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Q9R1V4

- ADA11_MOUSE

UniProt

Q9R1V4 - ADA11_MOUSE

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Protein

Disintegrin and metalloproteinase domain-containing protein 11

Gene
Adam11, Mdc
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. protein binding Source: MGI
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Protein family/group databases

MEROPSiM12.976.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 11
Short name:
ADAM 11
Alternative name(s):
Metalloproteinase-like, disintegrin-like, and cysteine-rich protein
Short name:
MDC
Gene namesi
Name:Adam11
Synonyms:Mdc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1098667. Adam11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini230 – 738509Extracellular Reviewed predictionAdd
BLAST
Transmembranei739 – 75921Helical; Reviewed predictionAdd
BLAST
Topological domaini760 – 77314Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Propeptidei25 – 229205 By similarityPRO_0000029076Add
BLAST
Chaini230 – 773544Disintegrin and metalloproteinase domain-containing protein 11PRO_0000029077Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi167 – 1671N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi353 ↔ 437 By similarity
Disulfide bondi396 ↔ 421 By similarity
Disulfide bondi398 ↔ 405 By similarity
Disulfide bondi507 ↔ 527 By similarity
Glycosylationi609 – 6091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi677 – 6771N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi681 ↔ 696 By similarity
Disulfide bondi690 ↔ 702 By similarity
Disulfide bondi704 ↔ 713 By similarity

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9R1V4.
PaxDbiQ9R1V4.
PRIDEiQ9R1V4.

PTM databases

PhosphoSiteiQ9R1V4.

Expressioni

Tissue specificityi

Highly expressed in the brain. Weakly detected in the heart, liver and testis.

Gene expression databases

ArrayExpressiQ9R1V4.
BgeeiQ9R1V4.
CleanExiMM_ADAM11.
GenevestigatoriQ9R1V4.

Interactioni

Subunit structurei

Can bind to LGI1 and LGI4.

Protein-protein interaction databases

IntActiQ9R1V4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9R1V4.
SMRiQ9R1V4. Positions 238-718.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini243 – 442200Peptidase M12BAdd
BLAST
Domaini448 – 53588DisintegrinAdd
BLAST
Domaini681 – 71333EGF-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi536 – 680145Cys-richAdd
BLAST

Domaini

A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.

Sequence similaritiesi

Contains 1 disintegrin domain.
Contains 1 EGF-like domain.

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256419.
GeneTreeiENSGT00680000099751.
HOGENOMiHOG000231962.
HOVERGENiHBG050456.
KOiK16067.
OrthoDBiEOG7B31M6.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R1V4-1 [UniParc]FASTAAdd to Basket

« Hide

MRRLRRWAIA ALLLLPLLPP PGLGALGPRG ALHWRSSAHV GSPESPEGSE    50
VTEPSRLVRQ SSGGEVRKPQ LDTRVRQDPP RGTPVHLAQV SFVIPAFDSN 100
FTLDLELNHH LLSSQYVERH FSREGTRQHS TGAGDHCYYH GKLRGNPQSF 150
AALSTCQGLH GVFSDGNLTY IVEPKEIAGP WGPPQGPLPH LIYRTPLLPA 200
PLGCREPGCL FAVPAQSALP NWPKLRRKRQ VRRGHPTVHS ETKYVELIVI 250
NDHQLFEQMR QSVVLTSNFA KSVVNLADVI YKEQLNTRIV LVAMETWADG 300
DKIQVQDDLL ETLARLMVYR REGLPEPSDA THLFSGRTFQ STSSGAAYVG 350
GICSLSRGGG VNEYGNMGAM AVTLAQTLGQ NLGMMWNKHR SSAGDCKCPD 400
IWLGCIMEDT GFYLPRKFSR CSIDEYNQFL QEGGGSCLFN KPLKLLDPPE 450
CGNGFVEAGE ECDCGSVQEC SRAGGNCCKK CTLTHDAMCS DGLCCRRCKY 500
EPRGVSCREA VNECDIAETC TGDSSQCPPN LHKLDGYYCD HEQGRCYGGR 550
CKTRDRQCQA LWGHAAADRF CYEKLNVEGT ERGNCGRKGS GWVQCSKQDV 600
LCGFLLCVNI SGAPRLGDLG GDISSVTFYH QGKELDCRGG HVQLADGSDL 650
SYVEDGTACG PNMLCLDHRC LPASAFNFST CPGSGERRIC SHHGVCSNEG 700
KCICQPDWTG KDCSIHNPLP TSPPTGETER YKGPSGTNII IGSIAGAVLV 750
AAIVLGGTGW GFKNIRRGRS GGA 773
Length:773
Mass (Da):84,134
Last modified:July 27, 2011 - v2
Checksum:iF3F0131ECDA58D72
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811W → R in BAA83384. 1 Publication
Sequence conflicti218 – 2181A → T in BAA83384. 1 Publication
Sequence conflicti340 – 3401Q → K in BAA83384. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009676 mRNA. Translation: BAA83384.1.
AL929067 Genomic DNA. Translation: CAM27995.1.
CCDSiCCDS25503.1.
RefSeqiNP_033743.2. NM_009613.2.
UniGeneiMm.89854.

Genome annotation databases

EnsembliENSMUST00000103081; ENSMUSP00000099370; ENSMUSG00000020926.
GeneIDi11488.
KEGGimmu:11488.
UCSCiuc007lsi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009676 mRNA. Translation: BAA83384.1 .
AL929067 Genomic DNA. Translation: CAM27995.1 .
CCDSi CCDS25503.1.
RefSeqi NP_033743.2. NM_009613.2.
UniGenei Mm.89854.

3D structure databases

ProteinModelPortali Q9R1V4.
SMRi Q9R1V4. Positions 238-718.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9R1V4. 1 interaction.

Protein family/group databases

MEROPSi M12.976.

PTM databases

PhosphoSitei Q9R1V4.

Proteomic databases

MaxQBi Q9R1V4.
PaxDbi Q9R1V4.
PRIDEi Q9R1V4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000103081 ; ENSMUSP00000099370 ; ENSMUSG00000020926 .
GeneIDi 11488.
KEGGi mmu:11488.
UCSCi uc007lsi.2. mouse.

Organism-specific databases

CTDi 4185.
MGIi MGI:1098667. Adam11.

Phylogenomic databases

eggNOGi NOG256419.
GeneTreei ENSGT00680000099751.
HOGENOMi HOG000231962.
HOVERGENi HBG050456.
KOi K16067.
OrthoDBi EOG7B31M6.

Miscellaneous databases

NextBioi 278852.
PROi Q9R1V4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9R1V4.
Bgeei Q9R1V4.
CleanExi MM_ADAM11.
Genevestigatori Q9R1V4.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProi IPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view ]
Pfami PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view ]
PRINTSi PR00289. DISINTEGRIN.
SMARTi SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57552. SSF57552. 1 hit.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23."
    Sagane K., Yamazaki K., Mizui Y., Tanaka I.
    Gene 236:79-86(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11."
    Sagane K., Ishihama Y., Sugimoto H.
    Int. J. Biol. Sci. 4:387-396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LGI1 AND LGI4.

Entry informationi

Entry nameiADA11_MOUSE
AccessioniPrimary (citable) accession number: Q9R1V4
Secondary accession number(s): A2AUA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi