Potassium voltage-gated channel subfamily H member 4

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Q9R1T9 (KCNH4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 105. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily H member 4

Alternative name(s):
Brain-specific eag-like channel 2
Short name=BEC2
Ether-a-go-go-like potassium channel 1
Short name=ELK channel 1
Short name=rElk1
Voltage-gated potassium channel subunit Kv12.3

Gene names

Name:	Kcnh4
Synonyms:	Elk1, Elk3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1017 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly.
Subunit structure	The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in adult testis, and in adult and embryonic brain. In adult brain found in piriform cortex, olfactory tubercle, cerebral cortex, hippocampus pyramidial cells and dentate gyrus and basal ganglia of caudate/putamen and accumbens nucleus. Detected at intermediate levels in lung, spinal cord, and pituitary. Ref.1 Ref.3
Developmental stage	Expressed at day E18 in embryonic brain.
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similarities	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.3/KCNH4 sub-subfamily. [View classification] Contains 1 cyclic nucleotide-binding domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 1 PAS (PER-ARNT-SIM) domain.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro signal transduction by phosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	phosphorelay sensor kinase activity Inferred from electronic annotation. Source: InterPro voltage-gated potassium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1017

1017

Potassium voltage-gated channel subfamily H member 4

PRO_0000054009

Regions

Topological domain

1 – 232

232

Cytoplasmic Potential

Transmembrane

233 – 253

Helical; Name=Segment S1; Potential

Topological domain

254 – 262

Extracellular Potential

Transmembrane

263 – 283

Helical; Name=Segment S2; Potential

Topological domain

284 – 305

Cytoplasmic Potential

Transmembrane

306 – 326

Helical; Name=Segment S3; Potential

Topological domain

327 – 334

Extracellular Potential

Transmembrane

335 – 355

Helical; Voltage-sensor; Name=Segment S4; Potential

Topological domain

356 – 364

Cytoplasmic Potential

Transmembrane

365 – 385

Helical; Name=Segment S5; Potential

Topological domain

386 – 427

Extracellular Potential

Intramembrane

428 – 448

Pore-forming; Name=Segment H5; Potential

Topological domain

449 – 454

Extracellular Potential

Transmembrane

455 – 475

Helical; Name=Segment S6; Potential

Topological domain

476 – 1017

542

Cytoplasmic Potential

Domain

14 – 90

PAS

Domain

93 – 145

PAC

Nucleotide binding

557 – 672

116

cNMP

Motif

440 – 445

Selectivity filter By similarity

Amino acid modifications

Glycosylation

415

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

825

R → W in CAA07587. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q9R1T9 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: BFDB0F1B35437C9F
Show »

FASTA

1,017

111,404

        10         20         30         40         50         60 
MPVMKGLLAP QNTFLDTIAT RFDGTHSNFL LANAQGPRGF PIVYCSDGFC ELTGYGRTEV 

        70         80         90        100        110        120 
MQKTCSCRFL YGPETSEPAL QRLQKALEGH QEHRAEICFY RKDGSAFWCL LDMMPIKNEL 

       130        140        150        160        170        180 
GEVVLFLFSF KDISQSGGPG LGSPGIHGDN NNHENSLGRR GASSRLRSTR RQNRTVLHRL 

       190        200        210        220        230        240 
TGHFGRRDQG SVKANSNVFE PKPSVPEYKV ASVGGSRCLL LHYSIPKAVW DGLILLATFY 

       250        260        270        280        290        300 
VAVTVPYNVC FAGDDDTPIT SRHTLVSDIA VEMLFILDII LNFRTTYVSQ SGQVVSAPRS 

       310        320        330        340        350        360 
IGLHYLATWF FVDLIAALPF DLLYVFNITV TSLVHLLKTV RLLRLLRLLQ KLERYSQCSA 

       370        380        390        400        410        420 
VVLTLLMSVF ALLAHWMACV WYVIGRREME ANDPLLWDIG WLHELGKRLE EPYVNGSAGG 

       430        440        450        460        470        480 
PSRRSAYIAA LYFTLSSLTS VGFGNVCANT DAEKIFSICT MLIGALMHAV VFGNVTAIIQ 

       490        500        510        520        530        540 
RMYSRRSLYH SRMKDLKDFI RVHRLPRPLK QRMLEYFQTT WAVNSGIDAN ELLRDFPDEL 

