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Protein

Cyclin-L1

Gene

Ccnl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing (PubMed:11683997). Functions in association with cyclin-dependent kinases (CDKs). May play a role in the regulation of RNA polymerase II (pol II). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-L1
Short name:
Cyclin-L
Alternative name(s):
Cyclin Ania-6a
Gene namesi
Name:Ccnl1
Synonyms:Ania6a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620864. Ccnl1.

Subcellular locationi

  • Nucleus speckle 2 Publications
  • Nucleusnucleoplasm By similarity

  • Note: Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.2 Publications

GO - Cellular componenti

  • cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
  • nuclear speck Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Cyclin-L1PRO_0000080482Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei326 – 3261PhosphothreonineBy similarity
Modified residuei336 – 3361PhosphoserineCombined sources
Modified residuei339 – 3391PhosphoserineCombined sources
Modified residuei353 – 3531PhosphoserineCombined sources
Modified residuei356 – 3561PhosphoserineBy similarity
Cross-linki363 – 363Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei375 – 3751PhosphoserineBy similarity
Modified residuei446 – 4461PhosphoserineBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9R1Q2.

PTM databases

iPTMnetiQ9R1Q2.
PhosphoSiteiQ9R1Q2.

Expressioni

Tissue specificityi

Ubiquitous with higher level in liver; expressed in striatal neurons.1 Publication

Inductioni

By anisomycin (activator of MAP kinase pathway) and by dopamine and cocaine in dopamine D1 receptor-expressing striatal neurons and by EGF/epidermal growth factor or NGF/nerve growth factor in PC12 pheochromocytoma cells. Isoform 1 also is specifically induced by cycloheximide, potassium chloride (KCl) and forskolin or brain neurotrophic factor (BDNF). Isoform 2 is induced by glutamate.3 Publications

Gene expression databases

ExpressionAtlasiQ9R1Q2. baseline and differential.
GenevisibleiQ9R1Q2. RN.

Interactioni

Subunit structurei

Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD). Interacts with CDK11A, CDK11B, CDK12 and CDK13. May form a ternary complex with CDK11B and casein kinase II (CKII). Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7.By similarity2 Publications

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016016.

Structurei

3D structure databases

ProteinModelPortaliQ9R1Q2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni89 – 191103Cyclin-like 1Add
BLAST
Regioni204 – 28885Cyclin-like 2Add
BLAST
Regioni391 – 43343RSAdd
BLAST

Domaini

Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity).By similarity

Sequence similaritiesi

Belongs to the cyclin family. Cyclin L subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0835. Eukaryota.
COG5333. LUCA.
GeneTreeiENSGT00760000119191.
HOGENOMiHOG000231292.
HOVERGENiHBG056044.
InParanoidiQ9R1Q2.
OMAiQEICLTT.
OrthoDBiEOG7K9K34.
PhylomeDBiQ9R1Q2.
TreeFamiTF101011.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR015429. Cyclin_L/T.
IPR015431. Cyclin_L1_chr.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10026:SF64. PTHR10026:SF64. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF036580. Cyclin_L. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Ccnl1 is an immediate-early gene with independently regulated isoforms.

Isoform 1 (identifier: Q9R1Q2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGPHPTST AAAASASSAA PSAGGSSSGT TTTTTTTTGG ILIGDRLYSE
60 70 80 90 100
VSLTIDHSVI PEERLSPTPS MQDGLDLPSE TDLRILGCEL IQAAGILLRL
110 120 130 140 150
PQVAMATGQV LFHRFFYSKS FVKHSFEIVA MACINLASKI EEAPRRIRDV
160 170 180 190 200
INVFHHLRQL RGKRTPSPLI LDQNYINTKN QVIKAERRVL KELGFCVHVK
210 220 230 240 250
HPHKIIVMYL QVLECERNQT LVQTAWNYMN DSLRTNVFVR FQPETIACAC
260 270 280 290 300
IYLAARALQI PLPTRPHWFL LFGTTEEEIQ EICIETLRLY TRKKPNYELL
310 320 330 340 350
EKEVEKRKVA LQEAKLKAKG LNLDGTPALS TLGGFSPASK PSSPREVKAE
360 370 380 390 400
EKSPVSINVK TVKKEPEDRQ QASKSPYNGV RKDSKRSRNS RSASRSRSRT
410 420 430 440 450
RSRSRSHTPR RHYNNRRSRS GTYSSRSRSR SRSHSESPRR HHNHGSPHLK
460 470 480 490 500
AKHTREDLKS SNRHGHKRKK SRSRSQSKTR DHSDVTKKHR HERGHHRDRR
510 520
ERSRSFERSH KGKHHGGSRS GHGRHRR
Length:527
Mass (Da):59,791
Last modified:May 1, 2000 - v1
Checksum:i444F5D632B15BC43
GO
Isoform 2 (identifier: Q9R1Q2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-173: RTPSPLILDQ → SDQLHLPKPG
     174-527: Missing.

Show »
Length:173
Mass (Da):18,421
Checksum:i64E8835E5F5BB7BF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei164 – 17310RTPSPLILDQ → SDQLHLPKPG in isoform 2. 2 PublicationsVSP_016128
Alternative sequencei174 – 527354Missing in isoform 2. 2 PublicationsVSP_016129Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030091 mRNA. Translation: AAD45558.1.
BC085686 mRNA. Translation: AAH85686.1.
RefSeqiNP_446114.1. NM_053662.3. [Q9R1Q2-1]
XP_003749343.1. XM_003749295.3. [Q9R1Q2-2]
UniGeneiRn.12962.

Genome annotation databases

EnsembliENSRNOT00000015763; ENSRNOP00000015763; ENSRNOG00000011586. [Q9R1Q2-2]
ENSRNOT00000016016; ENSRNOP00000016016; ENSRNOG00000011586. [Q9R1Q2-1]
GeneIDi100909712.
114121.
KEGGirno:100909712.
rno:114121.
UCSCiRGD:620864. rat. [Q9R1Q2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030091 mRNA. Translation: AAD45558.1.
BC085686 mRNA. Translation: AAH85686.1.
RefSeqiNP_446114.1. NM_053662.3. [Q9R1Q2-1]
XP_003749343.1. XM_003749295.3. [Q9R1Q2-2]
UniGeneiRn.12962.

3D structure databases

ProteinModelPortaliQ9R1Q2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016016.

PTM databases

iPTMnetiQ9R1Q2.
PhosphoSiteiQ9R1Q2.

Proteomic databases

PaxDbiQ9R1Q2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015763; ENSRNOP00000015763; ENSRNOG00000011586. [Q9R1Q2-2]
ENSRNOT00000016016; ENSRNOP00000016016; ENSRNOG00000011586. [Q9R1Q2-1]
GeneIDi100909712.
114121.
KEGGirno:100909712.
rno:114121.
UCSCiRGD:620864. rat. [Q9R1Q2-1]

Organism-specific databases

CTDi57018.
RGDi620864. Ccnl1.

Phylogenomic databases

eggNOGiKOG0835. Eukaryota.
COG5333. LUCA.
GeneTreeiENSGT00760000119191.
HOGENOMiHOG000231292.
HOVERGENiHBG056044.
InParanoidiQ9R1Q2.
OMAiQEICLTT.
OrthoDBiEOG7K9K34.
PhylomeDBiQ9R1Q2.
TreeFamiTF101011.

Miscellaneous databases

PROiQ9R1Q2.

Gene expression databases

ExpressionAtlasiQ9R1Q2. baseline and differential.
GenevisibleiQ9R1Q2. RN.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR015429. Cyclin_L/T.
IPR015431. Cyclin_L1_chr.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10026:SF64. PTHR10026:SF64. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF036580. Cyclin_L. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A complex program of striatal gene expression induced by dopaminergic stimulation."
    Berke J.D., Paletzki R.F., Aronson G.J., Hyman S.E., Gerfen C.R.
    J. Neurosci. 18:5301-5310(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, INDUCTION.
  2. "Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin."
    Berke J.D., Sgambato V., Zhu P.-P., Lavoie B., Vincent M., Krause M., Hyman S.E.
    Neuron 32:277-287(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, INTERACTION WITH POLR2A; CDC2L AND SFRS2.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "Regulation of ania-6 splice variants by distinct signaling pathways in striatal neurons."
    Sgambato V., Minassian R., Nairn A.C., Hyman S.E.
    J. Neurochem. 86:153-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. "Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation."
    Chen H.-H., Wang Y.-C., Fann M.-J.
    Mol. Cell. Biol. 26:2736-2745(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDK12.
  6. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336; SER-339 AND SER-353, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCCNL1_RAT
AccessioniPrimary (citable) accession number: Q9R1Q2
Secondary accession number(s): Q5U364
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.