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Q9R1K7

- TBD_MOUSE

UniProt

Q9R1K7 - TBD_MOUSE

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Protein

Tubulin delta chain

Gene
Tubd1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi143 – 1497GTP Reviewed prediction

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. structural constituent of cytoskeleton Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. microtubule-based process Source: InterPro
  3. multicellular organismal development Source: UniProtKB-KW
  4. protein polymerization Source: InterPro
  5. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin delta chain
Alternative name(s):
Delta-tubulin
Gene namesi
Name:Tubd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1891826. Tubd1.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole. Cytoplasm. Nucleus
Note: Associated with centrioles. Both cytoplasmic and nuclear.

GO - Cellular componenti

  1. centriole Source: UniProtKB-SubCell
  2. cytoplasm Source: MGI
  3. microtubule Source: UniProtKB-KW
  4. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Tubulin delta chainPRO_0000048485Add
BLAST

Proteomic databases

PRIDEiQ9R1K7.

PTM databases

PhosphoSiteiQ9R1K7.

Expressioni

Tissue specificityi

Highly expressed in testis.

Gene expression databases

ArrayExpressiQ9R1K7.
BgeeiQ9R1K7.
CleanExiMM_TUBD1.
GenevestigatoriQ9R1K7.

Structurei

3D structure databases

ProteinModelPortaliQ9R1K7.
SMRiQ9R1K7. Positions 3-450.

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.

Phylogenomic databases

eggNOGiCOG5023.
GeneTreeiENSGT00530000063251.
HOGENOMiHOG000006615.
HOVERGENiHBG000807.
KOiK10390.
OrthoDBiEOG7KH9JK.
TreeFamiTF329833.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002967. Delta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PTHR11588:SF4. PTHR11588:SF4. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR01224. DELTATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1K7-1 [UniParc]FASTAAdd to Basket

« Hide

MSIVTVQLGQ CGNQIGFEVF DALFRDSHCS QGLCSKRDNE AYQASCRERF    50
FREEENGVPV ARAVLVDMEP KVINQTLSKA AQSGRWNYGQ HTSFCQKQGS 100
GNNWAYGYSV HGPKHEESIM NLIQTEVEKC DSLSGFFIIM SMAGGTGSGL 150
GAFVTQKLQD QYSSSLKMNQ IIWPYGTGEV IVQNYNSILT LSHLYRSSDA 200
LLIHENDAVH KICAKRMNIK QISFRDLNQV LAHQLGSVFQ PTYSEDSSFH 250
YRRNPLGDLM EHLVPHPEFK MLGVRNIPQM SAASLAYSAF TWAGLLKHLR 300
QMLISSAKME EGINWQVRPP LTGLPPIGKA SAHKEHHFNT SLANLVVLRG 350
REVHSADVEG FKDPALYTSW LEPVDAFSVW KTQRAFDKYE KSAALVSNSQ 400
LLVKPLDMIV GKAWNMFSSK AFIHQYTKFG MEEEDFLDSF ALLEQVVASY 450
GSLGP 455
Length:455
Mass (Da):51,023
Last modified:May 1, 2000 - v1
Checksum:i97755668BC193092
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF081568 mRNA. Translation: AAD52009.1.
BC026465 mRNA. Translation: AAH26465.1.
CCDSiCCDS25202.1.
RefSeqiNP_001185976.1. NM_001199047.1.
NP_062730.1. NM_019756.3.
UniGeneiMm.383207.

Genome annotation databases

EnsembliENSMUST00000069503; ENSMUSP00000064383; ENSMUSG00000020513.
ENSMUST00000167178; ENSMUSP00000130909; ENSMUSG00000020513.
GeneIDi56427.
KEGGimmu:56427.
UCSCiuc007kss.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF081568 mRNA. Translation: AAD52009.1 .
BC026465 mRNA. Translation: AAH26465.1 .
CCDSi CCDS25202.1.
RefSeqi NP_001185976.1. NM_001199047.1.
NP_062730.1. NM_019756.3.
UniGenei Mm.383207.

3D structure databases

ProteinModelPortali Q9R1K7.
SMRi Q9R1K7. Positions 3-450.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9R1K7.

Proteomic databases

PRIDEi Q9R1K7.

Protocols and materials databases

DNASUi 56427.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000069503 ; ENSMUSP00000064383 ; ENSMUSG00000020513 .
ENSMUST00000167178 ; ENSMUSP00000130909 ; ENSMUSG00000020513 .
GeneIDi 56427.
KEGGi mmu:56427.
UCSCi uc007kss.1. mouse.

Organism-specific databases

CTDi 51174.
MGIi MGI:1891826. Tubd1.

Phylogenomic databases

eggNOGi COG5023.
GeneTreei ENSGT00530000063251.
HOGENOMi HOG000006615.
HOVERGENi HBG000807.
KOi K10390.
OrthoDBi EOG7KH9JK.
TreeFami TF329833.

Miscellaneous databases

NextBioi 312590.
PROi Q9R1K7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9R1K7.
Bgeei Q9R1K7.
CleanExi MM_TUBD1.
Genevestigatori Q9R1K7.

Family and domain databases

Gene3Di 1.10.287.600. 1 hit.
3.40.50.1440. 1 hit.
InterProi IPR002967. Delta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view ]
PANTHERi PTHR11588. PTHR11588. 1 hit.
PTHR11588:SF4. PTHR11588:SF4. 1 hit.
Pfami PF00091. Tubulin. 1 hit.
[Graphical view ]
PRINTSi PR01224. DELTATUBULIN.
PR01161. TUBULIN.
SMARTi SM00864. Tubulin. 1 hit.
[Graphical view ]
SUPFAMi SSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEi PS00227. TUBULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Tissue-specific expression and subcellular localisation of mammalian delta-tubulin."
    Smrzka O.W., Delgehyr N., Bornens M.
    Curr. Biol. 10:413-416(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiTBD_MOUSE
AccessioniPrimary (citable) accession number: Q9R1K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi