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Q9R1S7

- MRP6_MOUSE

UniProt

Q9R1S7 - MRP6_MOUSE

Protein

Multidrug resistance-associated protein 6

Gene

Abcc6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 3 (14 Dec 2011)
      Previous versions | rss
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    Functioni

    May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi661 – 6688ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1294 – 13018ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug resistance-associated protein 6
    Alternative name(s):
    ATP-binding cassette sub-family C member 6
    Gene namesi
    Name:Abcc6
    Synonyms:Mrp6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1351634. Abcc6.

    Subcellular locationi

    Basolateral cell membrane 1 Publication; Multi-pass membrane protein 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. lateral plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14981498Multidrug resistance-associated protein 6PRO_0000093367Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9R1S7.
    PRIDEiQ9R1S7.

    PTM databases

    PhosphoSiteiQ9R1S7.

    Expressioni

    Gene expression databases

    BgeeiQ9R1S7.
    GenevestigatoriQ9R1S7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000002850.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R1S7.
    SMRiQ9R1S7. Positions 314-891, 927-1495.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737ExtracellularBy similarityAdd
    BLAST
    Topological domaini59 – 7820CytoplasmicBy similarityAdd
    BLAST
    Topological domaini100 – 1045ExtracellularBy similarity
    Topological domaini126 – 13712CytoplasmicBy similarityAdd
    BLAST
    Topological domaini156 – 17318ExtracellularBy similarityAdd
    BLAST
    Topological domaini195 – 300106CytoplasmicBy similarityAdd
    BLAST
    Topological domaini322 – 34726ExtracellularBy similarityAdd
    BLAST
    Topological domaini369 – 42456CytoplasmicBy similarityAdd
    BLAST
    Topological domaini446 – 4483ExtracellularBy similarity
    Topological domaini470 – 53162CytoplasmicBy similarityAdd
    BLAST
    Topological domaini553 – 57422ExtracellularBy similarityAdd
    BLAST
    Topological domaini596 – 934339CytoplasmicBy similarityAdd
    BLAST
    Topological domaini956 – 99237ExtracellularBy similarityAdd
    BLAST
    Topological domaini1014 – 105643CytoplasmicBy similarityAdd
    BLAST
    Topological domaini1078 – 10781ExtracellularBy similarity
    Topological domaini1100 – 117071CytoplasmicBy similarityAdd
    BLAST
    Topological domaini1192 – 11932ExtracellularBy similarity
    Topological domaini1215 – 1498284CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821Helical; Name=1PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei79 – 9921Helical; Name=2PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei105 – 12521Helical; Name=3PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei138 – 15518Helical; Name=4PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei174 – 19421Helical; Name=5PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei301 – 32121Helical; Name=6PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei348 – 36821Helical; Name=7PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei425 – 44521Helical; Name=8PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei449 – 46921Helical; Name=9PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei532 – 55221Helical; Name=10PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei575 – 59521Helical; Name=11PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei935 – 95521Helical; Name=12PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei993 – 101321Helical; Name=13PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1057 – 107721Helical; Name=14PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1079 – 109921Helical; Name=15PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1171 – 119121Helical; Name=16PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1194 – 121421Helical; Name=17PROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini309 – 592284ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini627 – 851225ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini942 – 1223282ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1260 – 1494235ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    GeneTreeiENSGT00750000117309.
    HOVERGENiHBG108314.
    InParanoidiA2TAJ0.
    KOiK05669.
    OMAiHPTVWLT.
    OrthoDBiEOG7MWGW0.
    TreeFamiTF105199.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEiPS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9R1S7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNRGRSMATP GEQCAGLRVW NQTEQEPAAY HLLSLCFVRA ASSWVPPMYL     50
