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Q9R1J0 (NSDHL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

EC=1.1.1.170
Gene names
Name:Nsdhl
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis By similarity.

Catalytic activity

A 3-beta-hydroxysteroid-4-alpha-carboxylate + NAD(P)+ = a 3-oxosteroid + CO2 + NAD(P)H.

Pathway

Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 4/6.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Lipid droplet By similarity. Note: Trafficking through the Golgi is necessary for ER membrane localization By similarity.

Sequence similarities

Belongs to the 3-beta-HSD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
PRO_0000087800

Regions

Transmembrane287 – 30721Helical; Potential
Motif359 – 3624Prevents secretion from ER By similarity

Sites

Active site1611Proton acceptor By similarity
Binding site1651NAD By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9R1J0 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 4DB53EC0314885C3

FASTA36240,686
        10         20         30         40         50         60 
MEQAVHGESK RGQVTGTHLT NDISKAKKCT VIGGSGFLGQ HMVEQLLERG YTVNVFDIHQ 

        70         80         90        100        110        120 
GFDNPRVQFF IGDLCNQQDL YPALKGVSTV FHCASPPPYS NNKELFYRVN FIGTKTVIET 

       130        140        150        160        170        180 
CREAGVQKLI LTSSASVVFE GVDIKNGTED LPYAMKPIDY YTETKILQER AVLDANDPKK 

       190        200        210        220        230        240 
NFLTAAIRPH GIFGPRDPQL VPILIDAARK GKMKFMIGNG ENLVDFTFVE NVVHGHILAA 

       250        260        270        280        290        300 
EHLSQDAALG GKAFHITNDE PIPFWTFLSR ILTGLNYEAP KYHIPYWMAY YLAFLLSLLV 

       310        320        330        340        350        360 
MVVSPLIQIQ PTFTPIRVAL AGTFHYYSCE KAKKLFGYRP LVTMDEAVER TVQSFHHLRK 


DK 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF100198 mRNA. Translation: AAD38448.1.
AL021127 Genomic DNA. Translation: CAA15948.2.
CCDSCCDS30190.1.
RefSeqNP_035071.3. NM_010941.3.
UniGeneMm.38792.

3D structure databases

ProteinModelPortalQ9R1J0.
SMRQ9R1J0. Positions 26-355.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9R1J0. 3 interactions.
MINTMINT-1837653.
STRING10090.ENSMUSP00000033715.

PTM databases

PhosphoSiteQ9R1J0.

Proteomic databases

MaxQBQ9R1J0.
PaxDbQ9R1J0.
PRIDEQ9R1J0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033715; ENSMUSP00000033715; ENSMUSG00000031349.
GeneID18194.
KEGGmmu:18194.
UCSCuc009tkv.1. mouse.

Organism-specific databases

CTD50814.
MGIMGI:1099438. Nsdhl.

Phylogenomic databases

eggNOGCOG0451.
GeneTreeENSGT00550000074557.
HOGENOMHOG000167989.
HOVERGENHBG054675.
InParanoidQ9R1J0.
KOK07748.
OMAEPMRDQV.
OrthoDBEOG77M8NP.
PhylomeDBQ9R1J0.
TreeFamTF354279.

Enzyme and pathway databases

UniPathwayUPA00770; UER00757.

Gene expression databases

ArrayExpressQ9R1J0.
BgeeQ9R1J0.
CleanExMM_NSDHL.
GenevestigatorQ9R1J0.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002225. 3Beta_OHSteriod_DH/Estase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01073. 3Beta_HSD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNSDHL. mouse.
NextBio293544.
PROQ9R1J0.
SOURCESearch...

Entry information

Entry nameNSDHL_MOUSE
AccessionPrimary (citable) accession number: Q9R1J0
Secondary accession number(s): O55109
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot