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Q9R1Q7

- PLP2_MOUSE

UniProt

Q9R1Q7 - PLP2_MOUSE

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Protein

Proteolipid protein 2

Gene

Plp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in cell differentiation in the intestinal epithelium.By similarity

GO - Molecular functioni

  1. chemokine binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Proteolipid protein 2
Gene namesi
Name:Plp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13, UP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1298382. Plp2.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 152152Proteolipid protein 2PRO_0000156820Add
BLAST

Proteomic databases

MaxQBiQ9R1Q7.
PaxDbiQ9R1Q7.
PRIDEiQ9R1Q7.

PTM databases

PhosphoSiteiQ9R1Q7.

Expressioni

Gene expression databases

BgeeiQ9R1Q7.
CleanExiMM_PLP2.
ExpressionAtlasiQ9R1Q7. baseline and differential.
GenevestigatoriQ9R1Q7.

Interactioni

Protein-protein interaction databases

IntActiQ9R1Q7. 1 interaction.
MINTiMINT-1544053.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence AnalysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence AnalysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST
Transmembranei112 – 13221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 138120MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG296424.
GeneTreeiENSGT00530000063326.
HOGENOMiHOG000293179.
HOVERGENiHBG099247.
InParanoidiQ9R1Q7.
OMAiIYMCDLH.
OrthoDBiEOG7DNNXK.
PhylomeDBiQ9R1Q7.
TreeFamiTF317387.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1Q7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADSERLSAP GCWLACTSFS RTKKGILLFA EIILCLVILI CFSASTTSAY
60 70 80 90 100
SSLSVIEMIC AAVLLVFYTC DLHSKISFIN WPWTDFFRSL IATILYLITS
110 120 130 140 150
IVVLVEGRGS SRVVAGILGL LATLLFGYDA YITFPLKQQR HTAAPTDPTD

GP
Length:152
Mass (Da):16,608
Last modified:May 1, 2000 - v1
Checksum:iC651A5E43B2909D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB031292 mRNA. Translation: BAA83500.1.
AK003522 mRNA. Translation: BAB22835.1.
AK011282 mRNA. Translation: BAB27515.1.
AK154228 mRNA. Translation: BAE32448.1.
BC083078 mRNA. Translation: AAH83078.1.
CCDSiCCDS40842.1.
RefSeqiNP_062729.1. NM_019755.4.
UniGeneiMm.18565.

Genome annotation databases

EnsembliENSMUST00000033486; ENSMUSP00000033486; ENSMUSG00000031146.
ENSMUST00000071118; ENSMUSP00000132645; ENSMUSG00000057762.
GeneIDi18824.
KEGGimmu:18824.
UCSCiuc009slx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB031292 mRNA. Translation: BAA83500.1 .
AK003522 mRNA. Translation: BAB22835.1 .
AK011282 mRNA. Translation: BAB27515.1 .
AK154228 mRNA. Translation: BAE32448.1 .
BC083078 mRNA. Translation: AAH83078.1 .
CCDSi CCDS40842.1.
RefSeqi NP_062729.1. NM_019755.4.
UniGenei Mm.18565.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9R1Q7. 1 interaction.
MINTi MINT-1544053.

PTM databases

PhosphoSitei Q9R1Q7.

Proteomic databases

MaxQBi Q9R1Q7.
PaxDbi Q9R1Q7.
PRIDEi Q9R1Q7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033486 ; ENSMUSP00000033486 ; ENSMUSG00000031146 .
ENSMUST00000071118 ; ENSMUSP00000132645 ; ENSMUSG00000057762 .
GeneIDi 18824.
KEGGi mmu:18824.
UCSCi uc009slx.1. mouse.

Organism-specific databases

CTDi 5355.
MGIi MGI:1298382. Plp2.

Phylogenomic databases

eggNOGi NOG296424.
GeneTreei ENSGT00530000063326.
HOGENOMi HOG000293179.
HOVERGENi HBG099247.
InParanoidi Q9R1Q7.
OMAi IYMCDLH.
OrthoDBi EOG7DNNXK.
PhylomeDBi Q9R1Q7.
TreeFami TF317387.

Miscellaneous databases

NextBioi 295192.
PROi Q9R1Q7.
SOURCEi Search...

Gene expression databases

Bgeei Q9R1Q7.
CleanExi MM_PLP2.
ExpressionAtlasi Q9R1Q7. baseline and differential.
Genevestigatori Q9R1Q7.

Family and domain databases

InterProi IPR008253. Marvel.
[Graphical view ]
Pfami PF01284. MARVEL. 1 hit.
[Graphical view ]
PROSITEi PS51225. MARVEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse proteolipid protein 2 (PLP2)."
    Hayashi A., Hattori A., Okaze H., Kozuma S., Seki N., Saito T.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiPLP2_MOUSE
AccessioniPrimary (citable) accession number: Q9R1Q7
Secondary accession number(s): Q3U4I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3