Reviewed, UniProtKB/Swiss-Prot Q9R1V4 (ADA11_MOUSE)

Names and origin

Protein names

Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 11
      Short name=ADAM 11
Alternative name(s):
    Metalloproteinase-like, disintegrin-like, and cysteine-rich protein
      Short name=MDC

Gene names

Name:	Adam11
Synonyms:	Mdc

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	773 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Highly expressed in the brain. Weakly detected in the heart, liver and testis.
Domain	A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.
Post-translational modification	The precursor is cleaved by a furin endopeptidase By similarity.
Sequence similarities	Contains 1 disintegrin domain. Contains 1 EGF-like domain. Contains 1 peptidase M12B domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	EGF-like domain Signal Transmembrane
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Propeptide	25 – 229	205	By similarity		PRO_0000029076
	Chain	230 – 773	544	Disintegrin and metalloproteinase domain-containing protein 11		PRO_0000029077
Regions
	Topological domain	230 – 738	509	Extracellular Potential
	Transmembrane	739 – 759	21	Potential
	Topological domain	760 – 773	14	Cytoplasmic Potential
	Domain	243 – 442	200	Peptidase M12B
	Domain	448 – 535	88	Disintegrin
	Domain	681 – 713	33	EGF-like
	Compositional bias	536 – 680	145	Cys-rich
Amino acid modifications
	Glycosylation	100	1	N-linked (GlcNAc...) Potential
	Glycosylation	167	1	N-linked (GlcNAc...) Potential
	Glycosylation	609	1	N-linked (GlcNAc...) Potential
	Glycosylation	677	1	N-linked (GlcNAc...) Potential
	Disulfide bond	353 ↔ 437		By similarity
	Disulfide bond	396 ↔ 421		By similarity
	Disulfide bond	398 ↔ 405		By similarity
	Disulfide bond	507 ↔ 527		By similarity
	Disulfide bond	681 ↔ 696		By similarity
	Disulfide bond	690 ↔ 702		By similarity
	Disulfide bond	704 ↔ 713		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9R1V4-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 9A8A125FB3F743DD	FASTA	773	84,134
	10 20 30 40 50 60 MRRLRRWAIA ALLLLPLLPP PGLGALGPRG ALHWRSSAHV GSPESPEGSE VTEPSRLVRQ 70 80 90 100 110 120 SSGGEVRKPQ LDTRVRQDPP RGTPVHLAQV SFVIPAFDSN FTLDLELNHH LLSSQYVERH 130 140 150 160 170 180 FSREGTRQHS TGAGDHCYYH GKLRGNPQSF AALSTCQGLH GVFSDGNLTY IVEPKEIAGP 190 200 210 220 230 240 RGPPQGPLPH LIYRTPLLPA PLGCREPGCL FAVPAQSTLP NWPKLRRKRQ VRRGHPTVHS 250 260 270 280 290 300 ETKYVELIVI NDHQLFEQMR QSVVLTSNFA KSVVNLADVI YKEQLNTRIV LVAMETWADG 310 320 330 340 350 360 DKIQVQDDLL ETLARLMVYR REGLPEPSDA THLFSGRTFK STSSGAAYVG GICSLSRGGG 370 380 390 400 410 420 VNEYGNMGAM AVTLAQTLGQ NLGMMWNKHR SSAGDCKCPD IWLGCIMEDT GFYLPRKFSR 430 440 450 460 470 480 CSIDEYNQFL QEGGGSCLFN KPLKLLDPPE CGNGFVEAGE ECDCGSVQEC SRAGGNCCKK 490 500 510 520 530 540 CTLTHDAMCS DGLCCRRCKY EPRGVSCREA VNECDIAETC TGDSSQCPPN LHKLDGYYCD 550 560 570 580 590 600 HEQGRCYGGR CKTRDRQCQA LWGHAAADRF CYEKLNVEGT ERGNCGRKGS GWVQCSKQDV 610 620 630 640 650 660 LCGFLLCVNI SGAPRLGDLG GDISSVTFYH QGKELDCRGG HVQLADGSDL SYVEDGTACG 670 680 690 700 710 720 PNMLCLDHRC LPASAFNFST CPGSGERRIC SHHGVCSNEG KCICQPDWTG KDCSIHNPLP 730 740 750 760 770 TSPPTGETER YKGPSGTNII IGSIAGAVLV AAIVLGGTGW GFKNIRRGRS GGA

References

[1]	"Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23." Sagane K., Yamazaki K., Mizui Y., Tanaka I. Gene 236:79-86(1999) [PubMed: 10433968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB009676 mRNA. Translation: BAA83384.1.
IPI	IPI00648981.
RefSeq	NP_033743.2.
UniGene	Mm.89854
3D structure databases
HSSP	HSSP built from PDB template 1FVL based on UniProtKB P18619.
ModBase	Search...
Protein family/group databases
MEROPS	M12.976.
Proteomic databases
PRIDE	Q9R1V4.
Genome annotation databases
Ensembl	ENSMUSG00000020926. Mus musculus. [Contig view]
GeneID	11488.
Organism-specific databases
MGI	MGI:1098667. Adam11.
Phylogenomic databases
HOVERGEN	Q9R1V4.
Gene expression databases
ArrayExpress	Q9R1V4.
Bgee	Q9R1V4.
CleanEx	MM_ADAM11.
GermOnline	ENSMUSG00000020926. Mus musculus.
Family and domain databases
InterPro	IPR006586. ADAM_Cys-rich. IPR001762. Blood-coag_inhib_Disintegrin. IPR018358. Disintegrin_CS. IPR006210. EGF-like. IPR013032. EGF-like_reg_CS. IPR000742. EGF_3. IPR013111. EGF_extracell. IPR006025. Pept_M_Zn_BS. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. [Graphical view]
Gene3D	G3DSA:4.10.70.10. Blood-coag_inhib_Disintegrin. 1 hit.
Pfam	PF08516. ADAM_CR. 1 hit. PF00200. Disintegrin. 1 hit. PF07974. EGF_2. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. [Graphical view]
PRINTS	PR00289. DISINTEGRIN.
ProDom	PD000664. Disintegrin. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00608. ACR. 1 hit. SM00050. DISIN. 1 hit. SM00181. EGF. 1 hit. [Graphical view]
PROSITE	PS50215. ADAM_MEPRO. 1 hit. PS00427. DISINTEGRIN_1. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. PS00022. EGF_1. 1 hit. PS01186. EGF_2. False negative. PS50026. EGF_3. 1 hit. PS00142. ZINC_PROTEASE. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	278852.
SOURCE	Search...

Entry information

Entry name

ADA11_MOUSE

Accession

Primary (citable) accession number: Q9R1V4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)