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Q9R1S7

- MRP6_MOUSE

UniProt

Q9R1S7 - MRP6_MOUSE

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Protein

Multidrug resistance-associated protein 6

Gene

Abcc6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi661 – 6688ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1294 – 13018ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 6
Alternative name(s):
ATP-binding cassette sub-family C member 6
Gene namesi
Name:Abcc6
Synonyms:Mrp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1351634. Abcc6.

Subcellular locationi

Basolateral cell membrane 1 Publication; Multi-pass membrane protein 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. lateral plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14981498Multidrug resistance-associated protein 6PRO_0000093367Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9R1S7.
PRIDEiQ9R1S7.

PTM databases

PhosphoSiteiQ9R1S7.

Expressioni

Gene expression databases

BgeeiQ9R1S7.
GenevestigatoriQ9R1S7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002850.

Structurei

3D structure databases

ProteinModelPortaliQ9R1S7.
SMRiQ9R1S7. Positions 314-891, 1001-1494.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737ExtracellularBy similarityAdd
BLAST
Topological domaini59 – 7820CytoplasmicBy similarityAdd
BLAST
Topological domaini100 – 1045ExtracellularBy similarity
Topological domaini126 – 13712CytoplasmicBy similarityAdd
BLAST
Topological domaini156 – 17318ExtracellularBy similarityAdd
BLAST
Topological domaini195 – 300106CytoplasmicBy similarityAdd
BLAST
Topological domaini322 – 34726ExtracellularBy similarityAdd
BLAST
Topological domaini369 – 42456CytoplasmicBy similarityAdd
BLAST
Topological domaini446 – 4483ExtracellularBy similarity
Topological domaini470 – 53162CytoplasmicBy similarityAdd
BLAST
Topological domaini553 – 57422ExtracellularBy similarityAdd
BLAST
Topological domaini596 – 934339CytoplasmicBy similarityAdd
BLAST
Topological domaini956 – 99237ExtracellularBy similarityAdd
BLAST
Topological domaini1014 – 105643CytoplasmicBy similarityAdd
BLAST
Topological domaini1078 – 10781ExtracellularBy similarity
Topological domaini1100 – 117071CytoplasmicBy similarityAdd
BLAST
Topological domaini1192 – 11932ExtracellularBy similarity
Topological domaini1215 – 1498284CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821Helical; Name=1PROSITE-ProRule annotationAdd
BLAST
Transmembranei79 – 9921Helical; Name=2PROSITE-ProRule annotationAdd
BLAST
Transmembranei105 – 12521Helical; Name=3PROSITE-ProRule annotationAdd
BLAST
Transmembranei138 – 15518Helical; Name=4PROSITE-ProRule annotationAdd
BLAST
Transmembranei174 – 19421Helical; Name=5PROSITE-ProRule annotationAdd
BLAST
Transmembranei301 – 32121Helical; Name=6PROSITE-ProRule annotationAdd
BLAST
Transmembranei348 – 36821Helical; Name=7PROSITE-ProRule annotationAdd
BLAST
Transmembranei425 – 44521Helical; Name=8PROSITE-ProRule annotationAdd
BLAST
Transmembranei449 – 46921Helical; Name=9PROSITE-ProRule annotationAdd
BLAST
Transmembranei532 – 55221Helical; Name=10PROSITE-ProRule annotationAdd
BLAST
Transmembranei575 – 59521Helical; Name=11PROSITE-ProRule annotationAdd
BLAST
Transmembranei935 – 95521Helical; Name=12PROSITE-ProRule annotationAdd
BLAST
Transmembranei993 – 101321Helical; Name=13PROSITE-ProRule annotationAdd
BLAST
Transmembranei1057 – 107721Helical; Name=14PROSITE-ProRule annotationAdd
BLAST
Transmembranei1079 – 109921Helical; Name=15PROSITE-ProRule annotationAdd
BLAST
Transmembranei1171 – 119121Helical; Name=16PROSITE-ProRule annotationAdd
BLAST
Transmembranei1194 – 121421Helical; Name=17PROSITE-ProRule annotationAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini309 – 592284ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini627 – 851225ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini942 – 1223282ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1260 – 1494235ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00760000119364.
HOVERGENiHBG108314.
InParanoidiQ9R1S7.
KOiK05669.
OMAiHPTVWLT.
OrthoDBiEOG7MWGW0.
TreeFamiTF105199.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1S7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNRGRSMATP GEQCAGLRVW NQTEQEPAAY HLLSLCFVRA ASSWVPPMYL
60 70 80 90 100
WVLGPIYLLY IHRHGRCYLR MSHLFKTKMV LGLALILLYT FNVAVPLWRI
110 120 130 140 150
HQGVPQAPEL LIHPTVWLTT MSFATFLIHM ERRKGVRSSG VLFGYWLLCC
160 170 180 190 200
ILPGINTVQQ ASAGNFRQEP LHHLATYLCL SLVVAELVLS CLVDQPPFFS
210 220 230 240 250
EDSQPLNPCP EAEASFPSKA MFWWASGLLW RGYKKLLGPK DLWSLGRENS
260 270 280 290 300
SEELVSQLER EWRRSCNGLP GHKGHSSVGA PETEAFLQPE RSQRGPLLRA
