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Q9R1S7 (MRP6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multidrug resistance-associated protein 6
Alternative name(s):
ATP-binding cassette sub-family C member 6
Gene names
Name:Abcc6
Synonyms:Mrp6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1498 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly By similarity.

Subcellular location

Basolateral cell membrane; Multi-pass membrane protein Ref.6.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14981498Multidrug resistance-associated protein 6
PRO_0000093367

Regions

Topological domain1 – 3737Extracellular By similarity
Transmembrane38 – 5821Helical; Name=1; By similarity
Topological domain59 – 7820Cytoplasmic By similarity
Transmembrane79 – 9921Helical; Name=2; By similarity
Topological domain100 – 1045Extracellular By similarity
Transmembrane105 – 12521Helical; Name=3; By similarity
Topological domain126 – 13712Cytoplasmic By similarity
Transmembrane138 – 15518Helical; Name=4; By similarity
Topological domain156 – 17318Extracellular By similarity
Transmembrane174 – 19421Helical; Name=5; By similarity
Topological domain195 – 300106Cytoplasmic By similarity
Transmembrane301 – 32121Helical; Name=6; By similarity
Topological domain322 – 34726Extracellular By similarity
Transmembrane348 – 36821Helical; Name=7; By similarity
Topological domain369 – 42456Cytoplasmic By similarity
Transmembrane425 – 44521Helical; Name=8; By similarity
Topological domain446 – 4483Extracellular By similarity
Transmembrane449 – 46921Helical; Name=9; By similarity
Topological domain470 – 53162Cytoplasmic By similarity
Transmembrane532 – 55221Helical; Name=10; By similarity
Topological domain553 – 57422Extracellular By similarity
Transmembrane575 – 59521Helical; Name=11; By similarity
Topological domain596 – 934339Cytoplasmic By similarity
Transmembrane935 – 95521Helical; Name=12; By similarity
Topological domain956 – 99237Extracellular By similarity
Transmembrane993 – 101321Helical; Name=13; By similarity
Topological domain1014 – 105643Cytoplasmic By similarity
Transmembrane1057 – 107721Helical; Name=14; By similarity
Topological domain10781Extracellular By similarity
Transmembrane1079 – 109921Helical; Name=15; By similarity
Topological domain1100 – 117071Cytoplasmic By similarity
Transmembrane1171 – 119121Helical; Name=16; By similarity
Topological domain1192 – 11932Extracellular By similarity
Transmembrane1194 – 121421Helical; Name=17; By similarity
Topological domain1215 – 1498284Cytoplasmic By similarity
Domain309 – 592284ABC transmembrane type-1 1
Domain627 – 851225ABC transporter 1
Domain942 – 1223282ABC transmembrane type-1 2
Domain1260 – 1494235ABC transporter 2
Nucleotide binding661 – 6688ATP 1 Potential
Nucleotide binding1294 – 13018ATP 2 Potential

Amino acid modifications

Glycosylation211N-linked (GlcNAc...) Potential
Glycosylation3411N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict31R → S in BAA83820. Ref.1
Sequence conflict281A → V in ABM89087. Ref.2
Sequence conflict281A → V in ABM89088. Ref.2
Sequence conflict951V → M in ABM89087. Ref.2
Sequence conflict951V → M in ABM89088. Ref.2
Sequence conflict1271L → Q in ABM89087. Ref.2
Sequence conflict1381S → A in ABM89087. Ref.2
Sequence conflict1381S → A in ABM89088. Ref.2
Sequence conflict1511I → V in ABM89087. Ref.2
Sequence conflict1511I → V in ABM89088. Ref.2
Sequence conflict1661F → L in BAA83820. Ref.1
Sequence conflict2311R → G in ABM89087. Ref.2
Sequence conflict5281L → P in ABM89087. Ref.2
Sequence conflict5721V → L in ABM89087. Ref.2
Sequence conflict6211R → C in ABM89087. Ref.2
Sequence conflict6211R → C in ABM89088. Ref.2
Sequence conflict7061V → A in BAA83820. Ref.1
Sequence conflict7061V → A in ABM89087. Ref.2
Sequence conflict7061V → A in ABM89088. Ref.2
Sequence conflict7671K → R in ABM89087. Ref.2
Sequence conflict7671K → R in ABM89088. Ref.2
Sequence conflict8391L → P in ABM89087. Ref.2
Sequence conflict9271T → I in BAA83820. Ref.1
Sequence conflict9271T → I in ABM89087. Ref.2
Sequence conflict9271T → I in ABM89088. Ref.2
Sequence conflict10581L → Q in ABM89088. Ref.2
Sequence conflict13681A → T in ABM89087. Ref.2
Sequence conflict13681A → T in ABM89088. Ref.2
Sequence conflict13701L → P in ABM89087. Ref.2
Sequence conflict14011Q → H in BAA83820. Ref.1
Sequence conflict14481V → L in BAA83820. Ref.1
Sequence conflict14511I → T in ABM89088. Ref.2
Sequence conflict14771S → N in BAA83820. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9R1S7 [UniParc].

Last modified December 14, 2011. Version 3.
Checksum: 1F426D8CF629E835

FASTA1,498164,857
        10         20         30         40         50         60 
MNRGRSMATP GEQCAGLRVW NQTEQEPAAY HLLSLCFVRA ASSWVPPMYL WVLGPIYLLY 

        70         80         90        100        110        120 
IHRHGRCYLR MSHLFKTKMV LGLALILLYT FNVAVPLWRI HQGVPQAPEL LIHPTVWLTT 

       130        140        150        160        170        180 
MSFATFLIHM ERRKGVRSSG VLFGYWLLCC ILPGINTVQQ ASAGNFRQEP LHHLATYLCL 

       190        200        210        220        230        240 
SLVVAELVLS CLVDQPPFFS EDSQPLNPCP EAEASFPSKA MFWWASGLLW RGYKKLLGPK 

       250        260        270        280        290        300 
DLWSLGRENS SEELVSQLER EWRRSCNGLP GHKGHSSVGA PETEAFLQPE RSQRGPLLRA 

       310        320        330        340        350        360 
IWRVFRSTFL LGTLSLVISD AFRFAVPKLL SLFLEFMGDR NSSAWTGWLL AVLMFAAACL 

       370        380        390        400        410        420 
QTLFEQQHMY RAKVLQMRLR TAITGLVYRK VLVLSSGSRK SSAAGDVVNL VSVDIQRLAE 

       430        440        450        460        470        480 
SIIYLNGLWL LFLWIFVCFV YLWQLLGPSA LTAVAVFLSL LPLNFFITKK RGFHQEEQMR 

       490        500        510        520        530        540 
QKASRARLTS SMLRTVRTIK SHGWEHAFLE RLLHIRGQEL SALKTSTLLF SVSLVSFQVS 

       550        560        570        580        590        600 
TFLVALVVFA VHTLVAEDNA MDAEKAFVTL TVLSILNKAQ AFLPFSVHCI VQARVSFDRL 

       610        620        630        640        650        660 
AAFLCLEEVD PNGMIASNSR RSSKDRISVH NGTFAWSQES PPCLHGINLT VPQGCLLAVV 

       670        680        690        700        710        720 
GPVGAGKSSL LSALLGELLK VEGSVSIEGS VAYVPQEAWV QNTSVVENVC FRQELDLPWL 

       730        740        750        760        770        780 
QKVLDACALG SDVASFPAGV HTPIGEQGMN LSGGQKQRLS LARAVYKKAA IYLLDDPLAA 

       790        800        810        820        830        840 
LDAHVSQQVF KQVIGPSGLL QGTTRILVTH TLHVLPQADR ILVLANGTIA EMGSYQDLLQ 

       850        860        870        880        890        900 
RNGALVGLLD GARQPAGTHD AATSDDLGGF PGGGRPTCRP DRPRPTEAAP VKGRSTSEVQ 

       910        920        930        940        950        960 
MEASLDDPEA TGLTAEEDSV RYGRVKTTIY LSYLRAVGTP LCTYTLFLFL CQQVASFSQG 

       970        980        990       1000       1010       1020 
YWLSLWADDP VVDGRQMHAA LRGWVFGLLG CLQAIGLFAS MAAVFLGGAR ASGLLFRSLL 

      1030       1040       1050       1060       1070       1080 
WDVARSPIGF FERTPVGNLL NRFSKETDTV DVDIPDKLRS LLTYAFGLLE VGLAVTMATP 

      1090       1100       1110       1120       1130       1140 
LAIVAILPLM VLYAGFQSLY VATSCQLRRL ESARYSSVCS HMAETFQGSL VVRAFRAQAS 

      1150       1160       1170       1180       1190       1200 
FTAQHDALMD ENQRVSFPKL VADRWLATNL ELLGNGLVFV AATCAVLSKA HLSAGLVGFS 

      1210       1220       1230       1240       1250       1260 
VSAALQVTQT LQWVVRSWTD LENSMVAVER VQDYARIPKE APWRLPTCAA QPLWPCGGQI 

      1270       1280       1290       1300       1310       1320 
EFRDFGLRHR PELPLAVQGV SLKIHAGEKV GIVGRTGAGK SSLAWGLLRL QEAAEGNIWI 

      1330       1340       1350       1360       1370       1380 
DGVPITHVGL HTLRSRITII PQDPVLFPGS LRMNLDLLQE HTDEGIWAAL ETVQLKAFVT 

      1390       1400       1410       1420       1430       1440 
SLPGQLQYEC AGQGDDLSVG QKQLLCLARA LLRKTQILIL DEATASVDPG TEMQMQAALE 

      1450       1460       1470       1480       1490 
RWFTQCTVLL IAHRLRSVMD CARVLVMDEG QVAESGSPAQ LLAQKGLFYR LAHESGLA 

« Hide

References

« Hide 'large scale' references
[1]"Mus musculus mRNA for multidrug resistance-associated protein 6 (MRP6), complete cds."
Morikawa A., Suzuki H., Hirohashi T., Sugiyama Y.
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ddY.
Tissue: Liver.
[2]"Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics."
Meng H., Vera I., Che N., Wang X., Wang S.S., Ingram-Drake L., Schadt E.E., Drake T.A., Lusis A.J.
Proc. Natl. Acad. Sci. U.S.A. 104:4530-4535(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C3H/HeJ and DBA/2J.
Tissue: Kidney.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 685-1498.
Strain: FVB/N.
Tissue: Liver.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[6]"ABCC6 is a basolateral plasma membrane protein."
Pomozi V., Le Saux O., Brampton C., Apana A., Ilias A., Szeri F., Martin L., Monostory K., Paku S., Sarkadi B., Szakacs G., Varadi A.
Circ. Res. 112:E148-E151(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB028737 mRNA. Translation: BAA83820.1.
EF109740 mRNA. Translation: ABM89087.1.
EF109741 mRNA. Translation: ABM89088.1.
AC115036 Genomic DNA. No translation available.
BC049980 mRNA. Translation: AAH49980.1.
RefSeqNP_061265.2. NM_018795.2.
UniGeneMm.63514.

3D structure databases

ProteinModelPortalQ9R1S7.
SMRQ9R1S7. Positions 314-891, 927-1491.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000002850.

PTM databases

PhosphoSiteQ9R1S7.

Proteomic databases

PaxDbQ9R1S7.
PRIDEQ9R1S7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000002850; ENSMUSP00000002850; ENSMUSG00000030834.
GeneID27421.
KEGGmmu:27421.
UCSCuc009gya.1. mouse.

Organism-specific databases

CTD368.
MGIMGI:1351634. Abcc6.

Phylogenomic databases

eggNOGCOG1132.
GeneTreeENSGT00750000117309.
HOVERGENHBG108314.
InParanoidA2TAJ0.
KOK05669.
OMAHPTVWLT.
OrthoDBEOG7MWGW0.
TreeFamTF105199.

Gene expression databases

BgeeQ9R1S7.
GenevestigatorQ9R1S7.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio305464.
PROQ9R1S7.
SOURCESearch...

Entry information

Entry nameMRP6_MOUSE
AccessionPrimary (citable) accession number: Q9R1S7
Secondary accession number(s): A2TAJ0 expand/collapse secondary AC list , A2TAJ1, F8VPT2, Q80YB6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 14, 2011
Last modified: April 16, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot