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Protein

Calcitonin gene-related peptide type 1 receptor

Gene

Calcrl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • angiogenesis Source: MGI
  • calcium ion transport Source: MGI
  • cAMP biosynthetic process Source: MGI
  • cellular response to sucrose stimulus Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
  • heart development Source: MGI
  • negative regulation of inflammatory response Source: Ensembl
  • positive regulation of cAMP biosynthetic process Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of smooth muscle cell proliferation Source: MGI
  • protein transport Source: MGI
  • receptor internalization Source: MGI
  • regulation of muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_301868. Calcitonin-like ligand receptors.
REACT_313192. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide type 1 receptor
Short name:
CGRP type 1 receptor
Alternative name(s):
Calcitonin receptor-like receptor
Gene namesi
Name:Calcrl
Synonyms:Crlr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1926944. Calcrl.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 145123ExtracellularSequence AnalysisAdd
BLAST
Transmembranei146 – 16520Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini166 – 1727CytoplasmicSequence Analysis
Transmembranei173 – 19220Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini193 – 21220ExtracellularSequence AnalysisAdd
BLAST
Transmembranei213 – 23523Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini236 – 25217CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei253 – 27220Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini273 – 28816ExtracellularSequence AnalysisAdd
BLAST
Transmembranei289 – 31224Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini313 – 33523CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei336 – 35318Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini354 – 36512ExtracellularSequence AnalysisAdd
BLAST
Transmembranei366 – 38722Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini388 – 46376CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 463441Calcitonin gene-related peptide type 1 receptorPRO_0000012812Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi47 ↔ 73By similarity
Disulfide bondi64 ↔ 104By similarity
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi87 ↔ 126By similarity
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9R1W5.
PaxDbiQ9R1W5.
PRIDEiQ9R1W5.

PTM databases

PhosphoSiteiQ9R1W5.

Expressioni

Tissue specificityi

Expressed predominantly in the lung, thymus, heart and brain.2 Publications

Gene expression databases

BgeeiQ9R1W5.
CleanExiMM_CALCRL.
ExpressionAtlasiQ9R1W5. baseline and differential.
GenevisibleiQ9R1W5. MM.

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073875.

Structurei

3D structure databases

ProteinModelPortaliQ9R1W5.
SMRiQ9R1W5. Positions 33-127, 143-387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG255868.
GeneTreeiENSGT00790000123019.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiQ9R1W5.
KOiK04577.
OMAiLCWNDVA.
OrthoDBiEOG712TW2.
PhylomeDBiQ9R1W5.
TreeFamiTF315710.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR003289. GPCR_2_CGRP1_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01351. CGRPRECEPTOR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R1W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKKHILCFL VLLPLNMALI SAESEEGVNQ TDLGVTRNKI MTAQYECYQK
60 70 80 90 100
IMQDPIQQAE GLYCNRTWDG WLCWNDVAAG TESMQYCPDY FQDFDPSEKV
110 120 130 140 150
TKICDQDGHW FRHPDSNRTW TNYTLCNNST HEKVKTALNL FYLTIIGHGL
160 170 180 190 200
SIASLIISLI IFFYFKSLSC QRITLHKNLF FSFICNSIVT IIHLTAVANN
210 220 230 240 250
QALVATNPVS CKVSQFIHLY LMGCNYFWML CEGVYLHTLI VVAVFAEKQH
260 270 280 290 300
LMWYYFLGWG FPLLPACIHA IARSLYYNDN CWISSDTHLL YIIHGPICAA
310 320 330 340 350
LLVNLFFLLN IVRVLITKLK VTHQVESNLY MKAVRATLIL VPLLGIEFVL
360 370 380 390 400
FPWRPEGKVA EEVYDYVMHI LMHFQGLLVA TIFCFFNGEV QAILRRNWNQ
410 420 430 440 450
YKIQFGNGFS HSDALRSASY TVSTISDMQG YSHDCPTEHL NGKSIQDIEN
460
VALKSENMYD LVM
Length:463
Mass (Da):53,265
Last modified:September 26, 2003 - v2
Checksum:i630EC8956A4FB47E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti235 – 2351Y → C in BAA76492 (PubMed:12147211).Curated
Sequence conflicti458 – 4581M → T in AAD35021 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015595 mRNA. Translation: BAA76492.1.
AF146525 mRNA. Translation: AAD35021.1.
AF209905 mRNA. Translation: AAF21037.1.
CCDSiCCDS16184.1.
RefSeqiNP_061252.2. NM_018782.2.
XP_006499981.1. XM_006499918.2.
UniGeneiMm.75467.

Genome annotation databases

EnsembliENSMUST00000074262; ENSMUSP00000073875; ENSMUSG00000059588.
ENSMUST00000099944; ENSMUSP00000097527; ENSMUSG00000059588.
GeneIDi54598.
KEGGimmu:54598.
UCSCiuc008kii.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015595 mRNA. Translation: BAA76492.1.
AF146525 mRNA. Translation: AAD35021.1.
AF209905 mRNA. Translation: AAF21037.1.
CCDSiCCDS16184.1.
RefSeqiNP_061252.2. NM_018782.2.
XP_006499981.1. XM_006499918.2.
UniGeneiMm.75467.

3D structure databases

ProteinModelPortaliQ9R1W5.
SMRiQ9R1W5. Positions 33-127, 143-387.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073875.

Chemistry

BindingDBiQ9R1W5.
ChEMBLiCHEMBL2034811.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9R1W5.

Proteomic databases

MaxQBiQ9R1W5.
PaxDbiQ9R1W5.
PRIDEiQ9R1W5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074262; ENSMUSP00000073875; ENSMUSG00000059588.
ENSMUST00000099944; ENSMUSP00000097527; ENSMUSG00000059588.
GeneIDi54598.
KEGGimmu:54598.
UCSCiuc008kii.3. mouse.

Organism-specific databases

CTDi10203.
MGIiMGI:1926944. Calcrl.

Phylogenomic databases

eggNOGiNOG255868.
GeneTreeiENSGT00790000123019.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiQ9R1W5.
KOiK04577.
OMAiLCWNDVA.
OrthoDBiEOG712TW2.
PhylomeDBiQ9R1W5.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiREACT_301868. Calcitonin-like ligand receptors.
REACT_313192. G alpha (s) signalling events.

Miscellaneous databases

NextBioi311388.
PROiQ9R1W5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R1W5.
CleanExiMM_CALCRL.
ExpressionAtlasiQ9R1W5. baseline and differential.
GenevisibleiQ9R1W5. MM.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR003289. GPCR_2_CGRP1_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01351. CGRPRECEPTOR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of mouse calcitonin gene-related peptide receptor."
    Miyauchi K., Tadotsu N., Hayashi T., Ono Y., Tokoyoda K., Tsujikawa K., Yamamoto H.
    Neuropeptides 36:22-33(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Spleen.
  2. "Cloning and sequencing of mouse CGRP/adrenomedullin receptor subunits."
    Derst C., Preisig-Mueller R., Gerhardus J., Daut J.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis."
    Ono Y., Okano I., Kojima M., Okada K., Kangawa K.
    Biochem. Biophys. Res. Commun. 271:197-202(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Lung.

Entry informationi

Entry nameiCALRL_MOUSE
AccessioniPrimary (citable) accession number: Q9R1W5
Secondary accession number(s): Q9QXH8, Q9WUP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 26, 2003
Last modified: June 24, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.