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Q9R1V4

- ADA11_MOUSE

UniProt

Q9R1V4 - ADA11_MOUSE

Protein

Disintegrin and metalloproteinase domain-containing protein 11

Gene

Adam11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: InterPro
    2. protein binding Source: MGI
    3. zinc ion binding Source: InterPro

    Protein family/group databases

    MEROPSiM12.976.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 11
    Short name:
    ADAM 11
    Alternative name(s):
    Metalloproteinase-like, disintegrin-like, and cysteine-rich protein
    Short name:
    MDC
    Gene namesi
    Name:Adam11
    Synonyms:Mdc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1098667. Adam11.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Propeptidei25 – 229205By similarityPRO_0000029076Add
    BLAST
    Chaini230 – 773544Disintegrin and metalloproteinase domain-containing protein 11PRO_0000029077Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi353 ↔ 437By similarity
    Disulfide bondi396 ↔ 421By similarity
    Disulfide bondi398 ↔ 405By similarity
    Disulfide bondi507 ↔ 527By similarity
    Glycosylationi609 – 6091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi677 – 6771N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi681 ↔ 696By similarity
    Disulfide bondi690 ↔ 702By similarity
    Disulfide bondi704 ↔ 713By similarity

    Post-translational modificationi

    The precursor is cleaved by a furin endopeptidase.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9R1V4.
    PaxDbiQ9R1V4.
    PRIDEiQ9R1V4.

    PTM databases

    PhosphoSiteiQ9R1V4.

    Expressioni

    Tissue specificityi

    Highly expressed in the brain. Weakly detected in the heart, liver and testis.

    Gene expression databases

    ArrayExpressiQ9R1V4.
    BgeeiQ9R1V4.
    CleanExiMM_ADAM11.
    GenevestigatoriQ9R1V4.

    Interactioni

    Subunit structurei

    Can bind to LGI1 and LGI4.

    Protein-protein interaction databases

    IntActiQ9R1V4. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R1V4.
    SMRiQ9R1V4. Positions 238-718.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini230 – 738509ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini760 – 77314CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei739 – 75921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini243 – 442200Peptidase M12BPROSITE-ProRule annotationAdd
    BLAST
    Domaini448 – 53588DisintegrinPROSITE-ProRule annotationAdd
    BLAST
    Domaini681 – 71333EGF-likePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi536 – 680145Cys-richAdd
    BLAST

    Domaini

    A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.

    Sequence similaritiesi

    Contains 1 disintegrin domain.PROSITE-ProRule annotation
    Contains 1 EGF-like domain.PROSITE-ProRule annotation
    Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG256419.
    GeneTreeiENSGT00680000099751.
    HOGENOMiHOG000231962.
    HOVERGENiHBG050456.
    KOiK16067.
    OrthoDBiEOG7B31M6.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProiIPR006586. ADAM_Cys-rich.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view]
    PfamiPF08516. ADAM_CR. 1 hit.
    PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view]
    PRINTSiPR00289. DISINTEGRIN.
    SMARTiSM00608. ACR. 1 hit.
    SM00050. DISIN. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57552. SSF57552. 1 hit.
    PROSITEiPS50215. ADAM_MEPRO. 1 hit.
    PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9R1V4-1 [UniParc]FASTAAdd to Basket

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    MRRLRRWAIA ALLLLPLLPP PGLGALGPRG ALHWRSSAHV GSPESPEGSE    50
    VTEPSRLVRQ SSGGEVRKPQ LDTRVRQDPP RGTPVHLAQV SFVIPAFDSN 100
    FTLDLELNHH LLSSQYVERH FSREGTRQHS TGAGDHCYYH GKLRGNPQSF 150
    AALSTCQGLH GVFSDGNLTY IVEPKEIAGP WGPPQGPLPH LIYRTPLLPA 200
    PLGCREPGCL FAVPAQSALP NWPKLRRKRQ VRRGHPTVHS ETKYVELIVI 250
    NDHQLFEQMR QSVVLTSNFA KSVVNLADVI YKEQLNTRIV LVAMETWADG 300
    DKIQVQDDLL ETLARLMVYR REGLPEPSDA THLFSGRTFQ STSSGAAYVG 350
    GICSLSRGGG VNEYGNMGAM AVTLAQTLGQ NLGMMWNKHR SSAGDCKCPD 400
    IWLGCIMEDT GFYLPRKFSR CSIDEYNQFL QEGGGSCLFN KPLKLLDPPE 450
    CGNGFVEAGE ECDCGSVQEC SRAGGNCCKK CTLTHDAMCS DGLCCRRCKY 500
    EPRGVSCREA VNECDIAETC TGDSSQCPPN LHKLDGYYCD HEQGRCYGGR 550
    CKTRDRQCQA LWGHAAADRF CYEKLNVEGT ERGNCGRKGS GWVQCSKQDV 600
    LCGFLLCVNI SGAPRLGDLG GDISSVTFYH QGKELDCRGG HVQLADGSDL 650
    SYVEDGTACG PNMLCLDHRC LPASAFNFST CPGSGERRIC SHHGVCSNEG 700
    KCICQPDWTG KDCSIHNPLP TSPPTGETER YKGPSGTNII IGSIAGAVLV 750
    AAIVLGGTGW GFKNIRRGRS GGA 773
    Length:773
    Mass (Da):84,134
    Last modified:July 27, 2011 - v2
    Checksum:iF3F0131ECDA58D72
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti181 – 1811W → R in BAA83384. (PubMed:10433968)Curated
    Sequence conflicti218 – 2181A → T in BAA83384. (PubMed:10433968)Curated
    Sequence conflicti340 – 3401Q → K in BAA83384. (PubMed:10433968)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009676 mRNA. Translation: BAA83384.1.
    AL929067 Genomic DNA. Translation: CAM27995.1.
    CCDSiCCDS25503.1.
    RefSeqiNP_033743.2. NM_009613.2.
    UniGeneiMm.89854.

    Genome annotation databases

    EnsembliENSMUST00000103081; ENSMUSP00000099370; ENSMUSG00000020926.
    GeneIDi11488.
    KEGGimmu:11488.
    UCSCiuc007lsi.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009676 mRNA. Translation: BAA83384.1 .
    AL929067 Genomic DNA. Translation: CAM27995.1 .
    CCDSi CCDS25503.1.
    RefSeqi NP_033743.2. NM_009613.2.
    UniGenei Mm.89854.

    3D structure databases

    ProteinModelPortali Q9R1V4.
    SMRi Q9R1V4. Positions 238-718.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9R1V4. 1 interaction.

    Protein family/group databases

    MEROPSi M12.976.

    PTM databases

    PhosphoSitei Q9R1V4.

    Proteomic databases

    MaxQBi Q9R1V4.
    PaxDbi Q9R1V4.
    PRIDEi Q9R1V4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000103081 ; ENSMUSP00000099370 ; ENSMUSG00000020926 .
    GeneIDi 11488.
    KEGGi mmu:11488.
    UCSCi uc007lsi.2. mouse.

    Organism-specific databases

    CTDi 4185.
    MGIi MGI:1098667. Adam11.

    Phylogenomic databases

    eggNOGi NOG256419.
    GeneTreei ENSGT00680000099751.
    HOGENOMi HOG000231962.
    HOVERGENi HBG050456.
    KOi K16067.
    OrthoDBi EOG7B31M6.

    Miscellaneous databases

    NextBioi 278852.
    PROi Q9R1V4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9R1V4.
    Bgeei Q9R1V4.
    CleanExi MM_ADAM11.
    Genevestigatori Q9R1V4.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProi IPR006586. ADAM_Cys-rich.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view ]
    Pfami PF08516. ADAM_CR. 1 hit.
    PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view ]
    PRINTSi PR00289. DISINTEGRIN.
    SMARTi SM00608. ACR. 1 hit.
    SM00050. DISIN. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57552. SSF57552. 1 hit.
    PROSITEi PS50215. ADAM_MEPRO. 1 hit.
    PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23."
      Sagane K., Yamazaki K., Mizui Y., Tanaka I.
      Gene 236:79-86(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11."
      Sagane K., Ishihama Y., Sugimoto H.
      Int. J. Biol. Sci. 4:387-396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LGI1 AND LGI4.

    Entry informationi

    Entry nameiADA11_MOUSE
    AccessioniPrimary (citable) accession number: Q9R1V4
    Secondary accession number(s): A2AUA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3