Q9R1V6 (ADA22_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Disintegrin and metalloproteinase domain-containing protein 22
Short name=ADAM 22

Gene names

Name:

Adam22

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	904 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation By similarity. Neuronal receptor for LGI1. Ref.4
Subunit structure	Interacts with LGI1. Can bind to LGI4. Ref.4 Ref.6
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed at high levels in the brain. Strongly expressed in cerebellar granule cells and hippocampus. In spinal cord, expression is restricted to gray matter. Ref.3
Post-translational modification	The precursor is cleaved by a furin endopeptidase By similarity.
Disruption phenotype	Mice display severe ataxia within one week after birth and die before weaning, probably due to convulsions. They display marked hypomyelination of the peripheral nerves. Ref.3
Sequence similarities	Contains 1 disintegrin domain. Contains 1 EGF-like domain. Contains 1 peptidase M12B domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	EGF-like domain Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	adult locomotory behavior Inferred from mutant phenotype Ref.3. Source: MGI myelination in peripheral nervous system Inferred from mutant phenotype Ref.3. Source: MGI proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction Ref.6. Source: UniProtKB receptor activity Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 21 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9R1V6-3)

Also known as: ADAM22-G01; 22g;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9R1V6-4)

Also known as: ADAM22-G03; 22g(D27);

The sequence of this isoform differs from the canonical sequence as follows:
     766-801: Missing.

Isoform 3 (identifier: Q9R1V6-5)

Also known as: ADAM22-G06; 22g(D26D27);

The sequence of this isoform differs from the canonical sequence as follows:
     760-801: Missing.

Isoform 4 (identifier: Q9R1V6-6)

Also known as: ADAM22=G07; 22g(D26D27)+29.3;

The sequence of this isoform differs from the canonical sequence as follows:
     760-801: Missing.
     857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHR

Isoform 5 (identifier: Q9R1V6-7)

Also known as: ADAM22-G08; 22g(D27)+29.3;

The sequence of this isoform differs from the canonical sequence as follows:
     766-801: Missing.
     857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHR

Isoform 6 (identifier: Q9R1V6-8)

Also known as: ADAM22-G09; 22g+29.3;

The sequence of this isoform differs from the canonical sequence as follows:
     857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHR

Isoform 7 (identifier: Q9R1V6-9)

Also known as: ADAM22-G10; 22g+29.1;

The sequence of this isoform differs from the canonical sequence as follows:
     857-904: ETLSPAKSPSSSTGSIASSRKYPYPMPPLPDEGKTAGRQSARLWETSI → DLGIIT

Isoform 8 (identifier: Q9R1V6-10)

Also known as: ADAM22-G11; 22g(D27)+29.5+29.7;

The sequence of this isoform differs from the canonical sequence as follows:
     766-801: Missing.
     857-857: E → EYLNPWFKRDYNVAKWVEDVNKNTEGPYFSSQDSPHQQDR

Isoform 9 (identifier: Q9R1V6-11)

Also known as: ADAM22-G12; 22g+29.3+29.7;

The sequence of this isoform differs from the canonical sequence as follows:
     857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHRYLNPWFKRDYNVAKWVEDVNKNTEGPYFR

Isoform 10 (identifier: Q9R1V6-12)

Also known as: ADAM22-G17; 22G[27L]+29.3+29.7;

The sequence of this isoform differs from the canonical sequence as follows:
     802-802: S → SAFLSHFQISTCSITHYSISQNISLFCSRS
     857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHSSQDGPHQQDR

Isoform 11 (identifier: Q9R1V6-13)

Also known as: ADAM22-G18; 22g(D26)[27L];

The sequence of this isoform differs from the canonical sequence as follows:
     760-765: Missing.
     802-802: S → SAFLSHFQISTCSITHYSISQNISLFCSRS

Isoform 12 (identifier: Q9R1V6-14)

Also known as: ADAM22-G19; 22g[27L]+29.5;

The sequence of this isoform differs from the canonical sequence as follows:
     802-802: S → SAFLSHFQISTCSITHYSISQNISLFCSRS
     857-857: E → EYLNPWFKRDYNVAKWVEDVNKNTEGPYFR

Isoform 13 (identifier: Q9R1V6-15)

Also known as: ADAM22-G20; 22g[27L];

The sequence of this isoform differs from the canonical sequence as follows:
     802-802: S → SAFLSHFQISTCSITHYSISQNISLFCSRS

Isoform 14 (identifier: Q9R1V6-16)

Also known as: ADAM22-G21; 22g(D26)[27S];

The sequence of this isoform differs from the canonical sequence as follows:
     760-904: NYREQRQLPQ...QSARLWETSI → FPPVPSHIIP...RAPGYGRHPF

Isoform 15 (identifier: Q9R1V6-17)

Also known as: ADAM22-G22; 22g(D27)+29.7;

The sequence of this isoform differs from the canonical sequence as follows:
     766-801: Missing.
     857-857: E → DSQDGPHQQDR

Isoform 16 (identifier: Q9R1V6-18)

Also known as: ADAM22-G23; 22g(D25D26D27);

The sequence of this isoform differs from the canonical sequence as follows:
     730-904: VAGTNIIIGI...QSARLWETSI → QMDSLILGVK...RAPGYGRHPF

Isoform 17 (identifier: Q9R1V6-2)

Also known as: ADAM22-A05; Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     766-801: Missing.
     858-904: Missing.

Isoform 18 (identifier: Q9R1V6-19)

Also known as: ADAM22-A13;

The sequence of this isoform differs from the canonical sequence as follows:
     760-801: Missing.
     858-904: Missing.

Isoform 19 (identifier: Q9R1V6-20)

Also known as: ADAM22-A15;

The sequence of this isoform differs from the canonical sequence as follows:
     760-765: Missing.
     858-904: Missing.

Isoform 20 (identifier: Q9R1V6-1)

Also known as: ADAM22-A04; Alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     858-904: Missing.

Isoform 21 (identifier: Q9R1V6-21)

Also known as: ADAM22-A16;

