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Protein

Transmembrane protein 176B

Gene

Tmem176b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the process of maturation of dendritic cells (By similarity). Required for the development of cerebellar granule cells.By similarity1 Publication

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • negative regulation of dendritic cell differentiation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 176B
Alternative name(s):
Protein LR8
Gene namesi
Name:Tmem176b
Synonyms:Clast1, Lr8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1916348. Tmem176b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice exhibit abnormal development of the cerebellum and severe ataxia.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002798761 – 263Transmembrane protein 176BAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231PhosphoserineBy similarity1
Modified residuei240PhosphoserineBy similarity1
Modified residuei253PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9R1Q6.
MaxQBiQ9R1Q6.
PaxDbiQ9R1Q6.
PeptideAtlasiQ9R1Q6.
PRIDEiQ9R1Q6.

PTM databases

iPTMnetiQ9R1Q6.
PhosphoSitePlusiQ9R1Q6.

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in lung, liver, kidney and colon. Expressed in cerebellar granule cells.1 Publication

Developmental stagei

Expressed in the developing cerebellum at constant levels from E18 to P7.1 Publication

Gene expression databases

BgeeiENSMUSG00000029810.
CleanExiMM_TMEM176B.
ExpressionAtlasiQ9R1Q6. baseline and differential.
GenevisibleiQ9R1Q6. MM.

Interactioni

Protein-protein interaction databases

BioGridi211160. 1 interactor.
STRINGi10090.ENSMUSP00000098972.

Structurei

3D structure databases

ProteinModelPortaliQ9R1Q6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM176 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXII. Eukaryota.
ENOG410ZDNZ. LUCA.
GeneTreeiENSGT00530000064074.
HOGENOMiHOG000290691.
HOVERGENiHBG094020.
InParanoidiQ9R1Q6.
OMAiRASGCAF.
OrthoDBiEOG091G0OE0.
PhylomeDBiQ9R1Q6.
TreeFamiTF335389.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR009281. TMEM176A/TMEM176B.
[Graphical view]
PANTHERiPTHR15756. PTHR15756. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQSTVTVNG VKVASTHPQS AHISIHIHQK SALEQLLGAV GSLKKFLSWP
60 70 80 90 100
QARIHYGQLS LGVTQILLGL VSCALGVCLY FGPWTELCAF GCAFWSGSVA
110 120 130 140 150
ILAGVGTIVH EKRQGKLSGQ VSCLLLLACI ATAAAATVLG VNSLIRQTSV
160 170 180 190 200
PYYVEIFSTC NPLQSSMDPG YGTVRYSDDS DWKTERCREY LNMMMNLFLA
210 220 230 240 250
FCIMLTVVCI LEIVVSVASL GLSLRSMYGR SSQALNEEES ERKLLDGHPA
260
PASPAKEKIP AIL
Length:263
Mass (Da):28,367
Last modified:May 1, 2000 - v1
Checksum:i4D2C11EA67EB357C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54I → V in AAD28721 (PubMed:9922225).Curated1
Sequence conflicti260P → S in AAD28721 (PubMed:9922225).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115426 mRNA. Translation: AAD28721.1.
AB031386 mRNA. Translation: BAA83596.1.
AK007408 mRNA. Translation: BAB25020.1.
AK156042 mRNA. Translation: BAE33560.1.
CT010176 mRNA. Translation: CAJ18384.1.
BC019539 mRNA. Translation: AAH19539.1.
BC022166 mRNA. Translation: AAH22166.1.
CCDSiCCDS20116.1.
RefSeqiNP_001157679.1. NM_001164207.1.
NP_001157680.1. NM_001164208.1.
NP_001157681.1. NM_001164209.2.
NP_001273580.1. NM_001286651.1.
NP_001273581.1. NM_001286652.1.
NP_075543.1. NM_023056.4.
XP_006506519.1. XM_006506456.3.
XP_006506520.1. XM_006506457.3.
XP_006506521.1. XM_006506458.3.
XP_006506522.1. XM_006506459.3.
XP_006506523.1. XM_006506460.3.
XP_006506524.1. XM_006506461.3.
XP_017177199.1. XM_017321710.1.
UniGeneiMm.28385.

