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Q9R1V6 - ADA22_MOUSE

UniProt

Q9R1V6 - ADA22_MOUSE

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Protein

Disintegrin and metalloproteinase domain-containing protein 22

Gene

Adam22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1.By similarity1 Publication

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. adult locomotory behavior Source: MGI
  2. gliogenesis Source: MGI
  3. myelination in peripheral nervous system Source: MGI
  4. Schwann cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Protein family/group databases

MEROPSiM12.978.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 22
Short name:
ADAM 22
Gene namesi
Name:Adam22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1340046. Adam22.

Subcellular locationi

Membrane 1 Publication; Single-pass type I membrane protein Curated. Cell projection › axon 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 734711ExtracellularSequence AnalysisAdd
BLAST
Transmembranei735 – 75521HelicalSequence AnalysisAdd
BLAST
Topological domaini756 – 857102CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display severe ataxia within one week after birth and die before weaning, probably due to convulsions. They display marked hypomyelination of the peripheral nerves.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi509 – 5091D → N: Fails to bind to LGI1. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 223200By similarityPRO_0000029114Add
BLAST
Chaini224 – 904681Disintegrin and metalloproteinase domain-containing protein 22PRO_0000029115Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi347 ↔ 431By similarity
Disulfide bondi390 ↔ 415By similarity
Disulfide bondi392 ↔ 399By similarity
Disulfide bondi445 ↔ 475By similarity
Disulfide bondi456 ↔ 472By similarity
Disulfide bondi458 ↔ 464By similarity
Disulfide bondi471 ↔ 492By similarity
Disulfide bondi483 ↔ 489By similarity
Disulfide bondi488 ↔ 514By similarity
Disulfide bondi501 ↔ 521By similarity
Disulfide bondi508 ↔ 540By similarity
Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi533 ↔ 545By similarity
Disulfide bondi552 ↔ 603By similarity
Disulfide bondi567 ↔ 633By similarity
Disulfide bondi581 ↔ 591By similarity
Disulfide bondi598 ↔ 661By similarity
Glycosylationi632 – 6321N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi655 ↔ 666By similarity
Glycosylationi673 – 6731N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi677 ↔ 692By similarity
Disulfide bondi686 ↔ 698By similarity
Disulfide bondi700 ↔ 709By similarity
Modified residuei832 – 8321PhosphoserineBy similarity

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9R1V6.
PaxDbiQ9R1V6.
PRIDEiQ9R1V6.

PTM databases

PhosphoSiteiQ9R1V6.

Expressioni

Tissue specificityi

Detected in juxtaparanodal zones in the central nervous system and at nerve terminal plexuses of basket cells in the cerebellum (at protein level) (PubMed:20089912). Expressed at high levels in the brain. Strongly expressed in cerebellar granule cells and hippocampus. In spinal cord, expression is restricted to gray matter.2 Publications

Gene expression databases

BgeeiQ9R1V6.
CleanExiMM_ADAM22.
ExpressionAtlasiQ9R1V6. baseline and differential.
GenevestigatoriQ9R1V6.

Interactioni

Subunit structurei

Interacts with LGI1 (PubMed:18974846, PubMed:20089912). Can bind to LGI4(PubMed:18974846). Interacts with KCNA2, DLG2 and DLG4 (PubMed:20089912).3 Publications

Protein-protein interaction databases

IntActiQ9R1V6. 5 interactions.
MINTiMINT-4086922.

Structurei

3D structure databases

ProteinModelPortaliQ9R1V6.
SMRiQ9R1V6. Positions 231-716.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini237 – 436200Peptidase M12BPROSITE-ProRule annotationAdd
BLAST
Domaini442 – 52988DisintegrinPROSITE-ProRule annotationAdd
BLAST
Domaini673 – 71038EGF-likePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi533 – 666134Cys-richAdd
BLAST

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256419.
GeneTreeiENSGT00760000119181.
HOVERGENiHBG050456.
InParanoidiQ9R1V6.
KOiK16068.
OMAiFSGSQFE.
OrthoDBiEOG7B31M6.
PhylomeDBiQ9R1V6.
TreeFamiTF314733.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequences (21)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 21 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9R1V6-3) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-G01, 22g

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP 
        60         70         80         90        100
LRLIYRLGGE DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL 
       110        120        130        140        150
DVLLNHELLS SGYVERQIEH GGKVVENKGG EHCYYQGQIR GNPVSFVALS 
       160        170        180        190        200
TCHGLHGMFY DGNHTYLIEP EENEKSQESS HCHSVYKSRQ FEFPLDDLPS 
       210        220        230        240        250
EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE LMIVNDHLMF 
       260        270        280        290        300
KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 
       310        320        330        340        350
ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL 
       360        370        380        390        400
RGGGVNEFGK TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI 
       410        420        430        440        450
MGDTGYYLPK KFTQCNVEEY HDFLNSGGGA CLFNKPSKLL DPPECGNGFI 
       460        470        480        490        500
ETGEECDCGT PAECALEGAE CCKKCTLTQD SQCSDGLCCK KCKFQPLGTV 
       510        520        530        540        550
CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC FGGRCKTRDR 
       560        570        580        590        600
QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 
       610        620        630        640        650
LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE 
       660        670        680        690        700
DGTPCGPQMM CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC 
       710        720        730        740        750
NRHWTGADCG THFPHNDDAK TGITLSGNGV AGTNIIIGII AGTILVLALI 
       760        770        780        790        800
LGITAWGYKN YREQRQLPQG DYVKKPGDGD SFYSDFPPGG STNSASSSKK 
       810        820        830        840        850
RSNGLSHSWS ERIPDTKHIS DICENGRPRS NSWQGNMGGN KKKIRGKRFR 
       860        870        880        890        900
PRSNSTETLS PAKSPSSSTG SIASSRKYPY PMPPLPDEGK TAGRQSARLW 

ETSI
Length:904
Mass (Da):99,715
Last modified:May 2, 2006 - v2
Checksum:i0FBBD09398EE0B97
GO
Isoform 2 (identifier: Q9R1V6-4) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-G03, 22g(D27)

The sequence of this isoform differs from the canonical sequence as follows:
     766-801: Missing.

Show »
Length:868
Mass (Da):95,927
Checksum:iC0FA966057D2C5C8
GO
Isoform 3 (identifier: Q9R1V6-5) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-G06, 22g(D26D27)

The sequence of this isoform differs from the canonical sequence as follows:
     760-801: Missing.

Show »
Length:862
Mass (Da):95,080
Checksum:i17E4012489871450
GO
Isoform 4 (identifier: Q9R1V6-6) [UniParc]FASTAAdd to Basket

Also known as: ADAM22=G07, 22g(D26D27)+29.3

The sequence of this isoform differs from the canonical sequence as follows:
     760-801: Missing.
     857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHR

Show »
Length:899
Mass (Da):98,855
Checksum:iDAFB8A148524416E
GO
Isoform 5 (identifier: Q9R1V6-7) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-G08, 22g(D27)+29.3

The sequence of this isoform differs from the canonical sequence as follows:
     766-801: Missing.
     857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHR

Show »
Length:905
Mass (Da):99,702
Checksum:i6AAA73D541AFB536
GO
Isoform 6 (identifier: Q9R1V6-8) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-G09, 22g+29.3

The sequence of this isoform differs from the canonical sequence as follows:
     857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHR

Show »
Length:941
Mass (Da):103,490
Checksum:iD23B93F0032CBBCF
GO
Isoform 7 (identifier: Q9R1V6-9) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-G10, 22g+29.1

The sequence of this isoform differs from the canonical sequence as follows:
     857-904: ETLSPAKSPSSSTGSIASSRKYPYPMPPLPDEGKTAGRQSARLWETSI → DLGIIT

Show »
Length:862
Mass (Da):95,224
Checksum:i30A066885BBA38FB
GO
Isoform 8 (identifier: Q9R1V6-10) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-G11, 22g(D27)+29.5+29.7

The sequence of this isoform differs from the canonical sequence as follows:
     766-801: Missing.
     857-857: E → EYLNPWFKRDYNVAKWVEDVNKNTEGPYFSSQDSPHQQDR

Show »
Length:907
Mass (Da):100,669
Checksum:iE228AF65D914F778
GO
Isoform 9 (identifier: Q9R1V6-11) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-G12, 22g+29.3+29.7

The sequence of this isoform differs from the canonical sequence as follows:
     857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHRYLNPWFKRDYNVAKWVEDVNKNTEGPYFR

Show »
Length:970
Mass (Da):107,122
Checksum:iABBCD4AD024F349B
GO
Isoform 10 (identifier: Q9R1V6-12) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-G17, 22G[27L]+29.3+29.7

The sequence of this isoform differs from the canonical sequence as follows:
     802-802: S → SAFLSHFQISTCSITHYSISQNISLFCSRS
     857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHSSQDGPHQQDR

Show »
Length:980
Mass (Da):107,831
Checksum:i45BE20975A1D5820
GO
Isoform 11 (identifier: Q9R1V6-13) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-G18, 22g(D26)[27L]

The sequence of this isoform differs from the canonical sequence as follows:
     760-765: Missing.
     802-802: S → SAFLSHFQISTCSITHYSISQNISLFCSRS

Show »
Length:927
Mass (Da):102,129
Checksum:iBD4C6B317C47EFAB
GO
Isoform 12 (identifier: Q9R1V6-14) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-G19, 22g[27L]+29.5

The sequence of this isoform differs from the canonical sequence as follows:
     802-802: S → SAFLSHFQISTCSITHYSISQNISLFCSRS
     857-857: E → EYLNPWFKRDYNVAKWVEDVNKNTEGPYFR

Show »
Length:962
Mass (Da):106,608
Checksum:iD77057A06FD2A7E4
GO
Isoform 13 (identifier: Q9R1V6-15) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-G20, 22g[27L]

The sequence of this isoform differs from the canonical sequence as follows:
     802-802: S → SAFLSHFQISTCSITHYSISQNISLFCSRS

Show »
Length:933
Mass (Da):102,976
Checksum:i1052AC188694EDFC
GO
Isoform 14 (identifier: Q9R1V6-16) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-G21, 22g(D26)[27S]

The sequence of this isoform differs from the canonical sequence as follows:
     760-904: NYREQRQLPQ...QSARLWETSI → FPPVPSHIIP...RAPGYGRHPF

Show »
Length:883
Mass (Da):97,640
Checksum:iC3A2C695E08B72F9
GO
Isoform 15 (identifier: Q9R1V6-17) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-G22, 22g(D27)+29.7

The sequence of this isoform differs from the canonical sequence as follows:
     766-801: Missing.
     857-857: E → DSQDGPHQQDR

Show »
Length:878
Mass (Da):97,062
Checksum:i251D63D6D6CAF0A3
GO
Isoform 16 (identifier: Q9R1V6-18) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-G23, 22g(D25D26D27)

The sequence of this isoform differs from the canonical sequence as follows:
     730-904: VAGTNIIIGI...QSARLWETSI → QMDSLILGVK...RAPGYGRHPF

Show »
Length:832
Mass (Da):92,271
Checksum:i6BB6F0B5CA150F28
GO
Isoform 17 (identifier: Q9R1V6-2) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-A05, Beta

The sequence of this isoform differs from the canonical sequence as follows:
     766-801: Missing.
     858-904: Missing.

Show »
Length:821
Mass (Da):90,952
Checksum:i4F8F12B425EB683C
GO
Isoform 18 (identifier: Q9R1V6-19) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-A13

The sequence of this isoform differs from the canonical sequence as follows:
     760-801: Missing.
     858-904: Missing.

Show »
Length:815
Mass (Da):90,105
Checksum:i59F2A397E25E283F
GO
Isoform 19 (identifier: Q9R1V6-20) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-A15

The sequence of this isoform differs from the canonical sequence as follows:
     760-765: Missing.
     858-904: Missing.

Show »
Length:851
Mass (Da):93,893
Checksum:iB1A6A8713614459E
GO
Isoform 20 (identifier: Q9R1V6-1) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-A04, Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     858-904: Missing.

Show »
Length:857
Mass (Da):94,740
Checksum:iCB88FB7000208E09
GO
Isoform 21 (identifier: Q9R1V6-21) [UniParc]FASTAAdd to Basket

Also known as: ADAM22-A16

The sequence of this isoform differs from the canonical sequence as follows:
     766-846: QLPQGDYVKK...MGGNKKKIRG → FPPVPSHIIP...DLTQLSKLYL
     847-904: Missing.

