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Q9R1W5

- CALRL_MOUSE

UniProt

Q9R1W5 - CALRL_MOUSE

Protein

Calcitonin gene-related peptide type 1 receptor

Gene

Calcrl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (26 Sep 2003)
      Previous versions | rss
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    Functioni

    Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase By similarity.By similarity

    GO - Molecular functioni

    1. adrenomedullin receptor activity Source: Ensembl
    2. calcitonin gene-related peptide receptor activity Source: MGI
    3. calcitonin receptor activity Source: Ensembl
    4. protein transporter activity Source: Ensembl

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
    2. angiogenesis Source: Ensembl
    3. calcium ion transport Source: Ensembl
    4. cAMP biosynthetic process Source: Ensembl
    5. cellular response to sucrose stimulus Source: Ensembl
    6. G-protein coupled receptor signaling pathway Source: MGI
    7. heart development Source: MGI
    8. negative regulation of inflammatory response Source: Ensembl
    9. positive regulation of cAMP biosynthetic process Source: Ensembl
    10. positive regulation of cell proliferation Source: MGI
    11. positive regulation of smooth muscle cell proliferation Source: MGI
    12. receptor internalization Source: Ensembl
    13. regulation of muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcitonin gene-related peptide type 1 receptor
    Short name:
    CGRP type 1 receptor
    Alternative name(s):
    Calcitonin receptor-like receptor
    Gene namesi
    Name:Calcrl
    Synonyms:Crlr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1926944. Calcrl.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. endosome Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. lysosome Source: Ensembl
    5. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 463441Calcitonin gene-related peptide type 1 receptorPRO_0000012812Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi47 ↔ 73By similarity
    Disulfide bondi64 ↔ 104By similarity
    Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi87 ↔ 126By similarity
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9R1W5.
    PaxDbiQ9R1W5.
    PRIDEiQ9R1W5.

    PTM databases

    PhosphoSiteiQ9R1W5.

    Expressioni

    Tissue specificityi

    Expressed predominantly in the lung, thymus, heart and brain.2 Publications

    Gene expression databases

    ArrayExpressiQ9R1W5.
    BgeeiQ9R1W5.
    CleanExiMM_CALCRL.
    GenevestigatoriQ9R1W5.

    Interactioni

    Subunit structurei

    Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R1W5.
    SMRiQ9R1W5. Positions 33-127, 143-387.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 145123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini166 – 1727CytoplasmicSequence Analysis
    Topological domaini193 – 21220ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini236 – 25217CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini273 – 28816ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini313 – 33523CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini354 – 36512ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini388 – 46376CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei146 – 16520Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei173 – 19220Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei213 – 23523Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei253 – 27220Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei289 – 31224Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei336 – 35318Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei366 – 38722Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG255868.
    GeneTreeiENSGT00750000117654.
    HOGENOMiHOG000230695.
    HOVERGENiHBG102129.
    InParanoidiQ9R1W5.
    KOiK04577.
    OMAiLCWNDVA.
    OrthoDBiEOG712TW2.
    PhylomeDBiQ9R1W5.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
    IPR017981. GPCR_2-like.
    IPR003289. GPCR_2_CGRP1_rcpt.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR01351. CGRPRECEPTOR.
    PR01350. CTRFAMILY.
    PR00249. GPCRSECRETIN.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9R1W5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDKKHILCFL VLLPLNMALI SAESEEGVNQ TDLGVTRNKI MTAQYECYQK    50
    IMQDPIQQAE GLYCNRTWDG WLCWNDVAAG TESMQYCPDY FQDFDPSEKV 100
    TKICDQDGHW FRHPDSNRTW TNYTLCNNST HEKVKTALNL FYLTIIGHGL 150
    SIASLIISLI IFFYFKSLSC QRITLHKNLF FSFICNSIVT IIHLTAVANN 200
    QALVATNPVS CKVSQFIHLY LMGCNYFWML CEGVYLHTLI VVAVFAEKQH 250
    LMWYYFLGWG FPLLPACIHA IARSLYYNDN CWISSDTHLL YIIHGPICAA 300
    LLVNLFFLLN IVRVLITKLK VTHQVESNLY MKAVRATLIL VPLLGIEFVL 350
    FPWRPEGKVA EEVYDYVMHI LMHFQGLLVA TIFCFFNGEV QAILRRNWNQ 400
    YKIQFGNGFS HSDALRSASY TVSTISDMQG YSHDCPTEHL NGKSIQDIEN 450
    VALKSENMYD LVM 463
    Length:463
    Mass (Da):53,265
    Last modified:September 26, 2003 - v2
    Checksum:i630EC8956A4FB47E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti235 – 2351Y → C in BAA76492. (PubMed:12147211)Curated
    Sequence conflicti458 – 4581M → T in AAD35021. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015595 mRNA. Translation: BAA76492.1.
    AF146525 mRNA. Translation: AAD35021.1.
    AF209905 mRNA. Translation: AAF21037.1.
    CCDSiCCDS16184.1.
    RefSeqiNP_061252.2. NM_018782.2.
    XP_006499981.1. XM_006499918.1.
    UniGeneiMm.75467.

