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Q9R1T9

- KCNH4_RAT

UniProt

Q9R1T9 - KCNH4_RAT

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Protein

Potassium voltage-gated channel subfamily H member 4

Gene

Kcnh4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi557 – 672116cNMPAdd
BLAST

GO - Molecular functioni

  1. phosphorelay sensor kinase activity Source: InterPro
  2. voltage-gated potassium channel activity Source: RefGenome

GO - Biological processi

  1. potassium ion transmembrane transport Source: RefGenome
  2. regulation of membrane potential Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 4
Alternative name(s):
Brain-specific eag-like channel 2
Short name:
BEC2
Ether-a-go-go-like potassium channel 1
Short name:
ELK channel 1
Short name:
rElk1
Voltage-gated potassium channel subunit Kv12.3
Gene namesi
Name:Kcnh4
Synonyms:Elk1, Elk3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621415. Kcnh4.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10171017Potassium voltage-gated channel subfamily H member 4PRO_0000054009Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9R1T9.
PRIDEiQ9R1T9.

Expressioni

Tissue specificityi

Highly expressed in adult testis, and in adult and embryonic brain. In adult brain found in piriform cortex, olfactory tubercle, cerebral cortex, hippocampus pyramidial cells and dentate gyrus and basal ganglia of caudate/putamen and accumbens nucleus. Detected at intermediate levels in lung, spinal cord, and pituitary.2 Publications

Developmental stagei

Expressed at day E18 in embryonic brain.

Gene expression databases

GenevestigatoriQ9R1T9.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

Structurei

3D structure databases

ProteinModelPortaliQ9R1T9.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 232232CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini254 – 2629ExtracellularSequence Analysis
Topological domaini284 – 30522CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini327 – 3348ExtracellularSequence Analysis
Topological domaini356 – 3649CytoplasmicSequence Analysis
Topological domaini386 – 42742ExtracellularSequence AnalysisAdd
BLAST
Topological domaini449 – 4546ExtracellularSequence Analysis
Topological domaini476 – 1017542CytoplasmicSequence AnalysisAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei428 – 44821Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei233 – 25321Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei306 – 32621Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei335 – 35521Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei365 – 38521Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei455 – 47521Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 9077PASPROSITE-ProRule annotationAdd
BLAST
Domaini93 – 14553PACPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi440 – 4456Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 PAC (PAS-associated C-terminal) domain.PROSITE-ProRule annotation
Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2202.
HOGENOMiHOG000230794.
HOVERGENiHBG052232.
InParanoidiQ9R1T9.
KOiK04907.
PhylomeDBiQ9R1T9.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1T9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVMKGLLAP QNTFLDTIAT RFDGTHSNFL LANAQGPRGF PIVYCSDGFC
60 70 80 90 100
ELTGYGRTEV MQKTCSCRFL YGPETSEPAL QRLQKALEGH QEHRAEICFY
110 120 130 140 150
RKDGSAFWCL LDMMPIKNEL GEVVLFLFSF KDISQSGGPG LGSPGIHGDN
160 170 180 190 200
NNHENSLGRR GASSRLRSTR RQNRTVLHRL TGHFGRRDQG SVKANSNVFE
210 220 230 240 250
PKPSVPEYKV ASVGGSRCLL LHYSIPKAVW DGLILLATFY VAVTVPYNVC
260 270 280 290 300
FAGDDDTPIT SRHTLVSDIA VEMLFILDII LNFRTTYVSQ SGQVVSAPRS
310 320 330 340 350
IGLHYLATWF FVDLIAALPF DLLYVFNITV TSLVHLLKTV RLLRLLRLLQ
360 370 380 390 400
KLERYSQCSA VVLTLLMSVF ALLAHWMACV WYVIGRREME ANDPLLWDIG
410 420 430 440 450
WLHELGKRLE EPYVNGSAGG PSRRSAYIAA LYFTLSSLTS VGFGNVCANT
460 470 480 490 500
DAEKIFSICT MLIGALMHAV VFGNVTAIIQ RMYSRRSLYH SRMKDLKDFI
510 520 530 540 550
RVHRLPRPLK QRMLEYFQTT WAVNSGIDAN ELLRDFPDEL RADIAMHLNR
560 570 580 590 600
EILQLPLFGA ASRGCLRALS LHIKTSFCAP GEFLLRRGDA LQAHYYVCSG
610 620 630 640 650
SLEVLRDNTV LAILGKGDLI GADIPELGQE PGAGAGCVLK TSADVKALTY
660 670 680 690 700
CGLQQLSSRG LAEVLRLYPE YVAAFRAGLP RDLTFNLRQG SENNGLGRFS
710 720 730 740 750
RSPRLSQARS DTLGSSSDKT LPSITETEGG MEPGAGSKPR RPLLLPNLSP
760 770 780 790 800
ARPRGSLVSL LGEELPPFSA LVSSPSLSPT PSPALAGRGS SPSLHGPPRG
810 820 830 840 850
SAAWKPPQLL TPPLGTFGPP DLSPRIVDGI EDSSNTAEAP TFRFSKRPEP
860 870 880 890 900
TRTRSQAPLS GPRLSRELAT EAAEEVKEKV CRLNQEISRL NQEVSQLSRE
910 920 930 940 950
LRQVMGLLQA RLGPPSHPPD STWLPDLPCP HQRPPCISPH MSGPPPGLQN
960 970 980 990 1000
TTLAVVHCPA SVGTVEIGAT PSELRSSMVP PFPSEPDPLG PSPVPEASPL
1010
TPSLLKHSFQ SGSDTFH
Length:1,017
Mass (Da):111,404
Last modified:May 1, 2000 - v1
Checksum:iBFDB0F1B35437C9F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti825 – 8251R → W in CAA07587. (PubMed:9824707)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ007628 mRNA. Translation: CAA07587.1.
AB022699 mRNA. Translation: BAA83593.1.
PIRiT31354.
RefSeqiNP_446082.1. NM_053630.1.
UniGeneiRn.30035.

