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Q9R1S7

- MRP6_MOUSE

UniProt

Q9R1S7 - MRP6_MOUSE

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Protein
Multidrug resistance-associated protein 6
Gene
Abcc6, Mrp6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi661 – 6688ATP 1 Reviewed prediction
Nucleotide bindingi1294 – 13018ATP 2 Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 6
Alternative name(s):
ATP-binding cassette sub-family C member 6
Gene namesi
Name:Abcc6
Synonyms:Mrp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1351634. Abcc6.

Subcellular locationi

Basolateral cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737Extracellular By similarity
Add
BLAST
Transmembranei38 – 5821Helical; Name=1; By similarity
Add
BLAST
Topological domaini59 – 7820Cytoplasmic By similarity
Add
BLAST
Transmembranei79 – 9921Helical; Name=2; By similarity
Add
BLAST
Topological domaini100 – 1045Extracellular By similarity
Transmembranei105 – 12521Helical; Name=3; By similarity
Add
BLAST
Topological domaini126 – 13712Cytoplasmic By similarity
Add
BLAST
Transmembranei138 – 15518Helical; Name=4; By similarity
Add
BLAST
Topological domaini156 – 17318Extracellular By similarity
Add
BLAST
Transmembranei174 – 19421Helical; Name=5; By similarity
Add
BLAST
Topological domaini195 – 300106Cytoplasmic By similarity
Add
BLAST
Transmembranei301 – 32121Helical; Name=6; By similarity
Add
BLAST
Topological domaini322 – 34726Extracellular By similarity
Add
BLAST
Transmembranei348 – 36821Helical; Name=7; By similarity
Add
BLAST
Topological domaini369 – 42456Cytoplasmic By similarity
Add
BLAST
Transmembranei425 – 44521Helical; Name=8; By similarity
Add
BLAST
Topological domaini446 – 4483Extracellular By similarity
Transmembranei449 – 46921Helical; Name=9; By similarity
Add
BLAST
Topological domaini470 – 53162Cytoplasmic By similarity
Add
BLAST
Transmembranei532 – 55221Helical; Name=10; By similarity
Add
BLAST
Topological domaini553 – 57422Extracellular By similarity
Add
BLAST
Transmembranei575 – 59521Helical; Name=11; By similarity
Add
BLAST
Topological domaini596 – 934339Cytoplasmic By similarity
Add
BLAST
Transmembranei935 – 95521Helical; Name=12; By similarity
Add
BLAST
Topological domaini956 – 99237Extracellular By similarity
Add
BLAST
Transmembranei993 – 101321Helical; Name=13; By similarity
Add
BLAST
Topological domaini1014 – 105643Cytoplasmic By similarity
Add
BLAST
Transmembranei1057 – 107721Helical; Name=14; By similarity
Add
BLAST
Topological domaini1078 – 10781Extracellular By similarity
Transmembranei1079 – 109921Helical; Name=15; By similarity
Add
BLAST
Topological domaini1100 – 117071Cytoplasmic By similarity
Add
BLAST
Transmembranei1171 – 119121Helical; Name=16; By similarity
Add
BLAST
Topological domaini1192 – 11932Extracellular By similarity
Transmembranei1194 – 121421Helical; Name=17; By similarity
Add
BLAST
Topological domaini1215 – 1498284Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basolateral plasma membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. lateral plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14981498Multidrug resistance-associated protein 6
PRO_0000093367Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi341 – 3411N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9R1S7.
PRIDEiQ9R1S7.

PTM databases

PhosphoSiteiQ9R1S7.

Expressioni

Gene expression databases

BgeeiQ9R1S7.
GenevestigatoriQ9R1S7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002850.

Structurei

3D structure databases

ProteinModelPortaliQ9R1S7.
SMRiQ9R1S7. Positions 314-891, 927-1495.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini309 – 592284ABC transmembrane type-1 1
Add
BLAST
Domaini627 – 851225ABC transporter 1
Add
BLAST
Domaini942 – 1223282ABC transmembrane type-1 2
Add
BLAST
Domaini1260 – 1494235ABC transporter 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00750000117309.
HOVERGENiHBG108314.
InParanoidiA2TAJ0.
KOiK05669.
OMAiHPTVWLT.
OrthoDBiEOG7MWGW0.
TreeFamiTF105199.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1S7-1 [UniParc]FASTAAdd to Basket

