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Protein

E3 ubiquitin-protein ligase RNF103

Gene

Rnf103

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri619 – 66143RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF103 (EC:6.3.2.-)
Alternative name(s):
KF-1
Short name:
mKF-1
RING finger protein 103
Zinc finger protein 103
Short name:
Zfp-103
Gene namesi
Name:Rnf103
Synonyms:Zfp103
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:109483. Rnf103.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST
Transmembranei326 – 34621HelicalSequence analysisAdd
BLAST
Transmembranei366 – 38621HelicalSequence analysisAdd
BLAST
Transmembranei411 – 43121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 683683E3 ubiquitin-protein ligase RNF103PRO_0000056085Add
BLAST

Proteomic databases

PaxDbiQ9R1W3.
PRIDEiQ9R1W3.

PTM databases

iPTMnetiQ9R1W3.
PhosphoSiteiQ9R1W3.

Expressioni

Tissue specificityi

Highly expressed in the normal cerebellum but not in the cerebral cortex.1 Publication

Gene expression databases

BgeeiENSMUSG00000052656.
CleanExiMM_RNF103.
ExpressionAtlasiQ9R1W3. baseline and differential.
GenevisibleiQ9R1W3. MM.

Interactioni

Subunit structurei

Interacts with DERL1 and VCP.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066324.

Structurei

3D structure databases

ProteinModelPortaliQ9R1W3.
SMRiQ9R1W3. Positions 617-661.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri619 – 66143RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00390000006413.
HOGENOMiHOG000006578.
HOVERGENiHBG054144.
InParanoidiQ9R1W3.
KOiK15695.
OMAiGKVHWEK.
OrthoDBiEOG091G0EZD.
TreeFamiTF329229.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLKLFFLLL YFLVLFVLAR FFEAIVWYET GIFATQLVDP VALSFKKLKT
60 70 80 90 100
ILECRGLGYS GLPEKKDVRE LVEKSGDLME GELYSALKEE EASESVSSTN
110 120 130 140 150
FSGEMHFYEL VEDTKDGIWL VQVIANDRSP LVGKIHWEKM VKKVSRFGIR
160 170 180 190 200
TGTFNCSSDP RYCRRRGWVR STLIMSVPQT STSKGKVMLK EYSGRKIEVE
210 220 230 240 250
HIFKWITAHA ASRIKTIYNV EHLKEEWNKS DQYWVKIYLF ANLDQPPAFF
260 270 280 290 300
SALSIKFTGR VEFIFVNVEN WNNKSYMTDI GIYNMPSYIL RTPEGIYRYG
310 320 330 340 350
NHTGEFISLQ AMDSFLRSLQ PEVNDLFVLS LVLVNLMAWM DLFITQGATI
360 370 380 390 400
KRFVVLISTL GTYNSLLIIS WLPVLGFLQL PYLDSFYDYS LRLLRYSNTT
410 420 430 440 450
TLASWVRADW MFYTSHPALF LSTYLGHGLL IDYFEKKRRR SNNDEVNANN
460 470 480 490 500
LEWLSSLWDW YTSYLFHPIA SFQNFPVDSD WDEDPDLFLE RLAFPDLWLH
510 520 530 540 550
PLIPTDYIKN LPMWRFKCLG VQSEEEMSES SQDTENDSDS DNMDTFSSSK
560 570 580 590 600
DIFEDKQSVV HSSPGRTSHC DTEACSCANK CESSPCERKR RSYGSHNTDE
610 620 630 640 650
DMEPDWLTWP AGTLHCTECV VCLENFENGC LLMGLPCGHV FHQNCIVMWL
660 670 680
AGGRHCCPVC RWPSYKKKQP YAQQQPLSND VPS
Length:683
Mass (Da):79,189
Last modified:July 27, 2011 - v2
Checksum:iCF307FC74CE63A54
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701E → V in BAA19795 (PubMed:9070305).Curated
Sequence conflicti388 – 3881D → E in BAA19795 (PubMed:9070305).Curated
Sequence conflicti388 – 3881D → E in BAA34912 (Ref. 2) Curated
Sequence conflicti414 – 4141T → S in BAA19795 (PubMed:9070305).Curated
Sequence conflicti414 – 4141T → S in BAA34912 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D76445 mRNA. Translation: BAA19795.1.
AB012161 Genomic DNA. Translation: BAA34912.2.
BC137624 mRNA. Translation: AAI37625.1.
CCDSiCCDS39508.1.
PIRiJC5393.
RefSeqiNP_033569.2. NM_009543.3.
UniGeneiMm.422969.

Genome annotation databases

EnsembliENSMUST00000064637; ENSMUSP00000066324; ENSMUSG00000052656.
ENSMUST00000114179; ENSMUSP00000109817; ENSMUSG00000052656.
GeneIDi22644.
KEGGimmu:22644.
UCSCiuc009cgv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D76445 mRNA. Translation: BAA19795.1.
AB012161 Genomic DNA. Translation: BAA34912.2.
BC137624 mRNA. Translation: AAI37625.1.
CCDSiCCDS39508.1.
PIRiJC5393.
RefSeqiNP_033569.2. NM_009543.3.
UniGeneiMm.422969.

3D structure databases

ProteinModelPortaliQ9R1W3.
SMRiQ9R1W3. Positions 617-661.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066324.

PTM databases

iPTMnetiQ9R1W3.
PhosphoSiteiQ9R1W3.

Proteomic databases

PaxDbiQ9R1W3.
PRIDEiQ9R1W3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064637; ENSMUSP00000066324; ENSMUSG00000052656.
ENSMUST00000114179; ENSMUSP00000109817; ENSMUSG00000052656.
GeneIDi22644.
KEGGimmu:22644.
UCSCiuc009cgv.1. mouse.

Organism-specific databases

CTDi7844.
MGIiMGI:109483. Rnf103.

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00390000006413.
HOGENOMiHOG000006578.
HOVERGENiHBG054144.
InParanoidiQ9R1W3.
KOiK15695.
OMAiGKVHWEK.
OrthoDBiEOG091G0EZD.
TreeFamiTF329229.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiRnf103. mouse.
PROiQ9R1W3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052656.
CleanExiMM_RNF103.
ExpressionAtlasiQ9R1W3. baseline and differential.
GenevisibleiQ9R1W3. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRN103_MOUSE
AccessioniPrimary (citable) accession number: Q9R1W3
Secondary accession number(s): B9EHC2, O08670, O08883
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.