Disintegrin and metalloproteinase domain-containing protein 11 precursor

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Q9R1V4 (ADA11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 98. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Disintegrin and metalloproteinase domain-containing protein 11
Short name=ADAM 11

Alternative name(s):
Metalloproteinase-like, disintegrin-like, and cysteine-rich protein
Short name=MDC

Gene names

Name:	Adam11
Synonyms:	Mdc

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	773 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.
Subunit structure	Can bind to LGI1 and LGI4.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Highly expressed in the brain. Weakly detected in the heart, liver and testis.
Domain	A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.
Post-translational modification	The precursor is cleaved by a furin endopeptidase By similarity.
Sequence similarities	Contains 1 disintegrin domain. Contains 1 EGF-like domain. Contains 1 peptidase M12B domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	EGF-like domain Signal Transmembrane Transmembrane helix
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

Potential

Propeptide

25 – 229

205

By similarity

PRO_0000029076

Chain

230 – 773

544

Disintegrin and metalloproteinase domain-containing protein 11

PRO_0000029077

Regions

Topological domain

230 – 738

509

Extracellular Potential

Transmembrane

739 – 759

Helical; Potential

Topological domain

760 – 773

Cytoplasmic Potential

Domain

243 – 442

200

Peptidase M12B

Domain

448 – 535

Disintegrin

Domain

681 – 713

EGF-like

Compositional bias

536 – 680

145

Cys-rich

Amino acid modifications

Glycosylation

100

N-linked (GlcNAc...) Potential

Glycosylation

167

N-linked (GlcNAc...) Potential

Glycosylation

609

N-linked (GlcNAc...) Potential

Glycosylation

677

N-linked (GlcNAc...) Potential

Disulfide bond

353 ↔ 437

By similarity

Disulfide bond

396 ↔ 421

By similarity

Disulfide bond

398 ↔ 405

By similarity

Disulfide bond

507 ↔ 527

By similarity

Disulfide bond

681 ↔ 696

By similarity

Disulfide bond

690 ↔ 702

By similarity

Disulfide bond

704 ↔ 713

By similarity

Experimental info

Sequence conflict

181

W → R in BAA83384. Ref.1

Sequence conflict

218

A → T in BAA83384. Ref.1

Sequence conflict

340

Q → K in BAA83384. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q9R1V4 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: F3F0131ECDA58D72
Show »

FASTA

773

84,134

        10         20         30         40         50         60 
MRRLRRWAIA ALLLLPLLPP PGLGALGPRG ALHWRSSAHV GSPESPEGSE VTEPSRLVRQ 

        70         80         90        100        110        120 
SSGGEVRKPQ LDTRVRQDPP RGTPVHLAQV SFVIPAFDSN FTLDLELNHH LLSSQYVERH 

       130        140        150        160        170        180 
FSREGTRQHS TGAGDHCYYH GKLRGNPQSF AALSTCQGLH GVFSDGNLTY IVEPKEIAGP 

       190        200        210        220        230        240 
WGPPQGPLPH LIYRTPLLPA PLGCREPGCL FAVPAQSALP NWPKLRRKRQ VRRGHPTVHS 

       250        260        270        280        290        300 
ETKYVELIVI NDHQLFEQMR QSVVLTSNFA KSVVNLADVI YKEQLNTRIV LVAMETWADG 

       310        320        330        340        350        360 
DKIQVQDDLL ETLARLMVYR REGLPEPSDA THLFSGRTFQ STSSGAAYVG GICSLSRGGG 

       370        380        390        400        410        420 
VNEYGNMGAM AVTLAQTLGQ NLGMMWNKHR SSAGDCKCPD IWLGCIMEDT GFYLPRKFSR 

       430        440        450        460        470        480 
CSIDEYNQFL QEGGGSCLFN KPLKLLDPPE CGNGFVEAGE ECDCGSVQEC SRAGGNCCKK 

       490        500        510        520        530        540 
CTLTHDAMCS DGLCCRRCKY EPRGVSCREA VNECDIAETC TGDSSQCPPN LHKLDGYYCD 

       550        560        570        580        590        600 
HEQGRCYGGR CKTRDRQCQA LWGHAAADRF CYEKLNVEGT ERGNCGRKGS GWVQCSKQDV 

       610        620        630        640        650        660 
LCGFLLCVNI SGAPRLGDLG GDISSVTFYH QGKELDCRGG HVQLADGSDL SYVEDGTACG 

       670        680        690        700        710        720 
PNMLCLDHRC LPASAFNFST CPGSGERRIC SHHGVCSNEG KCICQPDWTG KDCSIHNPLP 

       730        740        750        760        770 
TSPPTGETER YKGPSGTNII IGSIAGAVLV AAIVLGGTGW GFKNIRRGRS GGA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23." Sagane K., Yamazaki K., Mizui Y., Tanaka I. Gene 236:79-86(1999) [PubMed: 10433968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6.
[3]	"LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11." Sagane K., Ishihama Y., Sugimoto H. Int. J. Biol. Sci. 4:387-396(2008) [PubMed: 18974846] [Abstract] Cited for: INTERACTION WITH LGI1 AND LGI4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB009676 mRNA. Translation: BAA83384.1. AL929067 Genomic DNA. Translation: CAM27995.1.
IPI	IPI00408232.
RefSeq	NP_033743.2. NM_009613.2.
UniGene	Mm.89854.
3D structure databases
ProteinModelPortal	Q9R1V4.
SMR	Q9R1V4. Positions 238-718.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9R1V4. 1 interaction.
STRING	Q9R1V4.
Protein family/group databases
MEROPS	M12.976.
PTM databases
PhosphoSite	Q9R1V4.
Proteomic databases
PRIDE	Q9R1V4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000103081; ENSMUSP00000099370; ENSMUSG00000020926.
GeneID	11488.
KEGG	mmu:11488.
Organism-specific databases
CTD	4185.
MGI	MGI:1098667. Adam11.
Phylogenomic databases
GeneTree	ENSGT00590000083076.
HOVERGEN	HBG050456.
OrthoDB	EOG4HT8RQ.
Gene expression databases
ArrayExpress	Q9R1V4.
Bgee	Q9R1V4.
CleanEx	MM_ADAM11.
Genevestigator	Q9R1V4.
GermOnline	ENSMUSG00000020926. Mus musculus.
Family and domain databases
InterPro	IPR006586. ADAM_Cys-rich. IPR001762. Blood-coag_inhib_Disintegrin. IPR018358. Disintegrin_CS. IPR006210. EGF-like. IPR013032. EGF-like_reg_CS. IPR000742. EGF_3. IPR024079. MetalloPept_cat_dom. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. [Graphical view]
Gene3D	G3DSA:4.10.70.10. Blood-coag_inhib_Disintegrin. 1 hit. G3DSA:3.40.390.10. G3DSA:3.40.390.10. 1 hit.
Pfam	PF08516. ADAM_CR. 1 hit. PF00200. Disintegrin. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. [Graphical view]
PRINTS	PR00289. DISINTEGRIN.
SMART	SM00608. ACR. 1 hit. SM00050. DISIN. 1 hit. SM00181. EGF. 1 hit. [Graphical view]
SUPFAM	SSF57552. Disintegrin. 1 hit.
PROSITE	PS50215. ADAM_MEPRO. 1 hit. PS00427. DISINTEGRIN_1. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. PS00022. EGF_1. 1 hit. PS01186. EGF_2. False negative. PS50026. EGF_3. 1 hit. PS00142. ZINC_PROTEASE. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	278852.
SOURCE	Search...

Entry information

Entry name

ADA11_MOUSE

Accession

Primary (citable) accession number: Q9R1V4
Secondary accession number(s): A2AUA8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	July 27, 2011
Last modified:	November 16, 2011
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents