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Entry version 142 (07 Sep 2016)
Sequence version 2 (02 May 2006)
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Protein

Disintegrin and metalloproteinase domain-containing protein 22

Gene

Adam22

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein levelⁱ

Functionⁱ

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1.By similarity1 Publication

GO - Molecular functionⁱ

metalloendopeptidase activity Source: InterPro
zinc ion binding Source: InterPro

GO - Biological processⁱ

adult locomotory behavior
Source: MGI
Inferred from mutant phenotypeⁱ
- 15876356
gliogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 21068328
myelination in peripheral nervous system
Source: MGI
Inferred from mutant phenotypeⁱ
- 15876356
- 20220021
Schwann cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 15876356

Complete GO annotation...

Keywords - Molecular functionⁱ

Receptor

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5682910. LGI-ADAM interactions.

Reactomeⁱ

R-MMU-5682910. LGI-ADAM interactions.

Protein family/group databases

MEROPSⁱ	M12.978.

MEROPSⁱ

M12.978.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Disintegrin and metalloproteinase domain-containing protein 22 Short name: ADAM 22
Gene namesⁱ	Name:Adam22
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:1340046. Adam22.

Subcellular locationⁱ

Membrane
1 Publication
Manual assertion based on experiment inⁱ
- Ref.7
  "ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons."
  Ogawa Y., Oses-Prieto J., Kim M.Y., Horresh I., Peles E., Burlingame A.L., Trimmer J.S., Meijer D., Rasband M.N.
  J. Neurosci. 30:1038-1048(2010) [PubMed] [Europe PMC] [Abstract]
  Cited for: INTERACTION WITH KCNA2; LGI1; DLG2 AND DLG4, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
; Single-pass type I membrane protein Curated
Cell projection › axon
1 Publication
Manual assertion based on experiment inⁱ
- Ref.7
  "ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons."
  Ogawa Y., Oses-Prieto J., Kim M.Y., Horresh I., Peles E., Burlingame A.L., Trimmer J.S., Meijer D., Rasband M.N.
  J. Neurosci. 30:1038-1048(2010) [PubMed] [Europe PMC] [Abstract]
  Cited for: INTERACTION WITH KCNA2; LGI1; DLG2 AND DLG4, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Topology

Feature key	Position(s)	Length	Description	Actions
Topological domainⁱ	24 – 734	711	ExtracellularSequence analysis	Add BLAST
Transmembraneⁱ	735 – 755	21	HelicalSequence analysis	Add BLAST
Topological domainⁱ	756 – 857	102	CytoplasmicSequence analysis	Add BLAST

GO - Cellular componentⁱ

axon
Source: UniProtKB
Inferred from direct assayⁱ
- 20089912
integral component of membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 20089912

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell projection, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice display severe ataxia within one week after birth and die before weaning, probably due to convulsions. They display marked hypomyelination of the peripheral nerves.1 Publication

Mutagenesis

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Mutagenesisⁱ	509 – 509	1	D → N: Fails to bind to LGI1. 1 Publication Manual assertion based on experiment inⁱ Ref.4 "Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission." Fukata Y., Adesnik H., Iwanaga T., Bredt D.S., Nicoll R.A., Fukata M. Science 313:1792-1795(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH LGI1, MUTAGENESIS OF ASP-509.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Feature identifier	Actions
Signal peptideⁱ	1 – 23	23	Sequence analysis		Add BLAST
Propeptideⁱ	24 – 223	200	By similarity	PRO_0000029114	Add BLAST
Chainⁱ	224 – 904	681	Disintegrin and metalloproteinase domain-containing protein 22	PRO_0000029115	Add BLAST

