, DEVELOPMENTAL STAGE, SUBUNIT, FUNCTION.
  9. Cited for: INTERACTION WITH PER1; PER2 AND PER3, INDUCTION.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen and Testis.
  11. "Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock."
    Engelen E., Janssens R.C., Yagita K., Smits V.A., van der Horst G.T., Tamanini F.
    PLoS ONE 8:E56623-E56623(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CRY1 AND CHEK1.
  12. "Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1."
    Kang T.H., Leem S.H.
    Nucleic Acids Res. 42:4427-4434(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CRY1, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTIM_MOUSE
AccessioniPrimary (citable) accession number: Q9R1X4
Secondary accession number(s): Q63ZX9
, Q6P204, Q6PDL4, Q7TPV8, Q8R0Q2, Q9R268, Q9Z0E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 13, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.