Reviewed,
UniProtKB/Swiss-Prot Q9R1V6 (ADA22_MOUSE)
Last modified
July 22, 2008.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: ADAM 22 Alternative name(s): A disintegrin and metalloproteinase domain 22 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 904 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation By similarity. |
| Subcellular location | |
| Tissue specificity | Expressed at high levels in the brain. Strongly expressed in cerebellar granule cells and hippocampus. In spinal cord, expression is restricted to gray matter. |
| Post-translational modification | The precursor is cleaved by a furin endopeptidase By similarity. |
| Miscellaneous | Mice lacking Adam22 display severe ataxia within one week after birth and die before weaning, probably due to convulsions. They display marked hypomyelination of the peripheral nerves. |
| Sequence similarities | Contains 1 disintegrin domain. Contains 1 EGF-like domain. Contains 1 peptidase M12B domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Alternative splicing |
| Domain | EGF-like domain Signal Transmembrane |
| PTM | Cleavage on pair of basic residues Glycoprotein Phosphoprotein |
Gene Ontology (GO) | |
| None. [Check GOA] | |
Alternative products
| This entry describes 21 isoforms produced by alternative splicing. [Align] [Select] | |||||
| Isoform 1 (identifier: Q9R1V6-3) Also known as: ADAM22-G01; 22g; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | |||||
| Isoform 2 (identifier: Q9R1V6-4) Also known as: ADAM22-G03; 22g(D27); The sequence of this isoform differs from the canonical sequence as follows: 766-801: Missing. | |||||
| Isoform 3 (identifier: Q9R1V6-5) Also known as: ADAM22-G06; 22g(D26D27); The sequence of this isoform differs from the canonical sequence as follows: 760-801: Missing. | |||||
| Isoform 4 (identifier: Q9R1V6-6) Also known as: ADAM22=G07; 22g(D26D27)+29.3; The sequence of this isoform differs from the canonical sequence as follows: 760-801: Missing. 857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHR | |||||
| Isoform 5 (identifier: Q9R1V6-7) Also known as: ADAM22-G08; 22g(D27)+29.3; The sequence of this isoform differs from the canonical sequence as follows: 766-801: Missing. 857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHR | |||||
| Isoform 6 (identifier: Q9R1V6-8) Also known as: ADAM22-G09; 22g+29.3; The sequence of this isoform differs from the canonical sequence as follows: 857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHR | |||||
| Isoform 7 (identifier: Q9R1V6-9) Also known as: ADAM22-G10; 22g+29.1; The sequence of this isoform differs from the canonical sequence as follows: 857-904: ETLSPAKSPSSSTGSIASSRKYPYPMPPLPDEGKTAGRQSARLWETSI → DLGIIT | |||||
| Isoform 8 (identifier: Q9R1V6-10) Also known as: ADAM22-G11; 22g(D27)+29.5+29.7; The sequence of this isoform differs from the canonical sequence as follows: 766-801: Missing. 857-857: E → EYLNPWFKRDYNVAKWVEDVNKNTEGPYFSSQDSPHQQDR | |||||
| Isoform 9 (identifier: Q9R1V6-11) Also known as: ADAM22-G12; 22g+29.3+29.7; The sequence of this isoform differs from the canonical sequence as follows: 857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHRYLNPWFKRDYNVAKWVEDVNKNTEGPYFR | |||||
