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Q9R1V7

- ADA23_MOUSE

UniProt

Q9R1V7 - ADA23_MOUSE

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Protein

Disintegrin and metalloproteinase domain-containing protein 23

Gene
Adam23, Mdc3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein By similarity.

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. protein binding Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Protein family/group databases

MEROPSiM12.979.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 23
Short name:
ADAM 23
Alternative name(s):
Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3
Short name:
MDC-3
Gene namesi
Name:Adam23
Synonyms:Mdc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1345162. Adam23.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini284 – 789506Extracellular Reviewed predictionAdd
BLAST
Transmembranei790 – 81021Helical; Reviewed predictionAdd
BLAST
Topological domaini811 – 82919Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5555 Reviewed predictionAdd
BLAST
Propeptidei56 – 283228 Reviewed predictionPRO_0000029120Add
BLAST
Chaini284 – 829546Disintegrin and metalloproteinase domain-containing protein 23PRO_0000029121Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi72 – 721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi92 – 921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi97 – 971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi260 – 2601N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi405 ↔ 488 By similarity
Disulfide bondi447 ↔ 472 By similarity
Disulfide bondi449 ↔ 456 By similarity
Glycosylationi544 – 5441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi545 – 5451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi557 ↔ 577 By similarity
Glycosylationi661 – 6611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi729 – 7291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi733 ↔ 748 By similarity
Disulfide bondi742 ↔ 754 By similarity
Disulfide bondi756 ↔ 765 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9R1V7.
PaxDbiQ9R1V7.
PRIDEiQ9R1V7.

PTM databases

PhosphoSiteiQ9R1V7.

Expressioni

Tissue specificityi

Brain specific.1 Publication

Developmental stagei

On E15 embryo the level of isoform Gamma exceeded that of isoform Alpha and isoform Beta and decreased after birth. On P10 post neonatal, the level of isoform Gamma is undetectable and isoform Alpha and isoform Beta are expressed again.1 Publication

Gene expression databases

ArrayExpressiQ9R1V7.
BgeeiQ9R1V7.
CleanExiMM_ADAM23.
GenevestigatoriQ9R1V7.

Interactioni

Subunit structurei

Can bind to LGI1 and LGI4.

Protein-protein interaction databases

BioGridi204715. 1 interaction.
IntActiQ9R1V7. 3 interactions.
MINTiMINT-1177148.
STRINGi10090.ENSMUSP00000109738.

Structurei

3D structure databases

ProteinModelPortaliQ9R1V7.
SMRiQ9R1V7. Positions 291-770.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini296 – 493198Peptidase M12BAdd
BLAST
Domaini499 – 58587DisintegrinAdd
BLAST
Domaini729 – 76638EGF-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi586 – 60823Cys-richAdd
BLAST

Sequence similaritiesi

Contains 1 disintegrin domain.
Contains 1 EGF-like domain.