310 320 330 340 350
IWRVFRSTFL LGTLSLVISD AFRFAVPKLL SLFLEFMGDR NSSAWTGWLL
360 370 380 390 400
AVLMFAAACL QTLFEQQHMY RAKVLQMRLR TAITGLVYRK VLVLSSGSRK
410 420 430 440 450
SSAAGDVVNL VSVDIQRLAE SIIYLNGLWL LFLWIFVCFV YLWQLLGPSA
460 470 480 490 500
LTAVAVFLSL LPLNFFITKK RGFHQEEQMR QKASRARLTS SMLRTVRTIK
510 520 530 540 550
SHGWEHAFLE RLLHIRGQEL SALKTSTLLF SVSLVSFQVS TFLVALVVFA
560 570 580 590 600
VHTLVAEDNA MDAEKAFVTL TVLSILNKAQ AFLPFSVHCI VQARVSFDRL
610 620 630 640 650
AAFLCLEEVD PNGMIASNSR RSSKDRISVH NGTFAWSQES PPCLHGINLT
660 670 680 690 700
VPQGCLLAVV GPVGAGKSSL LSALLGELLK VEGSVSIEGS VAYVPQEAWV
710 720 730 740 750
QNTSVVENVC FRQELDLPWL QKVLDACALG SDVASFPAGV HTPIGEQGMN
760 770 780 790 800
LSGGQKQRLS LARAVYKKAA IYLLDDPLAA LDAHVSQQVF KQVIGPSGLL
810 820 830 840 850
QGTTRILVTH TLHVLPQADR ILVLANGTIA EMGSYQDLLQ RNGALVGLLD
860 870 880 890 900
GARQPAGTHD AATSDDLGGF PGGGRPTCRP DRPRPTEAAP VKGRSTSEVQ
910 920 930 940 950
MEASLDDPEA TGLTAEEDSV RYGRVKTTIY LSYLRAVGTP LCTYTLFLFL
960 970 980 990 1000
CQQVASFSQG YWLSLWADDP VVDGRQMHAA LRGWVFGLLG CLQAIGLFAS
1010 1020 1030 1040 1050
MAAVFLGGAR ASGLLFRSLL WDVARSPIGF FERTPVGNLL NRFSKETDTV
1060 1070 1080 1090 1100
DVDIPDKLRS LLTYAFGLLE VGLAVTMATP LAIVAILPLM VLYAGFQSLY
1110 1120 1130 1140 1150
VATSCQLRRL ESARYSSVCS HMAETFQGSL VVRAFRAQAS FTAQHDALMD
1160 1170 1180 1190 1200
ENQRVSFPKL VADRWLATNL ELLGNGLVFV AATCAVLSKA HLSAGLVGFS
1210 1220 1230 1240 1250
VSAALQVTQT LQWVVRSWTD LENSMVAVER VQDYARIPKE APWRLPTCAA
1260 1270 1280 1290 1300
QPLWPCGGQI EFRDFGLRHR PELPLAVQGV SLKIHAGEKV GIVGRTGAGK
1310 1320 1330 1340 1350
SSLAWGLLRL QEAAEGNIWI DGVPITHVGL HTLRSRITII PQDPVLFPGS
1360 1370 1380 1390 1400
LRMNLDLLQE HTDEGIWAAL ETVQLKAFVT SLPGQLQYEC AGQGDDLSVG
1410 1420 1430 1440 1450
QKQLLCLARA LLRKTQILIL DEATASVDPG TEMQMQAALE RWFTQCTVLL
1460 1470 1480 1490
IAHRLRSVMD CARVLVMDEG QVAESGSPAQ LLAQKGLFYR LAHESGLA
Length:1,498
Mass (Da):164,857
Last modified:December 14, 2011 - v3
Checksum:i1F426D8CF629E835
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31R → S in BAA83820. 1 PublicationCurated
Sequence conflicti28 – 281A → V in ABM89087. (PubMed:17360558)Curated
Sequence conflicti28 – 281A → V in ABM89088. (PubMed:17360558)Curated
Sequence conflicti95 – 951V → M in ABM89087. (PubMed:17360558)Curated
Sequence conflicti95 – 951V → M in ABM89088. (PubMed:17360558)Curated
Sequence conflicti127 – 1271L → Q in ABM89087. (PubMed:17360558)Curated
Sequence conflicti138 – 1381S → A in ABM89087. (PubMed:17360558)Curated
Sequence conflicti138 – 1381S → A in ABM89088. (PubMed:17360558)Curated
Sequence conflicti151 – 1511I → V in ABM89087. (PubMed:17360558)Curated
Sequence conflicti151 – 1511I → V in ABM89088. (PubMed:17360558)Curated
Sequence conflicti166 – 1661F → L in BAA83820. 1 PublicationCurated
Sequence conflicti231 – 2311R → G in ABM89087. (PubMed:17360558)Curated
Sequence conflicti528 – 5281L → P in ABM89087. (PubMed:17360558)Curated
Sequence conflicti572 – 5721V → L in ABM89087. (PubMed:17360558)Curated
Sequence conflicti621 – 6211R → C in ABM89087. (PubMed:17360558)Curated
Sequence conflicti621 – 6211R → C in ABM89088. (PubMed:17360558)Curated
Sequence conflicti706 – 7061V → A in BAA83820. 1 PublicationCurated
Sequence conflicti706 – 7061V → A in ABM89087. (PubMed:17360558)Curated
Sequence conflicti706 – 7061V → A in ABM89088. (PubMed:17360558)Curated
Sequence conflicti767 – 7671K → R in ABM89087. (PubMed:17360558)Curated
Sequence conflicti767 – 7671K → R in ABM89088. (PubMed:17360558)Curated
Sequence conflicti839 – 8391L → P in ABM89087. (PubMed:17360558)Curated
Sequence conflicti927 – 9271T → I in BAA83820. 1 PublicationCurated
Sequence conflicti927 – 9271T → I in ABM89087. (PubMed:17360558)Curated
Sequence conflicti927 – 9271T → I in ABM89088. (PubMed:17360558)Curated
Sequence conflicti1058 – 10581L → Q in ABM89088. (PubMed:17360558)Curated
Sequence conflicti1368 – 13681A → T in ABM89087. (PubMed:17360558)Curated
Sequence conflicti1368 – 13681A → T in ABM89088. (PubMed:17360558)Curated
Sequence conflicti1370 – 13701L → P in ABM89087. (PubMed:17360558)Curated
Sequence conflicti1401 – 14011Q → H in BAA83820. 1 PublicationCurated
Sequence conflicti1448 – 14481V → L in BAA83820. 1 PublicationCurated
Sequence conflicti1451 – 14511I → T in ABM89088. (PubMed:17360558)Curated
Sequence conflicti1477 – 14771S → N in BAA83820. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028737 mRNA. Translation: BAA83820.1.
EF109740 mRNA. Translation: ABM89087.1.
EF109741 mRNA. Translation: ABM89088.1.
AC115036 Genomic DNA. No translation available.
BC049980 mRNA. Translation: AAH49980.1.
CCDSiCCDS21272.1.
RefSeqiNP_061265.2. NM_018795.2.
UniGeneiMm.63514.