Genome annotation databases

EnsembliENSMUST00000101429; ENSMUSP00000098972; ENSMUSG00000029810.
ENSMUST00000164733; ENSMUSP00000128705; ENSMUSG00000029810.
ENSMUST00000166247; ENSMUSP00000131064; ENSMUSG00000029810.
ENSMUST00000203355; ENSMUSP00000145395; ENSMUSG00000029810.
ENSMUST00000204073; ENSMUSP00000144864; ENSMUSG00000029810.
GeneIDi65963.
KEGGimmu:65963.
UCSCiuc009bvu.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115426 mRNA. Translation: AAD28721.1.
AB031386 mRNA. Translation: BAA83596.1.
AK007408 mRNA. Translation: BAB25020.1.
AK156042 mRNA. Translation: BAE33560.1.
CT010176 mRNA. Translation: CAJ18384.1.
BC019539 mRNA. Translation: AAH19539.1.
BC022166 mRNA. Translation: AAH22166.1.
CCDSiCCDS20116.1.
RefSeqiNP_001157679.1. NM_001164207.1.
NP_001157680.1. NM_001164208.1.
NP_001157681.1. NM_001164209.2.
NP_001273580.1. NM_001286651.1.
NP_001273581.1. NM_001286652.1.
NP_075543.1. NM_023056.4.
XP_006506519.1. XM_006506456.3.
XP_006506520.1. XM_006506457.3.
XP_006506521.1. XM_006506458.3.
XP_006506522.1. XM_006506459.3.
XP_006506523.1. XM_006506460.3.
XP_006506524.1. XM_006506461.3.
XP_017177199.1. XM_017321710.1.
UniGeneiMm.28385.

3D structure databases

ProteinModelPortaliQ9R1Q6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211160. 1 interactor.
STRINGi10090.ENSMUSP00000098972.

PTM databases

iPTMnetiQ9R1Q6.
PhosphoSitePlusiQ9R1Q6.

Proteomic databases

EPDiQ9R1Q6.
MaxQBiQ9R1Q6.
PaxDbiQ9R1Q6.
PeptideAtlasiQ9R1Q6.
PRIDEiQ9R1Q6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101429; ENSMUSP00000098972; ENSMUSG00000029810.
ENSMUST00000164733; ENSMUSP00000128705; ENSMUSG00000029810.
ENSMUST00000166247; ENSMUSP00000131064; ENSMUSG00000029810.
ENSMUST00000203355; ENSMUSP00000145395; ENSMUSG00000029810.
ENSMUST00000204073; ENSMUSP00000144864; ENSMUSG00000029810.
GeneIDi65963.
KEGGimmu:65963.
UCSCiuc009bvu.3. mouse.

Organism-specific databases

CTDi28959.
MGIiMGI:1916348. Tmem176b.

Phylogenomic databases

eggNOGiENOG410IXII. Eukaryota.
ENOG410ZDNZ. LUCA.
GeneTreeiENSGT00530000064074.
HOGENOMiHOG000290691.
HOVERGENiHBG094020.
InParanoidiQ9R1Q6.
OMAiRASGCAF.
OrthoDBiEOG091G0OE0.
PhylomeDBiQ9R1Q6.
TreeFamiTF335389.

Miscellaneous databases

ChiTaRSiTmem176b. mouse.
PROiQ9R1Q6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029810.
CleanExiMM_TMEM176B.
ExpressionAtlasiQ9R1Q6. baseline and differential.
GenevisibleiQ9R1Q6. MM.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR009281. TMEM176A/TMEM176B.
[Graphical view]
PANTHERiPTHR15756. PTHR15756. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT176B_MOUSE
AccessioniPrimary (citable) accession number: Q9R1Q6
Secondary accession number(s): Q9WU52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.