Reviewed, UniProtKB/Swiss-Prot Q9R1V6 (ADA22_MOUSE)

Names and origin

Protein names

Recommended name:
    ADAM 22
Alternative name(s):
    A disintegrin and metalloproteinase domain 22

Gene names

Name:

Adam22

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	904 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed at high levels in the brain. Strongly expressed in cerebellar granule cells and hippocampus. In spinal cord, expression is restricted to gray matter.
Post-translational modification	The precursor is cleaved by a furin endopeptidase By similarity.
Miscellaneous	Mice lacking Adam22 display severe ataxia within one week after birth and die before weaning, probably due to convulsions. They display marked hypomyelination of the peripheral nerves.
Sequence similarities	Contains 1 disintegrin domain. Contains 1 EGF-like domain. Contains 1 peptidase M12B domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	EGF-like domain Signal Transmembrane
PTM	Cleavage on pair of basic residues Glycoprotein Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 21 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9R1V6-3)

Also known as: ADAM22-G01; 22g;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9R1V6-4)

Also known as: ADAM22-G03; 22g(D27);

The sequence of this isoform differs from the canonical sequence as follows:
     766-801: Missing.

Isoform 3 (identifier: Q9R1V6-5)

Also known as: ADAM22-G06; 22g(D26D27);

The sequence of this isoform differs from the canonical sequence as follows:
     760-801: Missing.

Isoform 4 (identifier: Q9R1V6-6)

Also known as: ADAM22=G07; 22g(D26D27)+29.3;

The sequence of this isoform differs from the canonical sequence as follows:
     760-801: Missing.
     857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHR

Isoform 5 (identifier: Q9R1V6-7)

Also known as: ADAM22-G08; 22g(D27)+29.3;

The sequence of this isoform differs from the canonical sequence as follows:
     766-801: Missing.
     857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHR

Isoform 6 (identifier: Q9R1V6-8)

Also known as: ADAM22-G09; 22g+29.3;

The sequence of this isoform differs from the canonical sequence as follows:
     857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHR

Isoform 7 (identifier: Q9R1V6-9)

Also known as: ADAM22-G10; 22g+29.1;

The sequence of this isoform differs from the canonical sequence as follows:
     857-904: ETLSPAKSPSSSTGSIASSRKYPYPMPPLPDEGKTAGRQSARLWETSI → DLGIIT

Isoform 8 (identifier: Q9R1V6-10)

Also known as: ADAM22-G11; 22g(D27)+29.5+29.7;

The sequence of this isoform differs from the canonical sequence as follows:
     766-801: Missing.
     857-857: E → EYLNPWFKRDYNVAKWVEDVNKNTEGPYFSSQDSPHQQDR

Isoform 9 (identifier: Q9R1V6-11)

Also known as: ADAM22-G12; 22g+29.3+29.7;

The sequence of this isoform differs from the canonical sequence as follows:
     857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHRYLNPWFKRDYNVAKWVEDVNKNTEGPYFR

Isoform 10 (identifier: Q9R1V6-12)

Also known as: ADAM22-G17; 22G[27L]+29.3+29.7;

The sequence of this isoform differs from the canonical sequence as follows:
     802-802: S → SAFLSHFQISTCSITHYSISQNISLFCSRS
     857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHSSQDGPHQQDR

Isoform 11 (identifier: Q9R1V6-13)

Also known as: ADAM22-G18; 22g(D26)[27L];

The sequence of this isoform differs from the canonical sequence as follows:
     760-765: Missing.
     802-802: S → SAFLSHFQISTCSITHYSISQNISLFCSRS

Isoform 12 (identifier: Q9R1V6-14)

Also known as: ADAM22-G19; 22g[27L]+29.5;

The sequence of this isoform differs from the canonical sequence as follows:
     802-802: S → SAFLSHFQISTCSITHYSISQNISLFCSRS
     857-857: E → EYLNPWFKRDYNVAKWVEDVNKNTEGPYFR

Isoform 13 (identifier: Q9R1V6-15)

Also known as: ADAM22-G20; 22g[27L];

The sequence of this isoform differs from the canonical sequence as follows:
     802-802: S → SAFLSHFQISTCSITHYSISQNISLFCSRS

Isoform 14 (identifier: Q9R1V6-16)

Also known as: ADAM22-G21; 22g(D26)[27S];

The sequence of this isoform differs from the canonical sequence as follows:
     760-904: NYREQRQLPQ...QSARLWETSI → FPPVPSHIIP...RAPGYGRHPF

Isoform 15 (identifier: Q9R1V6-17)

Also known as: ADAM22-G22; 22g(D27)+29.7;

The sequence of this isoform differs from the canonical sequence as follows:
     766-801: Missing.
     857-857: E → DSQDGPHQQDR

Isoform 16 (identifier: Q9R1V6-18)

Also known as: ADAM22-G23; 22g(D25D26D27);

The sequence of this isoform differs from the canonical sequence as follows:
     730-904: VAGTNIIIGI...QSARLWETSI → QMDSLILGVK...RAPGYGRHPF

Isoform 17 (identifier: Q9R1V6-2)

Also known as: ADAM22-A05; Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     766-801: Missing.
     858-904: Missing.

Isoform 18 (identifier: Q9R1V6-19)

Also known as: ADAM22-A13;

The sequence of this isoform differs from the canonical sequence as follows:
     760-801: Missing.
     858-904: Missing.

Isoform 19 (identifier: Q9R1V6-20)

Also known as: ADAM22-A15;

The sequence of this isoform differs from the canonical sequence as follows:
     760-765: Missing.
     858-904: Missing.

Isoform 20 (identifier: Q9R1V6-1)

Also known as: ADAM22-A04; Alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     858-904: Missing.

Isoform 21 (identifier: Q9R1V6-21)

Also known as: ADAM22-A16;

The sequence of this isoform differs from the canonical sequence as follows:
     766-846: QLPQGDYVKK...MGGNKKKIRG → FPPVPSHIIP...DLTQLSKLYL
     847-904: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Propeptide	24 – 223	200	By similarity
	Chain	224 – 904	681	ADAM 22
Regions
	Topological domain	24 – 734	711	Extracellular Potential
	Transmembrane	735 – 755	21	Potential
	Topological domain	756 – 857	102	Cytoplasmic Potential
	Domain	237 – 436	200	Peptidase M12B
	Domain	442 – 529	88	Disintegrin
	Domain	673 – 710	38	EGF-like
	Compositional bias	533 – 666	134	Cys-rich
Amino acid modifications
	Modified residue	832	1	Phosphoserine
	Modified residue	864	1	Phosphoserine
	Modified residue	866	1	Phosphoserine
	Glycosylation	163	1	N-linked (GlcNAc...) Potential
	Glycosylation	517	1	N-linked (GlcNAc...) Potential
	Glycosylation	632	1	N-linked (GlcNAc...) Potential
	Glycosylation	673	1	N-linked (GlcNAc...) Potential
	Disulfide bond	347 ↔ 431		By similarity
	Disulfide bond	390 ↔ 415		By similarity
	Disulfide bond	392 ↔ 399		By similarity
	Disulfide bond	501 ↔ 521		By similarity
	Disulfide bond	677 ↔ 692		By similarity
	Disulfide bond	686 ↔ 698		By similarity
	Disulfide bond	700 ↔ 709		By similarity
Natural variations
	Alternative sequence	730 – 904	175	VAGTN…WETSI → QMDSLILGVKGFQTQNIFQT SVKMGDLAVTPGKVTWEATK RKSEGKDLDLDLTQLRPCHL PSLLLHQLGLLPPAENTRTL CLRFQTRGRQRADRAPGYGR HPF in isoform 16.
	Alternative sequence	760 – 904	145	NYREQ…WETSI → FPPVPSHIIPLVRTFHYFAA GQMDSLILGVKGFQTQNIFQ TSVKMGDLAVTPGKVTWEAT KRKSEGKDLDLDLTQLRPCH LPSLLLHQLGLLPPAENTRT LCLRFQTRGRQRADRAPGYG RHPF in isoform 14.
	Alternative sequence	760 – 801	42	Missing in isoform 3, isoform 4 and isoform 18.
	Alternative sequence	760 – 765	6	Missing in isoform 11 and isoform 19.
	Alternative sequence	766 – 846	81	QLPQG…KKIRG → FPPVPSHIIPLVRTFHYFAA GQMDSLILGVKGFQTQNIFQ TSVKMGDLAVTPGKVTWEAT KRKSEGKDLDLDLTQLSKLY L in isoform 21.
	Alternative sequence	766 – 801	36	Missing in isoform 2, isoform 5, isoform 8, isoform 15 and isoform 17.
	Alternative sequence	802	1	S → SAFLSHFQISTCSITHYSIS QNISLFCSRS in isoform 10, isoform 11, isoform 12 and isoform 13.
	Alternative sequence	847 – 904	58	Missing in isoform 21.
	Alternative sequence	857 – 904	48	ETLSP…WETSI → DLGIIT in isoform 7.
	Alternative sequence	857	1	E → EREPQAPEPGHSLAQTIPSQ GISPGGSDSPQTGSLDHSSQ DGPHQQDR in isoform 10.
	Alternative sequence	857	1	E → EYLNPWFKRDYNVAKWVEDV NKNTEGPYFR in isoform 12.
	Alternative sequence	857	1	E → DSQDGPHQQDR in isoform 15.
	Alternative sequence	857	1	E → EREPQAPEPGHSLAQTIPSQ GISPGGSDSPQTGSLDHR in isoform 4, isoform 5 and isoform 6.
	Alternative sequence	857	1	E → EYLNPWFKRDYNVAKWVEDV NKNTEGPYFSSQDSPHQQDR in isoform 8.
	Alternative sequence	857	1	E → EREPQAPEPGHSLAQTIPSQ GISPGGSDSPQTGSLDHRYL NPWFKRDYNVAKWVEDVNKN TEGPYFR in isoform 9.
	Alternative sequence	858 – 904	47	Missing in isoform 17, isoform 18, isoform 19 and isoform 20.
Experimental info
	Sequence conflict	639	1	K → R in BAC28742. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (ADAM22-G01) (22g) [UniParc]. Last modified May 2, 2006. Version 2. Checksum: 0FBBD09398EE0B97	FASTA	904	99,715
