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Protein

NACHT, LRR and PYD domains-containing protein 5

Gene

Nlrp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi249 – 2568ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • cellular protein complex assembly Source: MGI
  • cellular protein localization Source: MGI
  • embryo implantation Source: MGI
  • fertilization Source: MGI
  • in utero embryonic development Source: MGI
  • neuron death Source: MGI
  • organ morphogenesis Source: MGI
  • regulation of protein stability Source: MGI
  • regulation of RNA stability Source: MGI
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 5
Alternative name(s):
Maternal antigen that embryos require
Short name:
Mater protein
Ooplasm-specific protein 1
Short name:
OP1
Gene namesi
Name:Nlrp5
Synonyms:Mater, Nalp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1345193. Nlrp5.

Subcellular locationi

GO - Cellular componenti

  • apical cortex Source: MGI
  • cell cortex Source: MGI
  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • mitochondrion Source: UniProtKB
  • nucleolus Source: UniProtKB
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice appear phenotypically normal with no apparent defects in ovarian development, oocyte maturation or ovulation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11631163NACHT, LRR and PYD domains-containing protein 5PRO_0000080891Add
BLAST

Proteomic databases

MaxQBiQ9R1M5.
PaxDbiQ9R1M5.
PRIDEiQ9R1M5.

PTM databases

iPTMnetiQ9R1M5.
PhosphoSiteiQ9R1M5.

Expressioni

Tissue specificityi

Oocyte-specific.1 Publication

Developmental stagei

Expression is first detected in oocytes of type 3A primary follicles. Transcripts accumulate during oogenesis. During meiotic maturation, the vast majority of the transcripts are degraded and virtually none is detected by 2-cell stage embryogenesis. The protein however persists during preimplantation up to the blastocyst stage. At 2-cell stage, excluded from cell-cell contact regions. Continuous exclusion from these regions during preimplantation development leads to the absence of the protein from the inner cells of the morula and the inner cell mass of the blastocyst.2 Publications

Gene expression databases

BgeeiQ9R1M5.
CleanExiMM_NLRP5.
GenevisibleiQ9R1M5. MM.

Interactioni

Subunit structurei

Component of the SCMC which also includes KHDC3, OOEP and TLE6. Within the complex, interacts with KHDC3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Khdc3Q9CWU53EBI-2905719,EBI-2905804

Protein-protein interaction databases

BioGridi204829. 1 interaction.
IntActiQ9R1M5. 3 interactions.
STRINGi10090.ENSMUSP00000015866.

Structurei

3D structure databases

ProteinModelPortaliQ9R1M5.
SMRiQ9R1M5. Positions 678-1142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini243 – 565323NACHTPROSITE-ProRule annotationAdd
BLAST
Repeati801 – 82222LRR 1Add
BLAST
Repeati830 – 85122LRR 2Add
BLAST
Repeati858 – 87821LRR 3Add
BLAST
Repeati887 – 90620LRR 4Add
BLAST
Repeati915 – 93521LRR 5Add
BLAST
Repeati944 – 96421LRR 6Add
BLAST
Repeati972 – 99322LRR 7Add
BLAST
Repeati1001 – 102222LRR 8Add
BLAST
Repeati1029 – 105022LRR 9Add
BLAST
Repeati1058 – 107922LRR 10Add
BLAST
Repeati1086 – 110722LRR 11Add
BLAST

Sequence similaritiesi

Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 NACHT domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IIY8. Eukaryota.
ENOG4111BJJ. LUCA.
GeneTreeiENSGT00840000129675.
HOVERGENiHBG063656.
InParanoidiQ9R1M5.
OMAiMTSPEND.
OrthoDBiEOG7P5T07.
PhylomeDBiQ9R1M5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 4 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9R1M5-1) [UniParc]FASTAAdd to basket

Also known as: D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPPEKESKA ILKARGLEEE QKSERKMTSP ENDSKSIQKD QGPEQEQTSE
60 70 80 90 100
STMGPPEKES KAILKARGLE EEQKSERKMT SPENDSKSIQ KDQGPEQEQT
110 120 130 140 150
SESTMGPPEK DSKAILKARG LEEEQKSEST MSPSENVSRA ILKDSGSEEV
160 170 180 190 200
EQASERKMTS PENDSKSIQK DQGPEQEQTS ETLQSKEEDE VTEADKDNGG
210 220 230 240 250
DLQDYKAHVI AKFDTSVDLH YDSPEMKLLS DAFKPYQKTF QPHTIILHGR
260 270 280 290 300
PGVGKSALAR SIVLGWAQGK LFQKMSFVIF FSVREIKWTE KSSLAQLIAK
310 320 330 340 350
ECPDSWDLVT KIMSQPERLL FVIDGLDDMD SVLQHDDMTL SRDWKDEQPI
360 370 380 390 400
YILMYSLLRK ALLPQSFLII TTRNTGLEKL KSMVVSPLYI LVEGLSASRR
410 420 430 440 450
SQLVLENISN ESDRIQVFHS LIENHQLFDQ CQAPSVCSLV CEALQLQKKL
460 470 480 490 500
GKRCTLPCQT LTGLYATLVF HQLTLKRPSQ SALSQEEQIT LVGLCMMAAE
510 520 530 540 550
GVWTMRSVFY DDDLKNYSLK ESEILALFHM NILLQVGHNS EQCYVFSHLS
560 570 580 590 600
LQDFFAALYY VLEGLEEWNQ HFCFIENQRS IMEVKRTDDT RLLGMKRFLF
610 620 630 640 650
GLMNKDILKT LEVLFEYPVI PTVEQKLQHW VSLIAQQVNG TSPMDTLDAF
660 670 680 690 700
YCLFESQDEE FVGGALKRFQ EVWLLINQKM DLKVSSYCLK HCQNLKAIRV
710 720 730 740 750
DIRDLLSVDN TLELCPVVTV QETQCKPLLM EWWGNFCSVL GSLRNLKELD
760 770 780 790 800
LGDSILSQRA MKILCLELRN QSCRIQKLTF KSAEVVSGLK HLWKLLFSNQ
810 820 830 840 850
NLKYLNLGNT PMKDDDMKLA CEALKHPKCS VETLRLDSCE LTIIGYEMIS
860 870 880 890 900
TLLISTTRLK CLSLAKNRVG VKSMISLGNA LSSSMCLLQK LILDNCGLTP
910 920 930 940 950
ASCHLLVSAL FSNQNLTHLC LSNNSLGTEG VQQLCQFLRN PECALQRLIL
960 970 980 990 1000
NHCNIVDDAY GFLAMRLANN TKLTHLSLTM NPVGDGAMKL LCEALKEPTC
1010 1020 1030 1040 1050
YLQELELVDC QLTQNCCEDL ACMITTTKHL KSLDLGNNAL GDKGVITLCE
1060 1070 1080 1090 1100
GLKQSSSSLR RLGLGACKLT SNCCEALSLA ISCNPHLNSL NLVKNDFSTS
1110 1120 1130 1140 1150
GMLKLCSAFQ CPVSNLGIIG LWKQEYYARV RRQLEEVEFV KPHVVIDGDW
1160
YASDEDDRNW WKN
Length:1,163
Mass (Da):131,318
Last modified:May 1, 2007 - v2
Checksum:iEF14379B454E9376
GO
Isoform 2 (identifier: Q9R1M5-2) [UniParc]FASTAAdd to basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     25-74: RKMTSPENDSKSIQKDQGPEQEQTSESTMGPPEKESKAILKARGLEEEQK → STMSPSENVSRAILKDSGSEEVEQA

Show »
Length:1,138
Mass (Da):128,353
Checksum:i4E6F124DD7049254
GO
Isoform 3 (identifier: Q9R1M5-3) [UniParc]FASTAAdd to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.

Show »
Length:1,111
Mass (Da):125,503
Checksum:i4016A5D67A1C01F4
GO
Isoform 4 (identifier: Q9R1M5-4) [UniParc]FASTAAdd to basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.

Show »
Length:1,059
Mass (Da):119,687
Checksum:i97B55C54C16EA862
GO
Isoform 5 (identifier: Q9R1M5-5) [UniParc]FASTAAdd to basket

Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.
     181-196: Missing.

Show »
Length:1,095
Mass (Da):123,670
Checksum:iDDB219915C0F385C
GO
Isoform 6 (identifier: Q9R1M5-6) [UniParc]FASTAAdd to basket

Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.
     1065-1090: Missing.

Show »
Length:1,085
Mass (Da):122,857
Checksum:iFB8F4F35516DA926
GO
Isoform 7 (identifier: Q9R1M5-7) [UniParc]FASTAAdd to basket

Also known as: H

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.
     1037-1041: NNALG → WGHVS
     1042-1163: Missing.

Show »
Length:989
Mass (Da):111,920
Checksum:i125C9D27AB59123B
GO
Isoform 8 (identifier: Q9R1M5-8) [UniParc]FASTAAdd to basket

Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.
     780-1163: Missing.

Show »
Length:727
Mass (Da):83,001
Checksum:i0560C8AF9C2B88D1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti567 – 5671E → G in AAH53384 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591E → D in strain: 129/Sv and CBA/J. 1 Publication
Natural varianti94 – 941G → L in strain: 129/Sv; requires 2 nucleotide substitutions. 1 Publication
Natural varianti139 – 1391R → K in strain: 129/Sv and CBA/J. 1 Publication
Natural varianti283 – 2831V → G in strain: A/J.
Natural varianti308 – 3081L → P in strain: 129/Sv and CBA/J. 1 Publication
Natural varianti341 – 3411S → T in strain: A/J.
Natural varianti1029 – 10291H → Q in strain: 129/Sv and CBA/J. 1 Publication
Natural varianti1055 – 10562SS → NN in strain: 129/Sv and CBA/J.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 104104Missing in isoform 4. 1 PublicationVSP_024726Add
BLAST
Alternative sequencei1 – 5252Missing in isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8. 4 PublicationsVSP_024727Add
BLAST
Alternative sequencei25 – 7450RKMTS…EEEQK → STMSPSENVSRAILKDSGSE EVEQA in isoform 2. 1 PublicationVSP_024728Add
BLAST
Alternative sequencei181 – 19616Missing in isoform 5. 1 PublicationVSP_024729Add
BLAST
Alternative sequencei780 – 1163384Missing in isoform 8. 1 PublicationVSP_024730Add
BLAST
Alternative sequencei1037 – 10415NNALG → WGHVS in isoform 7. 1 PublicationVSP_024731
Alternative sequencei1042 – 1163122Missing in isoform 7. 1 PublicationVSP_024732Add
BLAST
Alternative sequencei1065 – 109026Missing in isoform 6. 1 PublicationVSP_024733Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074018 mRNA. Translation: AAD51762.1.
AF143573
, AF143559, AF143560, AF143561, AF143562, AF143563, AF143564, AF143565, AF143566, AF143567, AF143568, AF143569, AF143570, AF143571, AF143572 Genomic DNA. Translation: AAF64393.1.
AY196361 mRNA. Translation: AAO52697.1.
AY196362 mRNA. Translation: AAO52698.1.
AY329484 mRNA. Translation: AAQ94607.1.
AY329485 mRNA. Translation: AAQ94608.1.
AY329486 mRNA. Translation: AAQ94609.1.
AY329487 mRNA. Translation: AAQ94610.1.
AY329488 mRNA. Translation: AAQ94611.1.
AY329489 mRNA. Translation: AAQ94612.1.
AY329490 mRNA. Translation: AAQ94613.1.
AY329491 mRNA. Translation: AAQ94614.1.
BC053384 mRNA. Translation: AAH53384.1.
AK135731 mRNA. Translation: BAE22633.1.
CCDSiCCDS20929.1. [Q9R1M5-5]
CCDS20930.1. [Q9R1M5-3]
PIRiA59000.
RefSeqiNP_001034232.1. NM_001039143.2. [Q9R1M5-5]
NP_001292786.1. NM_001305857.1. [Q9R1M5-6]
NP_035990.1. NM_011860.3. [Q9R1M5-3]
UniGeneiMm.333653.

Genome annotation databases

EnsembliENSMUST00000015866; ENSMUSP00000015866; ENSMUSG00000015721. [Q9R1M5-3]
ENSMUST00000086341; ENSMUSP00000083524; ENSMUSG00000015721. [Q9R1M5-5]
ENSMUST00000108441; ENSMUSP00000104080; ENSMUSG00000015721. [Q9R1M5-6]
ENSMUST00000133237; ENSMUSP00000122007; ENSMUSG00000015721. [Q9R1M5-7]
ENSMUST00000139661; ENSMUSP00000118638; ENSMUSG00000015721. [Q9R1M5-8]
GeneIDi23968.
KEGGimmu:23968.
UCSCiuc009foe.2. mouse. [Q9R1M5-1]
uc009fof.2. mouse. [Q9R1M5-5]
uc012fev.2. mouse. [Q9R1M5-6]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074018 mRNA. Translation: AAD51762.1.
AF143573
, AF143559, AF143560, AF143561, AF143562, AF143563, AF143564, AF143565, AF143566, AF143567, AF143568, AF143569, AF143570, AF143571, AF143572 Genomic DNA. Translation: AAF64393.1.
AY196361 mRNA. Translation: AAO52697.1.
AY196362 mRNA. Translation: AAO52698.1.
AY329484 mRNA. Translation: AAQ94607.1.
AY329485 mRNA. Translation: AAQ94608.1.
AY329486 mRNA. Translation: AAQ94609.1.
AY329487 mRNA. Translation: AAQ94610.1.
AY329488 mRNA. Translation: AAQ94611.1.
AY329489 mRNA. Translation: AAQ94612.1.
AY329490 mRNA. Translation: AAQ94613.1.
AY329491 mRNA. Translation: AAQ94614.1.
BC053384 mRNA. Translation: AAH53384.1.
AK135731 mRNA. Translation: BAE22633.1.
CCDSiCCDS20929.1. [Q9R1M5-5]
CCDS20930.1. [Q9R1M5-3]
PIRiA59000.
RefSeqiNP_001034232.1. NM_001039143.2. [Q9R1M5-5]
NP_001292786.1. NM_001305857.1. [Q9R1M5-6]
NP_035990.1. NM_011860.3. [Q9R1M5-3]
UniGeneiMm.333653.