« Hide

MNRGRSMATP GEQCAGLRVW NQTEQEPAAY HLLSLCFVRA ASSWVPPMYL     50
WVLGPIYLLY IHRHGRCYLR MSHLFKTKMV LGLALILLYT FNVAVPLWRI 100
HQGVPQAPEL LIHPTVWLTT MSFATFLIHM ERRKGVRSSG VLFGYWLLCC 150
ILPGINTVQQ ASAGNFRQEP LHHLATYLCL SLVVAELVLS CLVDQPPFFS 200
EDSQPLNPCP EAEASFPSKA MFWWASGLLW RGYKKLLGPK DLWSLGRENS 250
SEELVSQLER EWRRSCNGLP GHKGHSSVGA PETEAFLQPE RSQRGPLLRA 300
IWRVFRSTFL LGTLSLVISD AFRFAVPKLL SLFLEFMGDR NSSAWTGWLL 350
AVLMFAAACL QTLFEQQHMY RAKVLQMRLR TAITGLVYRK VLVLSSGSRK 400
SSAAGDVVNL VSVDIQRLAE SIIYLNGLWL LFLWIFVCFV YLWQLLGPSA 450
LTAVAVFLSL LPLNFFITKK RGFHQEEQMR QKASRARLTS SMLRTVRTIK 500
SHGWEHAFLE RLLHIRGQEL SALKTSTLLF SVSLVSFQVS TFLVALVVFA 550
VHTLVAEDNA MDAEKAFVTL TVLSILNKAQ AFLPFSVHCI VQARVSFDRL 600
AAFLCLEEVD PNGMIASNSR RSSKDRISVH NGTFAWSQES PPCLHGINLT 650
VPQGCLLAVV GPVGAGKSSL LSALLGELLK VEGSVSIEGS VAYVPQEAWV 700
QNTSVVENVC FRQELDLPWL QKVLDACALG SDVASFPAGV HTPIGEQGMN 750
LSGGQKQRLS LARAVYKKAA IYLLDDPLAA LDAHVSQQVF KQVIGPSGLL 800
QGTTRILVTH TLHVLPQADR ILVLANGTIA EMGSYQDLLQ RNGALVGLLD 850
GARQPAGTHD AATSDDLGGF PGGGRPTCRP DRPRPTEAAP VKGRSTSEVQ 900
MEASLDDPEA TGLTAEEDSV RYGRVKTTIY LSYLRAVGTP LCTYTLFLFL 950
CQQVASFSQG YWLSLWADDP VVDGRQMHAA LRGWVFGLLG CLQAIGLFAS 1000
MAAVFLGGAR ASGLLFRSLL WDVARSPIGF FERTPVGNLL NRFSKETDTV 1050
DVDIPDKLRS LLTYAFGLLE VGLAVTMATP LAIVAILPLM VLYAGFQSLY 1100
VATSCQLRRL ESARYSSVCS HMAETFQGSL VVRAFRAQAS FTAQHDALMD 1150
ENQRVSFPKL VADRWLATNL ELLGNGLVFV AATCAVLSKA HLSAGLVGFS 1200
VSAALQVTQT LQWVVRSWTD LENSMVAVER VQDYARIPKE APWRLPTCAA 1250
QPLWPCGGQI EFRDFGLRHR PELPLAVQGV SLKIHAGEKV GIVGRTGAGK 1300
SSLAWGLLRL QEAAEGNIWI DGVPITHVGL HTLRSRITII PQDPVLFPGS 1350
LRMNLDLLQE HTDEGIWAAL ETVQLKAFVT SLPGQLQYEC AGQGDDLSVG 1400
QKQLLCLARA LLRKTQILIL DEATASVDPG TEMQMQAALE RWFTQCTVLL 1450
IAHRLRSVMD CARVLVMDEG QVAESGSPAQ LLAQKGLFYR LAHESGLA 1498
Length:1,498
Mass (Da):164,857
Last modified:December 14, 2011 - v3
Checksum:i1F426D8CF629E835
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31R → S in BAA83820. 1 Publication
Sequence conflicti28 – 281A → V in ABM89087. 1 Publication
Sequence conflicti28 – 281A → V in ABM89088. 1 Publication
Sequence conflicti95 – 951V → M in ABM89087. 1 Publication
Sequence conflicti95 – 951V → M in ABM89088. 1 Publication
Sequence conflicti127 – 1271L → Q in ABM89087. 1 Publication
Sequence conflicti138 – 1381S → A in ABM89087. 1 Publication
Sequence conflicti138 – 1381S → A in ABM89088. 1 Publication
Sequence conflicti151 – 1511I → V in ABM89087. 1 Publication
Sequence conflicti151 – 1511I → V in ABM89088. 1 Publication
Sequence conflicti166 – 1661F → L in BAA83820. 1 Publication
Sequence conflicti231 – 2311R → G in ABM89087. 1 Publication
Sequence conflicti528 – 5281L → P in ABM89087. 1 Publication
Sequence conflicti572 – 5721V → L in ABM89087. 1 Publication
Sequence conflicti621 – 6211R → C in ABM89087. 1 Publication
Sequence conflicti621 – 6211R → C in ABM89088. 1 Publication
Sequence conflicti706 – 7061V → A in BAA83820. 1 Publication
Sequence conflicti706 – 7061V → A in ABM89087. 1 Publication
Sequence conflicti706 – 7061V → A in ABM89088. 1 Publication
Sequence conflicti767 – 7671K → R in ABM89087. 1 Publication
Sequence conflicti767 – 7671K → R in ABM89088. 1 Publication
Sequence conflicti839 – 8391L → P in ABM89087. 1 Publication
Sequence conflicti927 – 9271T → I in BAA83820. 1 Publication
Sequence conflicti927 – 9271T → I in ABM89087. 1 Publication
Sequence conflicti927 – 9271T → I in ABM89088. 1 Publication
Sequence conflicti1058 – 10581L → Q in ABM89088. 1 Publication
Sequence conflicti1368 – 13681A → T in ABM89087. 1 Publication
Sequence conflicti1368 – 13681A → T in ABM89088. 1 Publication
Sequence conflicti1370 – 13701L → P in ABM89087. 1 Publication
Sequence conflicti1401 – 14011Q → H in BAA83820. 1 Publication
Sequence conflicti1448 – 14481V → L in BAA83820. 1 Publication
Sequence conflicti1451 – 14511I → T in ABM89088. 1 Publication
Sequence conflicti1477 – 14771S → N in BAA83820. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028737 mRNA. Translation: BAA83820.1.
EF109740 mRNA. Translation: ABM89087.1.
EF109741 mRNA. Translation: ABM89088.1.
AC115036 Genomic DNA. No translation available.
BC049980 mRNA. Translation: AAH49980.1.
CCDSiCCDS21272.1.
RefSeqiNP_061265.2. NM_018795.2.
UniGeneiMm.63514.

