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Protein

Proteolipid protein 2

Gene

Plp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in cell differentiation in the intestinal epithelium.By similarity

GO - Molecular functioni

  1. chemokine binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Proteolipid protein 2
Gene namesi
Name:Plp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componentsi: Chromosome 13, Chromosome X

Organism-specific databases

MGIiMGI:1298382. Plp2.

Subcellular locationi

  1. Membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence AnalysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence AnalysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 152152Proteolipid protein 2PRO_0000156820Add
BLAST

Proteomic databases

MaxQBiQ9R1Q7.
PaxDbiQ9R1Q7.
PRIDEiQ9R1Q7.

PTM databases

PhosphoSiteiQ9R1Q7.

Expressioni

Gene expression databases

BgeeiQ9R1Q7.
CleanExiMM_PLP2.
ExpressionAtlasiQ9R1Q7. baseline and differential.
GenevestigatoriQ9R1Q7.

Interactioni

Protein-protein interaction databases

IntActiQ9R1Q7. 1 interaction.
MINTiMINT-1544053.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 138120MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG296424.
GeneTreeiENSGT00530000063326.
HOGENOMiHOG000293179.
HOVERGENiHBG099247.
InParanoidiQ9R1Q7.
OMAiIYMCDLH.
OrthoDBiEOG7DNNXK.
PhylomeDBiQ9R1Q7.
TreeFamiTF317387.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1Q7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSERLSAP GCWLACTSFS RTKKGILLFA EIILCLVILI CFSASTTSAY
60 70 80 90 100
SSLSVIEMIC AAVLLVFYTC DLHSKISFIN WPWTDFFRSL IATILYLITS
110 120 130 140 150
IVVLVEGRGS SRVVAGILGL LATLLFGYDA YITFPLKQQR HTAAPTDPTD

GP
Length:152
Mass (Da):16,608
Last modified:May 1, 2000 - v1
Checksum:iC651A5E43B2909D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031292 mRNA. Translation: BAA83500.1.
AK003522 mRNA. Translation: BAB22835.1.
AK011282 mRNA. Translation: BAB27515.1.
AK154228 mRNA. Translation: BAE32448.1.
BC083078 mRNA. Translation: AAH83078.1.
CCDSiCCDS40842.1.
RefSeqiNP_062729.1. NM_019755.4.
UniGeneiMm.18565.

Genome annotation databases

EnsembliENSMUST00000033486; ENSMUSP00000033486; ENSMUSG00000031146.
ENSMUST00000071118; ENSMUSP00000132645; ENSMUSG00000057762.
GeneIDi18824.
KEGGimmu:18824.
UCSCiuc009slx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031292 mRNA. Translation: BAA83500.1.
AK003522 mRNA. Translation: BAB22835.1.
AK011282 mRNA. Translation: BAB27515.1.
AK154228 mRNA. Translation: BAE32448.1.
BC083078 mRNA. Translation: AAH83078.1.
CCDSiCCDS40842.1.
RefSeqiNP_062729.1. NM_019755.4.
UniGeneiMm.18565.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9R1Q7. 1 interaction.
MINTiMINT-1544053.

PTM databases

PhosphoSiteiQ9R1Q7.

Proteomic databases

MaxQBiQ9R1Q7.
PaxDbiQ9R1Q7.
PRIDEiQ9R1Q7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033486; ENSMUSP00000033486; ENSMUSG00000031146.
ENSMUST00000071118; ENSMUSP00000132645; ENSMUSG00000057762.
GeneIDi18824.
KEGGimmu:18824.
UCSCiuc009slx.1. mouse.

Organism-specific databases

CTDi5355.
MGIiMGI:1298382. Plp2.

Phylogenomic databases

eggNOGiNOG296424.
GeneTreeiENSGT00530000063326.
HOGENOMiHOG000293179.
HOVERGENiHBG099247.
InParanoidiQ9R1Q7.
OMAiIYMCDLH.
OrthoDBiEOG7DNNXK.
PhylomeDBiQ9R1Q7.
TreeFamiTF317387.

Miscellaneous databases

NextBioi295192.
PROiQ9R1Q7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R1Q7.
CleanExiMM_PLP2.
ExpressionAtlasiQ9R1Q7. baseline and differential.
GenevestigatoriQ9R1Q7.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse proteolipid protein 2 (PLP2)."
    Hayashi A., Hattori A., Okaze H., Kozuma S., Seki N., Saito T.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiPLP2_MOUSE
AccessioniPrimary (citable) accession number: Q9R1Q7
Secondary accession number(s): Q3U4I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.