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Q9R1T9

- KCNH4_RAT

UniProt

Q9R1T9 - KCNH4_RAT

Protein

Potassium voltage-gated channel subfamily H member 4

Gene

Kcnh4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi557 – 672116cNMPAdd
    BLAST

    GO - Molecular functioni

    1. phosphorelay sensor kinase activity Source: InterPro
    2. voltage-gated potassium channel activity Source: RefGenome

    GO - Biological processi

    1. potassium ion transmembrane transport Source: RefGenome
    2. regulation of membrane potential Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily H member 4
    Alternative name(s):
    Brain-specific eag-like channel 2
    Short name:
    BEC2
    Ether-a-go-go-like potassium channel 1
    Short name:
    ELK channel 1
    Short name:
    rElk1
    Voltage-gated potassium channel subunit Kv12.3
    Gene namesi
    Name:Kcnh4
    Synonyms:Elk1, Elk3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621415. Kcnh4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10171017Potassium voltage-gated channel subfamily H member 4PRO_0000054009Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9R1T9.
    PRIDEiQ9R1T9.

    Expressioni

    Tissue specificityi

    Highly expressed in adult testis, and in adult and embryonic brain. In adult brain found in piriform cortex, olfactory tubercle, cerebral cortex, hippocampus pyramidial cells and dentate gyrus and basal ganglia of caudate/putamen and accumbens nucleus. Detected at intermediate levels in lung, spinal cord, and pituitary.2 Publications

    Developmental stagei

    Expressed at day E18 in embryonic brain.

    Gene expression databases

    GenevestigatoriQ9R1T9.

    Interactioni

    Subunit structurei

    The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R1T9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 232232CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini254 – 2629ExtracellularSequence Analysis
    Topological domaini284 – 30522CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini327 – 3348ExtracellularSequence Analysis
    Topological domaini356 – 3649CytoplasmicSequence Analysis
    Topological domaini386 – 42742ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini449 – 4546ExtracellularSequence Analysis
    Topological domaini476 – 1017542CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei428 – 44821Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei233 – 25321Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei306 – 32621Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei335 – 35521Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei365 – 38521Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei455 – 47521Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 9077PASPROSITE-ProRule annotationAdd
    BLAST
    Domaini93 – 14553PACPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi440 – 4456Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 PAC (PAS-associated C-terminal) domain.PROSITE-ProRule annotation
    Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2202.
    HOGENOMiHOG000230794.
    HOVERGENiHBG052232.
    InParanoidiQ9R1T9.
    KOiK04907.
    PhylomeDBiQ9R1T9.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003950. K_chnl_volt-dep_ELK.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view]
    PRINTSiPR01463. EAGCHANLFMLY.
    PR01465. ELKCHANNEL.
    SMARTiSM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsiTIGR00229. sensory_box. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9R1T9-1 [UniParc]FASTAAdd to Basket

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    MPVMKGLLAP QNTFLDTIAT RFDGTHSNFL LANAQGPRGF PIVYCSDGFC     50
    ELTGYGRTEV MQKTCSCRFL YGPETSEPAL QRLQKALEGH QEHRAEICFY 100
    RKDGSAFWCL LDMMPIKNEL GEVVLFLFSF KDISQSGGPG LGSPGIHGDN 150
    NNHENSLGRR GASSRLRSTR RQNRTVLHRL TGHFGRRDQG SVKANSNVFE 200
    PKPSVPEYKV ASVGGSRCLL LHYSIPKAVW DGLILLATFY VAVTVPYNVC 250
    FAGDDDTPIT SRHTLVSDIA VEMLFILDII LNFRTTYVSQ SGQVVSAPRS 300
    IGLHYLATWF FVDLIAALPF DLLYVFNITV TSLVHLLKTV RLLRLLRLLQ 350
    KLERYSQCSA VVLTLLMSVF ALLAHWMACV WYVIGRREME ANDPLLWDIG 400
    WLHELGKRLE EPYVNGSAGG PSRRSAYIAA LYFTLSSLTS VGFGNVCANT 450
    DAEKIFSICT MLIGALMHAV VFGNVTAIIQ RMYSRRSLYH SRMKDLKDFI 500
    RVHRLPRPLK QRMLEYFQTT WAVNSGIDAN ELLRDFPDEL RADIAMHLNR 550
    EILQLPLFGA ASRGCLRALS LHIKTSFCAP GEFLLRRGDA LQAHYYVCSG 600
    SLEVLRDNTV LAILGKGDLI GADIPELGQE PGAGAGCVLK TSADVKALTY 650
    CGLQQLSSRG LAEVLRLYPE YVAAFRAGLP RDLTFNLRQG SENNGLGRFS 700
    RSPRLSQARS DTLGSSSDKT LPSITETEGG MEPGAGSKPR RPLLLPNLSP 750
    ARPRGSLVSL LGEELPPFSA LVSSPSLSPT PSPALAGRGS SPSLHGPPRG 800
    SAAWKPPQLL TPPLGTFGPP DLSPRIVDGI EDSSNTAEAP TFRFSKRPEP 850
    TRTRSQAPLS GPRLSRELAT EAAEEVKEKV CRLNQEISRL NQEVSQLSRE 900
    LRQVMGLLQA RLGPPSHPPD STWLPDLPCP HQRPPCISPH MSGPPPGLQN 950
    TTLAVVHCPA SVGTVEIGAT PSELRSSMVP PFPSEPDPLG PSPVPEASPL 1000
    TPSLLKHSFQ SGSDTFH 1017
    Length:1,017
    Mass (Da):111,404
    Last modified:May 1, 2000 - v1
    Checksum:iBFDB0F1B35437C9F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti825 – 8251R → W in CAA07587. (PubMed:9824707)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007628 mRNA. Translation: CAA07587.1.
    AB022699 mRNA. Translation: BAA83593.1.
    PIRiT31354.
    RefSeqiNP_446082.1. NM_053630.1.
    UniGeneiRn.30035.

    Genome annotation databases

    GeneIDi114032.
    KEGGirno:114032.
    UCSCiRGD:621415. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007628 mRNA. Translation: CAA07587.1 .
    AB022699 mRNA. Translation: BAA83593.1 .
    PIRi T31354.
    RefSeqi NP_446082.1. NM_053630.1.
    UniGenei Rn.30035.

    3D structure databases

    ProteinModelPortali Q9R1T9.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9R1T9.
    PRIDEi Q9R1T9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 114032.
    KEGGi rno:114032.
    UCSCi RGD:621415. rat.

    Organism-specific databases

    CTDi 23415.
    RGDi 621415. Kcnh4.

    Phylogenomic databases

    eggNOGi COG2202.
    HOGENOMi HOG000230794.
    HOVERGENi HBG052232.
    InParanoidi Q9R1T9.
    KOi K04907.
    PhylomeDBi Q9R1T9.

    Miscellaneous databases

    NextBioi 618205.
    PROi Q9R1T9.

    Gene expression databases

    Genevestigatori Q9R1T9.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003950. K_chnl_volt-dep_ELK.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view ]
    PRINTSi PR01463. EAGCHANLFMLY.
    PR01465. ELKCHANNEL.
    SMARTi SM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsi TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional expression of rat ether-a-go-go-like K+ channel genes."
      Engeland B., Neu A., Ludwig J., Roeper J., Pongs O.
      J. Physiol. (Lond.) 513:647-654(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Brain cortex.
    2. "New ether-a-go-go K+ channel family members localized in human telencephalon."
      Miyake A., Mochizuki S., Yokoi H., Kohda M., Furuichi K.
      J. Biol. Chem. 274:25018-25025(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain."
      Saganich M.J., Machado E., Rudy B.
      J. Neurosci. 21:4609-4624(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiKCNH4_RAT
    AccessioniPrimary (citable) accession number: Q9R1T9
    Secondary accession number(s): O89048
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3