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Q9R1R2

- TRIM3_MOUSE

UniProt

Q9R1R2 - TRIM3_MOUSE

Protein

Tripartite motif-containing protein 3

Gene

Trim3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri22 – 6342RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri110 – 15142B box-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. ubiquitin-protein transferase activity Source: FlyBase
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. protein ubiquitination Source: FlyBase

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripartite motif-containing protein 3
    Alternative name(s):
    RING finger protein 22
    RING finger protein HAC1
    Gene namesi
    Name:Trim3
    Synonyms:Hac1, Rnf22
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1860040. Trim3.

    Subcellular locationi

    Cytoplasm By similarity. Early endosome By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. early endosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Endosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 744743Tripartite motif-containing protein 3PRO_0000056198Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei7 – 71Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9R1R2.
    PaxDbiQ9R1R2.
    PRIDEiQ9R1R2.

    PTM databases

    PhosphoSiteiQ9R1R2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9R1R2.
    BgeeiQ9R1R2.
    CleanExiMM_TRIM3.
    GenevestigatoriQ9R1R2.

    Interactioni

    Subunit structurei

    Associates with myosin-Vb (MYO5B) and alpha-actinin-4 (ACTN4). Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with ZFYVE28/LST2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi207763. 3 interactions.
    IntActiQ9R1R2. 4 interactions.
    MINTiMINT-4138575.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9R1R2.
    SMRiQ9R1R2. Positions 18-63, 290-419, 475-744.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati317 – 418102FilaminAdd
    BLAST
    Repeati473 – 51644NHL 1Add
    BLAST
    Repeati520 – 56344NHL 2Add
    BLAST
    Repeati564 – 60542NHL 3Add
    BLAST
    Repeati609 – 65244NHL 4Add
    BLAST
    Repeati656 – 69944NHL 5Add
    BLAST
    Repeati700 – 74344NHL 6Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili153 – 22472Sequence AnalysisAdd
    BLAST

    Domaini

    The interaction with MYO5B is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.By similarity

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
    Contains 1 filamin repeat.PROSITE-ProRule annotation
    Contains 6 NHL repeats.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri22 – 6342RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri110 – 15142B box-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG3391.
    GeneTreeiENSGT00550000074377.
    HOGENOMiHOG000220817.
    HOVERGENiHBG054843.
    InParanoidiQ9R1R2.
    KOiK11997.
    OMAiINTTAEP.
    PhylomeDBiQ9R1R2.
    TreeFamiTF331018.

    Family and domain databases

    Gene3Di2.120.10.30. 1 hit.
    2.60.40.10. 1 hit.
    3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR003649. Bbox_C.
    IPR017868. Filamin/ABP280_repeat-like.
    IPR001298. Filamin/ABP280_rpt.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR001258. NHL_repeat.
    IPR013017. NHL_repeat_subgr.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF00630. Filamin. 1 hit.
    PF01436. NHL. 6 hits.
    PF00643. zf-B_box. 1 hit.
    PF14634. zf-RING_5. 1 hit.
    [Graphical view]
    SMARTiSM00502. BBC. 1 hit.
    SM00336. BBOX. 1 hit.
    SM00557. IG_FLMN. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF81296. SSF81296. 1 hit.
    PROSITEiPS50194. FILAMIN_REPEAT. 1 hit.
    PS51125. NHL. 6 hits.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9R1R2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKREDSPGP EVQPMDKQFL VCSICLDRYR CPKVLPCLHT FCERCLQNYI    50
    PPQSLTLSCP VCRQTSILPE QGVSALQNNF FISSLMEAMQ QAPEGAHDPE 100
    DPHPLSAVAG RPLSCPNHEG KTMEFYCEAC ETAMCGECRA GEHREHGTVL 150
    LRDVVEQHKA ALQRQLEAVR GRLPQLSAAI ALVGGISQQL QERKAEALAQ 200
    ISAAFEDLEQ ALQQRKQALV SDLESICGAK QKVLQTQLDT LRQGQEHIGS 250
    SCSFAEQALR LGSAPEVLLV RKHMRERLAA LAAQAFPERP HENAQLELVL 300
    EVDGLRRSVL NLGALLTTSA TAHETVATGE GLRQALVGQP ASLTVTTKDK 350
    DGRLVRTGSA ELCAEITGPD GVRLAVPVVD HKNGTYELVY TARTEGDLLL 400
    SVLLYGQPVR GSPFRVRALR PGDLPPSPDD VKRRVKSPGG PGSHVRQKAV 450
    RRPSSMYSTG GKRKDNPIED ELVFRVGSRG REKGEFTNLQ GVSAASSGRI 500
    VVADSNNQCI QVFSNEGQFK FRFGVRGRSP GQLQRPTGVA VDTNGDIIVA 550
    DYDNRWVSIF SPEGKFKTKI GAGRLMGPKG VAVDRNGHII VVDNKSCCVF 600
    TFQPNGKLVG RFGGRGATDR HFAGPHFVAV NNKNEIVVTD FHNHSVKVYS 650
    ADGEFLFKFG SHGEGNGQFN APTGVAVDSN GNIIVADWGN SRIQVFDSSG 700
    SFLSYINTSA EPLYGPQGLA LTSDGHVVVA DAGNHCFKAY RYLQ 744
    Length:744
    Mass (Da):80,774
    Last modified:May 1, 2000 - v1
    Checksum:iD9AEF4FA264BA168
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB030912 mRNA. Translation: BAA83343.1.
    AF220019 mRNA. Translation: AAG53473.1.
    AK019165 mRNA. Translation: BAB31580.1.
    AK144674 mRNA. Translation: BAE26003.1.
    BC034263 mRNA. Translation: AAH34263.1.
    CCDSiCCDS21655.1.
    RefSeqiNP_001272799.1. NM_001285870.1.
    NP_001272800.1. NM_001285871.1.
    NP_001272802.1. NM_001285873.1.
    NP_061368.1. NM_018880.3.
    UniGeneiMm.29290.

    Genome annotation databases

    EnsembliENSMUST00000057525; ENSMUSP00000053384; ENSMUSG00000036989.
    ENSMUST00000106789; ENSMUSP00000102401; ENSMUSG00000036989.
    GeneIDi55992.
    KEGGimmu:55992.
    UCSCiuc009iym.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB030912 mRNA. Translation: BAA83343.1 .
    AF220019 mRNA. Translation: AAG53473.1 .
    AK019165 mRNA. Translation: BAB31580.1 .
    AK144674 mRNA. Translation: BAE26003.1 .
    BC034263 mRNA. Translation: AAH34263.1 .
    CCDSi CCDS21655.1.
    RefSeqi NP_001272799.1. NM_001285870.1.
    NP_001272800.1. NM_001285871.1.
    NP_001272802.1. NM_001285873.1.
    NP_061368.1. NM_018880.3.
    UniGenei Mm.29290.

    3D structure databases

    ProteinModelPortali Q9R1R2.
    SMRi Q9R1R2. Positions 18-63, 290-419, 475-744.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207763. 3 interactions.
    IntActi Q9R1R2. 4 interactions.
    MINTi MINT-4138575.

    PTM databases

    PhosphoSitei Q9R1R2.

    Proteomic databases

    MaxQBi Q9R1R2.
    PaxDbi Q9R1R2.
    PRIDEi Q9R1R2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057525 ; ENSMUSP00000053384 ; ENSMUSG00000036989 .
    ENSMUST00000106789 ; ENSMUSP00000102401 ; ENSMUSG00000036989 .
    GeneIDi 55992.
    KEGGi mmu:55992.
    UCSCi uc009iym.1. mouse.

    Organism-specific databases

    CTDi 10612.
    MGIi MGI:1860040. Trim3.

    Phylogenomic databases

    eggNOGi COG3391.
    GeneTreei ENSGT00550000074377.
    HOGENOMi HOG000220817.
    HOVERGENi HBG054843.
    InParanoidi Q9R1R2.
    KOi K11997.
    OMAi INTTAEP.
    PhylomeDBi Q9R1R2.
    TreeFami TF331018.

    Miscellaneous databases

    ChiTaRSi TRIM3. mouse.
    NextBioi 311722.
    PROi Q9R1R2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9R1R2.
    Bgeei Q9R1R2.
    CleanExi MM_TRIM3.
    Genevestigatori Q9R1R2.

    Family and domain databases

    Gene3Di 2.120.10.30. 1 hit.
    2.60.40.10. 1 hit.
    3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR003649. Bbox_C.
    IPR017868. Filamin/ABP280_repeat-like.
    IPR001298. Filamin/ABP280_rpt.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR001258. NHL_repeat.
    IPR013017. NHL_repeat_subgr.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF00630. Filamin. 1 hit.
    PF01436. NHL. 6 hits.
    PF00643. zf-B_box. 1 hit.
    PF14634. zf-RING_5. 1 hit.
    [Graphical view ]
    SMARTi SM00502. BBC. 1 hit.
    SM00336. BBOX. 1 hit.
    SM00557. IG_FLMN. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81296. SSF81296. 1 hit.
    PROSITEi PS50194. FILAMIN_REPEAT. 1 hit.
    PS51125. NHL. 6 hits.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a new co-activator with ring finger motif."
      Yanai K., Shimamoto Y., Hirota K., Fukamizu A.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Lung.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Retina.
    5. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiTRIM3_MOUSE
    AccessioniPrimary (citable) accession number: Q9R1R2
    Secondary accession number(s): Q3UMU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3