    WVLGPIYLLY IHRHGRCYLR MSHLFKTKMV LGLALILLYT FNVAVPLWRI 100
    HQGVPQAPEL LIHPTVWLTT MSFATFLIHM ERRKGVRSSG VLFGYWLLCC 150
    ILPGINTVQQ ASAGNFRQEP LHHLATYLCL SLVVAELVLS CLVDQPPFFS 200
    EDSQPLNPCP EAEASFPSKA MFWWASGLLW RGYKKLLGPK DLWSLGRENS 250
    SEELVSQLER EWRRSCNGLP GHKGHSSVGA PETEAFLQPE RSQRGPLLRA 300
    IWRVFRSTFL LGTLSLVISD AFRFAVPKLL SLFLEFMGDR NSSAWTGWLL 350
    AVLMFAAACL QTLFEQQHMY RAKVLQMRLR TAITGLVYRK VLVLSSGSRK 400
    SSAAGDVVNL VSVDIQRLAE SIIYLNGLWL LFLWIFVCFV YLWQLLGPSA 450
    LTAVAVFLSL LPLNFFITKK RGFHQEEQMR QKASRARLTS SMLRTVRTIK 500
    SHGWEHAFLE RLLHIRGQEL SALKTSTLLF SVSLVSFQVS TFLVALVVFA 550
    VHTLVAEDNA MDAEKAFVTL TVLSILNKAQ AFLPFSVHCI VQARVSFDRL 600
    AAFLCLEEVD PNGMIASNSR RSSKDRISVH NGTFAWSQES PPCLHGINLT 650
    VPQGCLLAVV GPVGAGKSSL LSALLGELLK VEGSVSIEGS VAYVPQEAWV 700
    QNTSVVENVC FRQELDLPWL QKVLDACALG SDVASFPAGV HTPIGEQGMN 750
    LSGGQKQRLS LARAVYKKAA IYLLDDPLAA LDAHVSQQVF KQVIGPSGLL 800
    QGTTRILVTH TLHVLPQADR ILVLANGTIA EMGSYQDLLQ RNGALVGLLD 850
    GARQPAGTHD AATSDDLGGF PGGGRPTCRP DRPRPTEAAP VKGRSTSEVQ 900
    MEASLDDPEA TGLTAEEDSV RYGRVKTTIY LSYLRAVGTP LCTYTLFLFL 950
    CQQVASFSQG YWLSLWADDP VVDGRQMHAA LRGWVFGLLG CLQAIGLFAS 1000
    MAAVFLGGAR ASGLLFRSLL WDVARSPIGF FERTPVGNLL NRFSKETDTV 1050
    DVDIPDKLRS LLTYAFGLLE VGLAVTMATP LAIVAILPLM VLYAGFQSLY 1100
    VATSCQLRRL ESARYSSVCS HMAETFQGSL VVRAFRAQAS FTAQHDALMD 1150
    ENQRVSFPKL VADRWLATNL ELLGNGLVFV AATCAVLSKA HLSAGLVGFS 1200
    VSAALQVTQT LQWVVRSWTD LENSMVAVER VQDYARIPKE APWRLPTCAA 1250
    QPLWPCGGQI EFRDFGLRHR PELPLAVQGV SLKIHAGEKV GIVGRTGAGK 1300
    SSLAWGLLRL QEAAEGNIWI DGVPITHVGL HTLRSRITII PQDPVLFPGS 1350
    LRMNLDLLQE HTDEGIWAAL ETVQLKAFVT SLPGQLQYEC AGQGDDLSVG 1400
    QKQLLCLARA LLRKTQILIL DEATASVDPG TEMQMQAALE RWFTQCTVLL 1450
    IAHRLRSVMD CARVLVMDEG QVAESGSPAQ LLAQKGLFYR LAHESGLA 1498
    Length:1,498
    Mass (Da):164,857
    Last modified:December 14, 2011 - v3
    Checksum:i1F426D8CF629E835
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31R → S in BAA83820. 1 PublicationCurated
    Sequence conflicti28 – 281A → V in ABM89087. (PubMed:17360558)Curated
    Sequence conflicti28 – 281A → V in ABM89088. (PubMed:17360558)Curated
    Sequence conflicti95 – 951V → M in ABM89087. (PubMed:17360558)Curated
    Sequence conflicti95 – 951V → M in ABM89088. (PubMed:17360558)Curated
    Sequence conflicti127 – 1271L → Q in ABM89087. (PubMed:17360558)Curated
    Sequence conflicti138 – 1381S → A in ABM89087. (PubMed:17360558)Curated
    Sequence conflicti138 – 1381S → A in ABM89088. (PubMed:17360558)Curated
    Sequence conflicti151 – 1511I → V in ABM89087. (PubMed:17360558)Curated
    Sequence conflicti151 – 1511I → V in ABM89088. (PubMed:17360558)Curated
    Sequence conflicti166 – 1661F → L in BAA83820. 1 PublicationCurated
    Sequence conflicti231 – 2311R → G in ABM89087. (PubMed:17360558)Curated
    Sequence conflicti528 – 5281L → P in ABM89087. (PubMed:17360558)Curated
    Sequence conflicti572 – 5721V → L in ABM89087. (PubMed:17360558)Curated
    Sequence conflicti621 – 6211R → C in ABM89087. (PubMed:17360558)Curated
    Sequence conflicti621 – 6211R → C in ABM89088. (PubMed:17360558)Curated
    Sequence conflicti706 – 7061V → A in BAA83820. 1 PublicationCurated
    Sequence conflicti706 – 7061V → A in ABM89087. (PubMed:17360558)Curated
    Sequence conflicti706 – 7061V → A in ABM89088. (PubMed:17360558)Curated
    Sequence conflicti767 – 7671K → R in ABM89087. (PubMed:17360558)Curated
    Sequence conflicti767 – 7671K → R in ABM89088. (PubMed:17360558)Curated
    Sequence conflicti839 – 8391L → P in ABM89087. (PubMed:17360558)Curated
    Sequence conflicti927 – 9271T → I in BAA83820. 1 PublicationCurated
    Sequence conflicti927 – 9271T → I in ABM89087. (PubMed:17360558)Curated
    Sequence conflicti927 – 9271T → I in ABM89088. (PubMed:17360558)Curated
    Sequence conflicti1058 – 10581L → Q in ABM89088. (PubMed:17360558)Curated
    Sequence conflicti1368 – 13681A → T in ABM89087. (PubMed:17360558)Curated
    Sequence conflicti1368 – 13681A → T in ABM89088. (PubMed:17360558)Curated
    Sequence conflicti1370 – 13701L → P in ABM89087. (PubMed:17360558)Curated
    Sequence conflicti1401 – 14011Q → H in BAA83820. 1 PublicationCurated
    Sequence conflicti1448 – 14481V → L in BAA83820. 1 PublicationCurated
    Sequence conflicti1451 – 14511I → T in ABM89088. (PubMed:17360558)Curated
    Sequence conflicti1477 – 14771S → N in BAA83820. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028737 mRNA. Translation: BAA83820.1.
    EF109740 mRNA. Translation: ABM89087.1.
    EF109741 mRNA. Translation: ABM89088.1.
    AC115036 Genomic DNA. No translation available.
    BC049980 mRNA. Translation: AAH49980.1.
    CCDSiCCDS21272.1.
    RefSeqiNP_061265.2. NM_018795.2.
    UniGeneiMm.63514.

