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Q9R1V4

- ADA11_MOUSE

UniProt

Q9R1V4 - ADA11_MOUSE

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Protein

Disintegrin and metalloproteinase domain-containing protein 11

Gene

Adam11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Protein family/group databases

MEROPSiM12.976.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 11
Short name:
ADAM 11
Alternative name(s):
Metalloproteinase-like, disintegrin-like, and cysteine-rich protein
Short name:
MDC
Gene namesi
Name:Adam11
Synonyms:Mdc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1098667. Adam11.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Propeptidei25 – 229205By similarityPRO_0000029076Add
BLAST
Chaini230 – 773544Disintegrin and metalloproteinase domain-containing protein 11PRO_0000029077Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi353 ↔ 437By similarity
Disulfide bondi396 ↔ 421By similarity
Disulfide bondi398 ↔ 405By similarity
Disulfide bondi507 ↔ 527By similarity
Glycosylationi609 – 6091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi677 – 6771N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi681 ↔ 696By similarity
Disulfide bondi690 ↔ 702By similarity
Disulfide bondi704 ↔ 713By similarity

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9R1V4.
PaxDbiQ9R1V4.
PRIDEiQ9R1V4.

PTM databases

PhosphoSiteiQ9R1V4.

Expressioni

Tissue specificityi

Highly expressed in the brain. Weakly detected in the heart, liver and testis.

Gene expression databases

BgeeiQ9R1V4.
CleanExiMM_ADAM11.
ExpressionAtlasiQ9R1V4. baseline and differential.
GenevestigatoriQ9R1V4.

Interactioni

Subunit structurei

Can bind to LGI1 and LGI4.

Protein-protein interaction databases

IntActiQ9R1V4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9R1V4.
SMRiQ9R1V4. Positions 238-718.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini230 – 738509ExtracellularSequence AnalysisAdd
BLAST
Topological domaini760 – 77314CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei739 – 75921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini243 – 442200Peptidase M12BPROSITE-ProRule annotationAdd
BLAST
Domaini448 – 53588DisintegrinPROSITE-ProRule annotationAdd
BLAST
Domaini681 – 71333EGF-likePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi536 – 680145Cys-richAdd
BLAST

Domaini

A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256419.
GeneTreeiENSGT00760000119181.
HOGENOMiHOG000231962.
HOVERGENiHBG050456.
InParanoidiQ9R1V4.
KOiK16067.
OrthoDBiEOG7B31M6.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R1V4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRLRRWAIA ALLLLPLLPP PGLGALGPRG ALHWRSSAHV GSPESPEGSE
60 70 80 90 100
VTEPSRLVRQ SSGGEVRKPQ LDTRVRQDPP RGTPVHLAQV SFVIPAFDSN
110 120 130 140 150
FTLDLELNHH LLSSQYVERH FSREGTRQHS TGAGDHCYYH GKLRGNPQSF
160 170 180 190 200
AALSTCQGLH GVFSDGNLTY IVEPKEIAGP WGPPQGPLPH LIYRTPLLPA
210 220 230 240 250
PLGCREPGCL FAVPAQSALP NWPKLRRKRQ VRRGHPTVHS ETKYVELIVI
260 270 280 290 300
NDHQLFEQMR QSVVLTSNFA KSVVNLADVI YKEQLNTRIV LVAMETWADG
310 320 330 340 350
DKIQVQDDLL ETLARLMVYR REGLPEPSDA THLFSGRTFQ STSSGAAYVG
360 370 380 390 400
GICSLSRGGG VNEYGNMGAM AVTLAQTLGQ NLGMMWNKHR SSAGDCKCPD
410 420 430 440 450
IWLGCIMEDT GFYLPRKFSR CSIDEYNQFL QEGGGSCLFN KPLKLLDPPE
460 470 480 490 500
CGNGFVEAGE ECDCGSVQEC SRAGGNCCKK CTLTHDAMCS DGLCCRRCKY
510 520 530 540 550
EPRGVSCREA VNECDIAETC TGDSSQCPPN LHKLDGYYCD HEQGRCYGGR
560 570 580 590 600
CKTRDRQCQA LWGHAAADRF CYEKLNVEGT ERGNCGRKGS GWVQCSKQDV
610 620 630 640 650
LCGFLLCVNI SGAPRLGDLG GDISSVTFYH QGKELDCRGG HVQLADGSDL
660 670 680 690 700
SYVEDGTACG PNMLCLDHRC LPASAFNFST CPGSGERRIC SHHGVCSNEG
710 720 730 740 750
KCICQPDWTG KDCSIHNPLP TSPPTGETER YKGPSGTNII IGSIAGAVLV
760 770
AAIVLGGTGW GFKNIRRGRS GGA
Length:773
Mass (Da):84,134
Last modified:July 27, 2011 - v2
Checksum:iF3F0131ECDA58D72
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811W → R in BAA83384. (PubMed:10433968)Curated
Sequence conflicti218 – 2181A → T in BAA83384. (PubMed:10433968)Curated
Sequence conflicti340 – 3401Q → K in BAA83384. (PubMed:10433968)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009676 mRNA. Translation: BAA83384.1.
AL929067 Genomic DNA. Translation: CAM27995.1.
CCDSiCCDS25503.1.
RefSeqiNP_033743.2. NM_009613.2.
UniGeneiMm.89854.

Genome annotation databases

EnsembliENSMUST00000103081; ENSMUSP00000099370; ENSMUSG00000020926.
GeneIDi11488.
KEGGimmu:11488.
UCSCiuc007lsi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009676 mRNA. Translation: BAA83384.1 .
AL929067 Genomic DNA. Translation: CAM27995.1 .
CCDSi CCDS25503.1.
RefSeqi NP_033743.2. NM_009613.2.
UniGenei Mm.89854.

3D structure databases

ProteinModelPortali Q9R1V4.
SMRi Q9R1V4. Positions 238-718.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9R1V4. 1 interaction.

Protein family/group databases

MEROPSi M12.976.

PTM databases

PhosphoSitei Q9R1V4.

Proteomic databases

MaxQBi Q9R1V4.
PaxDbi Q9R1V4.
PRIDEi Q9R1V4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000103081 ; ENSMUSP00000099370 ; ENSMUSG00000020926 .
GeneIDi 11488.
KEGGi mmu:11488.
UCSCi uc007lsi.2. mouse.

Organism-specific databases

CTDi 4185.
MGIi MGI:1098667. Adam11.

Phylogenomic databases

eggNOGi NOG256419.
GeneTreei ENSGT00760000119181.
HOGENOMi HOG000231962.
HOVERGENi HBG050456.
InParanoidi Q9R1V4.
KOi K16067.
OrthoDBi EOG7B31M6.

Miscellaneous databases

NextBioi 278852.
PROi Q9R1V4.
SOURCEi Search...

Gene expression databases

Bgeei Q9R1V4.
CleanExi MM_ADAM11.
ExpressionAtlasi Q9R1V4. baseline and differential.
Genevestigatori Q9R1V4.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProi IPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view ]
Pfami PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view ]
PRINTSi PR00289. DISINTEGRIN.
SMARTi SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57552. SSF57552. 1 hit.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23."
    Sagane K., Yamazaki K., Mizui Y., Tanaka I.
    Gene 236:79-86(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11."
    Sagane K., Ishihama Y., Sugimoto H.
    Int. J. Biol. Sci. 4:387-396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LGI1 AND LGI4.

Entry informationi

Entry nameiADA11_MOUSE
AccessioniPrimary (citable) accession number: Q9R1V4
Secondary accession number(s): A2AUA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3