       550        560        570        580        590        600 
RADIAMHLNR EILQLPLFGA ASRGCLRALS LHIKTSFCAP GEFLLRRGDA LQAHYYVCSG 

       610        620        630        640        650        660 
SLEVLRDNTV LAILGKGDLI GADIPELGQE PGAGAGCVLK TSADVKALTY CGLQQLSSRG 

       670        680        690        700        710        720 
LAEVLRLYPE YVAAFRAGLP RDLTFNLRQG SENNGLGRFS RSPRLSQARS DTLGSSSDKT 

       730        740        750        760        770        780 
LPSITETEGG MEPGAGSKPR RPLLLPNLSP ARPRGSLVSL LGEELPPFSA LVSSPSLSPT 

       790        800        810        820        830        840 
PSPALAGRGS SPSLHGPPRG SAAWKPPQLL TPPLGTFGPP DLSPRIVDGI EDSSNTAEAP 

       850        860        870        880        890        900 
TFRFSKRPEP TRTRSQAPLS GPRLSRELAT EAAEEVKEKV CRLNQEISRL NQEVSQLSRE 

       910        920        930        940        950        960 
LRQVMGLLQA RLGPPSHPPD STWLPDLPCP HQRPPCISPH MSGPPPGLQN TTLAVVHCPA 

       970        980        990       1000       1010 
SVGTVEIGAT PSELRSSMVP PFPSEPDPLG PSPVPEASPL TPSLLKHSFQ SGSDTFH

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References

[1]	"Cloning and functional expression of rat ether-a-go-go-like K+ channel genes." Engeland B., Neu A., Ludwig J., Roeper J., Pongs O. J. Physiol. (Lond.) 513:647-654(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Brain cortex.
[2]	"New ether-a-go-go K+ channel family members localized in human telencephalon." Miyake A., Mochizuki S., Yokoi H., Kohda M., Furuichi K. J. Biol. Chem. 274:25018-25025(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain." Saganich M.J., Machado E., Rudy B. J. Neurosci. 21:4609-4624(2001) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ007628 mRNA. Translation: CAA07587.1. AB022699 mRNA. Translation: BAA83593.1.
IPI	IPI00207671.
PIR	T31354.
RefSeq	NP_446082.1. NM_053630.1.
UniGene	Rn.30035.
3D structure databases
ProteinModelPortal	Q9R1T9.
ModBase	Search...
Proteomic databases
PaxDb	Q9R1T9.
PRIDE	Q9R1T9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	114032.
KEGG	rno:114032.
UCSC	RGD:621415. rat.
Organism-specific databases
CTD	23415.
RGD	621415. Kcnh4.
Phylogenomic databases
eggNOG	COG2202.
HOGENOM	HOG000230794.
HOVERGEN	HBG052232.
InParanoid	Q9R1T9.
KO	K04907.
OrthoDB	EOG47WNN0.
Gene expression databases
ArrayExpress	Q9R1T9.
Genevestigator	Q9R1T9.
GermOnline	ENSRNOG00000018790. Rattus norvegicus.
Family and domain databases
Gene3D	2.60.120.10. 1 hit.
InterPro	IPR018490. cNMP-bd-like. IPR000595. cNMP-bd_dom. IPR005821. Ion_trans_dom. IPR003938. K_chnl_volt-dep_EAG/ELK/ERG. IPR003950. K_chnl_volt-dep_ELK. IPR001610. PAC. IPR000014. PAS. IPR000700. PAS-assoc_C. IPR014710. RmlC-like_jellyroll. [Graphical view]
Pfam	PF00027. cNMP_binding. 1 hit. PF00520. Ion_trans. 1 hit. [Graphical view]
PRINTS	PR01463. EAGCHANLFMLY. PR01465. ELKCHANNEL.
SMART	SM00100. cNMP. 1 hit. SM00086. PAC. 1 hit. SM00091. PAS. 1 hit. [Graphical view]
SUPFAM	SSF51206. cNMP_binding. 1 hit.
TIGRFAMs	TIGR00229. sensory_box. 1 hit.
PROSITE	PS00888. CNMP_BINDING_1. False negative. PS00889. CNMP_BINDING_2. False negative. PS50042. CNMP_BINDING_3. 1 hit. PS50113. PAC. 1 hit. PS50112. PAS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	618205.

Entry information

Entry name

KCNH4_RAT

Accession

Primary (citable) accession number: Q9R1T9
Secondary accession number(s): O89048

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2002
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents