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Protein

Calcitonin gene-related peptide type 1 receptor

Gene

Calcrl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • angiogenesis Source: MGI
  • calcium ion transport Source: MGI
  • cAMP biosynthetic process Source: MGI
  • cell surface receptor signaling pathway Source: InterPro
  • cellular response to sucrose stimulus Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
  • heart development Source: MGI
  • negative regulation of inflammatory response Source: Ensembl
  • negative regulation of smooth muscle contraction Source: Ensembl
  • positive regulation of cAMP biosynthetic process Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of smooth muscle cell proliferation Source: MGI
  • protein transport Source: MGI
  • receptor internalization Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide type 1 receptor
Short name:
CGRP type 1 receptor
Alternative name(s):
Calcitonin receptor-like receptor
Gene namesi
Name:Calcrl
Synonyms:Crlr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1926944. Calcrl.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 145ExtracellularSequence analysisAdd BLAST123
Transmembranei146 – 165Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini166 – 172CytoplasmicSequence analysis7
Transmembranei173 – 192Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini193 – 212ExtracellularSequence analysisAdd BLAST20
Transmembranei213 – 235Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini236 – 252CytoplasmicSequence analysisAdd BLAST17
Transmembranei253 – 272Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini273 – 288ExtracellularSequence analysisAdd BLAST16
Transmembranei289 – 312Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini313 – 335CytoplasmicSequence analysisAdd BLAST23
Transmembranei336 – 353Helical; Name=6Sequence analysisAdd BLAST18
Topological domaini354 – 365ExtracellularSequence analysisAdd BLAST12
Transmembranei366 – 387Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini388 – 463CytoplasmicSequence analysisAdd BLAST76

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2034811.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001281223 – 463Calcitonin gene-related peptide type 1 receptorAdd BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi47 ↔ 73By similarity
Disulfide bondi64 ↔ 104By similarity
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi87 ↔ 126By similarity
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1
Glycosylationi122N-linked (GlcNAc...)Sequence analysis1
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1
Modified residuei419PhosphoserineCombined sources1
Modified residuei444PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9R1W5.
PaxDbiQ9R1W5.
PRIDEiQ9R1W5.

PTM databases

iPTMnetiQ9R1W5.
PhosphoSitePlusiQ9R1W5.

Expressioni

Tissue specificityi

Expressed predominantly in the lung, thymus, heart and brain.2 Publications

Gene expression databases

BgeeiENSMUSG00000059588.
CleanExiMM_CALCRL.
ExpressionAtlasiQ9R1W5. baseline and differential.
GenevisibleiQ9R1W5. MM.

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073875.

Chemistry databases

BindingDBiQ9R1W5.

Structurei

3D structure databases

ProteinModelPortaliQ9R1W5.
SMRiQ9R1W5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiQ9R1W5.
KOiK04577.
OMAiIVTAQFE.
OrthoDBiEOG091G027C.
PhylomeDBiQ9R1W5.
TreeFamiTF315710.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR003289. GPCR_2_CGRP1_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01351. CGRPRECEPTOR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R1W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKKHILCFL VLLPLNMALI SAESEEGVNQ TDLGVTRNKI MTAQYECYQK
60 70 80 90 100
IMQDPIQQAE GLYCNRTWDG WLCWNDVAAG TESMQYCPDY FQDFDPSEKV
110 120 130 140 150
TKICDQDGHW FRHPDSNRTW TNYTLCNNST HEKVKTALNL FYLTIIGHGL
160 170 180 190 200
SIASLIISLI IFFYFKSLSC QRITLHKNLF FSFICNSIVT IIHLTAVANN
210 220 230 240 250
QALVATNPVS CKVSQFIHLY LMGCNYFWML CEGVYLHTLI VVAVFAEKQH
260 270 280 290 300
LMWYYFLGWG FPLLPACIHA IARSLYYNDN CWISSDTHLL YIIHGPICAA
310 320 330 340 350
LLVNLFFLLN IVRVLITKLK VTHQVESNLY MKAVRATLIL VPLLGIEFVL
360 370 380 390 400
FPWRPEGKVA EEVYDYVMHI LMHFQGLLVA TIFCFFNGEV QAILRRNWNQ
410 420 430 440 450
YKIQFGNGFS HSDALRSASY TVSTISDMQG YSHDCPTEHL NGKSIQDIEN
460
VALKSENMYD LVM
Length:463
Mass (Da):53,265
Last modified:September 26, 2003 - v2
Checksum:i630EC8956A4FB47E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235Y → C in BAA76492 (PubMed:12147211).Curated1
Sequence conflicti458M → T in AAD35021 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015595 mRNA. Translation: BAA76492.1.
AF146525 mRNA. Translation: AAD35021.1.
AF209905 mRNA. Translation: AAF21037.1.
CCDSiCCDS16184.1.
RefSeqiNP_061252.2. NM_018782.2.
XP_006499981.1. XM_006499918.3.
UniGeneiMm.75467.

Genome annotation databases

EnsembliENSMUST00000074262; ENSMUSP00000073875; ENSMUSG00000059588.
ENSMUST00000099944; ENSMUSP00000097527; ENSMUSG00000059588.
GeneIDi54598.
KEGGimmu:54598.
UCSCiuc008kii.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015595 mRNA. Translation: BAA76492.1.
AF146525 mRNA. Translation: AAD35021.1.
AF209905 mRNA. Translation: AAF21037.1.
CCDSiCCDS16184.1.
RefSeqiNP_061252.2. NM_018782.2.
XP_006499981.1. XM_006499918.3.
UniGeneiMm.75467.

3D structure databases

ProteinModelPortaliQ9R1W5.
SMRiQ9R1W5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073875.

Chemistry databases

BindingDBiQ9R1W5.
ChEMBLiCHEMBL2034811.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9R1W5.
PhosphoSitePlusiQ9R1W5.

Proteomic databases

MaxQBiQ9R1W5.
PaxDbiQ9R1W5.
PRIDEiQ9R1W5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074262; ENSMUSP00000073875; ENSMUSG00000059588.
ENSMUST00000099944; ENSMUSP00000097527; ENSMUSG00000059588.
GeneIDi54598.
KEGGimmu:54598.
UCSCiuc008kii.3. mouse.

Organism-specific databases

CTDi10203.
MGIiMGI:1926944. Calcrl.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiQ9R1W5.
KOiK04577.
OMAiIVTAQFE.
OrthoDBiEOG091G027C.
PhylomeDBiQ9R1W5.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Miscellaneous databases

PROiQ9R1W5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059588.
CleanExiMM_CALCRL.
ExpressionAtlasiQ9R1W5. baseline and differential.
GenevisibleiQ9R1W5. MM.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR003289. GPCR_2_CGRP1_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01351. CGRPRECEPTOR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALRL_MOUSE
AccessioniPrimary (citable) accession number: Q9R1W5
Secondary accession number(s): Q9QXH8, Q9WUP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 26, 2003
Last modified: November 2, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.