3D structure databases

ProteinModelPortaliQ9R1M5.
SMRiQ9R1M5. Positions 678-1142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204829. 1 interaction.
IntActiQ9R1M5. 3 interactions.
STRINGi10090.ENSMUSP00000015866.

PTM databases

iPTMnetiQ9R1M5.
PhosphoSiteiQ9R1M5.

Proteomic databases

MaxQBiQ9R1M5.
PaxDbiQ9R1M5.
PRIDEiQ9R1M5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015866; ENSMUSP00000015866; ENSMUSG00000015721. [Q9R1M5-3]
ENSMUST00000086341; ENSMUSP00000083524; ENSMUSG00000015721. [Q9R1M5-5]
ENSMUST00000108441; ENSMUSP00000104080; ENSMUSG00000015721. [Q9R1M5-6]
ENSMUST00000133237; ENSMUSP00000122007; ENSMUSG00000015721. [Q9R1M5-7]
ENSMUST00000139661; ENSMUSP00000118638; ENSMUSG00000015721. [Q9R1M5-8]
GeneIDi23968.
KEGGimmu:23968.
UCSCiuc009foe.2. mouse. [Q9R1M5-1]
uc009fof.2. mouse. [Q9R1M5-5]
uc012fev.2. mouse. [Q9R1M5-6]

Organism-specific databases

CTDi126206.
MGIiMGI:1345193. Nlrp5.

Phylogenomic databases

eggNOGiENOG410IIY8. Eukaryota.
ENOG4111BJJ. LUCA.
GeneTreeiENSGT00840000129675.
HOVERGENiHBG063656.
InParanoidiQ9R1M5.
OMAiMTSPEND.
OrthoDBiEOG7P5T07.
PhylomeDBiQ9R1M5.

Miscellaneous databases

PROiQ9R1M5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R1M5.
CleanExiMM_NLRP5.
GenevisibleiQ9R1M5. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 4 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A mouse gene encoding an oocyte antigen associated with autoimmune premature ovarian failure."
    Tong Z.-B., Nelson L.M.
    Endocrinology 140:3720-3726(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
    Strain: NIH Swiss.
    Tissue: Ovary.
  2. "Mater encodes a maternal protein in mice with a leucine-rich repeat domain homologous to porcine ribonuclease inhibitor."
    Tong Z.-B., Nelson L.M., Dean J.
    Mamm. Genome 11:281-287(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3), VARIANTS ASP-59; LEU-94; LYS-139; PRO-308; GLN-1029 AND 1055-ASN-ASN-1056.
    Strain: 129/Sv.
  3. "Interacting quantitative trait loci control loss of peripheral tolerance and susceptibility to autoimmune ovarian dysgenesis after day 3 thymectomy in mice."
    Roper R.J., Ma R.Z., Biggins J.E., Butterfield R.J., Michael S.D., Tung K.S.K., Doerge R.W., Teuscher C.
    J. Immunol. 169:1640-1646(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
    Strain: A/J and C57BL/6J.
  4. "Identification and characterization of alternatively splicing variants for murine mater gene."
    Cheng H., Zhang X.J., Liu H.B., Zhang Y., Huang Z.F., Ma R.L.
    Yi Chuan Xue Bao 31:795-800(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 5; 6; 7 AND 8).
    Strain: A/J, C57BL/6J, CBA/J and SWR/J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Egg.
  6. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 397-722.
    Strain: C57BL/6J.
    Tissue: Egg.
  7. "Mater, a maternal effect gene required for early embryonic development in mice."
    Tong Z.-B., Gold L., Pfeifer K.E., Dorward H., Lee E., Bondy C.A., Dean J., Nelson L.M.
    Nat. Genet. 26:267-268(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Developmental expression and subcellular localization of mouse MATER, an oocyte-specific protein essential for early development."
    Tong Z.-B., Gold L., De Pol A., Vanevski K., Dorward H., Sena P., Palumbo C., Bondy C.A., Nelson L.M.
    Endocrinology 145:1427-1434(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
  9. "A subcortical maternal complex essential for preimplantation mouse embryogenesis."
    Li L., Baibakov B., Dean J.
    Dev. Cell 15:416-425(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE SCMC COMPLEX WITH KHDC3; OOEP AND TLE6, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiNALP5_MOUSE
AccessioniPrimary (citable) accession number: Q9R1M5
Secondary accession number(s): Q3UXD0
, Q53ZD5, Q6VSF9, Q6VSG0, Q6VSG1, Q6VSG2, Q6VSG3, Q6VSG4, Q6VSG5, Q6XZF2, Q7TPU9, Q9JLR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: May 1, 2007
Last modified: June 8, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.