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Q9R1S8

- CAN7_MOUSE

UniProt

Q9R1S8 - CAN7_MOUSE

Protein

Calpain-7

Gene

Capn7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Calcium-regulated non-lysosomal thiol-protease.By similarity

    Catalytic activityi

    Broad endopeptidase specificity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei290 – 2901PROSITE-ProRule annotation
    Active sitei458 – 4581PROSITE-ProRule annotation
    Active sitei478 – 4781PROSITE-ProRule annotation

    GO - Molecular functioni

    1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome

    GO - Biological processi

    1. proteolysis Source: RefGenome
    2. self proteolysis Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Protein family/group databases

    MEROPSiC02.028.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calpain-7 (EC:3.4.22.-)
    Alternative name(s):
    PalB homolog
    Short name:
    PalBH
    Gene namesi
    Name:Capn7
    Synonyms:Palbh
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1338030. Capn7.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 813813Calpain-7PRO_0000207721Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei95 – 951PhosphothreonineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9R1S8.
    PaxDbiQ9R1S8.
    PRIDEiQ9R1S8.

    PTM databases

    PhosphoSiteiQ9R1S8.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ9R1S8.
    BgeeiQ9R1S8.
    CleanExiMM_CAPN7.
    GenevestigatoriQ9R1S8.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000022451.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R1S8.
    SMRiQ9R1S8. Positions 203-577, 684-813.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini232 – 540309Calpain catalyticPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni541 – 701161Domain IIIAdd
    BLAST
    Regioni702 – 813112Domain NAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C2 family.Curated
    Contains 1 calpain catalytic domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG277123.
    GeneTreeiENSGT00750000117668.
    HOGENOMiHOG000006940.
    HOVERGENiHBG036832.
    InParanoidiQ9R1S8.
    KOiK08576.
    OMAiSRWVRPD.
    OrthoDBiEOG7PK8Z7.
    PhylomeDBiQ9R1S8.
    TreeFamiTF322245.

    Family and domain databases

    Gene3Di1.20.58.280. 2 hits.
    InterProiIPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR007330. MIT.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view]
    PfamiPF01067. Calpain_III. 1 hit.
    PF04212. MIT. 2 hits.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view]
    PRINTSiPR00704. CALPAIN.
    SMARTiSM00720. calpain_III. 1 hit.
    SM00230. CysPc. 1 hit.
    SM00745. MIT. 2 hits.
    [Graphical view]
    SUPFAMiSSF116846. SSF116846. 2 hits.
    SSF49758. SSF49758. 2 hits.
    PROSITEiPS50203. CALPAIN_CAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9R1S8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDASALERDA VQFARLAVQR DHEGRYSEAV FYYKEAAQAL IYAEMAGSSL    50
    ERIQEKINEY LERVQALHSA VQSKSTDPLK SKHQLDLERA HFLVTQAFDE 100
    DEKGNVEDAI ELYTEAVELC LKTSSETADK TLQNKLKQLA RQALDRAEAL 150
    SEPLTKPFCK LKSANMKTKT PPVRTHFPLG PNPFVEKPQA FISPQSCDAQ 200
    GQKYTAEEIE VLRTTSKING VEYVPFMSVD LRERFAYPMP FCDRLGKLPL 250
    SPKQKTTFSK WVRPEDLTNN PTMIYTVSSF SIKQTIVSDC SFVASLAISA 300
    AYERRFNKKL ITSIIYPQNK DGEPEYNPCG KYMVKLHLNG VPRKVIIDDQ 350
    LPVDHKGELL CSYSNNKSEL WVSLIEKAYM KVMGGYDFPG SNSNIDLHAL 400
    TGWIPERIAM HSDSQTFSKD NSFRMLYQRF HKGDVLITAS TGVMTEAEGE 450
    KWGLVPTHAY AVLDIREFKG LRFIQLKNPW SHLRWKGRYS ENDVKNWTPE 500
    LQKYLNFDPR TAQKIDNGIF WISWDDLCQY YDVVYLSWNP ALFKESTCIH 550
    STWDAKQGPV KDAYSLANNP QYKLEVQCPQ GGAAVWVLLS RHITDKDDFA 600
    NNREFITMVV YKTDGKKVYY PADPPPYIDG IRINSPHYLT KIKLTTPGTH 650
    TFTLVVSQYE KQNTIHYTVR VYSACSFTFS KIPSPYTLSK RINGKWSGQS 700
    AGGCGNFQET HKNNPIYQFH IDKTGPLLIE LRGPRQYSVG FEVVAVSIMG 750
    DPGPHGFQRK SSGDYRCGFC YLELENIPAG IFNIIPSTFL PKQEGPFFLD 800
    FNSTVPIKTT QLQ 813
    Length:813
    Mass (Da):92,564
    Last modified:May 1, 2000 - v1
    Checksum:i81EB508DF7357655
    GO

    Sequence cautioni

    The sequence CAB39203.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028640 mRNA. Translation: BAA78731.1.
    AJ012475 mRNA. Translation: CAB39203.1. Different initiation.
    CCDSiCCDS26911.1.
    RefSeqiNP_033926.1. NM_009796.2.
    UniGeneiMm.201535.

    Genome annotation databases

    EnsembliENSMUST00000022451; ENSMUSP00000022451; ENSMUSG00000021893.
    GeneIDi12339.
    KEGGimmu:12339.
    UCSCiuc007sxm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028640 mRNA. Translation: BAA78731.1 .
    AJ012475 mRNA. Translation: CAB39203.1 . Different initiation.
    CCDSi CCDS26911.1.
    RefSeqi NP_033926.1. NM_009796.2.
    UniGenei Mm.201535.

    3D structure databases

    ProteinModelPortali Q9R1S8.
    SMRi Q9R1S8. Positions 203-577, 684-813.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000022451.

    Protein family/group databases

    MEROPSi C02.028.

    PTM databases

    PhosphoSitei Q9R1S8.

    Proteomic databases

    MaxQBi Q9R1S8.
    PaxDbi Q9R1S8.
    PRIDEi Q9R1S8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022451 ; ENSMUSP00000022451 ; ENSMUSG00000021893 .
    GeneIDi 12339.
    KEGGi mmu:12339.
    UCSCi uc007sxm.1. mouse.

    Organism-specific databases

    CTDi 23473.
    MGIi MGI:1338030. Capn7.

    Phylogenomic databases

    eggNOGi NOG277123.
    GeneTreei ENSGT00750000117668.
    HOGENOMi HOG000006940.
    HOVERGENi HBG036832.
    InParanoidi Q9R1S8.
    KOi K08576.
    OMAi SRWVRPD.
    OrthoDBi EOG7PK8Z7.
    PhylomeDBi Q9R1S8.
    TreeFami TF322245.

    Miscellaneous databases

    NextBioi 280964.
    PROi Q9R1S8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9R1S8.
    Bgeei Q9R1S8.
    CleanExi MM_CAPN7.
    Genevestigatori Q9R1S8.

    Family and domain databases

    Gene3Di 1.20.58.280. 2 hits.
    InterProi IPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR007330. MIT.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view ]
    Pfami PF01067. Calpain_III. 1 hit.
    PF04212. MIT. 2 hits.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view ]
    PRINTSi PR00704. CALPAIN.
    SMARTi SM00720. calpain_III. 1 hit.
    SM00230. CysPc. 1 hit.
    SM00745. MIT. 2 hits.
    [Graphical view ]
    SUPFAMi SSF116846. SSF116846. 2 hits.
    SSF49758. SSF49758. 2 hits.
    PROSITEi PS50203. CALPAIN_CAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB."
      Futai E., Kubo T., Sorimachi H., Suzuki K., Maeda T.
      Biochim. Biophys. Acta 1517:316-319(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Capn7: a highly divergent vertebrate calpain with a novel C-terminal domain."
      Franz T., Vingron M., Boehm T., Dear T.N.
      Mamm. Genome 10:318-321(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-813.

    Entry informationi

    Entry nameiCAN7_MOUSE
    AccessioniPrimary (citable) accession number: Q9R1S8
    Secondary accession number(s): Q9Z0P9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3