Amino acid modifications

Feature key	Position(s)	Length	Description
Glycosylationⁱ	163 – 163	1	N-linked (GlcNAc...)Sequence analysis
Disulfide bondⁱ	347 ↔ 431		By similarity
Disulfide bondⁱ	390 ↔ 415		By similarity
Disulfide bondⁱ	392 ↔ 399		By similarity
Disulfide bondⁱ	445 ↔ 475		By similarity
Disulfide bondⁱ	456 ↔ 472		By similarity
Disulfide bondⁱ	458 ↔ 464		By similarity
Disulfide bondⁱ	471 ↔ 492		By similarity
Disulfide bondⁱ	483 ↔ 489		By similarity
Disulfide bondⁱ	488 ↔ 514		By similarity
Disulfide bondⁱ	501 ↔ 521		By similarity
Disulfide bondⁱ	508 ↔ 540		By similarity
Glycosylationⁱ	517 – 517	1	N-linked (GlcNAc...)Sequence analysis
Disulfide bondⁱ	533 ↔ 545		By similarity
Disulfide bondⁱ	552 ↔ 603		By similarity
Disulfide bondⁱ	567 ↔ 633		By similarity
Disulfide bondⁱ	581 ↔ 591		By similarity
Disulfide bondⁱ	598 ↔ 661		By similarity
Glycosylationⁱ	632 – 632	1	N-linked (GlcNAc...)Sequence analysis
Disulfide bondⁱ	655 ↔ 666		By similarity
Glycosylationⁱ	673 – 673	1	N-linked (GlcNAc...)Sequence analysis
Disulfide bondⁱ	677 ↔ 692		By similarity
Disulfide bondⁱ	686 ↔ 698		By similarity
Disulfide bondⁱ	700 ↔ 709		By similarity
Modified residueⁱ	808 – 808	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.6 "A tissue-specific atlas of mouse protein phosphorylation and expression." Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P. Cell 143:1174-1189(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-808; SER-832; SER-855; SER-860; SER-864 AND SER-868, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-882 (ISOFORM 12), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-817 (ISOFORM 8), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	832 – 832	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.6 "A tissue-specific atlas of mouse protein phosphorylation and expression." Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P. Cell 143:1174-1189(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-808; SER-832; SER-855; SER-860; SER-864 AND SER-868, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-882 (ISOFORM 12), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-817 (ISOFORM 8), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	855 – 855	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.6 "A tissue-specific atlas of mouse protein phosphorylation and expression." Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P. Cell 143:1174-1189(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-808; SER-832; SER-855; SER-860; SER-864 AND SER-868, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-882 (ISOFORM 12), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-817 (ISOFORM 8), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	860 – 860	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.6 "A tissue-specific atlas of mouse protein phosphorylation and expression." Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P. Cell 143:1174-1189(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-808; SER-832; SER-855; SER-860; SER-864 AND SER-868, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-882 (ISOFORM 12), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-817 (ISOFORM 8), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	864 – 864	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.6 "A tissue-specific atlas of mouse protein phosphorylation and expression." Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P. Cell 143:1174-1189(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-808; SER-832; SER-855; SER-860; SER-864 AND SER-868, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-882 (ISOFORM 12), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-817 (ISOFORM 8), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Modified residueⁱ	868 – 868	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.6 "A tissue-specific atlas of mouse protein phosphorylation and expression." Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P. Cell 143:1174-1189(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-808; SER-832; SER-855; SER-860; SER-864 AND SER-868, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-882 (ISOFORM 12), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-817 (ISOFORM 8), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Isoform 8 (identifier: Q9R1V6-10)
Modified residueⁱ	817 – 817	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.6 "A tissue-specific atlas of mouse protein phosphorylation and expression." Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P. Cell 143:1174-1189(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-808; SER-832; SER-855; SER-860; SER-864 AND SER-868, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-882 (ISOFORM 12), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-817 (ISOFORM 8), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Isoform 12 (identifier: Q9R1V6-14)
Modified residueⁱ	882 – 882	1	PhosphoserineCombined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ Ref.6 "A tissue-specific atlas of mouse protein phosphorylation and expression." Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P. Cell 143:1174-1189(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-808; SER-832; SER-855; SER-860; SER-864 AND SER-868, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-882 (ISOFORM 12), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-817 (ISOFORM 8), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Post-translational modificationⁱ

The precursor is cleaved by a furin endopeptidase.By similarity

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBⁱ	Q9R1V6.
PaxDbⁱ	Q9R1V6.
PeptideAtlasⁱ	Q9R1V6.
PRIDEⁱ	Q9R1V6.

PTM databases

iPTMnetⁱ	Q9R1V6.
PhosphoSiteⁱ	Q9R1V6.

Expressionⁱ

Tissue specificityⁱ

Detected in juxtaparanodal zones in the central nervous system and at nerve terminal plexuses of basket cells in the cerebellum (at protein level) (PubMed:20089912). Expressed at high levels in the brain. Strongly expressed in cerebellar granule cells and hippocampus. In spinal cord, expression is restricted to gray matter.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000040537.
CleanExⁱ	MM_ADAM22.
ExpressionAtlasⁱ	Q9R1V6. baseline and differential.
Genevisibleⁱ	Q9R1V6. MM.

Interactionⁱ

Subunit structureⁱ

Interacts with LGI1 (PubMed:18974846, PubMed:20089912). Can bind to LGI4(PubMed:18974846). Interacts with KCNA2, DLG2 and DLG4 (PubMed:20089912).3 Publications

Protein-protein interaction databases

IntActⁱ	Q9R1V6. 5 interactions.
MINTⁱ	MINT-4086922.
STRINGⁱ	10090.ENSMUSP00000055000.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9R1V6.
SMRⁱ	Q9R1V6. Positions 231-716.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Actions
Domainⁱ	237 – 436	200	Peptidase M12BPROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00276	Add BLAST
Domainⁱ	442 – 529	88	DisintegrinPROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00068	Add BLAST
Domainⁱ	673 – 710	38	EGF-likePROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00076	Add BLAST

Compositional bias

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Compositional biasⁱ	533 – 666	134	Cys-rich			Add BLAST

Sequence similaritiesⁱ

Contains 1 disintegrin domain.PROSITE-ProRule annotation

Contains 1 EGF-like domain.PROSITE-ProRule annotation

Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domainⁱ

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3607. Eukaryota. ENOG410XX2M. LUCA.
GeneTreeⁱ	ENSGT00800000124044.
HOVERGENⁱ	HBG050456.
InParanoidⁱ	Q9R1V6.
KOⁱ	K16068.
OMAⁱ	KYIWGQK.
OrthoDBⁱ	EOG091G010C.
PhylomeDBⁱ	Q9R1V6.
TreeFamⁱ	TF314733.

Family and domain databases

Gene3Dⁱ	3.40.390.10. 1 hit. 4.10.70.10. 1 hit.
InterProⁱ	IPR006586. ADAM_Cys-rich. IPR018358. Disintegrin_CS. IPR001762. Disintegrin_dom. IPR013032. EGF-like_CS. IPR000742. EGF-like_dom. IPR013111. EGF_extracell. IPR024079. MetalloPept_cat_dom. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. [Graphical view]
Pfamⁱ	PF08516. ADAM_CR. 1 hit. PF00200. Disintegrin. 1 hit. PF07974. EGF_2. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. [Graphical view]
PRINTSⁱ	PR00289. DISINTEGRIN.
SMARTⁱ	SM00608. ACR. 1 hit. SM00050. DISIN. 1 hit. [Graphical view]
SUPFAMⁱ	SSF57552. SSF57552. 1 hit.
PROSITEⁱ	PS50215. ADAM_MEPRO. 1 hit. PS00427. DISINTEGRIN_1. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. PS00022. EGF_1. 1 hit. PS50026. EGF_3. 1 hit. [Graphical view]

Sequences (21)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 21 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Experimental Info

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Sequence conflictⁱ	639 – 639	1	K → R in BAC28742 (PubMed:16141072).Curated