The sequence of this isoform differs from the canonical sequence as follows:
     766-846: QLPQGDYVKK...MGGNKKKIRG → FPPVPSHIIP...DLTQLSKLYL
     847-904: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Propeptide	24 – 223	200	By similarity		PRO_0000029114
	Chain	224 – 904	681	Disintegrin and metalloproteinase domain-containing protein 22		PRO_0000029115
Regions
	Topological domain	24 – 734	711	Extracellular Potential
	Transmembrane	735 – 755	21	Helical; Potential
	Topological domain	756 – 857	102	Cytoplasmic Potential
	Domain	237 – 436	200	Peptidase M12B
	Domain	442 – 529	88	Disintegrin
	Domain	673 – 710	38	EGF-like
	Compositional bias	533 – 666	134	Cys-rich
Amino acid modifications
	Modified residue	832	1	Phosphoserine Ref.5
	Modified residue	864	1	Phosphoserine Ref.5
	Modified residue	866	1	Phosphoserine Ref.5
	Modified residue	867	1	Phosphoserine By similarity
	Modified residue	868	1	Phosphoserine By similarity
	Glycosylation	163	1	N-linked (GlcNAc...) Potential
	Glycosylation	517	1	N-linked (GlcNAc...) Potential
	Glycosylation	632	1	N-linked (GlcNAc...) Potential
	Glycosylation	673	1	N-linked (GlcNAc...) Potential
	Disulfide bond	347 ↔ 431		By similarity
	Disulfide bond	390 ↔ 415		By similarity
	Disulfide bond	392 ↔ 399		By similarity
	Disulfide bond	445 ↔ 475		By similarity
	Disulfide bond	456 ↔ 472		By similarity
	Disulfide bond	458 ↔ 464		By similarity
	Disulfide bond	471 ↔ 492		By similarity
	Disulfide bond	483 ↔ 489		By similarity
	Disulfide bond	488 ↔ 514		By similarity
	Disulfide bond	501 ↔ 521		By similarity
	Disulfide bond	508 ↔ 540		By similarity
	Disulfide bond	533 ↔ 545		By similarity
	Disulfide bond	552 ↔ 603		By similarity
	Disulfide bond	567 ↔ 633		By similarity
	Disulfide bond	581 ↔ 591		By similarity
	Disulfide bond	598 ↔ 661		By similarity
	Disulfide bond	655 ↔ 666		By similarity
	Disulfide bond	677 ↔ 692		By similarity
	Disulfide bond	686 ↔ 698		By similarity
	Disulfide bond	700 ↔ 709		By similarity
Natural variations
	Alternative sequence	730 – 904	175	VAGTN…WETSI → QMDSLILGVKGFQTQNIFQT SVKMGDLAVTPGKVTWEATK RKSEGKDLDLDLTQLRPCHL PSLLLHQLGLLPPAENTRTL CLRFQTRGRQRADRAPGYGR HPF in isoform 16.		VSP_018233
	Alternative sequence	760 – 904	145	NYREQ…WETSI → FPPVPSHIIPLVRTFHYFAA GQMDSLILGVKGFQTQNIFQ TSVKMGDLAVTPGKVTWEAT KRKSEGKDLDLDLTQLRPCH LPSLLLHQLGLLPPAENTRT LCLRFQTRGRQRADRAPGYG RHPF in isoform 14.		VSP_018234
	Alternative sequence	760 – 801	42	Missing in isoform 3, isoform 4 and isoform 18.		VSP_018235
	Alternative sequence	760 – 765	6	Missing in isoform 11 and isoform 19.		VSP_018236
	Alternative sequence	766 – 846	81	QLPQG…KKIRG → FPPVPSHIIPLVRTFHYFAA GQMDSLILGVKGFQTQNIFQ TSVKMGDLAVTPGKVTWEAT KRKSEGKDLDLDLTQLSKLY L in isoform 21.		VSP_018237
	Alternative sequence	766 – 801	36	Missing in isoform 2, isoform 5, isoform 8, isoform 15 and isoform 17.		VSP_018238
	Alternative sequence	802	1	S → SAFLSHFQISTCSITHYSIS QNISLFCSRS in isoform 10, isoform 11, isoform 12 and isoform 13.		VSP_018239
	Alternative sequence	847 – 904	58	Missing in isoform 21.		VSP_018240
	Alternative sequence	857 – 904	48	ETLSP…WETSI → DLGIIT in isoform 7.		VSP_018241
	Alternative sequence	857	1	E → EREPQAPEPGHSLAQTIPSQ GISPGGSDSPQTGSLDHSSQ DGPHQQDR in isoform 10.		VSP_018242
	Alternative sequence	857	1	E → EYLNPWFKRDYNVAKWVEDV NKNTEGPYFR in isoform 12.		VSP_018243
	Alternative sequence	857	1	E → DSQDGPHQQDR in isoform 15.		VSP_018244
	Alternative sequence	857	1	E → EREPQAPEPGHSLAQTIPSQ GISPGGSDSPQTGSLDHR in isoform 4, isoform 5 and isoform 6.		VSP_018245
	Alternative sequence	857	1	E → EYLNPWFKRDYNVAKWVEDV NKNTEGPYFSSQDSPHQQDR in isoform 8.		VSP_018246
	Alternative sequence	857	1	E → EREPQAPEPGHSLAQTIPSQ GISPGGSDSPQTGSLDHRYL NPWFKRDYNVAKWVEDVNKN TEGPYFR in isoform 9.		VSP_018247
	Alternative sequence	858 – 904	47	Missing in isoform 17, isoform 18, isoform 19 and isoform 20.		VSP_018248
Experimental info
	Mutagenesis	509	1	D → N: Fails to bind to LGI1. Ref.4
	Sequence conflict	639	1	K → R in BAC28742. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (ADAM22-G01) (22g) [UniParc]. Last modified May 2, 2006. Version 2. Checksum: 0FBBD09398EE0B97	FASTA	904	99,715
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRQLPQG DYVKKPGDGD 790 800 810 820 830 840 SFYSDFPPGG STNSASSSKK RSNGLSHSWS ERIPDTKHIS DICENGRPRS NSWQGNMGGN 850 860 870 880 890 900 KKKIRGKRFR PRSNSTETLS PAKSPSSSTG SIASSRKYPY PMPPLPDEGK TAGRQSARLW ETSI
	Isoform 2 (ADAM22-G03) (22g(D27)) [UniParc]. Checksum: C0FA966057D2C5C8	FASTA	868	95,927
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRSNGLS HSWSERIPDT 790 800 810 820 830 840 KHISDICENG RPRSNSWQGN MGGNKKKIRG KRFRPRSNST ETLSPAKSPS SSTGSIASSR 850 860 KYPYPMPPLP DEGKTAGRQS ARLWETSI
	Isoform 3 (ADAM22-G06) (22g(D26D27)) [UniParc]. Checksum: 17E4012489871450	FASTA	862	95,080
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKS NGLSHSWSER IPDTKHISDI 790 800 810 820 830 840 CENGRPRSNS WQGNMGGNKK KIRGKRFRPR SNSTETLSPA KSPSSSTGSI ASSRKYPYPM 850 860 PPLPDEGKTA GRQSARLWET SI
	Isoform 4 (ADAM22=G07) (22g(D26D27)+29.3) [UniParc]. Checksum: DAFB8A148524416E	FASTA	899	98,855
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKS NGLSHSWSER IPDTKHISDI 790 800 810 820 830 840 CENGRPRSNS WQGNMGGNKK KIRGKRFRPR SNSTEREPQA PEPGHSLAQT IPSQGISPGG 850 860 870 880 890 SDSPQTGSLD HRTLSPAKSP SSSTGSIASS RKYPYPMPPL PDEGKTAGRQ SARLWETSI
	Isoform 5 (ADAM22-G08) (22g(D27)+29.3) [UniParc]. Checksum: 6AAA73D541AFB536	FASTA	905	99,702
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRSNGLS HSWSERIPDT 790 800 810 820 830 840 KHISDICENG RPRSNSWQGN MGGNKKKIRG KRFRPRSNST EREPQAPEPG HSLAQTIPSQ 850 860 870 880 890 900 GISPGGSDSP QTGSLDHRTL SPAKSPSSST GSIASSRKYP YPMPPLPDEG KTAGRQSARL WETSI
	Isoform 6 (ADAM22-G09) (22g+29.3) [UniParc]. Checksum: D23B93F0032CBBCF	FASTA	941	103,490
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRQLPQG DYVKKPGDGD 790 800 810 820 830 840 SFYSDFPPGG STNSASSSKK RSNGLSHSWS ERIPDTKHIS DICENGRPRS NSWQGNMGGN 850 860 870 880 890 900 KKKIRGKRFR PRSNSTEREP QAPEPGHSLA QTIPSQGISP GGSDSPQTGS LDHRTLSPAK 910 920 930 940 SPSSSTGSIA SSRKYPYPMP PLPDEGKTAG RQSARLWETS I
	Isoform 7 (ADAM22-G10) (22g+29.1) [UniParc]. Checksum: 30A066885BBA38FB	FASTA	862	95,224
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRQLPQG DYVKKPGDGD 790 800 810 820 830 840 SFYSDFPPGG STNSASSSKK RSNGLSHSWS ERIPDTKHIS DICENGRPRS NSWQGNMGGN 850 860 KKKIRGKRFR PRSNSTDLGI IT
	Isoform 8 (ADAM22-G11) (22g(D27)+29.5+29.7) [UniParc]. Checksum: E228AF65D914F778	FASTA	907	100,669
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRSNGLS HSWSERIPDT 790 800 810 820 830 840 KHISDICENG RPRSNSWQGN MGGNKKKIRG KRFRPRSNST EYLNPWFKRD YNVAKWVEDV 850 860 870 880 890 900 NKNTEGPYFS SQDSPHQQDR TLSPAKSPSS STGSIASSRK YPYPMPPLPD EGKTAGRQSA RLWETSI
	Isoform 9 (ADAM22-G12) (22g+29.3+29.7) [UniParc]. Checksum: ABBCD4AD024F349B	FASTA	970	107,122
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRQLPQG DYVKKPGDGD 790 800 810 820 830 840 SFYSDFPPGG STNSASSSKK RSNGLSHSWS ERIPDTKHIS DICENGRPRS NSWQGNMGGN 850 860 870 880 890 900 KKKIRGKRFR PRSNSTEREP QAPEPGHSLA QTIPSQGISP GGSDSPQTGS LDHRYLNPWF 910 920 930 940 950 960 KRDYNVAKWV EDVNKNTEGP YFRTLSPAKS PSSSTGSIAS SRKYPYPMPP LPDEGKTAGR 970 QSARLWETSI
	Isoform 10 (ADAM22-G17) (22G[27L]+29.3+29.7) [UniParc]. Checksum: 45BE20975A1D5820	FASTA	980	107,831
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRQLPQG DYVKKPGDGD 790 800 810 820 830 840 SFYSDFPPGG STNSASSSKK RSAFLSHFQI STCSITHYSI SQNISLFCSR SNGLSHSWSE 850 860 870 880 890 900 RIPDTKHISD ICENGRPRSN SWQGNMGGNK KKIRGKRFRP RSNSTEREPQ APEPGHSLAQ 910 920 930 940 950 960 TIPSQGISPG GSDSPQTGSL DHSSQDGPHQ QDRTLSPAKS PSSSTGSIAS SRKYPYPMPP 970 980 LPDEGKTAGR QSARLWETSI
	Isoform 11 (ADAM22-G18) (22g(D26)[27L]) [UniParc]. Checksum: BD4C6B317C47EFAB	FASTA	927	102,129
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKQ LPQGDYVKKP GDGDSFYSDF 790 800 810 820 830 840 PPGGSTNSAS SSKKRSAFLS HFQISTCSIT HYSISQNISL FCSRSNGLSH SWSERIPDTK 850 860 870 880 890 900 HISDICENGR PRSNSWQGNM GGNKKKIRGK RFRPRSNSTE TLSPAKSPSS STGSIASSRK 910 920 YPYPMPPLPD EGKTAGRQSA RLWETSI
	Isoform 12 (ADAM22-G19) (22g[27L]+29.5) [UniParc]. Checksum: D77057A06FD2A7E4	FASTA	962	106,608
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRQLPQG DYVKKPGDGD 790 800 810 820 830 840 SFYSDFPPGG STNSASSSKK RSAFLSHFQI STCSITHYSI SQNISLFCSR SNGLSHSWSE 850 860 870 880 890 900 RIPDTKHISD ICENGRPRSN SWQGNMGGNK KKIRGKRFRP RSNSTEYLNP WFKRDYNVAK 910 920 930 940 950 960 WVEDVNKNTE GPYFRTLSPA KSPSSSTGSI ASSRKYPYPM PPLPDEGKTA GRQSARLWET SI
	Isoform 13 (ADAM22-G20) (22g[27L]) [UniParc]. Checksum: 1052AC188694EDFC	FASTA	933	102,976
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRQLPQG DYVKKPGDGD 790 800 810 820 830 840 SFYSDFPPGG STNSASSSKK RSAFLSHFQI STCSITHYSI SQNISLFCSR SNGLSHSWSE 850 860 870 880 890 900 RIPDTKHISD ICENGRPRSN SWQGNMGGNK KKIRGKRFRP RSNSTETLSP AKSPSSSTGS 910 920 930 IASSRKYPYP MPPLPDEGKT AGRQSARLWE TSI
	Isoform 14 (ADAM22-G21) (22g(D26)[27S]) [UniParc]. Checksum: C3A2C695E08B72F9	FASTA	883	97,640
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKF PPVPSHIIPL VRTFHYFAAG 790 800 810 820 830 840 QMDSLILGVK GFQTQNIFQT SVKMGDLAVT PGKVTWEATK RKSEGKDLDL DLTQLRPCHL 850 860 870 880 PSLLLHQLGL LPPAENTRTL CLRFQTRGRQ RADRAPGYGR HPF
	Isoform 15 (ADAM22-G22) (22g(D27)+29.7) [UniParc]. Checksum: 251D63D6D6CAF0A3	FASTA	878	97,062
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRSNGLS HSWSERIPDT 790 800 810 820 830 840 KHISDICENG RPRSNSWQGN MGGNKKKIRG KRFRPRSNST DSQDGPHQQD RTLSPAKSPS 850 860 870 SSTGSIASSR KYPYPMPPLP DEGKTAGRQS ARLWETSI
	Isoform 16 (ADAM22-G23) (22g(D25D26D27)) [UniParc]. Checksum: 6BB6F0B5CA150F28	FASTA	832	92,271
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGQ MDSLILGVKG FQTQNIFQTS VKMGDLAVTP GKVTWEATKR KSEGKDLDLD 790 800 810 820 830 LTQLRPCHLP SLLLHQLGLL PPAENTRTLC LRFQTRGRQR ADRAPGYGRH PF
	Isoform 17 (ADAM22-A05) (Beta) [UniParc]. Checksum: 4F8F12B425EB683C	FASTA	821	90,952
