Reviewed,
UniProtKB/Swiss-Prot Q9R1T7 (ICOS_RAT)
Last modified
October 13, 2009.
Version 37.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (1) |
 Third-party data |
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Names and origin
| Protein names | Recommended name: Inducible T-cell costimulator Alternative name(s): Activation-inducible lymphocyte immunomediatory molecule CD_antigen=CD278 | ||||
| Gene names |
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| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 200 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes By similarity. |
| Subunit structure | Homodimer; disulfide-linked. Ref.1 |
| Subcellular location | Membrane; Single-pass type I membrane protein Potential. |
| Tissue specificity | Strongly expressed in the spleen and lung. Lower expression seen in liver, kidney and testis. Ref.1 |
| Induction | Expression on T-cells is drastically induced by phorbol myristate acetate (PMA) and Ca-ionophore or the engagement of CD3 and CD28. Ref.1 |
| Post-translational modification | N-glycosylated By similarity. |
| Sequence similarities | Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Alternative splicing |
| Domain | Immunoglobulin domain Signal Transmembrane |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | T cell costimulation Ref.1 Inferred from direct assay. Source: RGD T cell tolerance inductionInferred from mutant phenotype. Source: RGD cell-cell adhesionInferred from direct assay. Source: RGD |
| Cellular component | integral to plasma membrane Ref.1 Non-traceable author statement. Source: RGD |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9R1T7-1) Also known as: AILIM-1; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9R1T7-2) Also known as: AILIM-2; The sequence of this isoform differs from the canonical sequence as follows: 198-200: MTS → TAPLRALGRGEHSSCQDRN |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 20 | 20 | Ref.1 | ||||||||
| Chain | 21 – 200 | 180 | Inducible T-cell costimulator | PRO_0000014808 | |||||||
Regions | |||||||||||
| Topological domain | 21 – 145 | 125 | Extracellular Potential | ||||||||
| Transmembrane | 146 – 166 | 21 | Potential | ||||||||
| Topological domain | 167 – 200 | 34 | Cytoplasmic Potential | ||||||||
| Domain | 30 – 133 | 104 | Ig-like V-type | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 89 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 123 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 42 ↔ 109 | By similarity | |||||||||
| Disulfide bond | 63 ↔ 83 | By similarity | |||||||||
Natural variations | |||||||||||
| Alternative sequence | 198 – 200 | 3 | MTS → TAPLRALGRGEHSSCQDRN in isoform 2. | VSP_010789 | |||||||
Sequences
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References
| [1] | "Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family." Tezuka K., Tsuji T., Hirano D., Tamatani T., Sakamaki K., Kobayashi Y., Kamada M. Biochem. Biophys. Res. Commun. 276:335-345(2000) [PubMed: 11006126] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PROTEIN SEQUENCE OF 21-40, FUNCTION, SUBUNIT, INDUCTION, TISSUE SPECIFICITY. Tissue: Spleen. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AB023133 mRNA. Translation: BAA82127.1. AB023134 mRNA. Translation: BAA82128.1. | |
| IPI | IPI00207669. IPI00454381. |
| PIR | JC7396. JC7397. |
| RefSeq | NP_072132.1. |
| UniGene | Rn.168816 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 64545. |
| KEGG | rno:64545. |
Organism-specific databases | |
| CTD | 64545. |
| RGD | 620123. Icos. |
Phylogenomic databases | |
| HOVERGEN | Q9R1T7. |
Gene expression databases | |
| Genevestigator | Q9R1T7. |
Family and domain databases | |
| PROSITE | PS50835. IG_LIKE. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 613416. |
Entry information
| Entry name | ICOS_RAT | ||||||||
| Accession | Primary (citable) accession number: Q9R1T7 Secondary accession number(s): Q9WVR9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
