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Protein

Septin-6

Gene

Sept6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation.By similarity

Miscellaneous

Coordinated expression with SEPT2 and SEPT7.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei104GTP; via amide nitrogenBy similarity1
Binding sitei239GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei254GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 56GTPBy similarity8
Nucleotide bindingi185 – 193GTPBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Differentiation, Spermatogenesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-6
Gene namesi
Name:Sept6
Synonyms:Kiaa0128
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1888939 Sept6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Centromere, Chromosome, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Kinetochore

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001735262 – 434Septin-6Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei27PhosphoserineBy similarity1
Modified residuei367N6-acetyllysineBy similarity1
Modified residuei416PhosphoserineBy similarity1
Modified residuei418PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9R1T4
PeptideAtlasiQ9R1T4
PRIDEiQ9R1T4

PTM databases

iPTMnetiQ9R1T4
PhosphoSitePlusiQ9R1T4
SwissPalmiQ9R1T4

Expressioni

Tissue specificityi

Associated with synaptic vesicles in various brain regions, including glomeruli of the olfactory bulb.1 Publication

Gene expression databases

BgeeiENSMUSG00000050379
CleanExiMM_SEPT6
ExpressionAtlasiQ9R1T4 baseline and differential
GenevisibleiQ9R1T4 MM

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPT2 and SEPT7. Also interacts with SEPT9 and SEPT12. Interaction with SEPT12 alters filament structure. Component of a septin core octomeric complex consisting of SEPT12, SEPT7, SEPT6 and SEPT2 or SEPT4 in the order 12-7-6-2-2-6-7-12 or 12-7-6-4-4-6-7-12 and located in the sperm annulus. Interacts with SOCS7. Interacts with HNRNPA1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi208037, 28 interactors
IntActiQ9R1T4, 28 interactors
MINTiQ9R1T4
STRINGi10090.ENSMUSP00000110894

Structurei

3D structure databases

ProteinModelPortaliQ9R1T4
SMRiQ9R1T4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 305Septin-type GAdd BLAST267

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili321 – 407Sequence analysisAdd BLAST87

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144070
HOVERGENiHBG065093
InParanoidiQ9R1T4
KOiK16939
OMAiCRTVPLS
OrthoDBiEOG091G0IKM
PhylomeDBiQ9R1T4
TreeFamiTF101080

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR030644 SEPT6
IPR016491 Septin
PANTHERiPTHR18884:SF55 PTHR18884:SF55, 1 hit
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform II (identifier: Q9R1T4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAADIARQV GEDCRTVPLA GHVGFDSLPD QLVNKSVSQG FCFNILCVGE
60 70 80 90 100
TGLGKSTLMD TLFNTKFEGE PATHTQPGVQ LQSNTYDLQE SNVGLKLTIV
110 120 130 140 150
STVGFGDQIN KEDSYKPIVE FIDAQFEAYL QEELKIRRVL HSYHDSRIHV
160 170 180 190 200
CLYFIAPTGH SLKSLDLVTM KKLDSKVNII PVIAKSDAIS KSELAKFKIK
210 220 230 240 250
ITSELVSNGV QIYQFPTDDE SVSEINGTMN AHLPFAVVGS TEEVKIGNKM
260 270 280 290 300
MRARQYPWGT VQVENEAHCD FVKLREMLIR VNMEDLREQT HARHYELYRR
310 320 330 340 350
CKLEEMGFKD TDPDSKPFSL QETYEAKRNE FLGELQKKEE EMRQMFVQRV
360 370 380 390 400
KEKEAELKEA EKELHEKFDR LKKLHQEEKK KLEDKKKCLD EEMNAFKQRK
410 420 430
AAAELLQSQG SQAGGSQTLK RDKEKKNNPW LCIE
Length:434
Mass (Da):49,620
Last modified:January 23, 2007 - v4
Checksum:i33DCD4F44607168A
GO
Isoform I (identifier: Q9R1T4-2) [UniParc]FASTAAdd to basket
Also known as: III

The sequence of this isoform differs from the canonical sequence as follows:
     428-434: Missing.

Show »
Length:427
Mass (Da):48,764
Checksum:i6A6315BB1E6B24C4
GO
Isoform V (identifier: Q9R1T4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     428-434: NPWLCIE → FF

Show »
Length:429
Mass (Da):49,058
Checksum:i59BB0A6315BB1E6B
GO

Sequence cautioni

The sequence BAD32172 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM19782 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10V → L in BAB28516 (PubMed:16141072).Curated1
Sequence conflicti10Missing in BAC33342 (PubMed:16141072).Curated1
Sequence conflicti62L → P in BAC40335 (PubMed:16141072).Curated1
Sequence conflicti141H → Y in BAA82838 (Ref. 1) Curated1
Sequence conflicti170M → I in BAE36069 (PubMed:16141072).Curated1
Sequence conflicti238 – 239VG → C in BAB28516 (PubMed:16141072).Curated2
Sequence conflicti350V → A in BAC40335 (PubMed:16141072).Curated1
Sequence conflicti403A → R in BAA82838 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006055428 – 434Missing in isoform I. 1 Publication7
Alternative sequenceiVSP_006056428 – 434NPWLCIE → FF in isoform V. 2 Publications7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023622 mRNA Translation: BAA82838.1
AK012858 mRNA Translation: BAB28516.1
AK048455 mRNA Translation: BAC33342.1
AK088406 mRNA Translation: BAC40335.1
AK088614 mRNA Translation: BAC40453.1
AK160884 mRNA Translation: BAE36069.1
AK162755 mRNA Translation: BAE37050.1
AL450399 Genomic DNA Translation: CAM19780.1
AL450399 Genomic DNA Translation: CAM19781.1
AL450399 Genomic DNA Translation: CAM19782.1 Sequence problems.
BC010489 mRNA Translation: AAH10489.1
AK172894 mRNA Translation: BAD32172.1 Different initiation.
CCDSiCCDS30066.1 [Q9R1T4-3]
CCDS53051.1 [Q9R1T4-1]
CCDS57749.1 [Q9R1T4-2]
RefSeqiNP_001170794.1, NM_001177323.2
NP_001170795.1, NM_001177324.1 [Q9R1T4-1]
NP_001240635.1, NM_001253706.1 [Q9R1T4-2]
NP_064326.2, NM_019942.5 [Q9R1T4-3]
XP_006541452.1, XM_006541389.3
XP_006541453.1, XM_006541390.2 [Q9R1T4-2]
UniGeneiMm.260036
Mm.470184

Genome annotation databases

EnsembliENSMUST00000053456; ENSMUSP00000054034; ENSMUSG00000050379 [Q9R1T4-2]
ENSMUST00000060474; ENSMUSP00000062014; ENSMUSG00000050379 [Q9R1T4-3]
ENSMUST00000115239; ENSMUSP00000110894; ENSMUSG00000050379 [Q9R1T4-1]
GeneIDi56526
KEGGimmu:56526
UCSCiuc009sxx.2 mouse [Q9R1T4-3]
uc009sxz.2 mouse [Q9R1T4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSEPT6_MOUSE
AccessioniPrimary (citable) accession number: Q9R1T4
Secondary accession number(s): A2A3V9
, A2A3W0, Q3TRH9, Q3TUA2, Q542H3, Q6A0C4, Q8C2L2, Q8C848, Q91XH2, Q9CZ94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 160 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health