Alternative sequence

Feature key	Position(s)	Length	Description	Feature identifier	Actions
Alternative sequenceⁱ	730 – 904	175	VAGTN…WETSI → QMDSLILGVKGFQTQNIFQT SVKMGDLAVTPGKVTWEATK RKSEGKDLDLDLTQLRPCHL PSLLLHQLGLLPPAENTRTL CLRFQTRGRQRADRAPGYGR HPF in isoform 16. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice." Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T. BMC Neurosci. 6:33-33(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.	VSP_018233	Add BLAST
Alternative sequenceⁱ	760 – 904	145	NYREQ…WETSI → FPPVPSHIIPLVRTFHYFAA GQMDSLILGVKGFQTQNIFQ TSVKMGDLAVTPGKVTWEAT KRKSEGKDLDLDLTQLRPCH LPSLLLHQLGLLPPAENTRT LCLRFQTRGRQRADRAPGYG RHPF in isoform 14. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice." Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T. BMC Neurosci. 6:33-33(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.	VSP_018234	Add BLAST
Alternative sequenceⁱ	760 – 801	42	Missing in isoform 3, isoform 4 and isoform 18. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice." Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T. BMC Neurosci. 6:33-33(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.	VSP_018235	Add BLAST
Alternative sequenceⁱ	760 – 765	6	Missing in isoform 11 and isoform 19. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice." Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T. BMC Neurosci. 6:33-33(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.	VSP_018236
Alternative sequenceⁱ	766 – 846	81	QLPQG…KKIRG → FPPVPSHIIPLVRTFHYFAA GQMDSLILGVKGFQTQNIFQ TSVKMGDLAVTPGKVTWEAT KRKSEGKDLDLDLTQLSKLY L in isoform 21. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice." Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T. BMC Neurosci. 6:33-33(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.	VSP_018237	Add BLAST
Alternative sequenceⁱ	766 – 801	36	Missing in isoform 2, isoform 5, isoform 8, isoform 15 and isoform 17. 3 Publications Manual assertion based on opinion inⁱ Ref.1 "Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23." Sagane K., Yamazaki K., Mizui Y., Tanaka I. Gene 236:79-86(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 17 AND 20). Ref.2 "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-904 (ISOFORM 2). Ref.3 "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice." Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T. BMC Neurosci. 6:33-33(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.	VSP_018238	Add BLAST
Alternative sequenceⁱ	802 – 802	1	S → SAFLSHFQISTCSITHYSIS QNISLFCSRS in isoform 10, isoform 11, isoform 12 and isoform 13. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice." Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T. BMC Neurosci. 6:33-33(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.	VSP_018239
Alternative sequenceⁱ	847 – 904	58	Missing in isoform 21. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice." Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T. BMC Neurosci. 6:33-33(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.	VSP_018240	Add BLAST
Alternative sequenceⁱ	857 – 904	48	ETLSP…WETSI → DLGIIT in isoform 7. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice." Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T. BMC Neurosci. 6:33-33(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.	VSP_018241	Add BLAST
Alternative sequenceⁱ	857 – 857	1	E → EREPQAPEPGHSLAQTIPSQ GISPGGSDSPQTGSLDHSSQ DGPHQQDR in isoform 10. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice." Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T. BMC Neurosci. 6:33-33(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.	VSP_018242
Alternative sequenceⁱ	857 – 857	1	E → EYLNPWFKRDYNVAKWVEDV NKNTEGPYFR in isoform 12. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice." Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T. BMC Neurosci. 6:33-33(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.	VSP_018243
Alternative sequenceⁱ	857 – 857	1	E → DSQDGPHQQDR in isoform 15. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice." Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T. BMC Neurosci. 6:33-33(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.	VSP_018244
Alternative sequenceⁱ	857 – 857	1	E → EREPQAPEPGHSLAQTIPSQ GISPGGSDSPQTGSLDHR in isoform 4, isoform 5 and isoform 6. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice." Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T. BMC Neurosci. 6:33-33(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.	VSP_018245
Alternative sequenceⁱ	857 – 857	1	E → EYLNPWFKRDYNVAKWVEDV NKNTEGPYFSSQDSPHQQDR in isoform 8. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice." Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T. BMC Neurosci. 6:33-33(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.	VSP_018246
Alternative sequenceⁱ	857 – 857	1	E → EREPQAPEPGHSLAQTIPSQ GISPGGSDSPQTGSLDHRYL NPWFKRDYNVAKWVEDVNKN TEGPYFR in isoform 9. 1 Publication Manual assertion based on opinion inⁱ Ref.3 "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice." Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T. BMC Neurosci. 6:33-33(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.	VSP_018247
Alternative sequenceⁱ	858 – 904	47	Missing in isoform 17, isoform 18, isoform 19 and isoform 20. 2 Publications Manual assertion based on opinion inⁱ Ref.1 "Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23." Sagane K., Yamazaki K., Mizui Y., Tanaka I. Gene 236:79-86(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 17 AND 20). Ref.3 "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice." Sagane K., Hayakawa K., Kai J., Hirohashi T., Takahashi E., Miyamoto N., Ino M., Oki T., Yamazaki K., Nagasu T. BMC Neurosci. 6:33-33(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.	VSP_018248	Add BLAST

