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Protein

Tudor domain-containing protein 7

Gene

Tdrd7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis (By similarity).By similarity

GO - Molecular functioni

  • mRNA binding Source: UniProtKB
  • protein N-terminus binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tudor domain-containing protein 7
Alternative name(s):
PCTAIRE2-binding protein
Tudor repeat associator with PCTAIRE-2
Short name:
Trap
Gene namesi
Name:Tdrd7
Synonyms:Pctaire2bp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi619724. Tdrd7.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Localizes to cytoplasmic RNA granules (By similarity). Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids (By similarity). According to PubMed:10727952 localizes preferentially on the periphery of mitochondria.By similarity1 Publication

GO - Cellular componenti

  • mitochondrial matrix Source: RGD
  • ribonucleoprotein granule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11131113Tudor domain-containing protein 7PRO_0000183171Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei874 – 8741PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9R1R4.
PRIDEiQ9R1R4.

PTM databases

iPTMnetiQ9R1R4.
PhosphoSiteiQ9R1R4.

Expressioni

Tissue specificityi

Expressed in brain and testis.1 Publication

Developmental stagei

Expressed in embryo at 16 dpc onwards.1 Publication

Gene expression databases

BgeeiENSRNOG00000009985.
GenevisibleiQ9R1R4. RN.

Interactioni

Subunit structurei

Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1 (By similarity).By similarity

GO - Molecular functioni

  • protein N-terminus binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013726.

Structurei

3D structure databases

ProteinModelPortaliQ9R1R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 7674HTH OST-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini249 – 31870HTH OST-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini352 – 42170HTH OST-type 3PROSITE-ProRule annotationAdd
BLAST
Domaini528 – 58558Tudor 1PROSITE-ProRule annotationAdd
BLAST
Domaini718 – 77558Tudor 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni876 – 1113238Interacts with CDK17Add
BLAST
Regioni908 – 1113206Interacts with CABLES1By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi334 – 3407Poly-Pro

Sequence similaritiesi

Belongs to the TDRD7 family.Curated
Contains 3 HTH OST-type domains.PROSITE-ProRule annotation
Contains 2 Tudor domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IPR1. Eukaryota.
ENOG410XST4. LUCA.
GeneTreeiENSGT00830000128334.
HOGENOMiHOG000294063.
HOVERGENiHBG055704.
InParanoidiQ9R1R4.
KOiK18405.
OMAiKCSQWSE.
OrthoDBiEOG091G00Z5.
PhylomeDBiQ9R1R4.

Family and domain databases

InterProiIPR025605. OST-HTH/LOTUS_dom.
IPR002999. Tudor.
[Graphical view]
PfamiPF12872. OST-HTH. 1 hit.
PF00567. TUDOR. 3 hits.
[Graphical view]
SMARTiSM00333. TUDOR. 3 hits.
[Graphical view]
PROSITEiPS51644. HTH_OST. 3 hits.
PS50304. TUDOR. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9R1R4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLEADLVSKM LRAVLQSHKN GIVLPRLQGE YRSLTGDWIP FKQLGYPTLE
60 70 80 90 100
AYLRSVPAVV RIEASRSGEI VCYAVACTET ARIAQLVARQ RTSKRKTGRQ
110 120 130 140 150
INCQMRVKKT MPFFLEGKPK ATLRQPGFAS DYSISKKPNP TLLREKGSTL
160 170 180 190 200
GAKADVDMPP YPDAPVQRHV SMSANSSVTV LRSHPEASKL QFMGYSPKPH
210 220 230 240 250
CLLLFSPKSS LPAPFQTHIS RACPKEVNDN LNQTVEKPNV TPPASYTNKM
260 270 280 290 300
DEVQNRIKEI LDKHNNGIWI SKLPHFYKEF YKEDLNQGVL QQFEHWPHIC
310 320 330 340 350
TVEKPCGGGQ DLLLYPAKRE QPLRSDQDPE KERPPPPPAP RQEVPSKGSP
360 370 380 390 400
AVMPDVKEKV AELLGKYSSG LWASALPKAF EDMYKVKFPE DALKNLASLS
410 420 430 440 450
DVCTINYISG NTQKAILYAK LPLPTDKILK DEAQAQGDFD IKSMIEQEYL
460 470 480 490 500
QIEKNMAESA DDFVEDITVP PLVIPTEASP SVLVVELSNT NDVVIRYVGK
510 520 530 540 550
DYSAAQELME DEMKEYYSRN PRVTPIQTVH VGQLLAVNAE EDAWLRAQII
560 570 580 590 600
STDENKIKVC YVDYGFCENI EKSKAYRLNP RFCSLSFQAT KCKLAGLEIL
610 620 630 640 650
NDDPNLVKVV ESLTCGKIFA VEILDKSDIP LVVLYDTSGE DDININATCL
660 670 680 690 700
KAICDRSLEV HLQVDAMYTN VKVTNICSDG TLYCQVPCKG LNKLNDLLHK
710 720 730 740 750
TEDYFHCKHM TSEYFISLPF CGKICLFHCK GKWLRVEITN VHSSRALDVQ
760 770 780 790 800
FLDSGNSTSV KVSELREIPP RFLQEMLAIP PQAIKCCLAD LPQSIGMWTP
810 820 830 840 850
DAVLWLRDSV LNCSDCSIKV TKVDEARGVA YVYLFTPKNF PDPHRSINRQ
860 870 880 890 900
ITNADLWKHQ KDVFLSAVSA AASSPGNRNA STPAPGSPAE SLRKSHPEVL
910 920 930 940 950
RKSVLDHTSS FSLEELPPPV HLSKSGEHMD VYVPVACHPG HFVIQPWQEI
960 970 980 990 1000
HKLEVLMEEM ILYYSVSEER HIAVERDQVY AAKVENKWYR VLLKGILTNG
1010 1020 1030 1040 1050
LVSVYELDYG KHELVNIRKV QPLVDVFRKL PFQAVTAQLA GVKCSQWSEE
1060 1070 1080 1090 1100
ASMVFRNHVE KKPLVALVQT VIEHANPWDR KVVVYLVDTS LPDTDTWIHD
1110
FMSQYLVELS KAN
Length:1,113
Mass (Da):125,310
Last modified:May 1, 2000 - v1
Checksum:i752E2C6CA0D6148A
GO
Isoform 2 (identifier: Q9R1R4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-204: SVTVLRSHPEASKLQFMGYSPKPHCLLL → R

Show »
Length:1,086
Mass (Da):122,345
Checksum:i92982E9D443654DB
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei177 – 20428SVTVL…HCLLL → R in isoform 2. 1 PublicationVSP_041317Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030644 mRNA. Translation: BAA82968.1.
BC090066 mRNA. Translation: AAH90066.1.
RefSeqiNP_620226.1. NM_138871.1. [Q9R1R4-1]
XP_006238173.1. XM_006238111.2. [Q9R1R4-2]
XP_008761926.1. XM_008763704.1. [Q9R1R4-2]
UniGeneiRn.16138.

Genome annotation databases

EnsembliENSRNOT00000085738; ENSRNOP00000068568; ENSRNOG00000055779. [Q9R1R4-1]
ENSRNOT00000089938; ENSRNOP00000070634; ENSRNOG00000055779. [Q9R1R4-1]
ENSRNOT00000090186; ENSRNOP00000070639; ENSRNOG00000055779. [Q9R1R4-2]
GeneIDi85425.
KEGGirno:85425.
UCSCiRGD:619724. rat. [Q9R1R4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030644 mRNA. Translation: BAA82968.1.
BC090066 mRNA. Translation: AAH90066.1.
RefSeqiNP_620226.1. NM_138871.1. [Q9R1R4-1]
XP_006238173.1. XM_006238111.2. [Q9R1R4-2]
XP_008761926.1. XM_008763704.1. [Q9R1R4-2]
UniGeneiRn.16138.

3D structure databases

ProteinModelPortaliQ9R1R4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013726.

PTM databases

iPTMnetiQ9R1R4.
PhosphoSiteiQ9R1R4.

Proteomic databases

PaxDbiQ9R1R4.
PRIDEiQ9R1R4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000085738; ENSRNOP00000068568; ENSRNOG00000055779. [Q9R1R4-1]
ENSRNOT00000089938; ENSRNOP00000070634; ENSRNOG00000055779. [Q9R1R4-1]
ENSRNOT00000090186; ENSRNOP00000070639; ENSRNOG00000055779. [Q9R1R4-2]
GeneIDi85425.
KEGGirno:85425.
UCSCiRGD:619724. rat. [Q9R1R4-1]

Organism-specific databases

CTDi23424.
RGDi619724. Tdrd7.

Phylogenomic databases

eggNOGiENOG410IPR1. Eukaryota.
ENOG410XST4. LUCA.
GeneTreeiENSGT00830000128334.
HOGENOMiHOG000294063.
HOVERGENiHBG055704.
InParanoidiQ9R1R4.
KOiK18405.
OMAiKCSQWSE.
OrthoDBiEOG091G00Z5.
PhylomeDBiQ9R1R4.

Miscellaneous databases

PROiQ9R1R4.

Gene expression databases

BgeeiENSRNOG00000009985.
GenevisibleiQ9R1R4. RN.

Family and domain databases

InterProiIPR025605. OST-HTH/LOTUS_dom.
IPR002999. Tudor.
[Graphical view]
PfamiPF12872. OST-HTH. 1 hit.
PF00567. TUDOR. 3 hits.
[Graphical view]
SMARTiSM00333. TUDOR. 3 hits.
[Graphical view]
PROSITEiPS51644. HTH_OST. 3 hits.
PS50304. TUDOR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTDRD7_RAT
AccessioniPrimary (citable) accession number: Q9R1R4
Secondary accession number(s): Q5FVD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.