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Protein

Midkine

Gene

Mdk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • adrenal gland development Source: UniProtKB
  • behavioral fear response Source: Ensembl
  • cell differentiation Source: UniProtKB-KW
  • cell migration Source: RGD
  • cerebellar granular layer development Source: Ensembl
  • cerebral cortex development Source: Ensembl
  • defecation Source: Ensembl
  • dentate gyrus development Source: Ensembl
  • negative regulation of neuron apoptotic process Source: Ensembl
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of transcription, DNA-templated Source: Ensembl
  • regulation of behavior Source: Ensembl
  • response to drug Source: RGD
  • response to glucocorticoid Source: RGD
  • response to hormone Source: RGD
  • response to wounding Source: UniProtKB
  • short-term memory Source: Ensembl

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Heparin-binding, Mitogen
Biological processDifferentiation

Enzyme and pathway databases

ReactomeiR-RNO-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Midkine
Short name:
MK
Gene namesi
Name:Mdk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi69073 Mdk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000002466421 – 140MidkineAdd BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 58By similarity
Disulfide bondi42 ↔ 67By similarity
Disulfide bondi49 ↔ 71By similarity
Disulfide bondi81 ↔ 113By similarity
Disulfide bondi91 ↔ 123By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9R1S9
PRIDEiQ9R1S9

Expressioni

Tissue specificityi

Expressed at a low level in arteries, and at higher levels in newly formed neointima. In brain, expressed in the caudate nucleus and the brain stem.2 Publications

Developmental stagei

In the cortices of the adrenal glands, expressed at 12.5 dpc, decreases considerably at 15.5 dpc and is almost undetectable in the newborn stage. In brain, expressed at low levels in early embryos, expression peaks between E12 and E14, and rapidly falls until birth when expression is barely detectable.2 Publications

Inductioni

In arteries 3 days after injury. Expression continues to increase until day 7 after injury and decreases slightly by day 14.1 Publication

Gene expression databases

BgeeiENSRNOG00000017560
ExpressionAtlasiQ9R1S9 baseline and differential
GenevisibleiQ9R1S9 RN

Interactioni

Subunit structurei

Homodimer. Interacts with ALK.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249514, 3 interactors
IntActiQ9R1S9, 1 interactor
STRINGi10116.ENSRNOP00000036207

Structurei

3D structure databases

ProteinModelPortaliQ9R1S9
SMRiQ9R1S9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pleiotrophin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0E8 Eukaryota
ENOG4111ZWP LUCA
GeneTreeiENSGT00390000007640
HOVERGENiHBG008317
InParanoidiQ9R1S9
KOiK06828
OMAiYKFESWG
OrthoDBiEOG091G0VCN
PhylomeDBiQ9R1S9

Family and domain databases

Gene3Di2.20.60.10, 1 hit
2.30.90.10, 1 hit
InterProiView protein in InterPro
IPR000762 Midkine_heparin-bd_GF
IPR020090 PTN/MK_C_dom
IPR038130 PTN/MK_C_dom_sf
IPR020091 PTN/MK_diS_sf
IPR020089 PTN/MK_N_dom
IPR037122 PTN/MK_N_dom_sf
IPR020092 PTN_MK_heparin-bd_GF_CS
PANTHERiPTHR13850 PTHR13850, 1 hit
PfamiView protein in Pfam
PF01091 PTN_MK_C, 1 hit
PF05196 PTN_MK_N, 1 hit
PRINTSiPR00269 PTNMIDKINE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005592 PTN_MK_hepar_bd, 1 hit
SMARTiView protein in SMART
SM00193 PTN, 1 hit
SUPFAMiSSF57288 SSF57288, 2 hits
PROSITEiView protein in PROSITE
PS00619 PTN_MK_1, 1 hit
PS00620 PTN_MK_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9R1S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHRSFFLLA LVALLAVTTA VAKKKDKVKK GSECSEWTWG PCTPSSKDCG
60 70 80 90 100
MGFREGTCGA QTQRIHCKVP CNWKKEFGAD CKYKFESWGA CDGSTGTKAR
110 120 130 140
QGTLKKARYN AQCQETIRVT KPCTSKTKSK AKAKKGKGKD
Length:140
Mass (Da):15,406
Last modified:May 1, 2000 - v1
Checksum:i10E340C43AA619CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025023 mRNA Translation: BAA83783.1
AF315950 mRNA Translation: AAG45151.1
RefSeqiNP_110486.1, NM_030859.2
XP_006234654.1, XM_006234592.2
XP_006234655.1, XM_006234593.3
UniGeneiRn.17447

Genome annotation databases

EnsembliENSRNOT00000033978; ENSRNOP00000036207; ENSRNOG00000017560
GeneIDi81517
KEGGirno:81517
UCSCiRGD:69073 rat

Similar proteinsi

Entry informationi

Entry nameiMK_RAT
AccessioniPrimary (citable) accession number: Q9R1S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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