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRQLPQG DYVKKPGDGD 790 800 810 820 830 840 SFYSDFPPGG STNSASSSKK RSNGLSHSWS ERIPDTKHIS DICENGRPRS NSWQGNMGGN 850 860 870 880 890 900 KKKIRGKRFR PRSNSTETLS PAKSPSSSTG SIASSRKYPY PMPPLPDEGK TAGRQSARLW ETSI
	Isoform 2 (ADAM22-G03) (22g(D27)) [UniParc]. Checksum: C0FA966057D2C5C8		868	95,927
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRSNGLS HSWSERIPDT 790 800 810 820 830 840 KHISDICENG RPRSNSWQGN MGGNKKKIRG KRFRPRSNST ETLSPAKSPS SSTGSIASSR 850 860 KYPYPMPPLP DEGKTAGRQS ARLWETSI
	Isoform 3 (ADAM22-G06) (22g(D26D27)) [UniParc]. Checksum: 17E4012489871450		862	95,080
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKS NGLSHSWSER IPDTKHISDI 790 800 810 820 830 840 CENGRPRSNS WQGNMGGNKK KIRGKRFRPR SNSTETLSPA KSPSSSTGSI ASSRKYPYPM 850 860 PPLPDEGKTA GRQSARLWET SI
	Isoform 4 (ADAM22=G07) (22g(D26D27)+29.3) [UniParc]. Checksum: DAFB8A148524416E		899	98,855
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKS NGLSHSWSER IPDTKHISDI 790 800 810 820 830 840 CENGRPRSNS WQGNMGGNKK KIRGKRFRPR SNSTEREPQA PEPGHSLAQT IPSQGISPGG 850 860 870 880 890 SDSPQTGSLD HRTLSPAKSP SSSTGSIASS RKYPYPMPPL PDEGKTAGRQ SARLWETSI
	Isoform 5 (ADAM22-G08) (22g(D27)+29.3) [UniParc]. Checksum: 6AAA73D541AFB536		905	99,702
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRSNGLS HSWSERIPDT 790 800 810 820 830 840 KHISDICENG RPRSNSWQGN MGGNKKKIRG KRFRPRSNST EREPQAPEPG HSLAQTIPSQ 850 860 870 880 890 900 GISPGGSDSP QTGSLDHRTL SPAKSPSSST GSIASSRKYP YPMPPLPDEG KTAGRQSARL WETSI
	Isoform 6 (ADAM22-G09) (22g+29.3) [UniParc]. Checksum: D23B93F0032CBBCF		941	103,490
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRQLPQG DYVKKPGDGD 790 800 810 820 830 840 SFYSDFPPGG STNSASSSKK RSNGLSHSWS ERIPDTKHIS DICENGRPRS NSWQGNMGGN 850 860 870 880 890 900 KKKIRGKRFR PRSNSTEREP QAPEPGHSLA QTIPSQGISP GGSDSPQTGS LDHRTLSPAK 910 920 930 940 SPSSSTGSIA SSRKYPYPMP PLPDEGKTAG RQSARLWETS I
	Isoform 7 (ADAM22-G10) (22g+29.1) [UniParc]. Checksum: 30A066885BBA38FB		862	95,224
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRQLPQG DYVKKPGDGD 790 800 810 820 830 840 SFYSDFPPGG STNSASSSKK RSNGLSHSWS ERIPDTKHIS DICENGRPRS NSWQGNMGGN 850 860 KKKIRGKRFR PRSNSTDLGI IT
	Isoform 8 (ADAM22-G11) (22g(D27)+29.5+29.7) [UniParc]. Checksum: E228AF65D914F778		907	100,669
	10 20 30 40 50 60 MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE 70 80 90 100 110 120 DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH 130 140 150 160 170 180 GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS 190 200 210 220 230 240 HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE 250 260 270 280 290 300 LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS 310 320 330 340 350 360 ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK 370 380 390 400 410 420 TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY 430 440 450 460 470 480 HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD 490 500 510 520 530 540 SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC 550 560 570 580 590 600 FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY 610 620 630 640 650 660 LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM 670 680 690 700 710 720 CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK 730 740 750 760 770 780 TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRSNGLS HSWSERIPDT 790 800 810 820 830 840 KHISDICENG RPRSNSWQGN MGGNKKKIRG KRFRPRSNST EYLNPWFKRD YNVAKWVEDV 850 860 870 880 890 900 NKNTEGPYFS SQDSPHQQDR TLSPAKSPSS STGSIASSRK YPYPMPPLPD EGKTAGRQSA RLWETSI
	Isoform 9 (ADAM22-G12) (22g+29.3+29.7) [UniParc]. Checksum: ABBCD4AD024F349B		970	107,122