Genome annotation databases

EnsembliENSMUST00000002850; ENSMUSP00000002850; ENSMUSG00000030834.
GeneIDi27421.
KEGGimmu:27421.
UCSCiuc009gya.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028737 mRNA. Translation: BAA83820.1 .
EF109740 mRNA. Translation: ABM89087.1 .
EF109741 mRNA. Translation: ABM89088.1 .
AC115036 Genomic DNA. No translation available.
BC049980 mRNA. Translation: AAH49980.1 .
CCDSi CCDS21272.1.
RefSeqi NP_061265.2. NM_018795.2.
UniGenei Mm.63514.

3D structure databases

ProteinModelPortali Q9R1S7.
SMRi Q9R1S7. Positions 314-891, 1001-1494.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000002850.

PTM databases

PhosphoSitei Q9R1S7.

Proteomic databases

PaxDbi Q9R1S7.
PRIDEi Q9R1S7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000002850 ; ENSMUSP00000002850 ; ENSMUSG00000030834 .
GeneIDi 27421.
KEGGi mmu:27421.
UCSCi uc009gya.1. mouse.

Organism-specific databases

CTDi 368.
MGIi MGI:1351634. Abcc6.

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00760000119364.
HOVERGENi HBG108314.
InParanoidi Q9R1S7.
KOi K05669.
OMAi HPTVWLT.
OrthoDBi EOG7MWGW0.
TreeFami TF105199.

Miscellaneous databases

NextBioi 305464.
PROi Q9R1S7.
SOURCEi Search...

Gene expression databases

Bgeei Q9R1S7.
Genevestigatori Q9R1S7.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mus musculus mRNA for multidrug resistance-associated protein 6 (MRP6), complete cds."
    Morikawa A., Suzuki H., Hirohashi T., Sugiyama Y.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ddY.
    Tissue: Liver.
  2. "Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics."
    Meng H., Vera I., Che N., Wang X., Wang S.S., Ingram-Drake L., Schadt E.E., Drake T.A., Lusis A.J.
    Proc. Natl. Acad. Sci. U.S.A. 104:4530-4535(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H/HeJ and DBA/2J.
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 685-1498.
    Strain: FVB/N.
    Tissue: Liver.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiMRP6_MOUSE
AccessioniPrimary (citable) accession number: Q9R1S7
Secondary accession number(s): A2TAJ0
, A2TAJ1, F8VPT2, Q80YB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 14, 2011
Last modified: October 29, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3