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Q9R1W5

- CALRL_MOUSE

UniProt

Q9R1W5 - CALRL_MOUSE

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Protein

Calcitonin gene-related peptide type 1 receptor

Gene

Calcrl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).By similarity

GO - Molecular functioni

  1. adrenomedullin receptor activity Source: Ensembl
  2. calcitonin gene-related peptide receptor activity Source: MGI
  3. calcitonin receptor activity Source: Ensembl
  4. protein transporter activity Source: Ensembl

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  2. angiogenesis Source: Ensembl
  3. calcium ion transport Source: Ensembl
  4. cAMP biosynthetic process Source: Ensembl
  5. cellular response to sucrose stimulus Source: Ensembl
  6. G-protein coupled receptor signaling pathway Source: MGI
  7. heart development Source: MGI
  8. negative regulation of inflammatory response Source: Ensembl
  9. positive regulation of cAMP biosynthetic process Source: Ensembl
  10. positive regulation of cell proliferation Source: MGI
  11. positive regulation of smooth muscle cell proliferation Source: MGI
  12. receptor internalization Source: Ensembl
  13. regulation of muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_242871. G alpha (s) signalling events.
REACT_255862. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide type 1 receptor
Short name:
CGRP type 1 receptor
Alternative name(s):
Calcitonin receptor-like receptor
Gene namesi
Name:Calcrl
Synonyms:Crlr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1926944. Calcrl.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 145123ExtracellularSequence AnalysisAdd
BLAST
Transmembranei146 – 16520Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini166 – 1727CytoplasmicSequence Analysis
Transmembranei173 – 19220Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini193 – 21220ExtracellularSequence AnalysisAdd
BLAST
Transmembranei213 – 23523Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini236 – 25217CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei253 – 27220Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini273 – 28816ExtracellularSequence AnalysisAdd
BLAST
Transmembranei289 – 31224Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini313 – 33523CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei336 – 35318Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini354 – 36512ExtracellularSequence AnalysisAdd
BLAST
Transmembranei366 – 38722Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini388 – 46376CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. endosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. lysosome Source: Ensembl
  5. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 463441Calcitonin gene-related peptide type 1 receptorPRO_0000012812Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi47 ↔ 73By similarity
Disulfide bondi64 ↔ 104By similarity
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi87 ↔ 126By similarity
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9R1W5.
PaxDbiQ9R1W5.
PRIDEiQ9R1W5.

PTM databases

PhosphoSiteiQ9R1W5.

Expressioni

Tissue specificityi

Expressed predominantly in the lung, thymus, heart and brain.2 Publications

Gene expression databases

BgeeiQ9R1W5.
CleanExiMM_CALCRL.
ExpressionAtlasiQ9R1W5. baseline and differential.
GenevestigatoriQ9R1W5.

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.

Structurei

3D structure databases

ProteinModelPortaliQ9R1W5.
SMRiQ9R1W5. Positions 33-127, 143-387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG255868.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiQ9R1W5.
KOiK04577.
OMAiLCWNDVA.
OrthoDBiEOG712TW2.
PhylomeDBiQ9R1W5.
TreeFamiTF315710.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR003289. GPCR_2_CGRP1_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01351. CGRPRECEPTOR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R1W5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKKHILCFL VLLPLNMALI SAESEEGVNQ TDLGVTRNKI MTAQYECYQK
60 70 80 90 100
IMQDPIQQAE GLYCNRTWDG WLCWNDVAAG TESMQYCPDY FQDFDPSEKV
110 120 130 140 150
TKICDQDGHW FRHPDSNRTW TNYTLCNNST HEKVKTALNL FYLTIIGHGL
160 170 180 190 200
SIASLIISLI IFFYFKSLSC QRITLHKNLF FSFICNSIVT IIHLTAVANN
210 220 230 240 250
QALVATNPVS CKVSQFIHLY LMGCNYFWML CEGVYLHTLI VVAVFAEKQH
260 270 280 290 300
LMWYYFLGWG FPLLPACIHA IARSLYYNDN CWISSDTHLL YIIHGPICAA
310 320 330 340 350
LLVNLFFLLN IVRVLITKLK VTHQVESNLY MKAVRATLIL VPLLGIEFVL
360 370 380 390 400
FPWRPEGKVA EEVYDYVMHI LMHFQGLLVA TIFCFFNGEV QAILRRNWNQ
410 420 430 440 450
YKIQFGNGFS HSDALRSASY TVSTISDMQG YSHDCPTEHL NGKSIQDIEN
460
VALKSENMYD LVM
Length:463
Mass (Da):53,265
Last modified:September 26, 2003 - v2
Checksum:i630EC8956A4FB47E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti235 – 2351Y → C in BAA76492. (PubMed:12147211)Curated
Sequence conflicti458 – 4581M → T in AAD35021. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015595 mRNA. Translation: BAA76492.1.
AF146525 mRNA. Translation: AAD35021.1.
AF209905 mRNA. Translation: AAF21037.1.
CCDSiCCDS16184.1.
RefSeqiNP_061252.2. NM_018782.2.
XP_006499981.1. XM_006499918.1.
UniGeneiMm.75467.

Genome annotation databases

EnsembliENSMUST00000074262; ENSMUSP00000073875; ENSMUSG00000059588.
ENSMUST00000099944; ENSMUSP00000097527; ENSMUSG00000059588.
GeneIDi54598.
KEGGimmu:54598.
UCSCiuc008kii.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015595 mRNA. Translation: BAA76492.1 .
AF146525 mRNA. Translation: AAD35021.1 .
AF209905 mRNA. Translation: AAF21037.1 .
CCDSi CCDS16184.1.
RefSeqi NP_061252.2. NM_018782.2.
XP_006499981.1. XM_006499918.1.
UniGenei Mm.75467.

3D structure databases

ProteinModelPortali Q9R1W5.
SMRi Q9R1W5. Positions 33-127, 143-387.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q9R1W5.
ChEMBLi CHEMBL2034811.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9R1W5.

Proteomic databases

MaxQBi Q9R1W5.
PaxDbi Q9R1W5.
PRIDEi Q9R1W5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000074262 ; ENSMUSP00000073875 ; ENSMUSG00000059588 .
ENSMUST00000099944 ; ENSMUSP00000097527 ; ENSMUSG00000059588 .
GeneIDi 54598.
KEGGi mmu:54598.
UCSCi uc008kii.3. mouse.

Organism-specific databases

CTDi 10203.
MGIi MGI:1926944. Calcrl.

Phylogenomic databases

eggNOGi NOG255868.
GeneTreei ENSGT00760000118800.
HOGENOMi HOG000230695.
HOVERGENi HBG102129.
InParanoidi Q9R1W5.
KOi K04577.
OMAi LCWNDVA.
OrthoDBi EOG712TW2.
PhylomeDBi Q9R1W5.
TreeFami TF315710.

Enzyme and pathway databases

Reactomei REACT_242871. G alpha (s) signalling events.
REACT_255862. Calcitonin-like ligand receptors.

Miscellaneous databases

NextBioi 311388.
PROi Q9R1W5.
SOURCEi Search...

Gene expression databases

Bgeei Q9R1W5.
CleanExi MM_CALCRL.
ExpressionAtlasi Q9R1W5. baseline and differential.
Genevestigatori Q9R1W5.

Family and domain databases

InterProi IPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR003289. GPCR_2_CGRP1_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR01351. CGRPRECEPTOR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of mouse calcitonin gene-related peptide receptor."
    Miyauchi K., Tadotsu N., Hayashi T., Ono Y., Tokoyoda K., Tsujikawa K., Yamamoto H.
    Neuropeptides 36:22-33(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Spleen.
  2. "Cloning and sequencing of mouse CGRP/adrenomedullin receptor subunits."
    Derst C., Preisig-Mueller R., Gerhardus J., Daut J.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis."
    Ono Y., Okano I., Kojima M., Okada K., Kangawa K.
    Biochem. Biophys. Res. Commun. 271:197-202(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Lung.

Entry informationi

Entry nameiCALRL_MOUSE
AccessioniPrimary (citable) accession number: Q9R1W5
Secondary accession number(s): Q9QXH8, Q9WUP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 26, 2003
Last modified: November 26, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3