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Protein

Tubulin delta chain

Gene

Tubd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a positive regulator of hedgehog signaling and regulates ciliary function (PubMed:29290584).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi143 – 149GTPSequence analysis7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processCilium biogenesis/degradation
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin delta chain
Alternative name(s):
Delta-tubulin
Gene namesi
Name:Tubd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1891826 Tubd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000484851 – 455Tubulin delta chainAdd BLAST455

Proteomic databases

PRIDEiQ9R1K7

PTM databases

iPTMnetiQ9R1K7
PhosphoSitePlusiQ9R1K7

Expressioni

Tissue specificityi

Highly expressed in testis.

Gene expression databases

BgeeiENSMUSG00000020513
CleanExiMM_TUBD1
ExpressionAtlasiQ9R1K7 baseline and differential
GenevisibleiQ9R1K7 MM

Structurei

3D structure databases

ProteinModelPortaliQ9R1K7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000119061
HOGENOMiHOG000006615
HOVERGENiHBG000807
InParanoidiQ9R1K7
KOiK10390
TreeFamiTF329833

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002967 Delta_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PTHR11588:SF4 PTHR11588:SF4, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PRINTSiPR01224 DELTATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9R1K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIVTVQLGQ CGNQIGFEVF DALFRDSHCS QGLCSKRDNE AYQASCRERF
60 70 80 90 100
FREEENGVPV ARAVLVDMEP KVINQTLSKA AQSGRWNYGQ HTSFCQKQGS
110 120 130 140 150
GNNWAYGYSV HGPKHEESIM NLIQTEVEKC DSLSGFFIIM SMAGGTGSGL
160 170 180 190 200
GAFVTQKLQD QYSSSLKMNQ IIWPYGTGEV IVQNYNSILT LSHLYRSSDA
210 220 230 240 250
LLIHENDAVH KICAKRMNIK QISFRDLNQV LAHQLGSVFQ PTYSEDSSFH
260 270 280 290 300
YRRNPLGDLM EHLVPHPEFK MLGVRNIPQM SAASLAYSAF TWAGLLKHLR
310 320 330 340 350
QMLISSAKME EGINWQVRPP LTGLPPIGKA SAHKEHHFNT SLANLVVLRG
360 370 380 390 400
REVHSADVEG FKDPALYTSW LEPVDAFSVW KTQRAFDKYE KSAALVSNSQ
410 420 430 440 450
LLVKPLDMIV GKAWNMFSSK AFIHQYTKFG MEEEDFLDSF ALLEQVVASY

GSLGP
Length:455
Mass (Da):51,023
Last modified:May 1, 2000 - v1
Checksum:i97755668BC193092
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081568 mRNA Translation: AAD52009.1
BC026465 mRNA Translation: AAH26465.1
CCDSiCCDS25202.1
RefSeqiNP_001185976.1, NM_001199047.1
NP_062730.1, NM_019756.3
UniGeneiMm.383207

Genome annotation databases

EnsembliENSMUST00000069503; ENSMUSP00000064383; ENSMUSG00000020513
ENSMUST00000167178; ENSMUSP00000130909; ENSMUSG00000020513
GeneIDi56427
KEGGimmu:56427
UCSCiuc007kss.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTBD_MOUSE
AccessioniPrimary (citable) accession number: Q9R1K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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