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Protein

Probable G-protein coupled receptor 34

Gene

Gpr34

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 34
Gene namesi
Name:Gpr34
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1346334. Gpr34.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454ExtracellularSequence analysisAdd
BLAST
Transmembranei55 – 7521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini76 – 816CytoplasmicSequence analysis
Transmembranei82 – 10221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini103 – 12119ExtracellularSequence analysisAdd
BLAST
Transmembranei122 – 14221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini143 – 16422CytoplasmicSequence analysisAdd
BLAST
Transmembranei165 – 18521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini186 – 20924ExtracellularSequence analysisAdd
BLAST
Transmembranei210 – 23021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini231 – 26232CytoplasmicSequence analysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini284 – 30320ExtracellularSequence analysisAdd
BLAST
Transmembranei304 – 32421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini325 – 37551CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1075291.
GuidetoPHARMACOLOGYi101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Probable G-protein coupled receptor 34PRO_0000069560Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence analysis
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence analysis
Disulfide bondi120 ↔ 197PROSITE-ProRule annotation
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence analysis
Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9R1K6.
PRIDEiQ9R1K6.

PTM databases

PhosphoSiteiQ9R1K6.

Expressioni

Tissue specificityi

Broadly expressed.

Gene expression databases

BgeeiQ9R1K6.
CleanExiMM_GPR34.
ExpressionAtlasiQ9R1K6. baseline and differential.
GenevisibleiQ9R1K6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042715.

Structurei

3D structure databases

ProteinModelPortaliQ9R1K6.
SMRiQ9R1K6. Positions 3-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH53. Eukaryota.
ENOG410ZHRR. LUCA.
GeneTreeiENSGT00640000091213.
HOVERGENiHBG063715.
InParanoidiQ9R1K6.
KOiK08383.
OMAiYHAFRFV.
OrthoDBiEOG7NGQCP.
PhylomeDBiQ9R1K6.
TreeFamiTF330969.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9R1K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTSVDSWL CSSHGMHFIT NYSDQASQNF SGVPNVTSCP MDEKLLSTVL
60 70 80 90 100
TTFYSVIFLV GLVGNIIALY VFLGIHRKRN SIQIYLLNVA VADLLLIFCL
110 120 130 140 150
PFRIMYHINQ NKWTLGVILC KVVGTLFYMN MYISIILLGF ISLDRYIKIN
160 170 180 190 200
RSIQQRRAIT TKQSIYVCCI VWTVALAGFL TMIILTLKKG GHNSTMCFHY
210 220 230 240 250
RDRHNAKGEA IFNFVLVVMF WLIFLLIILS YIKIGKNLLR ISKRRSKFPN
260 270 280 290 300
SGKYATTARN SFIVLIIFTI CFVPYHAFRF IYISSQLNVS SCYWKEIIHK
310 320 330 340 350
TNEIMLVFSS FNSCLDPVMY FLMSSNIRKI MCQLLFRRFQ SEASRSESTS
360 370
EFKPGHSLHD LSVTVKMPQY STKGN
Length:375
Mass (Da):43,173
Last modified:May 1, 2000 - v1
Checksum:iC04E1C1A52521045
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081916 Genomic DNA. Translation: AAD50550.2.
CCDSiCCDS30028.1.
RefSeqiNP_035953.3. NM_011823.4.
XP_006527687.1. XM_006527624.2.
XP_006527688.1. XM_006527625.2.
XP_006527689.1. XM_006527626.2.
UniGeneiMm.487326.

Genome annotation databases

EnsembliENSMUST00000041708; ENSMUSP00000042715; ENSMUSG00000040229.
ENSMUST00000096492; ENSMUSP00000094236; ENSMUSG00000040229.
GeneIDi23890.
KEGGimmu:23890.
UCSCiuc009srs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081916 Genomic DNA. Translation: AAD50550.2.
CCDSiCCDS30028.1.
RefSeqiNP_035953.3. NM_011823.4.
XP_006527687.1. XM_006527624.2.
XP_006527688.1. XM_006527625.2.
XP_006527689.1. XM_006527626.2.
UniGeneiMm.487326.

3D structure databases

ProteinModelPortaliQ9R1K6.
SMRiQ9R1K6. Positions 3-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042715.

Chemistry

ChEMBLiCHEMBL1075291.
GuidetoPHARMACOLOGYi101.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9R1K6.

Proteomic databases

PaxDbiQ9R1K6.
PRIDEiQ9R1K6.

Protocols and materials databases

DNASUi23890.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041708; ENSMUSP00000042715; ENSMUSG00000040229.
ENSMUST00000096492; ENSMUSP00000094236; ENSMUSG00000040229.
GeneIDi23890.
KEGGimmu:23890.
UCSCiuc009srs.1. mouse.

Organism-specific databases

CTDi2857.
MGIiMGI:1346334. Gpr34.

Phylogenomic databases

eggNOGiENOG410IH53. Eukaryota.
ENOG410ZHRR. LUCA.
GeneTreeiENSGT00640000091213.
HOVERGENiHBG063715.
InParanoidiQ9R1K6.
KOiK08383.
OMAiYHAFRFV.
OrthoDBiEOG7NGQCP.
PhylomeDBiQ9R1K6.
TreeFamiTF330969.

Miscellaneous databases

NextBioi303645.
PROiQ9R1K6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9R1K6.
CleanExiMM_GPR34.
ExpressionAtlasiQ9R1K6. baseline and differential.
GenevisibleiQ9R1K6. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel subgroup of class I G-protein-coupled receptors."
    Schoneberg T., Schulz A., Grosse R., Schade R., Henklein P., Schultz G., Gudermann T.
    Biochim. Biophys. Acta 1446:57-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGPR34_MOUSE
AccessioniPrimary (citable) accession number: Q9R1K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.