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB009674 mRNA. Translation: BAA83382.1. AB009674 mRNA. Translation: BAA83383.1. AK034528 mRNA. Translation: BAC28742.1. AB179842 mRNA. Translation: BAD72803.1. AB179843 mRNA. Translation: BAD72804.1. AB179844 mRNA. Translation: BAD72805.1. AB179845 mRNA. Translation: BAD72806.1. AB179846 mRNA. Translation: BAD72807.1. AB179847 mRNA. Translation: BAD72808.1. AB179848 mRNA. Translation: BAD72809.1. AB179849 mRNA. Translation: BAD72810.1. AB179850 mRNA. Translation: BAD72811.1. AB179851 mRNA. Translation: BAD72812.1. AB179852 mRNA. Translation: BAD72813.1. AB179853 mRNA. Translation: BAD72814.1. AB179854 mRNA. Translation: BAD72815.1. AB179855 mRNA. Translation: BAD72816.1. AB179856 mRNA. Translation: BAD72817.1. AB179857 mRNA. Translation: BAD72818.1. AB179858 mRNA. Translation: BAD72819.1. AB179859 mRNA. Translation: BAD72820.1. AB179860 mRNA. Translation: BAD72821.1. AB179861 mRNA. Translation: BAD72822.1. AB179862 mRNA. Translation: BAD72823.1.
CCDSⁱ	CCDS19080.1. [Q9R1V6-1] CCDS51411.1. [Q9R1V6-4] CCDS80205.1. [Q9R1V6-6] CCDS80207.1. [Q9R1V6-3]
RefSeqⁱ	NP_001007221.1. NM_001007220.3. [Q9R1V6-1] NP_001007222.1. NM_001007221.3. [Q9R1V6-2] NP_001091695.1. NM_001098225.2. [Q9R1V6-4] NP_001297368.1. NM_001310439.1. [Q9R1V6-6] NP_001297369.1. NM_001310440.1. [Q9R1V6-3] XP_006503592.1. XM_006503529.2. [Q9R1V6-12] XP_006503593.1. XM_006503530.2. [Q9R1V6-11] XP_006503594.1. XM_006503531.2. [Q9R1V6-14] XP_006503596.1. XM_006503533.2. [Q9R1V6-8] XP_006503598.1. XM_006503535.2. [Q9R1V6-15] XP_006503600.1. XM_006503537.2. [Q9R1V6-7] XP_006503605.1. XM_006503542.2. [Q9R1V6-5]
UniGeneⁱ	Mm.275895.

Genome annotation databases

Ensemblⁱ	ENSMUST00000046838; ENSMUSP00000049120; ENSMUSG00000040537. [Q9R1V6-1] ENSMUST00000050166; ENSMUSP00000055000; ENSMUSG00000040537. [Q9R1V6-4] ENSMUST00000088744; ENSMUSP00000086122; ENSMUSG00000040537. [Q9R1V6-13] ENSMUST00000088761; ENSMUSP00000086139; ENSMUSG00000040537. [Q9R1V6-3] ENSMUST00000115388; ENSMUSP00000111046; ENSMUSG00000040537. [Q9R1V6-6]
GeneIDⁱ	11496.
KEGGⁱ	mmu:11496.
UCSCⁱ	uc008wjk.2. mouse. [Q9R1V6-3] uc008wjv.1. mouse. [Q9R1V6-4] uc008wjy.1. mouse. [Q9R1V6-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB009674 mRNA. Translation: BAA83382.1. AB009674 mRNA. Translation: BAA83383.1. AK034528 mRNA. Translation: BAC28742.1. AB179842 mRNA. Translation: BAD72803.1. AB179843 mRNA. Translation: BAD72804.1. AB179844 mRNA. Translation: BAD72805.1. AB179845 mRNA. Translation: BAD72806.1. AB179846 mRNA. Translation: BAD72807.1. AB179847 mRNA. Translation: BAD72808.1. AB179848 mRNA. Translation: BAD72809.1. AB179849 mRNA. Translation: BAD72810.1. AB179850 mRNA. Translation: BAD72811.1. AB179851 mRNA. Translation: BAD72812.1. AB179852 mRNA. Translation: BAD72813.1. AB179853 mRNA. Translation: BAD72814.1. AB179854 mRNA. Translation: BAD72815.1. AB179855 mRNA. Translation: BAD72816.1. AB179856 mRNA. Translation: BAD72817.1. AB179857 mRNA. Translation: BAD72818.1. AB179858 mRNA. Translation: BAD72819.1. AB179859 mRNA. Translation: BAD72820.1. AB179860 mRNA. Translation: BAD72821.1. AB179861 mRNA. Translation: BAD72822.1. AB179862 mRNA. Translation: BAD72823.1.
CCDSⁱ	CCDS19080.1. [Q9R1V6-1] CCDS51411.1. [Q9R1V6-4] CCDS80205.1. [Q9R1V6-6] CCDS80207.1. [Q9R1V6-3]
RefSeqⁱ	NP_001007221.1. NM_001007220.3. [Q9R1V6-1] NP_001007222.1. NM_001007221.3. [Q9R1V6-2] NP_001091695.1. NM_001098225.2. [Q9R1V6-4] NP_001297368.1. NM_001310439.1. [Q9R1V6-6] NP_001297369.1. NM_001310440.1. [Q9R1V6-3] XP_006503592.1. XM_006503529.2. [Q9R1V6-12] XP_006503593.1. XM_006503530.2. [Q9R1V6-11] XP_006503594.1. XM_006503531.2. [Q9R1V6-14] XP_006503596.1. XM_006503533.2. [Q9R1V6-8] XP_006503598.1. XM_006503535.2. [Q9R1V6-15] XP_006503600.1. XM_006503537.2. [Q9R1V6-7] XP_006503605.1. XM_006503542.2. [Q9R1V6-5]
UniGeneⁱ	Mm.275895.

3D structure databases

ProteinModelPortalⁱ	Q9R1V6.
SMRⁱ	Q9R1V6. Positions 231-716.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q9R1V6. 5 interactions.
MINTⁱ	MINT-4086922.
STRINGⁱ	10090.ENSMUSP00000055000.

Protein family/group databases

MEROPSⁱ	M12.978.

MEROPSⁱ

M12.978.

PTM databases

iPTMnetⁱ	Q9R1V6.
PhosphoSiteⁱ	Q9R1V6.

