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Protein

Multidrug resistance-associated protein 6

Gene

Abcc6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi661 – 668ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1294 – 1301ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-382556. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 6
Alternative name(s):
ATP-binding cassette sub-family C member 6
Gene namesi
Name:Abcc6
Synonyms:Mrp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1351634. Abcc6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularBy similarityAdd BLAST37
Transmembranei38 – 58Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini59 – 78CytoplasmicBy similarityAdd BLAST20
Transmembranei79 – 99Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini100 – 104ExtracellularBy similarity5
Transmembranei105 – 125Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini126 – 137CytoplasmicBy similarityAdd BLAST12
Transmembranei138 – 155Helical; Name=4PROSITE-ProRule annotationAdd BLAST18
Topological domaini156 – 173ExtracellularBy similarityAdd BLAST18
Transmembranei174 – 194Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini195 – 300CytoplasmicBy similarityAdd BLAST106
Transmembranei301 – 321Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini322 – 347ExtracellularBy similarityAdd BLAST26
Transmembranei348 – 368Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini369 – 424CytoplasmicBy similarityAdd BLAST56
Transmembranei425 – 445Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini446 – 448ExtracellularBy similarity3
Transmembranei449 – 469Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini470 – 531CytoplasmicBy similarityAdd BLAST62
Transmembranei532 – 552Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini553 – 574ExtracellularBy similarityAdd BLAST22
Transmembranei575 – 595Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini596 – 934CytoplasmicBy similarityAdd BLAST339
Transmembranei935 – 955Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini956 – 992ExtracellularBy similarityAdd BLAST37
Transmembranei993 – 1013Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1014 – 1056CytoplasmicBy similarityAdd BLAST43
Transmembranei1057 – 1077Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1078ExtracellularBy similarity1
Transmembranei1079 – 1099Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1100 – 1170CytoplasmicBy similarityAdd BLAST71
Transmembranei1171 – 1191Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1192 – 1193ExtracellularBy similarity2
Transmembranei1194 – 1214Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1215 – 1498CytoplasmicBy similarityAdd BLAST284

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933671 – 1498Multidrug resistance-associated protein 6Add BLAST1498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Glycosylationi341N-linked (GlcNAc...)Sequence analysis1
Modified residuei1281PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9R1S7.
PaxDbiQ9R1S7.
PeptideAtlasiQ9R1S7.
PRIDEiQ9R1S7.

PTM databases

iPTMnetiQ9R1S7.
PhosphoSitePlusiQ9R1S7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030834.
GenevisibleiQ9R1S7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002850.

Structurei

3D structure databases

ProteinModelPortaliQ9R1S7.
SMRiQ9R1S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini309 – 592ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini627 – 851ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini942 – 1223ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST282
Domaini1260 – 1494ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133687.
HOVERGENiHBG108314.
InParanoidiQ9R1S7.
KOiK05669.
OMAiLWADDPT.
OrthoDBiEOG091G00IN.
TreeFamiTF105199.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030239. ABCC6.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF226. PTHR24223:SF226. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRGRSMATP GEQCAGLRVW NQTEQEPAAY HLLSLCFVRA ASSWVPPMYL
60 70 80 90 100
WVLGPIYLLY IHRHGRCYLR MSHLFKTKMV LGLALILLYT FNVAVPLWRI
110 120 130 140 150
HQGVPQAPEL LIHPTVWLTT MSFATFLIHM ERRKGVRSSG VLFGYWLLCC
160 170 180 190 200
ILPGINTVQQ ASAGNFRQEP LHHLATYLCL SLVVAELVLS CLVDQPPFFS
210 220 230 240 250
EDSQPLNPCP EAEASFPSKA MFWWASGLLW RGYKKLLGPK DLWSLGRENS
260 270 280 290 300
SEELVSQLER EWRRSCNGLP GHKGHSSVGA PETEAFLQPE RSQRGPLLRA
310 320 330 340 350
IWRVFRSTFL LGTLSLVISD AFRFAVPKLL SLFLEFMGDR NSSAWTGWLL
360 370 380 390 400
AVLMFAAACL QTLFEQQHMY RAKVLQMRLR TAITGLVYRK VLVLSSGSRK
410 420 430 440 450
SSAAGDVVNL VSVDIQRLAE SIIYLNGLWL LFLWIFVCFV YLWQLLGPSA
460 470 480 490 500
LTAVAVFLSL LPLNFFITKK RGFHQEEQMR QKASRARLTS SMLRTVRTIK
510 520 530 540 550
SHGWEHAFLE RLLHIRGQEL SALKTSTLLF SVSLVSFQVS TFLVALVVFA
560 570 580 590 600
VHTLVAEDNA MDAEKAFVTL TVLSILNKAQ AFLPFSVHCI VQARVSFDRL
610 620 630 640 650
AAFLCLEEVD PNGMIASNSR RSSKDRISVH NGTFAWSQES PPCLHGINLT
660 670 680 690 700
VPQGCLLAVV GPVGAGKSSL LSALLGELLK VEGSVSIEGS VAYVPQEAWV
710 720 730 740 750
QNTSVVENVC FRQELDLPWL QKVLDACALG SDVASFPAGV HTPIGEQGMN
760 770 780 790 800
LSGGQKQRLS LARAVYKKAA IYLLDDPLAA LDAHVSQQVF KQVIGPSGLL
810 820 830 840 850
QGTTRILVTH TLHVLPQADR ILVLANGTIA EMGSYQDLLQ RNGALVGLLD
860 870 880 890 900
GARQPAGTHD AATSDDLGGF PGGGRPTCRP DRPRPTEAAP VKGRSTSEVQ
910 920 930 940 950
MEASLDDPEA TGLTAEEDSV RYGRVKTTIY LSYLRAVGTP LCTYTLFLFL
960 970 980 990 1000
CQQVASFSQG YWLSLWADDP VVDGRQMHAA LRGWVFGLLG CLQAIGLFAS
1010 1020 1030 1040 1050
MAAVFLGGAR ASGLLFRSLL WDVARSPIGF FERTPVGNLL NRFSKETDTV
1060 1070 1080 1090 1100
DVDIPDKLRS LLTYAFGLLE VGLAVTMATP LAIVAILPLM VLYAGFQSLY
1110 1120 1130 1140 1150
VATSCQLRRL ESARYSSVCS HMAETFQGSL VVRAFRAQAS FTAQHDALMD
1160 1170 1180 1190 1200
ENQRVSFPKL VADRWLATNL ELLGNGLVFV AATCAVLSKA HLSAGLVGFS
1210 1220 1230 1240 1250
VSAALQVTQT LQWVVRSWTD LENSMVAVER VQDYARIPKE APWRLPTCAA
1260 1270 1280 1290 1300
QPLWPCGGQI EFRDFGLRHR PELPLAVQGV SLKIHAGEKV GIVGRTGAGK
1310 1320 1330 1340 1350
SSLAWGLLRL QEAAEGNIWI DGVPITHVGL HTLRSRITII PQDPVLFPGS
1360 1370 1380 1390 1400
LRMNLDLLQE HTDEGIWAAL ETVQLKAFVT SLPGQLQYEC AGQGDDLSVG
1410 1420 1430 1440 1450
QKQLLCLARA LLRKTQILIL DEATASVDPG TEMQMQAALE RWFTQCTVLL
1460 1470 1480 1490
IAHRLRSVMD CARVLVMDEG QVAESGSPAQ LLAQKGLFYR LAHESGLA
Length:1,498
Mass (Da):164,857
Last modified:December 14, 2011 - v3
Checksum:i1F426D8CF629E835
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3R → S in BAA83820 (Ref. 1) Curated1
Sequence conflicti28A → V in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti28A → V in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti95V → M in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti95V → M in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti127L → Q in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti138S → A in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti138S → A in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti151I → V in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti151I → V in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti166F → L in BAA83820 (Ref. 1) Curated1
Sequence conflicti231R → G in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti528L → P in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti572V → L in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti621R → C in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti621R → C in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti706V → A in BAA83820 (Ref. 1) Curated1
Sequence conflicti706V → A in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti706V → A in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti767K → R in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti767K → R in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti839L → P in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti927T → I in BAA83820 (Ref. 1) Curated1
Sequence conflicti927T → I in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti927T → I in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti1058L → Q in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti1368A → T in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti1368A → T in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti1370L → P in ABM89087 (PubMed:17360558).Curated1
Sequence conflicti1401Q → H in BAA83820 (Ref. 1) Curated1
Sequence conflicti1448V → L in BAA83820 (Ref. 1) Curated1
Sequence conflicti1451I → T in ABM89088 (PubMed:17360558).Curated1
Sequence conflicti1477S → N in BAA83820 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028737 mRNA. Translation: BAA83820.1.
EF109740 mRNA. Translation: ABM89087.1.
EF109741 mRNA. Translation: ABM89088.1.
AC115036 Genomic DNA. No translation available.
BC049980 mRNA. Translation: AAH49980.1.
CCDSiCCDS21272.1.
RefSeqiNP_061265.2. NM_018795.2.
UniGeneiMm.63514.

Genome annotation databases

EnsembliENSMUST00000002850; ENSMUSP00000002850; ENSMUSG00000030834.
GeneIDi27421.
KEGGimmu:27421.
UCSCiuc009gya.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028737 mRNA. Translation: BAA83820.1.
EF109740 mRNA. Translation: ABM89087.1.
EF109741 mRNA. Translation: ABM89088.1.
AC115036 Genomic DNA. No translation available.
BC049980 mRNA. Translation: AAH49980.1.
CCDSiCCDS21272.1.
RefSeqiNP_061265.2. NM_018795.2.
UniGeneiMm.63514.

3D structure databases

ProteinModelPortaliQ9R1S7.
SMRiQ9R1S7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002850.

PTM databases

iPTMnetiQ9R1S7.
PhosphoSitePlusiQ9R1S7.

Proteomic databases

MaxQBiQ9R1S7.
PaxDbiQ9R1S7.
PeptideAtlasiQ9R1S7.
PRIDEiQ9R1S7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002850; ENSMUSP00000002850; ENSMUSG00000030834.
GeneIDi27421.
KEGGimmu:27421.
UCSCiuc009gya.1. mouse.

Organism-specific databases

CTDi368.
MGIiMGI:1351634. Abcc6.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133687.
HOVERGENiHBG108314.
InParanoidiQ9R1S7.
KOiK05669.
OMAiLWADDPT.
OrthoDBiEOG091G00IN.
TreeFamiTF105199.

Enzyme and pathway databases

ReactomeiR-MMU-382556. ABC-family proteins mediated transport.

Miscellaneous databases

PROiQ9R1S7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030834.
GenevisibleiQ9R1S7. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030239. ABCC6.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF226. PTHR24223:SF226. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRP6_MOUSE
AccessioniPrimary (citable) accession number: Q9R1S7
Secondary accession number(s): A2TAJ0
, A2TAJ1, F8VPT2, Q80YB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 14, 2011
Last modified: November 30, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.