    Genome annotation databases

    EnsembliENSMUST00000074262; ENSMUSP00000073875; ENSMUSG00000059588.
    ENSMUST00000099944; ENSMUSP00000097527; ENSMUSG00000059588.
    GeneIDi54598.
    KEGGimmu:54598.
    UCSCiuc008kii.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015595 mRNA. Translation: BAA76492.1 .
    AF146525 mRNA. Translation: AAD35021.1 .
    AF209905 mRNA. Translation: AAF21037.1 .
    CCDSi CCDS16184.1.
    RefSeqi NP_061252.2. NM_018782.2.
    XP_006499981.1. XM_006499918.1.
    UniGenei Mm.75467.

    3D structure databases

    ProteinModelPortali Q9R1W5.
    SMRi Q9R1W5. Positions 33-127, 143-387.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2034811.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9R1W5.

    Proteomic databases

    MaxQBi Q9R1W5.
    PaxDbi Q9R1W5.
    PRIDEi Q9R1W5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000074262 ; ENSMUSP00000073875 ; ENSMUSG00000059588 .
    ENSMUST00000099944 ; ENSMUSP00000097527 ; ENSMUSG00000059588 .
    GeneIDi 54598.
    KEGGi mmu:54598.
    UCSCi uc008kii.3. mouse.

    Organism-specific databases

    CTDi 10203.
    MGIi MGI:1926944. Calcrl.

    Phylogenomic databases

    eggNOGi NOG255868.
    GeneTreei ENSGT00750000117654.
    HOGENOMi HOG000230695.
    HOVERGENi HBG102129.
    InParanoidi Q9R1W5.
    KOi K04577.
    OMAi LCWNDVA.
    OrthoDBi EOG712TW2.
    PhylomeDBi Q9R1W5.
    TreeFami TF315710.

    Miscellaneous databases

    NextBioi 311388.
    PROi Q9R1W5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9R1W5.
    Bgeei Q9R1W5.
    CleanExi MM_CALCRL.
    Genevestigatori Q9R1W5.

    Family and domain databases

    InterProi IPR003287. GCPR_2_calcitonin_rcpt_fam.
    IPR017981. GPCR_2-like.
    IPR003289. GPCR_2_CGRP1_rcpt.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR01351. CGRPRECEPTOR.
    PR01350. CTRFAMILY.
    PR00249. GPCRSECRETIN.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of mouse calcitonin gene-related peptide receptor."
      Miyauchi K., Tadotsu N., Hayashi T., Ono Y., Tokoyoda K., Tsujikawa K., Yamamoto H.
      Neuropeptides 36:22-33(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Spleen.
    2. "Cloning and sequencing of mouse CGRP/adrenomedullin receptor subunits."
      Derst C., Preisig-Mueller R., Gerhardus J., Daut J.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis."
      Ono Y., Okano I., Kojima M., Okada K., Kangawa K.
      Biochem. Biophys. Res. Commun. 271:197-202(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: C57BL/6.
      Tissue: Lung.

    Entry informationi

    Entry nameiCALRL_MOUSE
    AccessioniPrimary (citable) accession number: Q9R1W5
    Secondary accession number(s): Q9QXH8, Q9WUP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: September 26, 2003
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3