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256419.
GeneTreeiENSGT00680000099751.
HOGENOMiHOG000231962.
HOVERGENiHBG050456.
KOiK06837.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform Alpha (identifier: Q9R1V7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKPPGSISRR PTLTGCSLPG ASCGPGRCPA GPVPARAPPC RLLLVLLLLP    50
ALATSSRPRA RGAAAPSAPH WNETAEKTLG VLADEDNTLQ QNSSSRNTSY 100
SSAVQKEITL PSRLVYYINQ DSESPYHVLD TKARHQQKHN KAVHLAQASF 150
QIEAFGSKFI LDLTLNNGLL SSDYVEIHYE DGKQMYSKGG EHCYYHGSIR 200
GVKDSRVALS TCNGLHGMFE DDTFVYMIEP LELTDDEKST GRPHIIQKTL 250
AGQYSKQMKN LSTDGSDQWP LLPELQWLRR RKRAVNPSRG VFEEMKYLEL 300
MIVNDHKTYK KHRSSHAHTN NFAKSVVNLV DSIYKEQLNT RVVLVAVETW 350
TEKDHIDITI NPVQMLHDFS KYRQRIKQHA DAVHLISRVT FHYKRSSLSY 400
FGGVCSRIRG VGVNEYGLPM AVAQVLSQSL AQNLGIQWEP SSRKPKCECI 450
ESWGGCIMEE TGVSHSRKFS KCSILEYRDF LQRGGGACLF NRPTKLFEPT 500
ECGNGYVEAG EECDCGFHVE CYGVCCKKCS LSNGAHCSDG PCCNNTSCLF 550
QSRGYECRDA VNSCDITEYC TGDSGQCPPN LHKQDGYSCN QNQGRCYNGE 600
CKTRDNQCQY IWGTKAAGSD KFCYEKLNTE GTEKGNCGKD GDRWIPCSKH 650
DVFCGFLLCT NLTRAPRIGQ LQGEIIPTSF YHQGRVIDCS GAHVVLDDDT 700
DVGYVEDGTP CGPSMMCLDR KCLQIQALNM SSCPLDSRGK VCSGHGVCSN 750
EATCICDFTW AGTDCSIRDP VRNPNPPKDE GPKGPSATNL IIGSIAGAIL 800
VAAIVLGGTG WGFKNVKKRR FDPTQQGPI 829
Length:829
Mass (Da):91,548
Last modified:May 1, 2000 - v1
Checksum:iF6EBCD69DD50F53A
GO
Isoform Beta (identifier: Q9R1V7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     784-814: GPSATNLIIGSIAGAILVAAIVLGGTGWGFK → VNMATSRLIGAVAGTVLALGVIFGGTGWGIE

Show »
Length:829
Mass (Da):91,654
Checksum:i96C2C8EBC078CF58
GO
Isoform Gamma (identifier: Q9R1V7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     784-829: GPSATNLIIG...RFDPTQQGPI → ETSRRGDSIP...SAMLPELLSL

Show »
Length:829
Mass (Da):91,718
Checksum:iFFDA2310B64408E3
GO
Isoform Delta (identifier: Q9R1V7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     690-690: S → R
     691-829: Missing.

Note: No experimental confirmation available.

Show »
Length:690
Mass (Da):77,058
Checksum:i43B6B1AFABE35AB3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei690 – 6901S → R in isoform Delta. VSP_012047
Alternative sequencei691 – 829139Missing in isoform Delta. VSP_012048Add
BLAST
Alternative sequencei784 – 82946GPSAT…QQGPI → ETSRRGDSIPLSKAPSESSA LEECHLALLGSGNDMFSAML PELLSL in isoform Gamma. VSP_012049Add
BLAST
Alternative sequencei784 – 81431GPSAT…GWGFK → VNMATSRLIGAVAGTVLALG VIFGGTGWGIE in isoform Beta. VSP_012050Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61S → I in BAC28550. 1 Publication
Sequence conflicti11 – 111P → S in BAC28550. 1 Publication
Sequence conflicti19 – 224PGAS → SGTF in BAC28550. 1 Publication
Sequence conflicti30 – 301A → S in BAC28550. 1 Publication
Sequence conflicti33 – 353VPA → EPV in BAC28550. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009673 mRNA. Translation: BAA83381.1.
AK034022 mRNA. Translation: BAC28550.1.
AL645534 Genomic DNA. Translation: CAI25281.1.
AL645534, AL645637 Genomic DNA. Translation: CAI25282.1.
AL645534, AL645637 Genomic DNA. Translation: CAI25284.1.
AL645637, AL645534 Genomic DNA. Translation: CAI25456.1.
AL645637, AL645534 Genomic DNA. Translation: CAI25458.1.
AL683801 Genomic DNA. Translation: CAI26241.1.
AY545640 mRNA. Translation: AAS49900.1.
AY545641 mRNA. Translation: AAS49901.1.
CCDSiCCDS14999.1. [Q9R1V7-1]
RefSeqiNP_035910.1. NM_011780.2. [Q9R1V7-1]
XP_006496032.1. XM_006495969.1. [Q9R1V7-2]
XP_006496033.1. XM_006495970.1. [Q9R1V7-3]
UniGeneiMm.124892.

