Reviewed,
UniProtKB/Swiss-Prot Q9R1V4 (ADA11_MOUSE)
Last modified
June 16, 2009.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Disintegrin and metalloproteinase domain-containing protein 11 Short name=ADAM 11 Alternative name(s): Metalloproteinase-like, disintegrin-like, and cysteine-rich protein Short name=MDC | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 773 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. |
| Subcellular location | |
| Tissue specificity | Highly expressed in the brain. Weakly detected in the heart, liver and testis. |
| Domain | A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor. |
| Post-translational modification | The precursor is cleaved by a furin endopeptidase By similarity. |
| Sequence similarities | Contains 1 disintegrin domain. Contains 1 EGF-like domain. Contains 1 peptidase M12B domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | EGF-like domain Signal Transmembrane |
| PTM | Cleavage on pair of basic residues Disulfide bond Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | proteolysis Inferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 24 | 24 | Potential | ||||||||
| Propeptide | 25 – 229 | 205 | By similarity | PRO_0000029076 | |||||||
| Chain | 230 – 773 | 544 | Disintegrin and metalloproteinase domain-containing protein 11 | PRO_0000029077 | |||||||
Regions | |||||||||||
| Topological domain | 230 – 738 | 509 | Extracellular Potential | ||||||||
| Transmembrane | 739 – 759 | 21 | Potential | ||||||||
| Topological domain | 760 – 773 | 14 | Cytoplasmic Potential | ||||||||
| Domain | 243 – 442 | 200 | Peptidase M12B | ||||||||
| Domain | 448 – 535 | 88 | Disintegrin | ||||||||
| Domain | 681 – 713 | 33 | EGF-like | ||||||||
| Compositional bias | 536 – 680 | 145 | Cys-rich | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 100 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 167 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 609 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 677 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 353 ↔ 437 | By similarity | |||||||||
| Disulfide bond | 396 ↔ 421 | By similarity | |||||||||
| Disulfide bond | 398 ↔ 405 | By similarity | |||||||||
| Disulfide bond | 507 ↔ 527 | By similarity | |||||||||
| Disulfide bond | 681 ↔ 696 | By similarity | |||||||||
| Disulfide bond | 690 ↔ 702 | By similarity | |||||||||
| Disulfide bond | 704 ↔ 713 | By similarity | |||||||||
Sequences
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References
| [1] | "Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23." Sagane K., Yamazaki K., Mizui Y., Tanaka I. Gene 236:79-86(1999) [PubMed: 10433968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AB009676 mRNA. Translation: BAA83384.1. | |
| IPI | IPI00648981. |
| RefSeq | NP_033743.2. |
| UniGene | Mm.89854 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FVL based on UniProtKB P18619. |
| ModBase | Search... |
Protein family/group databases | |
| MEROPS | M12.976. |
Proteomic databases | |
| PRIDE | Q9R1V4. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000020926. Mus musculus. [Contig view] |
| GeneID | 11488. |
Organism-specific databases | |
| MGI | MGI:1098667. Adam11. |
Phylogenomic databases | |
| HOVERGEN | Q9R1V4. |
Gene expression databases | |
| ArrayExpress | Q9R1V4. |
| Bgee | Q9R1V4. |
| CleanEx | MM_ADAM11. |
| GermOnline | ENSMUSG00000020926. Mus musculus. |
Family and domain databases | |
| InterPro | IPR006586. ADAM_Cys-rich. IPR001762. Blood-coag_inhib_Disintegrin. IPR018358. Disintegrin_CS. IPR006210. EGF-like. IPR013032. EGF-like_reg_CS. IPR000742. EGF_3. IPR013111. EGF_extracell. IPR006025. Pept_M_Zn_BS. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. [Graphical view] |
| Gene3D | G3DSA:4.10.70.10. Blood-coag_inhib_Disintegrin. 1 hit. |
| Pfam | PF08516. ADAM_CR. 1 hit. PF00200. Disintegrin. 1 hit. PF07974. EGF_2. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. [Graphical view] |
| PRINTS | PR00289. DISINTEGRIN. |
| ProDom | PD000664. Disintegrin. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00608. ACR. 1 hit. SM00050. DISIN. 1 hit. SM00181. EGF. 1 hit. [Graphical view] |
| PROSITE | PS50215. ADAM_MEPRO. 1 hit. PS00427. DISINTEGRIN_1. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. PS00022. EGF_1. 1 hit. PS01186. EGF_2. False negative. PS50026. EGF_3. 1 hit. PS00142. ZINC_PROTEASE. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 278852. |
| SOURCE | Search... |
Entry information
| Entry name | ADA11_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9R1V4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


