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Protein

Tubulin delta chain

Gene

Tubd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi143 – 1497GTPSequence Analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin delta chain
Alternative name(s):
Delta-tubulin
Gene namesi
Name:Tubd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1891826. Tubd1.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB-SubCell
  • cytoplasm Source: MGI
  • microtubule Source: UniProtKB-KW
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Tubulin delta chainPRO_0000048485Add
BLAST

Proteomic databases

PRIDEiQ9R1K7.

PTM databases

PhosphoSiteiQ9R1K7.

Expressioni

Tissue specificityi

Highly expressed in testis.

Gene expression databases

BgeeiQ9R1K7.
CleanExiMM_TUBD1.
ExpressionAtlasiQ9R1K7. baseline and differential.
GenevisibleiQ9R1K7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020821.

Structurei

3D structure databases

ProteinModelPortaliQ9R1K7.
SMRiQ9R1K7. Positions 3-450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiCOG5023.
GeneTreeiENSGT00530000063251.
HOGENOMiHOG000006615.
HOVERGENiHBG000807.
InParanoidiQ9R1K7.
KOiK10390.
OrthoDBiEOG7KH9JK.
TreeFamiTF329833.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002967. Delta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PTHR11588:SF4. PTHR11588:SF4. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR01224. DELTATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIVTVQLGQ CGNQIGFEVF DALFRDSHCS QGLCSKRDNE AYQASCRERF
60 70 80 90 100
FREEENGVPV ARAVLVDMEP KVINQTLSKA AQSGRWNYGQ HTSFCQKQGS
110 120 130 140 150
GNNWAYGYSV HGPKHEESIM NLIQTEVEKC DSLSGFFIIM SMAGGTGSGL
160 170 180 190 200
GAFVTQKLQD QYSSSLKMNQ IIWPYGTGEV IVQNYNSILT LSHLYRSSDA
210 220 230 240 250
LLIHENDAVH KICAKRMNIK QISFRDLNQV LAHQLGSVFQ PTYSEDSSFH
260 270 280 290 300
YRRNPLGDLM EHLVPHPEFK MLGVRNIPQM SAASLAYSAF TWAGLLKHLR
310 320 330 340 350
QMLISSAKME EGINWQVRPP LTGLPPIGKA SAHKEHHFNT SLANLVVLRG
360 370 380 390 400
REVHSADVEG FKDPALYTSW LEPVDAFSVW KTQRAFDKYE KSAALVSNSQ
410 420 430 440 450
LLVKPLDMIV GKAWNMFSSK AFIHQYTKFG MEEEDFLDSF ALLEQVVASY

GSLGP
Length:455
Mass (Da):51,023
Last modified:May 1, 2000 - v1
Checksum:i97755668BC193092
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081568 mRNA. Translation: AAD52009.1.
BC026465 mRNA. Translation: AAH26465.1.
CCDSiCCDS25202.1.
RefSeqiNP_001185976.1. NM_001199047.1.
NP_062730.1. NM_019756.3.
UniGeneiMm.383207.

Genome annotation databases

EnsembliENSMUST00000069503; ENSMUSP00000064383; ENSMUSG00000020513.
ENSMUST00000167178; ENSMUSP00000130909; ENSMUSG00000020513.
GeneIDi56427.
KEGGimmu:56427.
UCSCiuc007kss.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081568 mRNA. Translation: AAD52009.1.
BC026465 mRNA. Translation: AAH26465.1.
CCDSiCCDS25202.1.
RefSeqiNP_001185976.1. NM_001199047.1.
NP_062730.1. NM_019756.3.
UniGeneiMm.383207.

3D structure databases

ProteinModelPortaliQ9R1K7.
SMRiQ9R1K7. Positions 3-450.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020821.

PTM databases

PhosphoSiteiQ9R1K7.

Proteomic databases

PRIDEiQ9R1K7.

Protocols and materials databases

DNASUi56427.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069503; ENSMUSP00000064383; ENSMUSG00000020513.
ENSMUST00000167178; ENSMUSP00000130909; ENSMUSG00000020513.
GeneIDi56427.
KEGGimmu:56427.
UCSCiuc007kss.1. mouse.

Organism-specific databases

CTDi51174.
MGIiMGI:1891826. Tubd1.

Phylogenomic databases

eggNOGiCOG5023.
GeneTreeiENSGT00530000063251.
HOGENOMiHOG000006615.
HOVERGENiHBG000807.
InParanoidiQ9R1K7.
KOiK10390.
OrthoDBiEOG7KH9JK.
TreeFamiTF329833.

Miscellaneous databases

NextBioi312590.
PROiQ9R1K7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R1K7.
CleanExiMM_TUBD1.
ExpressionAtlasiQ9R1K7. baseline and differential.
GenevisibleiQ9R1K7. MM.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002967. Delta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PTHR11588:SF4. PTHR11588:SF4. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR01224. DELTATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Tissue-specific expression and subcellular localisation of mammalian delta-tubulin."
    Smrzka O.W., Delgehyr N., Bornens M.
    Curr. Biol. 10:413-416(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiTBD_MOUSE
AccessioniPrimary (citable) accession number: Q9R1K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.