Genome annotation databases

EnsembliENSMUST00000087374; ENSMUSP00000084633; ENSMUSG00000025964. [Q9R1V7-1]
ENSMUST00000114107; ENSMUSP00000109742; ENSMUSG00000025964. [Q9R1V7-2]
GeneIDi23792.
KEGGimmu:23792.
UCSCiuc007bge.1. mouse. [Q9R1V7-4]
uc007bgg.1. mouse. [Q9R1V7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009673 mRNA. Translation: BAA83381.1 .
AK034022 mRNA. Translation: BAC28550.1 .
AL645534 Genomic DNA. Translation: CAI25281.1 .
AL645534 , AL645637 Genomic DNA. Translation: CAI25282.1 .
AL645534 , AL645637 Genomic DNA. Translation: CAI25284.1 .
AL645637 , AL645534 Genomic DNA. Translation: CAI25456.1 .
AL645637 , AL645534 Genomic DNA. Translation: CAI25458.1 .
AL683801 Genomic DNA. Translation: CAI26241.1 .
AY545640 mRNA. Translation: AAS49900.1 .
AY545641 mRNA. Translation: AAS49901.1 .
CCDSi CCDS14999.1. [Q9R1V7-1 ]
RefSeqi NP_035910.1. NM_011780.2. [Q9R1V7-1 ]
XP_006496032.1. XM_006495969.1. [Q9R1V7-2 ]
XP_006496033.1. XM_006495970.1. [Q9R1V7-3 ]
UniGenei Mm.124892.

3D structure databases

ProteinModelPortali Q9R1V7.
SMRi Q9R1V7. Positions 291-770.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204715. 1 interaction.
IntActi Q9R1V7. 3 interactions.
MINTi MINT-1177148.
STRINGi 10090.ENSMUSP00000109738.

Protein family/group databases

MEROPSi M12.979.

PTM databases

PhosphoSitei Q9R1V7.

Proteomic databases

MaxQBi Q9R1V7.
PaxDbi Q9R1V7.
PRIDEi Q9R1V7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000087374 ; ENSMUSP00000084633 ; ENSMUSG00000025964 . [Q9R1V7-1 ]
ENSMUST00000114107 ; ENSMUSP00000109742 ; ENSMUSG00000025964 . [Q9R1V7-2 ]
GeneIDi 23792.
KEGGi mmu:23792.
UCSCi uc007bge.1. mouse. [Q9R1V7-4 ]
uc007bgg.1. mouse. [Q9R1V7-1 ]

Organism-specific databases

CTDi 8745.
MGIi MGI:1345162. Adam23.

Phylogenomic databases

eggNOGi NOG256419.
GeneTreei ENSGT00680000099751.
HOGENOMi HOG000231962.
HOVERGENi HBG050456.
KOi K06837.

Miscellaneous databases

NextBioi 303395.
PROi Q9R1V7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9R1V7.
Bgeei Q9R1V7.
CleanExi MM_ADAM23.
Genevestigatori Q9R1V7.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProi IPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view ]
Pfami PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view ]
SMARTi SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57552. SSF57552. 1 hit.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23."
    Sagane K., Yamazaki K., Mizui Y., Tanaka I.
    Gene 236:79-86(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DELTA).
    Strain: C57BL/6J.
    Tissue: Diencephalon.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains."
    Sun Y.P., Deng K.J., Wang F., Zhang J., Huang X., Qiao S., Zhao S.
    Gene 325:171-178(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 666-829 (ISOFORMS ALPHA; BETA AND GAMMA), DEVELOPMENTAL STAGE.
    Strain: BALB/c.
    Tissue: Brain.
  5. "LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11."
    Sagane K., Ishihama Y., Sugimoto H.
    Int. J. Biol. Sci. 4:387-396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LGI1 AND LGI4.

Entry informationi

Entry nameiADA23_MOUSE
AccessioniPrimary (citable) accession number: Q9R1V7
Secondary accession number(s): Q6QDY9, Q6QDZ0, Q8CC33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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