Genome annotation databases

GeneIDi114032.
KEGGirno:114032.
UCSCiRGD:621415. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ007628 mRNA. Translation: CAA07587.1 .
AB022699 mRNA. Translation: BAA83593.1 .
PIRi T31354.
RefSeqi NP_446082.1. NM_053630.1.
UniGenei Rn.30035.

3D structure databases

ProteinModelPortali Q9R1T9.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9R1T9.
PRIDEi Q9R1T9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 114032.
KEGGi rno:114032.
UCSCi RGD:621415. rat.

Organism-specific databases

CTDi 23415.
RGDi 621415. Kcnh4.

Phylogenomic databases

eggNOGi COG2202.
HOGENOMi HOG000230794.
HOVERGENi HBG052232.
InParanoidi Q9R1T9.
KOi K04907.
PhylomeDBi Q9R1T9.

Miscellaneous databases

NextBioi 618205.
PROi Q9R1T9.

Gene expression databases

Genevestigatori Q9R1T9.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view ]
PRINTSi PR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTi SM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and functional expression of rat ether-a-go-go-like K+ channel genes."
    Engeland B., Neu A., Ludwig J., Roeper J., Pongs O.
    J. Physiol. (Lond.) 513:647-654(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain cortex.
  2. "New ether-a-go-go K+ channel family members localized in human telencephalon."
    Miyake A., Mochizuki S., Yokoi H., Kohda M., Furuichi K.
    J. Biol. Chem. 274:25018-25025(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain."
    Saganich M.J., Machado E., Rudy B.
    J. Neurosci. 21:4609-4624(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiKCNH4_RAT
AccessioniPrimary (citable) accession number: Q9R1T9
Secondary accession number(s): O89048
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: May 1, 2000
Last modified: October 1, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3