Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Potassium voltage-gated channel subfamily H member 4

Gene

Kcnh4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi557 – 672cNMPAdd BLAST116

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 4
Alternative name(s):
Brain-specific eag-like channel 2
Short name:
BEC2
Ether-a-go-go-like potassium channel 1
Short name:
ELK channel 1
Short name:
rElk1
Voltage-gated potassium channel subunit Kv12.3
Gene namesi
Name:Kcnh4
Synonyms:Elk1, Elk3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621415. Kcnh4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 232CytoplasmicSequence analysisAdd BLAST232
Transmembranei233 – 253Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini254 – 262ExtracellularSequence analysis9
Transmembranei263 – 283Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini284 – 305CytoplasmicSequence analysisAdd BLAST22
Transmembranei306 – 326Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini327 – 334ExtracellularSequence analysis8
Transmembranei335 – 355Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini356 – 364CytoplasmicSequence analysis9
Transmembranei365 – 385Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini386 – 427ExtracellularSequence analysisAdd BLAST42
Intramembranei428 – 448Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Topological domaini449 – 454ExtracellularSequence analysis6
Transmembranei455 – 475Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini476 – 1017CytoplasmicSequence analysisAdd BLAST542

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540091 – 1017Potassium voltage-gated channel subfamily H member 4Add BLAST1017

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi415N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9R1T9.
PRIDEiQ9R1T9.

Expressioni

Tissue specificityi

Highly expressed in adult testis, and in adult and embryonic brain. In adult brain found in piriform cortex, olfactory tubercle, cerebral cortex, hippocampus pyramidial cells and dentate gyrus and basal ganglia of caudate/putamen and accumbens nucleus. Detected at intermediate levels in lung, spinal cord, and pituitary.2 Publications

Developmental stagei

Expressed at day E18 in embryonic brain.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025518.

Structurei

3D structure databases

ProteinModelPortaliQ9R1T9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 90PASPROSITE-ProRule annotationAdd BLAST77
Domaini93 – 145PACPROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi440 – 445Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 PAC (PAS-associated C-terminal) domain.PROSITE-ProRule annotation
Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
HOGENOMiHOG000230794.
HOVERGENiHBG052232.
InParanoidiQ9R1T9.
KOiK04907.
PhylomeDBiQ9R1T9.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVMKGLLAP QNTFLDTIAT RFDGTHSNFL LANAQGPRGF PIVYCSDGFC
60 70 80 90 100
ELTGYGRTEV MQKTCSCRFL YGPETSEPAL QRLQKALEGH QEHRAEICFY
110 120 130 140 150
RKDGSAFWCL LDMMPIKNEL GEVVLFLFSF KDISQSGGPG LGSPGIHGDN
160 170 180 190 200
NNHENSLGRR GASSRLRSTR RQNRTVLHRL TGHFGRRDQG SVKANSNVFE
210 220 230 240 250
PKPSVPEYKV ASVGGSRCLL LHYSIPKAVW DGLILLATFY VAVTVPYNVC
260 270 280 290 300
FAGDDDTPIT SRHTLVSDIA VEMLFILDII LNFRTTYVSQ SGQVVSAPRS
310 320 330 340 350
IGLHYLATWF FVDLIAALPF DLLYVFNITV TSLVHLLKTV RLLRLLRLLQ
360 370 380 390 400
KLERYSQCSA VVLTLLMSVF ALLAHWMACV WYVIGRREME ANDPLLWDIG
410 420 430 440 450
WLHELGKRLE EPYVNGSAGG PSRRSAYIAA LYFTLSSLTS VGFGNVCANT
460 470 480 490 500
DAEKIFSICT MLIGALMHAV VFGNVTAIIQ RMYSRRSLYH SRMKDLKDFI
510 520 530 540 550
RVHRLPRPLK QRMLEYFQTT WAVNSGIDAN ELLRDFPDEL RADIAMHLNR
560 570 580 590 600
EILQLPLFGA ASRGCLRALS LHIKTSFCAP GEFLLRRGDA LQAHYYVCSG
610 620 630 640 650
SLEVLRDNTV LAILGKGDLI GADIPELGQE PGAGAGCVLK TSADVKALTY
660 670 680 690 700
CGLQQLSSRG LAEVLRLYPE YVAAFRAGLP RDLTFNLRQG SENNGLGRFS
710 720 730 740 750
RSPRLSQARS DTLGSSSDKT LPSITETEGG MEPGAGSKPR RPLLLPNLSP
760 770 780 790 800
ARPRGSLVSL LGEELPPFSA LVSSPSLSPT PSPALAGRGS SPSLHGPPRG
810 820 830 840 850
SAAWKPPQLL TPPLGTFGPP DLSPRIVDGI EDSSNTAEAP TFRFSKRPEP
860 870 880 890 900
TRTRSQAPLS GPRLSRELAT EAAEEVKEKV CRLNQEISRL NQEVSQLSRE
910 920 930 940 950
LRQVMGLLQA RLGPPSHPPD STWLPDLPCP HQRPPCISPH MSGPPPGLQN
960 970 980 990 1000
TTLAVVHCPA SVGTVEIGAT PSELRSSMVP PFPSEPDPLG PSPVPEASPL
1010
TPSLLKHSFQ SGSDTFH
Length:1,017
Mass (Da):111,404
Last modified:May 1, 2000 - v1
Checksum:iBFDB0F1B35437C9F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti825R → W in CAA07587 (PubMed:9824707).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007628 mRNA. Translation: CAA07587.1.
AB022699 mRNA. Translation: BAA83593.1.
PIRiT31354.
RefSeqiNP_446082.1. NM_053630.1.
UniGeneiRn.30035.

Genome annotation databases

GeneIDi114032.
KEGGirno:114032.
UCSCiRGD:621415. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007628 mRNA. Translation: CAA07587.1.
AB022699 mRNA. Translation: BAA83593.1.
PIRiT31354.
RefSeqiNP_446082.1. NM_053630.1.
UniGeneiRn.30035.

3D structure databases

ProteinModelPortaliQ9R1T9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025518.

Proteomic databases

PaxDbiQ9R1T9.
PRIDEiQ9R1T9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114032.
KEGGirno:114032.
UCSCiRGD:621415. rat.

Organism-specific databases

CTDi23415.
RGDi621415. Kcnh4.

Phylogenomic databases

eggNOGiKOG0498. Eukaryota.
ENOG410XPSE. LUCA.
HOGENOMiHOG000230794.
HOVERGENiHBG052232.
InParanoidiQ9R1T9.
KOiK04907.
PhylomeDBiQ9R1T9.

Miscellaneous databases

PROiQ9R1T9.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKCNH4_RAT
AccessioniPrimary (citable) accession number: Q9R1T9
Secondary accession number(s): O89048
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.