    Genome annotation databases

    EnsembliENSMUST00000002850; ENSMUSP00000002850; ENSMUSG00000030834.
    GeneIDi27421.
    KEGGimmu:27421.
    UCSCiuc009gya.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028737 mRNA. Translation: BAA83820.1 .
    EF109740 mRNA. Translation: ABM89087.1 .
    EF109741 mRNA. Translation: ABM89088.1 .
    AC115036 Genomic DNA. No translation available.
    BC049980 mRNA. Translation: AAH49980.1 .
    CCDSi CCDS21272.1.
    RefSeqi NP_061265.2. NM_018795.2.
    UniGenei Mm.63514.

    3D structure databases

    ProteinModelPortali Q9R1S7.
    SMRi Q9R1S7. Positions 314-891, 927-1495.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000002850.

    PTM databases

    PhosphoSitei Q9R1S7.

    Proteomic databases

    PaxDbi Q9R1S7.
    PRIDEi Q9R1S7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000002850 ; ENSMUSP00000002850 ; ENSMUSG00000030834 .
    GeneIDi 27421.
    KEGGi mmu:27421.
    UCSCi uc009gya.1. mouse.

    Organism-specific databases

    CTDi 368.
    MGIi MGI:1351634. Abcc6.

    Phylogenomic databases

    eggNOGi COG1132.
    GeneTreei ENSGT00750000117309.
    HOVERGENi HBG108314.
    InParanoidi A2TAJ0.
    KOi K05669.
    OMAi HPTVWLT.
    OrthoDBi EOG7MWGW0.
    TreeFami TF105199.

    Miscellaneous databases

    NextBioi 305464.
    PROi Q9R1S7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9R1S7.
    Genevestigatori Q9R1S7.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEi PS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mus musculus mRNA for multidrug resistance-associated protein 6 (MRP6), complete cds."
      Morikawa A., Suzuki H., Hirohashi T., Sugiyama Y.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ddY.
      Tissue: Liver.
    2. "Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics."
      Meng H., Vera I., Che N., Wang X., Wang S.S., Ingram-Drake L., Schadt E.E., Drake T.A., Lusis A.J.
      Proc. Natl. Acad. Sci. U.S.A. 104:4530-4535(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C3H/HeJ and DBA/2J.
      Tissue: Kidney.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 685-1498.
      Strain: FVB/N.
      Tissue: Liver.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiMRP6_MOUSE
    AccessioniPrimary (citable) accession number: Q9R1S7
    Secondary accession number(s): A2TAJ0
    , A2TAJ1, F8VPT2, Q80YB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 111 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3