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRSNGLS HSWSERIPDT 790 800 810 820 KHISDICENG RPRSNSWQGN MGGNKKKIRG KRFRPRSNST E
	Isoform 18 (ADAM22-A13) [UniParc]. Checksum: 59F2A397E25E283F	FASTA	815	90,105
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKS NGLSHSWSER IPDTKHISDI 790 800 810 CENGRPRSNS WQGNMGGNKK KIRGKRFRPR SNSTE
	Isoform 19 (ADAM22-A15) [UniParc]. Checksum: B1A6A8713614459E	FASTA	851	93,893
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKQ LPQGDYVKKP GDGDSFYSDF 790 800 810 820 830 840 PPGGSTNSAS SSKKRSNGLS HSWSERIPDT KHISDICENG RPRSNSWQGN MGGNKKKIRG 850 KRFRPRSNST E
	Isoform 20 (ADAM22-A04) (Alpha) [UniParc]. Checksum: CB88FB7000208E09	FASTA	857	94,740
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRQLPQG DYVKKPGDGD 790 800 810 820 830 840 SFYSDFPPGG STNSASSSKK RSNGLSHSWS ERIPDTKHIS DICENGRPRS NSWQGNMGGN 850 KKKIRGKRFR PRSNSTE
	Isoform 21 (ADAM22-A16) [UniParc]. Checksum: 08A647F010B67028	FASTA	846	93,592
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRFPPVP SHIIPLVRTF 790 800 810 820 830 840 HYFAAGQMDS LILGVKGFQT QNIFQTSVKM GDLAVTPGKV TWEATKRKSE GKDLDLDLTQ LSKLYL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23." Sagane K., Yamazaki K., Mizui Y., Tanaka I. Gene 236:79-86(1999) [PubMed: 10433968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 17 AND 20). Tissue: Brain.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-904 (ISOFORM 2). Strain: C57BL/6J. Tissue: Embryo.
[3]	"Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice." Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T. BMC Neurosci. 6:33-33(2005) [PubMed: 15876356] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[4]	"Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission." Fukata Y., Adesnik H., Iwanaga T., Bredt D.S., Nicoll R.A., Fukata M. Science 313:1792-1795(2006) [PubMed: 16990550] [Abstract] Cited for: FUNCTION, INTERACTION WITH LGI1, MUTAGENESIS OF ASP-509.
[5]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed: 17114649] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832; SER-864 AND SER-866, MASS SPECTROMETRY. Tissue: Brain cortex.
[6]	"LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11." Sagane K., Ishihama Y., Sugimoto H. Int. J. Biol. Sci. 4:387-396(2008) [PubMed: 18974846] [Abstract] Cited for: INTERACTION WITH LIGI1 AND LGI4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB009674 mRNA. Translation: BAA83382.1. AB009674 mRNA. Translation: BAA83383.1. AK034528 mRNA. Translation: BAC28742.1. AB179842 mRNA. Translation: BAD72803.1. AB179843 mRNA. Translation: BAD72804.1. AB179844 mRNA. Translation: BAD72805.1. AB179845 mRNA. Translation: BAD72806.1. AB179846 mRNA. Translation: BAD72807.1. AB179847 mRNA. Translation: BAD72808.1. AB179848 mRNA. Translation: BAD72809.1. AB179849 mRNA. Translation: BAD72810.1. AB179850 mRNA. Translation: BAD72811.1. AB179851 mRNA. Translation: BAD72812.1. AB179852 mRNA. Translation: BAD72813.1. AB179853 mRNA. Translation: BAD72814.1. AB179854 mRNA. Translation: BAD72815.1. AB179855 mRNA. Translation: BAD72816.1. AB179856 mRNA. Translation: BAD72817.1. AB179857 mRNA. Translation: BAD72818.1. AB179858 mRNA. Translation: BAD72819.1. AB179859 mRNA. Translation: BAD72820.1. AB179860 mRNA. Translation: BAD72821.1. AB179861 mRNA. Translation: BAD72822.1. AB179862 mRNA. Translation: BAD72823.1.
IPI	IPI00378796. IPI00379467. IPI00404650. IPI00515160. IPI00515396. IPI00515509. IPI00515580. IPI00515604. IPI00515681. IPI00623219. IPI00627016. IPI00749834. IPI00752301. IPI00752342. IPI00753070. IPI00753519. IPI00753532. IPI00753983. IPI00754961. IPI00755165. IPI01008448.
RefSeq	NP_001007221.1. NM_001007220.2. NP_001007222.1. NM_001007221.2. NP_001091695.1. NM_001098225.1.
UniGene	Mm.275895.
3D structure databases
ProteinModelPortal	Q9R1V6.
SMR	Q9R1V6. Positions 231-716.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9R1V6. 4 interactions.
STRING	Q9R1V6.
Protein family/group databases
MEROPS	M12.978.
PTM databases
PhosphoSite	Q9R1V6.
Proteomic databases
PRIDE	Q9R1V6.
Protocols and materials databases
DNASU	11496.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000046838; ENSMUSP00000049120; ENSMUSG00000040537. ENSMUST00000050166; ENSMUSP00000055000; ENSMUSG00000040537. ENSMUST00000078296; ENSMUSP00000077412; ENSMUSG00000040537. ENSMUST00000088744; ENSMUSP00000086122; ENSMUSG00000040537. ENSMUST00000088745; ENSMUSP00000086123; ENSMUSG00000040537. ENSMUST00000088746; ENSMUSP00000086124; ENSMUSG00000040537. ENSMUST00000088752; ENSMUSP00000086130; ENSMUSG00000040537. ENSMUST00000088761; ENSMUSP00000086139; ENSMUSG00000040537. ENSMUST00000088762; ENSMUSP00000086140; ENSMUSG00000040537. ENSMUST00000102987; ENSMUSP00000100052; ENSMUSG00000040537. ENSMUST00000115388; ENSMUSP00000111046; ENSMUSG00000040537.
GeneID	11496.
KEGG	mmu:11496.
UCSC	uc008wjv.1. mouse. uc008wjy.1. mouse. uc008wjz.1. mouse.
Organism-specific databases
CTD	53616.
MGI	MGI:1340046. Adam22.
Phylogenomic databases
eggNOG	NOG256419.
GeneTree	ENSGT00650000092917.
HOVERGEN	HBG050456.
OMA	VHLFSGS.
OrthoDB	EOG44J2HD.
Gene expression databases
ArrayExpress	Q9R1V6.
Bgee	Q9R1V6.
CleanEx	MM_ADAM22.
Genevestigator	Q9R1V6.
GermOnline	ENSMUSG00000040537. Mus musculus.
Family and domain databases
Gene3D	G3DSA:4.10.70.10. Blood-coag_inhib_Disintegrin. 1 hit. G3DSA:3.40.390.10. G3DSA:3.40.390.10. 1 hit.
InterPro	IPR006586. ADAM_Cys-rich. IPR001762. Blood-coag_inhib_Disintegrin. IPR018358. Disintegrin_CS. IPR000742. EG-like_dom. IPR006210. EGF-like. IPR013032. EGF-like_reg_CS. IPR024079. MetalloPept_cat_dom. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. [Graphical view]
Pfam	PF08516. ADAM_CR. 1 hit. PF00200. Disintegrin. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. [Graphical view]
PRINTS	PR00289. DISINTEGRIN.
SMART	SM00608. ACR. 1 hit. SM00050. DISIN. 1 hit. SM00181. EGF. 1 hit. [Graphical view]
SUPFAM	SSF57552. Disintegrin. 1 hit.
PROSITE	PS50215. ADAM_MEPRO. 1 hit. PS00427. DISINTEGRIN_1. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. PS00022. EGF_1. 1 hit. PS01186. EGF_2. False negative. PS50026. EGF_3. 1 hit. PS00142. ZINC_PROTEASE. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	278878.
SOURCE	Search...

Entry information

Entry name

ADA22_MOUSE

Accession

Primary (citable) accession number: Q9R1V6
Secondary accession number(s): Q5TLI8 , Q5TLI9, Q5TLJ0, Q5TLJ1, Q5TLJ2, Q5TLJ3, Q5TLJ4, Q5TLJ5, Q5TLJ6, Q5TLJ7, Q5TLJ8, Q5TLJ9, Q5TLK0, Q5TLK1, Q5TLK2, Q5TLK3, Q5TLK4, Q5TLK5, Q5TLK6, Q5TLK7, Q5TLK8, Q8BSF2, Q9R1V5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	May 2, 2006
Last modified:	April 18, 2012
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program