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Q9R1S8 (CAN7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Calpain-7
EC=3.4.22.-
Alternative name(s):
PalB homolog
Short name=PalBH
Gene names
Name:Capn7
Synonyms:Palbh
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length813 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Calcium-regulated non-lysosomal thiol-protease By similarity.

Catalytic activity

Broad endopeptidase specificity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the peptidase C2 family.

Contains 1 calpain catalytic domain.

Sequence caution

The sequence CAB39203.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentNucleus
   DomainRepeat
   Molecular functionHydrolase
Protease
Thiol protease
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium-dependent cysteine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 813813Calpain-7
PRO_0000207721

Regions

Domain232 – 540309Calpain catalytic
Region541 – 701161Domain III
Region702 – 813112Domain N

Sites

Active site2901 By similarity
Active site4581 By similarity
Active site5781 By similarity

Amino acid modifications

Modified residue951Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9R1S8 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 81EB508DF7357655

FASTA81392,564
        10         20         30         40         50         60 
MDASALERDA VQFARLAVQR DHEGRYSEAV FYYKEAAQAL IYAEMAGSSL ERIQEKINEY 

        70         80         90        100        110        120 
LERVQALHSA VQSKSTDPLK SKHQLDLERA HFLVTQAFDE DEKGNVEDAI ELYTEAVELC 

       130        140        150        160        170        180 
LKTSSETADK TLQNKLKQLA RQALDRAEAL SEPLTKPFCK LKSANMKTKT PPVRTHFPLG 

       190        200        210        220        230        240 
PNPFVEKPQA FISPQSCDAQ GQKYTAEEIE VLRTTSKING VEYVPFMSVD LRERFAYPMP 

       250        260        270        280        290        300 
FCDRLGKLPL SPKQKTTFSK WVRPEDLTNN PTMIYTVSSF SIKQTIVSDC SFVASLAISA 

       310        320        330        340        350        360 
AYERRFNKKL ITSIIYPQNK DGEPEYNPCG KYMVKLHLNG VPRKVIIDDQ LPVDHKGELL 

       370        380        390        400        410        420 
CSYSNNKSEL WVSLIEKAYM KVMGGYDFPG SNSNIDLHAL TGWIPERIAM HSDSQTFSKD 

       430        440        450        460        470        480 
NSFRMLYQRF HKGDVLITAS TGVMTEAEGE KWGLVPTHAY AVLDIREFKG LRFIQLKNPW 

       490        500        510        520        530        540 
SHLRWKGRYS ENDVKNWTPE LQKYLNFDPR TAQKIDNGIF WISWDDLCQY YDVVYLSWNP 

       550        560        570        580        590        600 
ALFKESTCIH STWDAKQGPV KDAYSLANNP QYKLEVQCPQ GGAAVWVLLS RHITDKDDFA 

       610        620        630        640        650        660 
NNREFITMVV YKTDGKKVYY PADPPPYIDG IRINSPHYLT KIKLTTPGTH TFTLVVSQYE 

       670        680        690        700        710        720 
KQNTIHYTVR VYSACSFTFS KIPSPYTLSK RINGKWSGQS AGGCGNFQET HKNNPIYQFH 

       730        740        750        760        770        780 
IDKTGPLLIE LRGPRQYSVG FEVVAVSIMG DPGPHGFQRK SSGDYRCGFC YLELENIPAG 

       790        800        810 
IFNIIPSTFL PKQEGPFFLD FNSTVPIKTT QLQ

« Hide

References

[1]"Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB."
Futai E., Kubo T., Sorimachi H., Suzuki K., Maeda T.
Biochim. Biophys. Acta 1517:316-319(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Capn7: a highly divergent vertebrate calpain with a novel C-terminal domain."
Franz T., Vingron M., Boehm T., Dear T.N.
Mamm. Genome 10:318-321(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-813.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB028640 mRNA. Translation: BAA78731.1.
AJ012475 mRNA. Translation: CAB39203.1. Different initiation.
IPIIPI00314522.
RefSeqNP_033926.1. NM_009796.2.
UniGeneMm.201535.

3D structure databases

ProteinModelPortalQ9R1S8.
SMRQ9R1S8. Positions 9-72, 86-153, 203-577, 684-813.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000022451.

Protein family/group databases

MEROPSC02.028.

PTM databases

PhosphoSiteQ9R1S8.

Proteomic databases

PaxDbQ9R1S8.
PRIDEQ9R1S8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022451; ENSMUSP00000022451; ENSMUSG00000021893.
GeneID12339.
KEGGmmu:12339.
UCSCuc007sxm.1. mouse.

Organism-specific databases

CTD23473.
MGIMGI:1338030. Capn7.

Phylogenomic databases

eggNOGNOG277123.
GeneTreeENSGT00700000104120.
HOGENOMHOG000006940.
HOVERGENHBG036832.
InParanoidQ9R1S8.
KOK08576.
OMAVFYYKEA.
OrthoDBEOG4HMJ8K.

Gene expression databases

ArrayExpressQ9R1S8.
BgeeQ9R1S8.
CleanExMM_CAPN7.
GenevestigatorQ9R1S8.
GermOnlineENSMUSG00000021893. Mus musculus.

Family and domain databases

InterProIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR007330. MIT.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamPF01067. Calpain_III. 1 hit.
PF04212. MIT. 2 hits.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSPR00704. CALPAIN.
SMARTSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00745. MIT. 2 hits.
[Graphical view]
SUPFAMSSF49758. Peptidase_C2. 2 hits.
PROSITEPS50203. CALPAIN_CAT. 1 hit.
PS00640. THIOL_PROTEASE_ASN. False negative.
PS00139. THIOL_PROTEASE_CYS. False negative.
PS00639. THIOL_PROTEASE_HIS. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio280964.
SOURCESearch...

Entry information

Entry nameCAN7_MOUSE
AccessionPrimary (citable) accession number: Q9R1S8
Secondary accession number(s): Q9Z0P9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 1, 2000
Last modified: May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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