Show »
Length:846
Mass (Da):93,592
Checksum:i08A647F010B67028
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti639 – 6391K → R in BAC28742. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei730 – 904175VAGTN…WETSI → QMDSLILGVKGFQTQNIFQT SVKMGDLAVTPGKVTWEATK RKSEGKDLDLDLTQLRPCHL PSLLLHQLGLLPPAENTRTL CLRFQTRGRQRADRAPGYGR HPF in isoform 16. 1 PublicationVSP_018233Add
BLAST
Alternative sequencei760 – 904145NYREQ…WETSI → FPPVPSHIIPLVRTFHYFAA GQMDSLILGVKGFQTQNIFQ TSVKMGDLAVTPGKVTWEAT KRKSEGKDLDLDLTQLRPCH LPSLLLHQLGLLPPAENTRT LCLRFQTRGRQRADRAPGYG RHPF in isoform 14. 1 PublicationVSP_018234Add
BLAST
Alternative sequencei760 – 80142Missing in isoform 3, isoform 4 and isoform 18. 1 PublicationVSP_018235Add
BLAST
Alternative sequencei760 – 7656Missing in isoform 11 and isoform 19. 1 PublicationVSP_018236
Alternative sequencei766 – 84681QLPQG…KKIRG → FPPVPSHIIPLVRTFHYFAA GQMDSLILGVKGFQTQNIFQ TSVKMGDLAVTPGKVTWEAT KRKSEGKDLDLDLTQLSKLY L in isoform 21. 1 PublicationVSP_018237Add
BLAST
Alternative sequencei766 – 80136Missing in isoform 2, isoform 5, isoform 8, isoform 15 and isoform 17. 3 PublicationsVSP_018238Add
BLAST
Alternative sequencei802 – 8021S → SAFLSHFQISTCSITHYSIS QNISLFCSRS in isoform 10, isoform 11, isoform 12 and isoform 13. 1 PublicationVSP_018239
Alternative sequencei847 – 90458Missing in isoform 21. 1 PublicationVSP_018240Add
BLAST
Alternative sequencei857 – 90448ETLSP…WETSI → DLGIIT in isoform 7. 1 PublicationVSP_018241Add
BLAST
Alternative sequencei857 – 8571E → EREPQAPEPGHSLAQTIPSQ GISPGGSDSPQTGSLDHSSQ DGPHQQDR in isoform 10. 1 PublicationVSP_018242
Alternative sequencei857 – 8571E → EYLNPWFKRDYNVAKWVEDV NKNTEGPYFR in isoform 12. 1 PublicationVSP_018243
Alternative sequencei857 – 8571E → DSQDGPHQQDR in isoform 15. 1 PublicationVSP_018244
Alternative sequencei857 – 8571E → EREPQAPEPGHSLAQTIPSQ GISPGGSDSPQTGSLDHR in isoform 4, isoform 5 and isoform 6. 1 PublicationVSP_018245
Alternative sequencei857 – 8571E → EYLNPWFKRDYNVAKWVEDV NKNTEGPYFSSQDSPHQQDR in isoform 8. 1 PublicationVSP_018246
Alternative sequencei857 – 8571E → EREPQAPEPGHSLAQTIPSQ GISPGGSDSPQTGSLDHRYL NPWFKRDYNVAKWVEDVNKN TEGPYFR in isoform 9. 1 PublicationVSP_018247
Alternative sequencei858 – 90447Missing in isoform 17, isoform 18, isoform 19 and isoform 20. 2 PublicationsVSP_018248Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009674 mRNA. Translation: BAA83382.1.
AB009674 mRNA. Translation: BAA83383.1.
AK034528 mRNA. Translation: BAC28742.1.
AB179842 mRNA. Translation: BAD72803.1.
AB179843 mRNA. Translation: BAD72804.1.
AB179844 mRNA. Translation: BAD72805.1.
AB179845 mRNA. Translation: BAD72806.1.
AB179846 mRNA. Translation: BAD72807.1.
AB179847 mRNA. Translation: BAD72808.1.
AB179848 mRNA. Translation: BAD72809.1.
AB179849 mRNA. Translation: BAD72810.1.
AB179850 mRNA. Translation: BAD72811.1.
AB179851 mRNA. Translation: BAD72812.1.
AB179852 mRNA. Translation: BAD72813.1.
AB179853 mRNA. Translation: BAD72814.1.
AB179854 mRNA. Translation: BAD72815.1.
AB179855 mRNA. Translation: BAD72816.1.
AB179856 mRNA. Translation: BAD72817.1.
AB179857 mRNA. Translation: BAD72818.1.
AB179858 mRNA. Translation: BAD72819.1.
AB179859 mRNA. Translation: BAD72820.1.
AB179860 mRNA. Translation: BAD72821.1.
AB179861 mRNA. Translation: BAD72822.1.
AB179862 mRNA. Translation: BAD72823.1.
CCDSiCCDS19080.1. [Q9R1V6-1]
CCDS51411.1. [Q9R1V6-4]
RefSeqiNP_001007221.1. NM_001007220.2. [Q9R1V6-1]
NP_001007222.1. NM_001007221.2. [Q9R1V6-2]
NP_001091695.1. NM_001098225.1. [Q9R1V6-4]
XP_006503592.1. XM_006503529.1. [Q9R1V6-12]
XP_006503593.1. XM_006503530.1. [Q9R1V6-11]
XP_006503594.1. XM_006503531.1. [Q9R1V6-14]
XP_006503596.1. XM_006503533.1. [Q9R1V6-8]
XP_006503598.1. XM_006503535.1. [Q9R1V6-15]
XP_006503600.1. XM_006503537.1. [Q9R1V6-7]
XP_006503601.1. XM_006503538.1. [Q9R1V6-3]
XP_006503602.1. XM_006503539.1. [Q9R1V6-6]
XP_006503605.1. XM_006503542.1. [Q9R1V6-5]
UniGeneiMm.275895.

Genome annotation databases

EnsembliENSMUST00000046838; ENSMUSP00000049120; ENSMUSG00000040537. [Q9R1V6-1]
ENSMUST00000050166; ENSMUSP00000055000; ENSMUSG00000040537. [Q9R1V6-4]
ENSMUST00000088744; ENSMUSP00000086122; ENSMUSG00000040537. [Q9R1V6-13]
ENSMUST00000088761; ENSMUSP00000086139; ENSMUSG00000040537. [Q9R1V6-3]
ENSMUST00000115388; ENSMUSP00000111046; ENSMUSG00000040537. [Q9R1V6-6]
GeneIDi11496.
KEGGimmu:11496.
UCSCiuc008wjk.2. mouse. [Q9R1V6-3]
uc008wjv.1. mouse. [Q9R1V6-4]
uc008wjy.1. mouse. [Q9R1V6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009674 mRNA. Translation: BAA83382.1.
AB009674 mRNA. Translation: BAA83383.1.
AK034528 mRNA. Translation: BAC28742.1.
AB179842 mRNA. Translation: BAD72803.1.
AB179843 mRNA. Translation: BAD72804.1.
AB179844 mRNA. Translation: BAD72805.1.
AB179845 mRNA. Translation: BAD72806.1.
AB179846 mRNA. Translation: BAD72807.1.
AB179847 mRNA. Translation: BAD72808.1.
AB179848 mRNA. Translation: BAD72809.1.
AB179849 mRNA. Translation: BAD72810.1.
AB179850 mRNA. Translation: BAD72811.1.
AB179851 mRNA. Translation: BAD72812.1.
AB179852 mRNA. Translation: BAD72813.1.
AB179853 mRNA. Translation: BAD72814.1.
AB179854 mRNA. Translation: BAD72815.1.
AB179855 mRNA. Translation: BAD72816.1.
AB179856 mRNA. Translation: BAD72817.1.
AB179857 mRNA. Translation: BAD72818.1.
AB179858 mRNA. Translation: BAD72819.1.
AB179859 mRNA. Translation: BAD72820.1.
AB179860 mRNA. Translation: BAD72821.1.
AB179861 mRNA. Translation: BAD72822.1.
AB179862 mRNA. Translation: BAD72823.1.
CCDSiCCDS19080.1. [Q9R1V6-1]
CCDS51411.1. [Q9R1V6-4]
RefSeqiNP_001007221.1. NM_001007220.2. [Q9R1V6-1]
NP_001007222.1. NM_001007221.2. [Q9R1V6-2]
NP_001091695.1. NM_001098225.1. [Q9R1V6-4]
XP_006503592.1. XM_006503529.1. [Q9R1V6-12]
XP_006503593.1. XM_006503530.1. [Q9R1V6-11]
XP_006503594.1. XM_006503531.1. [Q9R1V6-14]
XP_006503596.1. XM_006503533.1. [Q9R1V6-8]
XP_006503598.1. XM_006503535.1. [Q9R1V6-15]
XP_006503600.1. XM_006503537.1. [Q9R1V6-7]
XP_006503601.1. XM_006503538.1. [Q9R1V6-3]
XP_006503602.1. XM_006503539.1. [Q9R1V6-6]
XP_006503605.1. XM_006503542.1. [Q9R1V6-5]
UniGeneiMm.275895.

3D structure databases

ProteinModelPortaliQ9R1V6.
SMRiQ9R1V6. Positions 231-716.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9R1V6. 5 interactions.
MINTiMINT-4086922.

Protein family/group databases

MEROPSiM12.978.

PTM databases

PhosphoSiteiQ9R1V6.

Proteomic databases

MaxQBiQ9R1V6.
PaxDbiQ9R1V6.
PRIDEiQ9R1V6.

Protocols and materials databases

DNASUi11496.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046838; ENSMUSP00000049120; ENSMUSG00000040537. [Q9R1V6-1]
ENSMUST00000050166; ENSMUSP00000055000; ENSMUSG00000040537. [Q9R1V6-4]
ENSMUST00000088744; ENSMUSP00000086122; ENSMUSG00000040537. [Q9R1V6-13]
ENSMUST00000088761; ENSMUSP00000086139; ENSMUSG00000040537. [Q9R1V6-3]
ENSMUST00000115388; ENSMUSP00000111046; ENSMUSG00000040537. [Q9R1V6-6]
GeneIDi11496.
KEGGimmu:11496.
UCSCiuc008wjk.2. mouse. [Q9R1V6-3]
uc008wjv.1. mouse. [Q9R1V6-4]
uc008wjy.1. mouse. [Q9R1V6-2]

Organism-specific databases

CTDi53616.
MGIiMGI:1340046. Adam22.

Phylogenomic databases

eggNOGiNOG256419.
GeneTreeiENSGT00760000119181.
HOVERGENiHBG050456.
InParanoidiQ9R1V6.
KOiK16068.
OMAiFSGSQFE.
OrthoDBiEOG7B31M6.
PhylomeDBiQ9R1V6.
TreeFamiTF314733.

Miscellaneous databases

ChiTaRSiAdam22. mouse.
NextBioi278878.
PROiQ9R1V6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R1V6.
CleanExiMM_ADAM22.
ExpressionAtlasiQ9R1V6. baseline and differential.
GenevestigatoriQ9R1V6.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23."
    Sagane K., Yamazaki K., Mizui Y., Tanaka I.
    Gene 236:79-86(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 17 AND 20).
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-904 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Embryo.
  3. "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice."
    Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T.
    BMC Neurosci. 6:33-33(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  4. "Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission."
    Fukata Y., Adesnik H., Iwanaga T., Bredt D.S., Nicoll R.A., Fukata M.
    Science 313:1792-1795(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH LGI1, MUTAGENESIS OF ASP-509.
  5. "LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11."
    Sagane K., Ishihama Y., Sugimoto H.
    Int. J. Biol. Sci. 4:387-396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LIGI1 AND LGI4.
  6. "ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons."
    Ogawa Y., Oses-Prieto J., Kim M.Y., Horresh I., Peles E., Burlingame A.L., Trimmer J.S., Meijer D., Rasband M.N.
    J. Neurosci. 30:1038-1048(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KCNA2; LGI1; DLG2 AND DLG4, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Entry informationi

Entry nameiADA22_MOUSE
AccessioniPrimary (citable) accession number: Q9R1V6
Secondary accession number(s): Q5TLI8
, Q5TLI9, Q5TLJ0, Q5TLJ1, Q5TLJ2, Q5TLJ3, Q5TLJ4, Q5TLJ5, Q5TLJ6, Q5TLJ7, Q5TLJ8, Q5TLJ9, Q5TLK0, Q5TLK1, Q5TLK2, Q5TLK3, Q5TLK4, Q5TLK5, Q5TLK6, Q5TLK7, Q5TLK8, Q8BSF2, Q9R1V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 2, 2006
Last modified: February 4, 2015
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.