Proteomic databases

MaxQBⁱ	Q9R1V6.
PaxDbⁱ	Q9R1V6.
PeptideAtlasⁱ	Q9R1V6.
PRIDEⁱ	Q9R1V6.

Protocols and materials databases

DNASUⁱ	11496.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000046838; ENSMUSP00000049120; ENSMUSG00000040537. [Q9R1V6-1] ENSMUST00000050166; ENSMUSP00000055000; ENSMUSG00000040537. [Q9R1V6-4] ENSMUST00000088744; ENSMUSP00000086122; ENSMUSG00000040537. [Q9R1V6-13] ENSMUST00000088761; ENSMUSP00000086139; ENSMUSG00000040537. [Q9R1V6-3] ENSMUST00000115388; ENSMUSP00000111046; ENSMUSG00000040537. [Q9R1V6-6]
GeneIDⁱ	11496.
KEGGⁱ	mmu:11496.
UCSCⁱ	uc008wjk.2. mouse. [Q9R1V6-3] uc008wjv.1. mouse. [Q9R1V6-4] uc008wjy.1. mouse. [Q9R1V6-2]

Organism-specific databases

CTDⁱ	53616.
MGIⁱ	MGI:1340046. Adam22.

Phylogenomic databases

eggNOGⁱ	KOG3607. Eukaryota. ENOG410XX2M. LUCA.
GeneTreeⁱ	ENSGT00800000124044.
HOVERGENⁱ	HBG050456.
InParanoidⁱ	Q9R1V6.
KOⁱ	K16068.
OMAⁱ	KYIWGQK.
OrthoDBⁱ	EOG091G010C.
PhylomeDBⁱ	Q9R1V6.
TreeFamⁱ	TF314733.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5682910. LGI-ADAM interactions.

Reactomeⁱ

R-MMU-5682910. LGI-ADAM interactions.

Miscellaneous databases

ChiTaRSⁱ	Adam22. mouse.
PROⁱ	Q9R1V6.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000040537.
CleanExⁱ	MM_ADAM22.
ExpressionAtlasⁱ	Q9R1V6. baseline and differential.
Genevisibleⁱ	Q9R1V6. MM.

Family and domain databases

Gene3Dⁱ	3.40.390.10. 1 hit. 4.10.70.10. 1 hit.
InterProⁱ	IPR006586. ADAM_Cys-rich. IPR018358. Disintegrin_CS. IPR001762. Disintegrin_dom. IPR013032. EGF-like_CS. IPR000742. EGF-like_dom. IPR013111. EGF_extracell. IPR024079. MetalloPept_cat_dom. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. [Graphical view]
Pfamⁱ	PF08516. ADAM_CR. 1 hit. PF00200. Disintegrin. 1 hit. PF07974. EGF_2. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. [Graphical view]
PRINTSⁱ	PR00289. DISINTEGRIN.
SMARTⁱ	SM00608. ACR. 1 hit. SM00050. DISIN. 1 hit. [Graphical view]
SUPFAMⁱ	SSF57552. SSF57552. 1 hit.
PROSITEⁱ	PS50215. ADAM_MEPRO. 1 hit. PS00427. DISINTEGRIN_1. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. PS00022. EGF_1. 1 hit. PS50026. EGF_3. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

ADA22_MOUSE

Accessionⁱ

Primary (citable) accession number: Q9R1V6
Secondary accession number(s): Q5TLI8

Q9R1V5

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	May 2, 2006
Last modified:	September 7, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
Peptidase families
Classification of peptidase families and list of entries
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9R1V6 (ADA22_MOUSE)

UniProt

Q9R1V6 - ADA22_MOUSE

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Disintegrin and metalloproteinase domain-containing protein 22

Adam22

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Provides information on the disease(s) and phenotype(s) associated with a protein.</p><p><a href='../manual/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequences (21)i

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (21)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