| Isoform 10 (identifier: Q9R1V6-12) Also known as: ADAM22-G17; 22G[27L]+29.3+29.7; The sequence of this isoform differs from the canonical sequence as follows: 802-802: S → SAFLSHFQISTCSITHYSISQNISLFCSRS 857-857: E → EREPQAPEPGHSLAQTIPSQGISPGGSDSPQTGSLDHSSQDGPHQQDR | |||||
| Isoform 11 (identifier: Q9R1V6-13) Also known as: ADAM22-G18; 22g(D26)[27L]; The sequence of this isoform differs from the canonical sequence as follows: 760-765: Missing. 802-802: S → SAFLSHFQISTCSITHYSISQNISLFCSRS | |||||
| Isoform 12 (identifier: Q9R1V6-14) Also known as: ADAM22-G19; 22g[27L]+29.5; The sequence of this isoform differs from the canonical sequence as follows: 802-802: S → SAFLSHFQISTCSITHYSISQNISLFCSRS 857-857: E → EYLNPWFKRDYNVAKWVEDVNKNTEGPYFR | |||||
| Isoform 13 (identifier: Q9R1V6-15) Also known as: ADAM22-G20; 22g[27L]; The sequence of this isoform differs from the canonical sequence as follows: 802-802: S → SAFLSHFQISTCSITHYSISQNISLFCSRS | |||||
| Isoform 14 (identifier: Q9R1V6-16) Also known as: ADAM22-G21; 22g(D26)[27S]; The sequence of this isoform differs from the canonical sequence as follows: 760-904: NYREQRQLPQ...QSARLWETSI → FPPVPSHIIP...RAPGYGRHPF | |||||
| Isoform 15 (identifier: Q9R1V6-17) Also known as: ADAM22-G22; 22g(D27)+29.7; The sequence of this isoform differs from the canonical sequence as follows: 766-801: Missing. 857-857: E → DSQDGPHQQDR | |||||
| Isoform 16 (identifier: Q9R1V6-18) Also known as: ADAM22-G23; 22g(D25D26D27); The sequence of this isoform differs from the canonical sequence as follows: 730-904: VAGTNIIIGI...QSARLWETSI → QMDSLILGVK...RAPGYGRHPF | |||||
| Isoform 17 (identifier: Q9R1V6-2) Also known as: ADAM22-A05; Beta; The sequence of this isoform differs from the canonical sequence as follows: 766-801: Missing. 858-904: Missing. | |||||
| Isoform 18 (identifier: Q9R1V6-19) Also known as: ADAM22-A13; The sequence of this isoform differs from the canonical sequence as follows: 760-801: Missing. 858-904: Missing. | |||||
| Isoform 19 (identifier: Q9R1V6-20) Also known as: ADAM22-A15; The sequence of this isoform differs from the canonical sequence as follows: 760-765: Missing. 858-904: Missing. | |||||
| Isoform 20 (identifier: Q9R1V6-1) Also known as: ADAM22-A04; Alpha; The sequence of this isoform differs from the canonical sequence as follows: 858-904: Missing. | |||||
| Isoform 21 (identifier: Q9R1V6-21) Also known as: ADAM22-A16; The sequence of this isoform differs from the canonical sequence as follows: 766-846: QLPQGDYVKK...MGGNKKKIRG → FPPVPSHIIP...DLTQLSKLYL 847-904: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||||
Molecule processing | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 23 | 23 | Potential | |||||||
| Propeptide | 24 – 223 | 200 | By similarity | |||||||
| Chain | 224 – 904 | 681 | ADAM 22 | |||||||
Regions | ||||||||||
| Topological domain | 24 – 734 | 711 | Extracellular Potential | |||||||
| Transmembrane | 735 – 755 | 21 | Potential | |||||||
| Topological domain | 756 – 857 | 102 | Cytoplasmic Potential | |||||||
| Domain | 237 – 436 | 200 | Peptidase M12B | |||||||
| Domain | 442 – 529 | 88 | Disintegrin | |||||||
| Domain | 673 – 710 | 38 | EGF-like | |||||||
| Compositional bias | 533 – 666 | 134 | Cys-rich | |||||||
Amino acid modifications | ||||||||||
| Modified residue | 832 | 1 | Phosphoserine | |||||||
| Modified residue | 864 | 1 | Phosphoserine | |||||||
| Modified residue | 866 | 1 | Phosphoserine | |||||||
| Glycosylation | 163 | 1 | N-linked (GlcNAc...) Potential | |||||||
| Glycosylation | 517 | 1 | N-linked (GlcNAc...) Potential | |||||||
| Glycosylation | 632 | 1 | N-linked (GlcNAc...) Potential | |||||||
| Glycosylation | 673 | 1 | N-linked (GlcNAc...) Potential | |||||||
| Disulfide bond | 347 ↔ 431 | By similarity | ||||||||
| Disulfide bond | 390 ↔ 415 | By similarity | ||||||||
| Disulfide bond | 392 ↔ 399 | By similarity | ||||||||
| Disulfide bond | 501 ↔ 521 | By similarity | ||||||||
| Disulfide bond | 677 ↔ 692 | By similarity | ||||||||
| Disulfide bond | 686 ↔ 698 | By similarity | ||||||||
| Disulfide bond | 700 ↔ 709 | By similarity | ||||||||
Natural variations | ||||||||||
| Alternative sequence | 730 – 904 | 175 | VAGTN…WETSI → QMDSLILGVKGFQTQNIFQT SVKMGDLAVTPGKVTWEATK RKSEGKDLDLDLTQLRPCHL PSLLLHQLGLLPPAENTRTL CLRFQTRGRQRADRAPGYGR HPF in isoform 16. | |||||||
| Alternative sequence | 760 – 904 | 145 | NYREQ…WETSI → FPPVPSHIIPLVRTFHYFAA GQMDSLILGVKGFQTQNIFQ TSVKMGDLAVTPGKVTWEAT KRKSEGKDLDLDLTQLRPCH LPSLLLHQLGLLPPAENTRT LCLRFQTRGRQRADRAPGYG RHPF in isoform 14. | |||||||
| Alternative sequence | 760 – 801 | 42 | Missing in isoform 3, isoform 4 and isoform 18. | |||||||
| Alternative sequence | 760 – 765 | 6 | Missing in isoform 11 and isoform 19. | |||||||
| Alternative sequence | 766 – 846 | 81 | QLPQG…KKIRG → FPPVPSHIIPLVRTFHYFAA GQMDSLILGVKGFQTQNIFQ TSVKMGDLAVTPGKVTWEAT KRKSEGKDLDLDLTQLSKLY L in isoform 21. | |||||||
| Alternative sequence | 766 – 801 | 36 | Missing in isoform 2, isoform 5, isoform 8, isoform 15 and isoform 17. | |||||||
| Alternative sequence | 802 | 1 | S → SAFLSHFQISTCSITHYSIS QNISLFCSRS in isoform 10, isoform 11, isoform 12 and isoform 13. | |||||||
| Alternative sequence | 847 – 904 | 58 | Missing in isoform 21. | |||||||
| Alternative sequence | 857 – 904 | 48 | ETLSP…WETSI → DLGIIT in isoform 7. | |||||||
| Alternative sequence | 857 | 1 | E → EREPQAPEPGHSLAQTIPSQ GISPGGSDSPQTGSLDHSSQ DGPHQQDR in isoform 10. | |||||||
| Alternative sequence | 857 | 1 | E → EYLNPWFKRDYNVAKWVEDV NKNTEGPYFR in isoform 12. | |||||||
| Alternative sequence | 857 | 1 | E → DSQDGPHQQDR in isoform 15. | |||||||
| Alternative sequence | 857 | 1 | E → EREPQAPEPGHSLAQTIPSQ GISPGGSDSPQTGSLDHR in isoform 4, isoform 5 and isoform 6. | |||||||
| Alternative sequence | 857 | 1 | E → EYLNPWFKRDYNVAKWVEDV NKNTEGPYFSSQDSPHQQDR in isoform 8. | |||||||
| Alternative sequence | 857 | 1 | E → EREPQAPEPGHSLAQTIPSQ GISPGGSDSPQTGSLDHRYL NPWFKRDYNVAKWVEDVNKN TEGPYFR in isoform 9. | |||||||
| Alternative sequence | 858 – 904 | 47 | Missing in isoform 17, isoform 18, isoform 19 and isoform 20. | |||||||
Experimental info | ||||||||||
| Sequence conflict | 639 | 1 | K → R in BAC28742. Ref.2 | |||||||
Sequences
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Clusters with