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Q9R1K7

- TBD_MOUSE

UniProt

Q9R1K7 - TBD_MOUSE

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Protein

Tubulin delta chain

Gene

Tubd1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi143 – 1497GTPSequence Analysis

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. structural constituent of cytoskeleton Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. microtubule-based process Source: InterPro
  3. multicellular organismal development Source: UniProtKB-KW
  4. protein polymerization Source: InterPro
  5. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin delta chain
Alternative name(s):
Delta-tubulin
Gene namesi
Name:Tubd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1891826. Tubd1.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole. Cytoplasm. Nucleus
Note: Associated with centrioles. Both cytoplasmic and nuclear.

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. microtubule Source: UniProtKB-KW
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Tubulin delta chainPRO_0000048485Add
BLAST

Proteomic databases

PRIDEiQ9R1K7.

PTM databases

PhosphoSiteiQ9R1K7.

Expressioni

Tissue specificityi

Highly expressed in testis.

Gene expression databases

BgeeiQ9R1K7.
CleanExiMM_TUBD1.
ExpressionAtlasiQ9R1K7. baseline and differential.
GenevestigatoriQ9R1K7.

Structurei

3D structure databases

ProteinModelPortaliQ9R1K7.
SMRiQ9R1K7. Positions 3-450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiCOG5023.
GeneTreeiENSGT00530000063251.
HOGENOMiHOG000006615.
HOVERGENiHBG000807.
InParanoidiQ9R1K7.
KOiK10390.
OrthoDBiEOG7KH9JK.
TreeFamiTF329833.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002967. Delta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PTHR11588:SF4. PTHR11588:SF4. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR01224. DELTATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1K7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIVTVQLGQ CGNQIGFEVF DALFRDSHCS QGLCSKRDNE AYQASCRERF
60 70 80 90 100
FREEENGVPV ARAVLVDMEP KVINQTLSKA AQSGRWNYGQ HTSFCQKQGS
110 120 130 140 150
GNNWAYGYSV HGPKHEESIM NLIQTEVEKC DSLSGFFIIM SMAGGTGSGL
160 170 180 190 200
GAFVTQKLQD QYSSSLKMNQ IIWPYGTGEV IVQNYNSILT LSHLYRSSDA
210 220 230 240 250
LLIHENDAVH KICAKRMNIK QISFRDLNQV LAHQLGSVFQ PTYSEDSSFH
260 270 280 290 300
YRRNPLGDLM EHLVPHPEFK MLGVRNIPQM SAASLAYSAF TWAGLLKHLR
310 320 330 340 350
QMLISSAKME EGINWQVRPP LTGLPPIGKA SAHKEHHFNT SLANLVVLRG
360 370 380 390 400
REVHSADVEG FKDPALYTSW LEPVDAFSVW KTQRAFDKYE KSAALVSNSQ
410 420 430 440 450
LLVKPLDMIV GKAWNMFSSK AFIHQYTKFG MEEEDFLDSF ALLEQVVASY

GSLGP
Length:455
Mass (Da):51,023
Last modified:May 1, 2000 - v1
Checksum:i97755668BC193092
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081568 mRNA. Translation: AAD52009.1.
BC026465 mRNA. Translation: AAH26465.1.
CCDSiCCDS25202.1.
RefSeqiNP_001185976.1. NM_001199047.1.
NP_062730.1. NM_019756.3.
UniGeneiMm.383207.

Genome annotation databases

EnsembliENSMUST00000069503; ENSMUSP00000064383; ENSMUSG00000020513.
ENSMUST00000167178; ENSMUSP00000130909; ENSMUSG00000020513.
GeneIDi56427.
KEGGimmu:56427.
UCSCiuc007kss.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081568 mRNA. Translation: AAD52009.1 .
BC026465 mRNA. Translation: AAH26465.1 .
CCDSi CCDS25202.1.
RefSeqi NP_001185976.1. NM_001199047.1.
NP_062730.1. NM_019756.3.
UniGenei Mm.383207.

3D structure databases

ProteinModelPortali Q9R1K7.
SMRi Q9R1K7. Positions 3-450.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9R1K7.

Proteomic databases

PRIDEi Q9R1K7.

Protocols and materials databases

DNASUi 56427.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000069503 ; ENSMUSP00000064383 ; ENSMUSG00000020513 .
ENSMUST00000167178 ; ENSMUSP00000130909 ; ENSMUSG00000020513 .
GeneIDi 56427.
KEGGi mmu:56427.
UCSCi uc007kss.1. mouse.

Organism-specific databases

CTDi 51174.
MGIi MGI:1891826. Tubd1.

Phylogenomic databases

eggNOGi COG5023.
GeneTreei ENSGT00530000063251.
HOGENOMi HOG000006615.
HOVERGENi HBG000807.
InParanoidi Q9R1K7.
KOi K10390.
OrthoDBi EOG7KH9JK.
TreeFami TF329833.

Miscellaneous databases

NextBioi 312590.
PROi Q9R1K7.
SOURCEi Search...

Gene expression databases

Bgeei Q9R1K7.
CleanExi MM_TUBD1.
ExpressionAtlasi Q9R1K7. baseline and differential.
Genevestigatori Q9R1K7.

Family and domain databases

Gene3Di 1.10.287.600. 1 hit.
3.40.50.1440. 1 hit.
InterProi IPR002967. Delta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view ]
PANTHERi PTHR11588. PTHR11588. 1 hit.
PTHR11588:SF4. PTHR11588:SF4. 1 hit.
Pfami PF00091. Tubulin. 1 hit.
[Graphical view ]
PRINTSi PR01224. DELTATUBULIN.
PR01161. TUBULIN.
SMARTi SM00864. Tubulin. 1 hit.
[Graphical view ]
SUPFAMi SSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEi PS00227. TUBULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Tissue-specific expression and subcellular localisation of mammalian delta-tubulin."
    Smrzka O.W., Delgehyr N., Bornens M.
    Curr. Biol. 10:413-416(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiTBD_MOUSE
AccessioniPrimary (citable) accession number: Q9R1K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3