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Protein
Submitted name:

Lecithin-cholesterol acyltransferase

Gene

Lcat

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. phosphatidylcholine-sterol O-acyltransferase activity Source: Ensembl

GO - Biological processi

  1. cholesterol esterification Source: Ensembl
  2. cholesterol homeostasis Source: Ensembl
  3. cholesterol metabolic process Source: Ensembl
  4. high-density lipoprotein particle remodeling Source: Ensembl
  5. lipoprotein biosynthetic process Source: Ensembl
  6. phosphatidylcholine biosynthetic process Source: Ensembl
  7. regulation of high-density lipoprotein particle assembly Source: Ensembl
  8. reverse cholesterol transport Source: Ensembl
  9. very-low-density lipoprotein particle remodeling Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Enzyme and pathway databases

ReactomeiREACT_346849. HDL-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Submitted name:
Lecithin-cholesterol acyltransferaseImported
Gene namesi
Name:LcatImported
Synonyms:LCATImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2993. Lcat.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. high-density lipoprotein particle Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ9R1M1. baseline and differential.
GenevestigatoriQ9R1M1.

Family & Domainsi

Family and domain databases

InterProiIPR003386. LACT/PDAT_acylTrfase.
[Graphical view]
PfamiPF02450. LCAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9R1M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
DGFISLGAPW GGSIKPMRIL ASGDNQGIPI MSNIKLREEQ RITTTSP
Length:47
Mass (Da):5,055
Last modified:May 1, 2000 - v1
Checksum:iAFECF1C4BD6D2372
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei47 – 471Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074964 Genomic DNA. Translation: AAD40188.1.
UniGeneiRn.10481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074964 Genomic DNA. Translation: AAD40188.1.
UniGeneiRn.10481.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi2993. Lcat.

Enzyme and pathway databases

ReactomeiREACT_346849. HDL-mediated lipid transport.

Gene expression databases

ExpressionAtlasiQ9R1M1. baseline and differential.
GenevestigatoriQ9R1M1.

Family and domain databases

InterProiIPR003386. LACT/PDAT_acylTrfase.
[Graphical view]
PfamiPF02450. LCAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of QTLs for serum total cholesterol levels in stroke-prone spontaneously hypertensive rats."
    Kato N., Tamada T., Nabika T., Ueno K., Gotoda T., Matsumoto C., Mashimo T., Sawamura M., Ikeda K., Nara Y., Yamori Y.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Stroke-prone spontaneously hypertensive ratImported.

Entry informationi

Entry nameiQ9R1M1_RAT
AccessioniPrimary (citable) accession number: Q9R1M1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 1, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.