Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Inducible T-cell costimulator

Gene

Icos

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).By similarity1 Publication

GO - Biological processi

  • single organismal cell-cell adhesion Source: RGD
  • T cell costimulation Source: RGD
  • T cell tolerance induction Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-388841. Costimulation by the CD28 family.

Names & Taxonomyi

Protein namesi
Recommended name:
Inducible T-cell costimulator
Alternative name(s):
Activation-inducible lymphocyte immunomediatory molecule
CD_antigen: CD278
Gene namesi
Name:Icos
Synonyms:Ailim
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi620123. Icos.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 145125ExtracellularSequence analysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence analysisAdd
BLAST
Topological domaini167 – 20034CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • external side of plasma membrane Source: Ensembl
  • integral component of plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 200180Inducible T-cell costimulatorPRO_0000014808Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 109By similarity
Disulfide bondi63 ↔ 83By similarity
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence analysis
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R1T7.

PTM databases

PhosphoSiteiQ9R1T7.

Expressioni

Tissue specificityi

Strongly expressed in the spleen and lung. Lower expression seen in liver, kidney and testis.1 Publication

Inductioni

Expression on T-cells is drastically induced by phorbol myristate acetate (PMA) and Ca-ionophore or the engagement of CD3 and CD28.1 Publication

Gene expression databases

BgeeiENSRNOG00000046196.
ExpressionAtlasiQ9R1T7. baseline and differential.
GenevisibleiQ9R1T7. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064455.

Structurei

3D structure databases

ProteinModelPortaliQ9R1T7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 133104Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J005. Eukaryota.
ENOG41117EH. LUCA.
GeneTreeiENSGT00390000000801.
HOVERGENiHBG052079.
InParanoidiQ9R1T7.
KOiK06713.
OMAiLFCFQVE.
OrthoDBiEOG091G0IRJ.
PhylomeDBiQ9R1T7.

Family and domain databases

InterProiIPR013106. Ig_V-set.
[Graphical view]
PfamiPF15910. V-set_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9R1T7-1) [UniParc]FASTAAdd to basket
Also known as: AILIM-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPYFSCVFV FCFLIKLLTG ELNDLANHRM FSFHDGGVQI SCNYPETVQQ
60 70 80 90 100
LKMQLFKDRE VLCDLTKTKG SGNTVSIKNP MSCPYQLSNN SVSFFLDNAD
110 120 130 140 150
SSQGSYFLCS LSIFDPPPFQ EKNLSGGYLL IYESQLCCQL KLWLPVGCAA
160 170 180 190 200
FVAALLFGCI FIVWFAKKKY RSSVHDPNSE YMFMAAVNTN KKSRLAGMTS
Length:200
Mass (Da):22,529
Last modified:May 1, 2000 - v1
Checksum:i0A74C35581F129D4
GO
Isoform 2 (identifier: Q9R1T7-2) [UniParc]FASTAAdd to basket
Also known as: AILIM-2

The sequence of this isoform differs from the canonical sequence as follows:
     198-200: MTS → TAPLRALGRGEHSSCQDRN

Show »
Length:216
Mass (Da):24,260
Checksum:i772E01320982B15A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei198 – 2003MTS → TAPLRALGRGEHSSCQDRN in isoform 2. 1 PublicationVSP_010789

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023133 mRNA. Translation: BAA82127.1.
AB023134 mRNA. Translation: BAA82128.1.
PIRiJC7396.
JC7397.
RefSeqiNP_072132.1. NM_022610.1. [Q9R1T7-1]
XP_006245099.1. XM_006245037.2. [Q9R1T7-2]
XP_006245100.1. XM_006245038.2. [Q9R1T7-1]
XP_008765358.1. XM_008767136.1. [Q9R1T7-2]
UniGeneiRn.168816.

Genome annotation databases

EnsembliENSRNOT00000071226; ENSRNOP00000064455; ENSRNOG00000046196. [Q9R1T7-1]
GeneIDi64545.
KEGGirno:64545.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023133 mRNA. Translation: BAA82127.1.
AB023134 mRNA. Translation: BAA82128.1.
PIRiJC7396.
JC7397.
RefSeqiNP_072132.1. NM_022610.1. [Q9R1T7-1]
XP_006245099.1. XM_006245037.2. [Q9R1T7-2]
XP_006245100.1. XM_006245038.2. [Q9R1T7-1]
XP_008765358.1. XM_008767136.1. [Q9R1T7-2]
UniGeneiRn.168816.

3D structure databases

ProteinModelPortaliQ9R1T7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064455.

PTM databases

PhosphoSiteiQ9R1T7.

Proteomic databases

PaxDbiQ9R1T7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000071226; ENSRNOP00000064455; ENSRNOG00000046196. [Q9R1T7-1]
GeneIDi64545.
KEGGirno:64545.

Organism-specific databases

CTDi29851.
RGDi620123. Icos.

Phylogenomic databases

eggNOGiENOG410J005. Eukaryota.
ENOG41117EH. LUCA.
GeneTreeiENSGT00390000000801.
HOVERGENiHBG052079.
InParanoidiQ9R1T7.
KOiK06713.
OMAiLFCFQVE.
OrthoDBiEOG091G0IRJ.
PhylomeDBiQ9R1T7.

Enzyme and pathway databases

ReactomeiR-RNO-388841. Costimulation by the CD28 family.

Miscellaneous databases

PROiQ9R1T7.

Gene expression databases

BgeeiENSRNOG00000046196.
ExpressionAtlasiQ9R1T7. baseline and differential.
GenevisibleiQ9R1T7. RN.

Family and domain databases

InterProiIPR013106. Ig_V-set.
[Graphical view]
PfamiPF15910. V-set_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiICOS_RAT
AccessioniPrimary (citable) accession number: Q9R1T7
Secondary accession number(s): Q9WVR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.