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Q9R1S8

- CAN7_MOUSE

UniProt

Q9R1S8 - CAN7_MOUSE

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Protein
Calpain-7
Gene
Capn7, Palbh
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease By similarity.

Catalytic activityi

Broad endopeptidase specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei290 – 2901 By similarity
Active sitei458 – 4581 By similarity
Active sitei478 – 4781 By similarity

GO - Molecular functioni

  1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. proteolysis Source: RefGenome
  2. self proteolysis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC02.028.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-7 (EC:3.4.22.-)
Alternative name(s):
PalB homolog
Short name:
PalBH
Gene namesi
Name:Capn7
Synonyms:Palbh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1338030. Capn7.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 813813Calpain-7
PRO_0000207721Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei95 – 951Phosphothreonine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9R1S8.
PaxDbiQ9R1S8.
PRIDEiQ9R1S8.

PTM databases

PhosphoSiteiQ9R1S8.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiQ9R1S8.
BgeeiQ9R1S8.
CleanExiMM_CAPN7.
GenevestigatoriQ9R1S8.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022451.

Structurei

3D structure databases

ProteinModelPortaliQ9R1S8.
SMRiQ9R1S8. Positions 203-577, 684-813.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini232 – 540309Calpain catalytic
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni541 – 701161Domain III
Add
BLAST
Regioni702 – 813112Domain N
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG277123.
GeneTreeiENSGT00750000117668.
HOGENOMiHOG000006940.
HOVERGENiHBG036832.
InParanoidiQ9R1S8.
KOiK08576.
OMAiSRWVRPD.
OrthoDBiEOG7PK8Z7.
PhylomeDBiQ9R1S8.
TreeFamiTF322245.

Family and domain databases

Gene3Di1.20.58.280. 2 hits.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR007330. MIT.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF04212. MIT. 2 hits.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00745. MIT. 2 hits.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 2 hits.
SSF49758. SSF49758. 2 hits.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1S8-1 [UniParc]FASTAAdd to Basket

« Hide

MDASALERDA VQFARLAVQR DHEGRYSEAV FYYKEAAQAL IYAEMAGSSL    50
ERIQEKINEY LERVQALHSA VQSKSTDPLK SKHQLDLERA HFLVTQAFDE 100
DEKGNVEDAI ELYTEAVELC LKTSSETADK TLQNKLKQLA RQALDRAEAL 150
SEPLTKPFCK LKSANMKTKT PPVRTHFPLG PNPFVEKPQA FISPQSCDAQ 200
GQKYTAEEIE VLRTTSKING VEYVPFMSVD LRERFAYPMP FCDRLGKLPL 250
SPKQKTTFSK WVRPEDLTNN PTMIYTVSSF SIKQTIVSDC SFVASLAISA 300
AYERRFNKKL ITSIIYPQNK DGEPEYNPCG KYMVKLHLNG VPRKVIIDDQ 350
LPVDHKGELL CSYSNNKSEL WVSLIEKAYM KVMGGYDFPG SNSNIDLHAL 400
TGWIPERIAM HSDSQTFSKD NSFRMLYQRF HKGDVLITAS TGVMTEAEGE 450
KWGLVPTHAY AVLDIREFKG LRFIQLKNPW SHLRWKGRYS ENDVKNWTPE 500
LQKYLNFDPR TAQKIDNGIF WISWDDLCQY YDVVYLSWNP ALFKESTCIH 550
STWDAKQGPV KDAYSLANNP QYKLEVQCPQ GGAAVWVLLS RHITDKDDFA 600
NNREFITMVV YKTDGKKVYY PADPPPYIDG IRINSPHYLT KIKLTTPGTH 650
TFTLVVSQYE KQNTIHYTVR VYSACSFTFS KIPSPYTLSK RINGKWSGQS 700
AGGCGNFQET HKNNPIYQFH IDKTGPLLIE LRGPRQYSVG FEVVAVSIMG 750
DPGPHGFQRK SSGDYRCGFC YLELENIPAG IFNIIPSTFL PKQEGPFFLD 800
FNSTVPIKTT QLQ 813
Length:813
Mass (Da):92,564
Last modified:May 1, 2000 - v1
Checksum:i81EB508DF7357655
GO

Sequence cautioni

The sequence CAB39203.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028640 mRNA. Translation: BAA78731.1.
AJ012475 mRNA. Translation: CAB39203.1. Different initiation.
CCDSiCCDS26911.1.
RefSeqiNP_033926.1. NM_009796.2.
UniGeneiMm.201535.

Genome annotation databases

EnsembliENSMUST00000022451; ENSMUSP00000022451; ENSMUSG00000021893.
GeneIDi12339.
KEGGimmu:12339.
UCSCiuc007sxm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028640 mRNA. Translation: BAA78731.1 .
AJ012475 mRNA. Translation: CAB39203.1 . Different initiation.
CCDSi CCDS26911.1.
RefSeqi NP_033926.1. NM_009796.2.
UniGenei Mm.201535.

3D structure databases

ProteinModelPortali Q9R1S8.
SMRi Q9R1S8. Positions 203-577, 684-813.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000022451.

Protein family/group databases

MEROPSi C02.028.

PTM databases

PhosphoSitei Q9R1S8.

Proteomic databases

MaxQBi Q9R1S8.
PaxDbi Q9R1S8.
PRIDEi Q9R1S8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022451 ; ENSMUSP00000022451 ; ENSMUSG00000021893 .
GeneIDi 12339.
KEGGi mmu:12339.
UCSCi uc007sxm.1. mouse.

Organism-specific databases

CTDi 23473.
MGIi MGI:1338030. Capn7.

Phylogenomic databases

eggNOGi NOG277123.
GeneTreei ENSGT00750000117668.
HOGENOMi HOG000006940.
HOVERGENi HBG036832.
InParanoidi Q9R1S8.
KOi K08576.
OMAi SRWVRPD.
OrthoDBi EOG7PK8Z7.
PhylomeDBi Q9R1S8.
TreeFami TF322245.

Miscellaneous databases

NextBioi 280964.
PROi Q9R1S8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9R1S8.
Bgeei Q9R1S8.
CleanExi MM_CAPN7.
Genevestigatori Q9R1S8.

Family and domain databases

Gene3Di 1.20.58.280. 2 hits.
InterProi IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR007330. MIT.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view ]
Pfami PF01067. Calpain_III. 1 hit.
PF04212. MIT. 2 hits.
PF00648. Peptidase_C2. 1 hit.
[Graphical view ]
PRINTSi PR00704. CALPAIN.
SMARTi SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00745. MIT. 2 hits.
[Graphical view ]
SUPFAMi SSF116846. SSF116846. 2 hits.
SSF49758. SSF49758. 2 hits.
PROSITEi PS50203. CALPAIN_CAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB."
    Futai E., Kubo T., Sorimachi H., Suzuki K., Maeda T.
    Biochim. Biophys. Acta 1517:316-319(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Capn7: a highly divergent vertebrate calpain with a novel C-terminal domain."
    Franz T., Vingron M., Boehm T., Dear T.N.
    Mamm. Genome 10:318-321(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-813.

Entry informationi

Entry nameiCAN7_MOUSE
AccessioniPrimary (citable) accession number: Q9R1S8
Secondary accession number(s): Q9Z0P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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