Genome annotation databases

EnsembliENSMUST00000002850; ENSMUSP00000002850; ENSMUSG00000030834.
GeneIDi27421.
KEGGimmu:27421.
UCSCiuc009gya.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028737 mRNA. Translation: BAA83820.1 .
EF109740 mRNA. Translation: ABM89087.1 .
EF109741 mRNA. Translation: ABM89088.1 .
AC115036 Genomic DNA. No translation available.
BC049980 mRNA. Translation: AAH49980.1 .
CCDSi CCDS21272.1.
RefSeqi NP_061265.2. NM_018795.2.
UniGenei Mm.63514.

3D structure databases

ProteinModelPortali Q9R1S7.
SMRi Q9R1S7. Positions 314-891, 927-1495.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000002850.

PTM databases

PhosphoSitei Q9R1S7.

Proteomic databases

PaxDbi Q9R1S7.
PRIDEi Q9R1S7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000002850 ; ENSMUSP00000002850 ; ENSMUSG00000030834 .
GeneIDi 27421.
KEGGi mmu:27421.
UCSCi uc009gya.1. mouse.

Organism-specific databases

CTDi 368.
MGIi MGI:1351634. Abcc6.

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00750000117309.
HOVERGENi HBG108314.
InParanoidi A2TAJ0.
KOi K05669.
OMAi HPTVWLT.
OrthoDBi EOG7MWGW0.
TreeFami TF105199.

Miscellaneous databases

NextBioi 305464.
PROi Q9R1S7.
SOURCEi Search...

Gene expression databases

Bgeei Q9R1S7.
Genevestigatori Q9R1S7.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mus musculus mRNA for multidrug resistance-associated protein 6 (MRP6), complete cds."
    Morikawa A., Suzuki H., Hirohashi T., Sugiyama Y.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ddY.
    Tissue: Liver.
  2. "Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics."
    Meng H., Vera I., Che N., Wang X., Wang S.S., Ingram-Drake L., Schadt E.E., Drake T.A., Lusis A.J.
    Proc. Natl. Acad. Sci. U.S.A. 104:4530-4535(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H/HeJ and DBA/2J.
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 685-1498.
    Strain: FVB/N.
    Tissue: Liver.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiMRP6_MOUSE
AccessioniPrimary (citable) accession number: Q9R1S7
Secondary accession number(s): A2TAJ0
, A2TAJ1, F8VPT2, Q80YB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 14, 2011
Last modified: July 9, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi