Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9R1S8

- CAN7_MOUSE

UniProt

Q9R1S8 - CAN7_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Calpain-7

Gene

Capn7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease.By similarity

Catalytic activityi

Broad endopeptidase specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei290 – 2901PROSITE-ProRule annotation
Active sitei458 – 4581PROSITE-ProRule annotation
Active sitei478 – 4781PROSITE-ProRule annotation

GO - Molecular functioni

  1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome

GO - Biological processi

  1. positive regulation of epithelial cell migration Source: Ensembl
  2. proteolysis Source: RefGenome
  3. self proteolysis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC02.028.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-7 (EC:3.4.22.-)
Alternative name(s):
PalB homolog
Short name:
PalBH
Gene namesi
Name:Capn7
Synonyms:Palbh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1338030. Capn7.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. extracellular vesicular exosome Source: Ensembl
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 813813Calpain-7PRO_0000207721Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei95 – 951PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9R1S8.
PaxDbiQ9R1S8.
PRIDEiQ9R1S8.

PTM databases

PhosphoSiteiQ9R1S8.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ9R1S8.
CleanExiMM_CAPN7.
ExpressionAtlasiQ9R1S8. baseline and differential.
GenevestigatoriQ9R1S8.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022451.

Structurei

3D structure databases

ProteinModelPortaliQ9R1S8.
SMRiQ9R1S8. Positions 203-577, 684-813.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini232 – 540309Calpain catalyticPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni541 – 701161Domain IIIAdd
BLAST
Regioni702 – 813112Domain NAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated
Contains 1 calpain catalytic domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG277123.
GeneTreeiENSGT00750000117668.
HOGENOMiHOG000006940.
HOVERGENiHBG036832.
InParanoidiQ9R1S8.
KOiK08576.
OMAiSRWVRPD.
OrthoDBiEOG7PK8Z7.
PhylomeDBiQ9R1S8.
TreeFamiTF322245.

Family and domain databases

Gene3Di1.20.58.280. 2 hits.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR007330. MIT.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF04212. MIT. 2 hits.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00745. MIT. 2 hits.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 2 hits.
SSF49758. SSF49758. 2 hits.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1S8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDASALERDA VQFARLAVQR DHEGRYSEAV FYYKEAAQAL IYAEMAGSSL
60 70 80 90 100
ERIQEKINEY LERVQALHSA VQSKSTDPLK SKHQLDLERA HFLVTQAFDE
110 120 130 140 150
DEKGNVEDAI ELYTEAVELC LKTSSETADK TLQNKLKQLA RQALDRAEAL
160 170 180 190 200
SEPLTKPFCK LKSANMKTKT PPVRTHFPLG PNPFVEKPQA FISPQSCDAQ
210 220 230 240 250
GQKYTAEEIE VLRTTSKING VEYVPFMSVD LRERFAYPMP FCDRLGKLPL
260 270 280 290 300
SPKQKTTFSK WVRPEDLTNN PTMIYTVSSF SIKQTIVSDC SFVASLAISA
310 320 330 340 350
AYERRFNKKL ITSIIYPQNK DGEPEYNPCG KYMVKLHLNG VPRKVIIDDQ
360 370 380 390 400
LPVDHKGELL CSYSNNKSEL WVSLIEKAYM KVMGGYDFPG SNSNIDLHAL
410 420 430 440 450
TGWIPERIAM HSDSQTFSKD NSFRMLYQRF HKGDVLITAS TGVMTEAEGE
460 470 480 490 500
KWGLVPTHAY AVLDIREFKG LRFIQLKNPW SHLRWKGRYS ENDVKNWTPE
510 520 530 540 550
LQKYLNFDPR TAQKIDNGIF WISWDDLCQY YDVVYLSWNP ALFKESTCIH
560 570 580 590 600
STWDAKQGPV KDAYSLANNP QYKLEVQCPQ GGAAVWVLLS RHITDKDDFA
610 620 630 640 650
NNREFITMVV YKTDGKKVYY PADPPPYIDG IRINSPHYLT KIKLTTPGTH
660 670 680 690 700
TFTLVVSQYE KQNTIHYTVR VYSACSFTFS KIPSPYTLSK RINGKWSGQS
710 720 730 740 750
AGGCGNFQET HKNNPIYQFH IDKTGPLLIE LRGPRQYSVG FEVVAVSIMG
760 770 780 790 800
DPGPHGFQRK SSGDYRCGFC YLELENIPAG IFNIIPSTFL PKQEGPFFLD
810
FNSTVPIKTT QLQ
Length:813
Mass (Da):92,564
Last modified:May 1, 2000 - v1
Checksum:i81EB508DF7357655
GO

Sequence cautioni

The sequence CAB39203.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028640 mRNA. Translation: BAA78731.1.
AJ012475 mRNA. Translation: CAB39203.1. Different initiation.
CCDSiCCDS26911.1.
RefSeqiNP_033926.1. NM_009796.2.
UniGeneiMm.201535.

Genome annotation databases

EnsembliENSMUST00000022451; ENSMUSP00000022451; ENSMUSG00000021893.
GeneIDi12339.
KEGGimmu:12339.
UCSCiuc007sxm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028640 mRNA. Translation: BAA78731.1 .
AJ012475 mRNA. Translation: CAB39203.1 . Different initiation.
CCDSi CCDS26911.1.
RefSeqi NP_033926.1. NM_009796.2.
UniGenei Mm.201535.

3D structure databases

ProteinModelPortali Q9R1S8.
SMRi Q9R1S8. Positions 203-577, 684-813.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000022451.

Protein family/group databases

MEROPSi C02.028.

PTM databases

PhosphoSitei Q9R1S8.

Proteomic databases

MaxQBi Q9R1S8.
PaxDbi Q9R1S8.
PRIDEi Q9R1S8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022451 ; ENSMUSP00000022451 ; ENSMUSG00000021893 .
GeneIDi 12339.
KEGGi mmu:12339.
UCSCi uc007sxm.1. mouse.

Organism-specific databases

CTDi 23473.
MGIi MGI:1338030. Capn7.

Phylogenomic databases

eggNOGi NOG277123.
GeneTreei ENSGT00750000117668.
HOGENOMi HOG000006940.
HOVERGENi HBG036832.
InParanoidi Q9R1S8.
KOi K08576.
OMAi SRWVRPD.
OrthoDBi EOG7PK8Z7.
PhylomeDBi Q9R1S8.
TreeFami TF322245.

Miscellaneous databases

NextBioi 280964.
PROi Q9R1S8.
SOURCEi Search...

Gene expression databases

Bgeei Q9R1S8.
CleanExi MM_CAPN7.
ExpressionAtlasi Q9R1S8. baseline and differential.
Genevestigatori Q9R1S8.

Family and domain databases

Gene3Di 1.20.58.280. 2 hits.
InterProi IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR007330. MIT.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view ]
Pfami PF01067. Calpain_III. 1 hit.
PF04212. MIT. 2 hits.
PF00648. Peptidase_C2. 1 hit.
[Graphical view ]
PRINTSi PR00704. CALPAIN.
SMARTi SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00745. MIT. 2 hits.
[Graphical view ]
SUPFAMi SSF116846. SSF116846. 2 hits.
SSF49758. SSF49758. 2 hits.
PROSITEi PS50203. CALPAIN_CAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB."
    Futai E., Kubo T., Sorimachi H., Suzuki K., Maeda T.
    Biochim. Biophys. Acta 1517:316-319(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Capn7: a highly divergent vertebrate calpain with a novel C-terminal domain."
    Franz T., Vingron M., Boehm T., Dear T.N.
    Mamm. Genome 10:318-321(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-813.

Entry informationi

Entry nameiCAN7_MOUSE
AccessioniPrimary (citable) accession number: Q9R1S8
Secondary accession number(s): Q9Z0P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3